Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: Restoration of mitochondrial function and phospholipids remodeling

American Journal of Translational Research

Volumn 4, Issue 1, 2012, Pages 60-71

  Yang, Bo ^a   Fan, Pengcheng ^a   Xu, Aimin ^a   Lam, Karen S L ^a   Berger, Thorsten ^b   Mak, Tak W ^b   Tse, Hung Fat ^a   Yue, Jessie W S ^a   Song, Erfei ^a   Vanhoutte, Paul M ^a   Sweeney, Gary ^c   Wang, Yu ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c YORK UNIVERSITY   (Canada)

Author keywords

Adipokine; Heart; Lipocalin 2; Mitochondria; Phospholipids

Indexed keywords

CARDIOLIPIN; LINOLEIC ACID; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CELL DENSITY; CELL FUNCTION; CELL ULTRASTRUCTURE; CHEMICAL ANALYSIS; CONTROLLED STUDY; CONVALESCENCE; ECHOCARDIOGRAPHY; ELECTRON MICROSCOPY; HEART; HEART CONTRACTION; HEART FUNCTION; HEART INFARCTION SIZE; INTERMETHOD COMPARISON; LIPID DIET; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REPERFUSION INJURY; RESPIRATORY CHAIN;

MUS;

EID: 84863031506     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 1993; 268: 10425-10432.
2. Goetz DH, Willie ST, Armen RS, Bratt T, Borregaard N, Strong RK. Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin. Biochemistry 2000; 39: 1935-1941.
3. Hoo RC, Yeung CY, Lam KS, Xu A. Inflammatory biomarkers associated with obesity and insulin resistance: a focus on lipocalin-2 and adipocyte fatty acid-binding protein. Expert Rev Endocrinol Metab 2008; 3: 29-41.
4. Lin Y, Rajala MW, Berger JP, Moller DE, Barzilai N, Scherer PE. Hyperglycemia-induced production of acute phase reactants in adipose tissue. J Biol Chem 2001; 276: 42077-42083.
5. Kratchmarova I, Kalume DE, Blagoev B, Scherer PE, Podtelejnikov AV, Molina H, Bickel PE, Andersen JS, Fernandez MM, Bunkenborg J, Roepstorff P, Kristiansen K, Lodish HF, Mann M, Pandey A. A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes. Mol Cell Proteomics 2002; 1: 213-222.
6. Wang Y, Lam KS, Kraegen EW, Sweeney G, Zhang J, Tso AW, Chow WS, Wat NM, Xu JY, Hoo RL, Xu A. Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clin Chem 2007; 53: 34-41.
7. Baudry A, Yang ZZ, Hemmings BA. PKBα is required for adipose differentiation of mouse embryonic fibroblasts. J Cell Sci 2006; 119: 889-897.
8. Karlsen JR, Borregaard N, Cowland JB. Induction of neutrophil gelatinase-associated lipocalin expression by co-stimulation with interleukin-17 and tumor necrosis factor-α is controlled by IkappaB-zeta but neither by C/EBPbeta nor C/EBP-delta. J Biol Chem 2010; 285: 14088-14100.
9. Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 2005; 365: 1231-1238.
10. Wang Y. Small lipid-binding proteins in regulating endothelial and vascular functions: focusing on adipocyte fatty acid binding protein and lipocalin-2. Br J Pharmacol 2011.
11. Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Silva C, Rotellar F, Gil M, Cienfuegos J, Salvador J, Frühbeck G. Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans. J Mol Med 2009; 87: 803-813.
12. Law IK, Xu A, Lam KS, Berger T, Mak TW, Vanhoutte PM, Liu JT, Sweeney G, Zhou M, Yang B, Wang Y. Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes 2010; 59: 872-882.
13. Panidis D, Tziomalos K, Koiou E, Kandaraki EA, Tsourdi E, Delkos D, Kalaitzakis E, Katsikis I. The effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a crosssectional study. Reprod Biol Endocrinol 2010; 8: 151.
14. van Dam RM, Hu FB. Lipocalins and insulin resistance: etiological role of retinol-binding protein 4 and lipocalin-2? Clin Chem 2007; 53: 5-7.
15. Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, Rosen ED. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes 2007; 56: 2533-2540.
16. Liu JT, Song E, Xu A, Berger T, Mak TW, Tse HF, Law IK, Huang B, Liang Y, Vanhoutte PM, Wang Y. Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition. Br J Pharmacol 2012; 165: 520-531.
17. Bolignano D, Coppolino G, Lacquaniti A, Buemi M. From kidney to cardiovascular diseases: NGAL as a biomarker beyond the confines of nephrology. Eur J Clin Invest 2010; 40: 273-276.
18. Choi KM, Lee JS, Kim EJ, Baik SH, Seo HS, Choi DS, Oh DJ, Park CG. Implication of lipocalin-2 and visfatin levels in patients with coronary heart disease. Eur J Endocrinol 2008; 158: 203-207.
19. Lee YH, Lee SH, Jung ES, Kim JS, Shim CY, Ko YG, Choi D, Jang Y, Chung N, Ha JW. Visceral adiposity and the severity of coronary artery disease in middle-aged subjects with normal waist circumference and its relation with lipocalin-2 and MCP-1. Atherosclerosis 2010; 213: 592-597.
20. Alvelos M, Pimentel R, Pinho E, Gomes A, Lourenco P, Teles MJ, Almeida P, Guimaraes JT, Bettencourt P. Neutrophil Gelatinase-Associated Lipocalin in the Diagnosirs of Type 1 Cardio-Renal Syndrome in the General Ward. Clin J Am Soc Nephrol 2010; 6: 476-481.
21. Bolignano D, Basile G, Parisi P, Coppolino G, Nicocia G, Buemi M. Increased plasma neutrophil gelatinase-associated lipocalin levels predict mortality in elderly patients with chronic heart failure. Rejuvenation Res 2009; 12: 7-14.
22. Ding L, Hanawa H, Ota Y, Hasegawa G, Hao K, Asami F, Watanabe R, Yoshida T, Toba K, Yoshida K, Ogura M, Kodama M, Aizawa Y. Lipocalin-2/neutrophil gelatinase-B associated lipocalin is strongly induced in hearts of rats with autoimmune myocarditis and in human myocarditis. Circ J 2010; 74: 523-530.
23. Hemdahl AL, Gabrielsen A, Zhu C, Eriksson P, Hedin U, Kastrup J, Thoren P, Hansson GK. Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction. Arterioscler Thromb Vasc Biol 2006; 26: 136-142.
24. Yndestad A, Landro L, Ueland T, Dahl CP, Flo TH, Vinge LE, Espevik T, Froland SS, Husberg C, Christensen G, Dickstein K, Kjekshus J, Oie E, Gullestad L, Aukrust P. Increased systemic and myocardial expression of neutrophil gelatinaseassociated lipocalin in clinical and experimental heart failure. Eur Heart J 2009; 30: 1229-1236.
25. Aigner F, Maier HT, Schwelberger HG, Wallnofer EA, Amberger A, Obrist P, Berger T, Mak TW, Maglione M, Margreiter R, Schneeberger S, Troppmair J. Lipocalin-2 regulates the inflammatory response during ischemia and reperfusion of the transplanted heart. Am J Transplant 2007; 7: 779-788.
26. Amberger A, Schneeberger S, Hernegger G, Brandacher G, Obrist P, Lackner P, Margreiter R, Mark W. Gene expression profiling of prolonged cold ischemia and reperfusion in murine heart transplants. Transplantation 2002; 74: 1441-1449.
27. Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C, Trush MA, Semenza GL. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. Cardiovasc Res 2008; 77: 463-470.
28. Zhou M, Xu A, Tam PK, Lam KS, Chan L, Hoo RL, Liu J, Chow KH, Wang Y. Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury. Hepatology 2008; 48: 1087-1096.
29. Pietsch A, Lorenz R. Rapid separation of the major phospholipid classes on a single aminopropyl cartridge Lipids 1993; 28: 945-947.
30. Minkler PE, Hoppel CL. Separation and characterization of cardiolipin molecular species by reverse-phase ion pair high-performance liquid chromatography-mass spectrometry. J Lipid Res 2010; 51: 856-865.
31. Damman K, van Veldhuisen DJ, Navis G, Voors AA, Hillege HL. Urinary neutrophil gelatinase associated lipocalin (NGAL), a marker of tubular damage, is increased in patients with chronic heart failure. Eur J Heart Fail 2008; 10: 997-1000.
32. Gustafsson AB, Gottlieb RA. Heart mitochondria: gates of life and death. Cardiovasc Res 2008; 77: 334-343.
33. Neubauer S. The failing heart-an engine out of fuel. N Engl J Med 2007; 356: 1140-1151.
34. Sadek HA, Nulton-Persson AC, Szweda PA, Szweda LI. Cardiac ischemia/reperfusion, aging, and redox-dependent alterations in mitochondrial function. Arch Biochem Biophys 2003; 420: 201-208.
35. Hatch GM. Cardiolipin: biosynthesis, remodeling and trafficking in the heart and mammalian cells (Review). Int J Mol Med 1998; 1: 33-41.
36. Shi Y. Emerging roles of cardiolipin remodeling in mitochondrial dysfunction associated with disbetes, obesity and cardiovascular diseases. Journal of Biomedical Research 2010; 24: 6-15.
37. Pfeiffer K, Gohil V, Stuart RA, Hunte C, Brandt U, Greenberg ML, Schagger H. Cardiolipin stabilizes respiratory chain supercomplexes. J Biol Chem 2003; 278: 52873-52880.
38. Schlame M, Ren M. The role of cardiolipin in the structural organization of mitochondrial membranes. Biochim Biophys Acta 2009; 1788: 2080-2083.
39. Sparagna GC, Lesnefsky EJ. Cardiolipin remodeling in the heart. J Cardiovasc Pharmacol 2009; 53: 290-301.
40. Lesnefsky EJ, Minkler P, Hoppel CL. Enhanced modification of cardiolipin during ischemia in the aged heart. J Mol Cell Cardiol 2009; 46: 1008-1015.
41. Sparagna GC, Johnson CA, McCune SA, Moore RL, Murphy RC. Quantitation of cardiolipin molecular species in spontaneously hypertensive heart failure rats using electrospray ionization mass spectrometry. J Lipid Res 2005; 46: 1196-1204.
42. Han X, Yang J, Yang K, Zhao Z, Abendschein DR, Gross RW. Alterations in myocardial cardiolipin content and composition occur at the very earliest stages of diabetes: a shotgun lipidomics study. Biochemistry 2007; 46: 6417-6428.
43. Jenkins CM, Cedars A, Gross RW. Eicosanoid signalling pathways in the heart. Cardiovasc Res 2009; 82: 240-249.
44. Brown JH, Martinson EA. Phosphoinositidegenerated second messengers in cardiac signal transduction. Trends Cardiovasc Med 1992; 2: 209-214.
45. Shepherd PR, Withers DJ, Siddle K. Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 1998; 333: 471-490.
46. Hermelink A, Kirsch C, Klinger R, Reiter G, Brezesinski G. Adsorption of GST-PI3Kgamma at the air-buffer interface and at substrate and nonsubstrate phospholipid monolayers. Biophys J 2009; 96: 1026-1025.
47. MacDonalda JI, Sprecher H. Phospholipid fatty acid remodeling in mammalian cells Biochimica et Biophysica Acta-Lipids and Lipid Metabolism 1991; 1084: 105-121.
48. Houtkooper RH, Turkenburg M, Poll-The BT, Karall D, Pérez-Cerdá C, Morrone A, Malvagia S, Wanders RJ, Kulik W, Vaz FM. The enigmatic role of tafazzin in cardiolipin metabolism. Biochim Biophys Acta 2009; 1788: 2003-2014.
49. Yamashita A, Sugiura T, Waku K. Acyltransferases and transacylases involved in fatty acid remodeling of phospholipids and metabolism of bioactive lipids in mammalian cells. J Biochem 1997; 122: 1-16.