IL-6 is an independent risk factor for resistance to erythropoiesis-stimulating agents in hemodialysis patients without iron deficiency

Hemodialysis International

Volumn 16, Issue 1, 2012, Pages 31-37

  Won, Hye Sung ^a   Kim, Hyun Gyung ^b   Yun, Yu Seon ^a   Jeon, Eun Kyoung ^a   Ko, Yoon Ho ^a   Kim, Young Soo ^a   Kim, Young Ok ^a   Yoon, Sun Ae ^a  

^a Uijeongbu St Mary's Hospital   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

Erythropoiesis stimulating agents; Hemodialysis; Hepcidin; Hyporesponsiveness; Interleukin 6

Indexed keywords

C REACTIVE PROTEIN; ERYTHROPOIETIN; FERROUS SULFATE; HEMOGLOBIN; HEPCIDIN; INTERLEUKIN 6; IRON; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; RECOMBINANT ERYTHROPOIETIN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HEMODIALYSIS; HUMAN; IRON BLOOD LEVEL; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; RISK FACTOR; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; ANEMIA; ANTIMICROBIAL CATIONIC PEPTIDES; C-REACTIVE PROTEIN; CROSS-SECTIONAL STUDIES; DRUG RESISTANCE; FEMALE; HEMATINICS; HUMANS; INTERLEUKIN-6; IRON; MALE; MIDDLE AGED; RENAL DIALYSIS; RISK FACTORS;

EID: 84863073172     PISSN: 14927535     EISSN: 15424758     Source Type: Journal    
DOI: 10.1111/j.1542-4758.2011.00635.x     Document Type: Article

References (16)

1. Panichi V, Rosati A, Bigazzi R, etal. Anaemia and resistance to erythropoiesis-stimulating agents as prognostic factors in haemodialysis patients: Results from the RISCAVID study. Nephrol Dial Transplant. 2011; 26:2641-2648.
2. Smrzova J, Balla J, Bárány P. Inflammation and resistance to erythropoiesis-stimulating agents-What do we know and what needs to be clarified? Nephrol Dial Transplant. 2005; 20(Suppl 8):viii2-viii7.
3. Priyadarshi A, Shapiro JI. Erythropoietin resistance in the treatment of the anemia of chronic renal failure. Semin Dial. 2006; 19:273-278.
4. van der Putten K, Braam B, Jie KE, Gaillard CA. Mechanisms of disease: Erythropoietin resistance in patients with both heart and kidney failure. Nat Clin Pract Nephrol. 2008; 4:47-57.
5. Kalantar-Zadeh K, McAllister CJ, Lehn RS, Lee GH, Nissenson AR, Kopple JD. Effect of malnutrition-inflammation complex syndrome on EPO hyporesponsiveness in maintenance hemodialysis patients. Am J Kidney Dis. 2003; 42:761-773.
6. Eleftheriadis T, Vassilios L, Georgia A, Kartsios C, Stefanidis I. The role of hepcidin in iron homeostasis and anemia in hemodialysis patients. Semin Dial. 2009; 22:70-77.
7. Eleftheriadis T, Kartsios C, Liakopoulos V, etal. Does hepcidin affect erythropoiesis in hemodialysis patients? Acta Haematol. 2006; 116:2382-2344.
8. Daugirdas J. Second generation logarithmic estimates of single-pool variable Kt/V: An analysis of error. J Am Soc Nephrol. 1993; 4:1205-1213.
9. Daugirdas J, Depner T. A nomogram approach to hemodialysis urea modeling. Am J Kidney Dis. 1994; 23:33-40.
10. Macdougall IC, Gray SJ, Elston O, etal. Pharmacokinetics of novel erythropoiesis stimulating protein compared with epoetin alfa in dialysis patients. J Am Soc Nephrol. 1999; 10:2392-2395.
11. Eleftheriadis T, Antoniadi G, Liakopoulos V, Kartsios C, Stefanidis I. Disturbances of acquired immunity in hemodialysis patients. Semin Dial. 2007; 20:440-451.
12. Kwon KH, Hwang KH, Kim KS. Determinants of erythropoietin resistance in hemodialysis patients: EPO resistance in HD patients. Korean J Med. 2000; 58:510-515.
13. Brǎtescu LO, Bârsan L, Munteanu D, Stancu S, Mircescu G. Is hepcidin-25 a clinically relevant parameter for the iron status in hemodialysis patients? J Ren Nutr. 2010; 25(Suppl 5):S77-S83.
14. Vokurka M, Krijt J, Sulc K, Hepcidin NE. mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res. 2006; 55:667-674.
15. Costa E, Swinkels DW, Laarakkers CM, etal. Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in haemodialysis patients. Acta Haematol. 2009; 122:226-229.
16. Malyszko J, Malyszko JS, Pawlak K, Mysliwiec M. Hepcidin, iron status, and renal function in chronic renal failure, kidney transplantation, and hemodialysis. Am J Hematol. 2006; 81:832-837.