Preparation of verapamil hydrochloride controlled-onset extended-release pellets and its pharmacokinetics in dogs

Yaoxue Xuebao

Volumn 41, Issue 8, 2006, Pages 765-771

  Chen, Zhi Peng ^a   Xiao, Yan Yu ^a   Chen, Hong Xuan ^b   Chen, Xi Jing ^a   Li, La Rui ^a   Zhu, Jia Bi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b HENAN UNIVERSITY   (China)

Author keywords

Controlled onset; Extended release; Pellet; Pharmacokinetics; Verapamil hydrochloride

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CELLULOSE; DRUG DERIVATIVE; ETHYL CELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; METHYLCELLULOSE; VERAPAMIL;

ANIMAL; ARTICLE; BIOAVAILABILITY; CHEMISTRY; DELAYED RELEASE FORMULATION; DOG; DRUG STABILITY; ORAL DRUG ADMINISTRATION; SCANNING ELECTRON MICROSCOPY;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALCIUM CHANNEL BLOCKERS; CELLULOSE; DELAYED-ACTION PREPARATIONS; DOGS; DRUG STABILITY; METHYLCELLULOSE; MICROSCOPY, ELECTRON, SCANNING; VERAPAMIL;

EID: 33750198985     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. 2-blockers and cardiovascular active drugs [J]. Adv Drug Deliv Rev, 1991, 6: 83-100.
2. Zhang Y, Zhang ZR. Preperation of terbutaline sulphate pulsatile release tablet and mechanism elucidation [J]. Acta Pharm Sin, 2003, 38:854-858.
3. Guo T, Zheng CL, Song HT, et al. Studies on diclofenac sodium pulsatile release pellets [J]. Acta Pharm Sin, 2003, 38:707-710.
4. Culter NR, Andrs RJ. Placebo-controlled evaluation of three doses of a controlled-onset, extended-release formulation of verapamil in the treatment of stable angina pectoris [J]. Am J Cardiol, 1995, 75:1102-1106.
5. Li YH, Zhu JB. Modulation of combined-release behaviors from a novel "tablets-in-capsule system" [J]. J Control Release, 2004, 95:381-389.
6. Anwar YA, White WB. Chronotherapeutics for cardiovascular disease [J]. Drugs, 1998, 55:639-643.
7. White WB, Sica DA, Calhoun D, et al. Preventing increases in early-morning blood pressure, heart rate, and the rate-pressure product with controlled onset extended release verapamil at bedtime versus enalapril, losartan, and placebo on arising [J]. Am Heart J, 2002, 144: 657-665.
8. Satoshi UEDA, Hisani Y, Masateru K, et al. Development of a novel drug release system, time-controlled explosion system (TES). II. Design of multiparticulate TES and in vitro drug release properties [J]. Chem Pharm Bull, 1994, 42:359-363.