Human endogenous retrovirus K(HML-2) Gag- and Env-specific T-cell responses are infrequently detected in HIV-1-infected subjects using standard peptide matrix-based screening

Clinical and Vaccine Immunology

Volumn 19, Issue 2, 2012, Pages 288-292

  Jones, R Brad ^a,b   John, Vivek M ^a,b   Hunter, Diana V ^a,b   Martin, Eric ^a,b   Mujib, Shariq ^a,b   Mihajlovic, Vesna ^a,b   Burgers, Peter C ^c   Luider, Theo M ^c   Gyenes, Gabor ^a,b   Sheppard, Neil C ^d   SenGupta, Devi ^e   Tandon, Ravi ^e   Yue, Feng Yun ^a,b   Benko, Erika ^f   Kovacs, Colin ^f   Nixon, Douglas F ^e   Ostrowski, Mario A ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d PFIZER INC   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f MAPLE LEAF MEDICAL CLINIC   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GAG PROTEIN; PEPTIDE; VIRUS ENVELOPE PROTEIN;

ANALYTIC METHOD; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTAMINATION; CONTROLLED STUDY; ENDOGENOUS RETROVIRUS; FALSE POSITIVE RESULT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LYMPHOCYTE CLONE; PEPTIDE MAPPING; PRIORITY JOURNAL; SCREENING TEST; SENSITIVITY AND SPECIFICITY;

ENDOGENOUS RETROVIRUSES; GENE PRODUCTS, ENV; GENE PRODUCTS, GAG; HIV INFECTIONS; HIV-1; HUMANS; PEPTIDE MAPPING; RNA, VIRAL; T-LYMPHOCYTES;

EID: 84863038092     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.05583-11     Document Type: Article

References (30)

1. Addo MM, et al. 2003. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol. 77:2081-2092. (Pubitemid 36110021)
2. Bannert N, Kurth R. 2006. The evolutionary dynamics of human endogenous retroviral families. Annu. Rev. Genomics Hum. Genet. 7:149-173. (Pubitemid 44627926)
3. Barbulescu M, et al. 1999. Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans. Curr. Biol. 9:861-868. (Pubitemid 29456003)
4. Beattie T, et al. 2004. Screening for HIV-specific T-cell responses using overlapping 15-mer peptide pools or optimized epitopes. AIDS 18:1595-1598. (Pubitemid 39037485)
5. Berkhout B, Jebbink M, Zsiros J. 1999. Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus. J. Virol. 73:2365-2375. (Pubitemid 29098142)
6. + T-cell responses: relationship to viral load in untreated HIV infection. J. Virol. 75:11983-11991.
7. Currier JR, et al. 2008. Peptide impurities in commercial synthetic peptides and their implications for vaccine trial assessment. Clin. Vaccine Immunol. 15:267-276. (Pubitemid 352025532)
8. de Beukelaar JW, et al. 2007. The impact of impurities in synthetic peptides on the outcome of T-cell stimulation assays. Rapid Commun. Mass Spectrom. 21:1282-1288.
9. de Graaf MT, et al. 2008. Contamination of synthetic HuD protein spanning peptide pools with a CMV-encoded peptide. Cytometry A 73:1079-1085.
10. Dewannieux M, Blaise S, Heidmann T. 2005. Identification of a functional envelope protein from the HERV-K family of human endogenous retroviruses. J. Virol. 79:15573-15577. (Pubitemid 43032339)
11. Draenert R, et al. 2003. Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4T cell responses. J. Immunol. Methods 275:19-29. (Pubitemid 36351539)
12. Garrison KE, et al. 2007. T cell responses to human endogenous retroviruses in HIV-1 infection. PLoS Pathog. 3:e165.
13. Harris JM, Haynes RH, McIntosh EM. 1997. A consensus sequence for a functional human endogenous retrovirus K (HERV-K) dUTPase. Biochem. Cell Biol. 75:143-151. (Pubitemid 127733138)
14. Jern P, Sperber GO, Blomberg J. 2005. Use of endogenous retroviral sequences (ERVs) and structural markers for retroviral phylogenetic inference and taxonomy. Retrovirology 2:50.
15. Jones RB, et al. 2008. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J. Exp. Med. 205:2763-2779.
16. + T-cell responses without highfrequency fixation of mutations. J. Virol. 83:8722- 8732.
17. Kiecker F, et al. 2004. Analysis of antigen-specific T-cell responses with synthetic peptides - what kind of peptide for which purpose? Hum. Immunol. 65:523-536. (Pubitemid 38686777)
18. Luckey CJ, et al. 1998. Proteasomes can either generate or destroy MHC class I epitopes: evidence for nonproteasomal epitope generation in the cytosol. J. Immunol. 161:112-121. (Pubitemid 28285513)
19. Magin C, Lower R, Lower J. 1999. cORF and RcRE, the Rev/Rex and RRE/RxRE homologues of the human endogenous retrovirus family HTDV/HERV-K. J. Virol. 73:9496-9507. (Pubitemid 29487105)
20. Mayer J, et al. 1999. An almost-intact human endogenous retrovirus K on human chromosome 7. Nat. Genet. 21:257-258. (Pubitemid 29124927)
21. Mueller-Lantzsch N, et al. 1993. Human endogenous retroviral element K10 (HERV-K10) encodes a full-length gag homologous 73-kDa protein and a functional protease. AIDS Res. Hum. Retroviruses 9:343-350. (Pubitemid 23144058)
22. Nixon DF, et al. 1988. HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides. Nature 336:484-487.
23. Reus K, et al. 2001. Genomic organization of the human endogenous retrovirus HERV-K(HML-2.HOM) (ERVK6) on chromosome 7. Genomics 72:314-320. (Pubitemid 32281533)
24. Rodda SJ. 2002. Peptide libraries for T cell epitope screening and characterization. J. Immunol. Methods 267:71-77. (Pubitemid 34804813)
25. SenGupta D, et al. 2011. Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection. J. Virol. 85:6977-6985.
26. Takahashi Y, et al. 2008. Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells. J. Clin. Invest. 118:1099-1109. (Pubitemid 351364617)
27. Tandon R, et al. 2011. Identification of human endogenous retrovirusspecific T cell responses in vertically HIV-1-infected subjects. J. Virol. 85:11526-11531.
28. Tristem M. 2000. Identification and characterization of novel human endogenous retrovirus families by phylogenetic screening of the human genome mapping project database. J. Virol. 74:3715-3730. (Pubitemid 30180315)
29. Turner G, et al. 2001. Insertional polymorphisms of full-length endogenous retroviruses in humans. Curr. Biol. 11:1531-1535. (Pubitemid 32931016)
30. Yang J, et al. 1999. An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein. Proc. Natl. Acad. Sci. U. S. A. 96:13404-13408.