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Volumn 3, Issue 1, 2008, Pages 29-41

Inflammatory biomarkers associated with obesity and insulin resistance: A focus on lipocalin-2 and adipocyte fatty acid-binding protein

Author keywords

Adipocyte fatty acid binding protein; Adipokine; Cardiovascular disease; Diabetes; Inflammation; Lipocalin 2; Obesity

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPOCYTE FATTY ACID BINDING PROTEIN; ADIPOCYTE FATTY ACID BINDING PROTEIN INHIBITOR; ADIPOCYTOKINE; ANTIINFLAMMATORY AGENT; BINDING PROTEIN; C REACTIVE PROTEIN; CHEMOKINE; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOCALIN 2 PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; ROSIGLITAZONE; SALICYLIC ACID DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG;

EID: 37549058420     PISSN: 17446651     EISSN: None     Source Type: Journal    
DOI: 10.1586/17446651.3.1.29     Document Type: Review
Times cited : (26)

References (132)
  • 2
    • 34247869042 scopus 로고    scopus 로고
    • The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas
    • Giovannucci E, Michaud D. The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology 132, 2208-2225 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 2208-2225
    • Giovannucci, E.1    Michaud, D.2
  • 3
    • 37549056727 scopus 로고    scopus 로고
    • Cellular inflammatory responses: Novel insights for obesity and insulin resistance
    • Chen H. Cellular inflammatory responses: novel insights for obesity and insulin resistance. Pharmacol. Res. 22, 22 (2006).
    • (2006) Pharmacol. Res , vol.22 , pp. 22
    • Chen, H.1
  • 4
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • Shoelson,SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology 132, 2169-2180 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 5
    • 0030731621 scopus 로고    scopus 로고
    • NIDDM as a disease of the innate immune system: Association of acute-phase reactants and interleukin-6 with metabolic syndrome X
    • Pickup JC, Mattock MB, Chusney GD, Burt D. NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 40, 1286-1292 (1997).
    • (1997) Diabetologia , vol.40 , pp. 1286-1292
    • Pickup, J.C.1    Mattock, M.B.2    Chusney, G.D.3    Burt, D.4
  • 6
    • 4644337374 scopus 로고    scopus 로고
    • Elevations in markers of liver injury and risk of Type 2 diabetes: The insulin resistance atherosclerosis study
    • Hanley AJ, Williams K, Festa A et al. Elevations in markers of liver injury and risk of Type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes 53, 2623-2632(2004).
    • (2004) Diabetes , vol.53 , pp. 2623-2632
    • Hanley, A.J.1    Williams, K.2    Festa, A.3
  • 7
    • 0042524670 scopus 로고    scopus 로고
    • C-reactive protein predicts the deterioration of glycemia in Chinese subjects with impaired glucose tolerance
    • Tan KC, War NM, Tam SC, Janus ED, Lam TH, Lam KS. C-reactive protein predicts the deterioration of glycemia in Chinese subjects with impaired glucose tolerance. Diabetes Care 26, 2323-2328 (2003).
    • (2003) Diabetes Care , vol.26 , pp. 2323-2328
    • Tan, K.C.1    War, N.M.2    Tam, S.C.3    Janus, E.D.4    Lam, T.H.5    Lam, K.S.6
  • 8
    • 0346365086 scopus 로고    scopus 로고
    • Explaining how "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis
    • Sattar N, McCarey DW, Capell H, McInnes IB. Explaining how "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation 108, 2957-2963 (2003).
    • (2003) Circulation , vol.108 , pp. 2957-2963
    • Sattar, N.1    McCarey, D.W.2    Capell, H.3    McInnes, I.B.4
  • 10
    • 3142590775 scopus 로고    scopus 로고
    • Association of diabetes and hepatitis C infection: Epidemiologic evidence and pathophysiologic insights
    • Bahtiyar G, Shin JJ, Aytaman A, Sowers JR, McFarlane SI. Association of diabetes and hepatitis C infection: epidemiologic evidence and pathophysiologic insights. Curr. Diab. Rep. 4, 194-198 (2004).
    • (2004) Curr. Diab. Rep , vol.4 , pp. 194-198
    • Bahtiyar, G.1    Shin, J.J.2    Aytaman, A.3    Sowers, J.R.4    McFarlane, S.I.5
  • 11
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ
    • Yuan M, Konstantopoulos N, Lee J et al Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ. Science 293, 1673-1677 (2001).
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3
  • 12
    • 0035936527 scopus 로고    scopus 로고
    • Pravastatin and the development of diabetes mellitus: Evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study
    • Freeman DJ, Norrie J, Sattar N et al. Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study. Circulation 103, 357-362 (2001).
    • (2001) Circulation , vol.103 , pp. 357-362
    • Freeman, D.J.1    Norrie, J.2    Sattar, N.3
  • 13
    • 33745685394 scopus 로고    scopus 로고
    • The reduction of inflammatory biomarkers by statin, fibrate, and combination therapy among diabetic patients with mixed dyslipidemia: The DIACOR (Diabetes and Combined Lipid Therapy Regimen) study
    • Muhlestein JB, May HT, Jensen JR et al. The reduction of inflammatory biomarkers by statin, fibrate, and combination therapy among diabetic patients with mixed dyslipidemia: the DIACOR (Diabetes and Combined Lipid Therapy Regimen) study. J. Am. Coll. Cardiol. 48, 396-401 (2006).
    • (2006) J. Am. Coll. Cardiol , vol.48 , pp. 396-401
    • Muhlestein, J.B.1    May, H.T.2    Jensen, J.R.3
  • 15
    • 2942655390 scopus 로고    scopus 로고
    • Evidence for a potent antiinflammatory effect of rosightazone
    • Mohanty P, Aljada A, Ghanim H et al. Evidence for a potent antiinflammatory effect of rosightazone. J. Clin. Endocrinol. Metab. 89, 2728-2735 (2004).
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , pp. 2728-2735
    • Mohanty, P.1    Aljada, A.2    Ghanim, H.3
  • 16
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259, 87-91 (1993).
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 17
    • 33644750396 scopus 로고    scopus 로고
    • Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes
    • Hotamisligil GS. Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 54(Suppl. 2), S73-S78 (2005).
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Hotamisligil, G.S.1
  • 18
    • 7044230885 scopus 로고    scopus 로고
    • Possible novel therapy for diabetes with cell-permeable JNK-irihibitory peptide
    • Kaneto H, Nakatani Y, Miyatsuka T et al. Possible novel therapy for diabetes with cell-permeable JNK-irihibitory peptide. Nat. Med. 10, 1128-1132 (2004).
    • (2004) Nat. Med , vol.10 , pp. 1128-1132
    • Kaneto, H.1    Nakatani, Y.2    Miyatsuka, T.3
  • 19
    • 20044387026 scopus 로고    scopus 로고
    • IKK-β links inflammation to obesity-induced insulin resistance
    • Arkan MC, Hevener AL, Greten FR et al. IKK-β links inflammation to obesity-induced insulin resistance. Nat. Med. 11, 191-198 (2005).
    • (2005) Nat. Med , vol.11 , pp. 191-198
    • Arkan, M.C.1    Hevener, A.L.2    Greten, F.R.3
  • 20
    • 2942628012 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
    • Ueki K, Kondo T, Kahn CR. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol. Cell Biol. 24, 5434-5446 (2004).
    • (2004) Mol. Cell Biol , vol.24 , pp. 5434-5446
    • Ueki, K.1    Kondo, T.2    Kahn, C.R.3
  • 21
    • 4544256147 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling
    • Shi H, Tzameli I, Bjorbaek C, Flier JS. Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling. J Biol. Chem. 279, 34733-34740 (2004).
    • (2004) J Biol. Chem , vol.279 , pp. 34733-34740
    • Shi, H.1    Tzameli, I.2    Bjorbaek, C.3    Flier, J.S.4
  • 22
    • 3142782772 scopus 로고    scopus 로고
    • Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
    • Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjorbaek C, Flier JS. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat. Med. 10, 734-738 (2004).
    • (2004) Nat. Med , vol.10 , pp. 734-738
    • Howard, J.K.1    Cave, B.J.2    Oksanen, L.J.3    Tzameli, I.4    Bjorbaek, C.5    Flier, J.S.6
  • 23
    • 33751552452 scopus 로고    scopus 로고
    • Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-ldnase signaling
    • Steinberg GR, Michell BJ, van Denderen BJ et al. Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-ldnase signaling. Cell Metab. 4, 465-474 (2006).
    • (2006) Cell Metab , vol.4 , pp. 465-474
    • Steinberg, G.R.1    Michell, B.J.2    van Denderen, B.J.3
  • 24
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: Mediators linking adipose tissue, inflammation and immunity
    • Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat. Rev. Immunol. 6, 772-783 (2006).
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 25
    • 18144408371 scopus 로고    scopus 로고
    • Adipose tissue, adipokines, and inflammation
    • Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin. Immunol. 115, 911-919 (2005).
    • (2005) J Allergy Clin. Immunol , vol.115 , pp. 911-919
    • Fantuzzi, G.1
  • 27
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112, 1821-1830 (2003).
    • (2003) J. Clin. Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 28
    • 2342537773 scopus 로고    scopus 로고
    • From blood monocytes to adipose tissue-resident macrophages: Induction of diapedesis by human mature adipocytes
    • Curat CA, Miranville A, Sengenes C et al. From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes 53, 1285-1292 (2004).
    • (2004) Diabetes , vol.53 , pp. 1285-1292
    • Curat, C.A.1    Miranville, A.2    Sengenes, C.3
  • 29
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti S, Mitchell G, Barbatelli G et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46, 2347-2355 (2005).
    • (2005) J. Lipid Res , vol.46 , pp. 2347-2355
    • Cinti, S.1    Mitchell, G.2    Barbatelli, G.3
  • 31
    • 0038660699 scopus 로고    scopus 로고
    • Preadipocyte conversion to macrophage. Evidence of plasticity
    • Charriere G, Cousin B, Arnaud E et al. Preadipocyte conversion to macrophage. Evidence of plasticity. J. Biol. Chem. 278, 9850-9855 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 9850-9855
    • Charriere, G.1    Cousin, B.2    Arnaud, E.3
  • 32
    • 33748750917 scopus 로고    scopus 로고
    • Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance
    • Kamei N, Tobe K, Suzuki R et al. Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J. Biol. Chem. 281, 26602-26614 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 26602-26614
    • Kamei, N.1    Tobe, K.2    Suzuki, R.3
  • 33
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • Kanda H, Tateya S, Tamori Y et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Invest. 116, 1494-1505 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 1494-1505
    • Kanda, H.1    Tateya, S.2    Tamori, Y.3
  • 34
    • 35148854599 scopus 로고    scopus 로고
    • Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    • Ye J, Gao Z, Yin J, He Q. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am. J. Physiol. Endocrinol. Metab. (2007).
    • (2007) Am. J. Physiol. Endocrinol. Metab
    • Ye, J.1    Gao, Z.2    Yin, J.3    He, Q.4
  • 35
    • 34948902196 scopus 로고    scopus 로고
    • Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: The Framingham Heart Study
    • Pou KM, Massaro JM, Hoffmann U et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation 116, 1234-1241 (2007).
    • (2007) Circulation , vol.116 , pp. 1234-1241
    • Pou, K.M.1    Massaro, J.M.2    Hoffmann, U.3
  • 36
    • 0033515761 scopus 로고    scopus 로고
    • Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
    • Arita Y, Kihara S, Ouchi N et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257, 79-83 (1999).
    • (1999) Biochem. Biophys. Res. Commun , vol.257 , pp. 79-83
    • Arita, Y.1    Kihara, S.2    Ouchi, N.3
  • 37
    • 0027256664 scopus 로고
    • Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase
    • Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J. Biol. Chem. 268, 10425-10432 (1993).
    • (1993) J. Biol. Chem , vol.268 , pp. 10425-10432
    • Kjeldsen, L.1    Johnsen, A.H.2    Sengelov, H.3    Borregaard, N.4
  • 38
    • 0034728351 scopus 로고    scopus 로고
    • Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin
    • Goetz DH, Willie ST, Armen RS, Bratt T, Borregaard N, Strong RK. Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin. Biochemistry 39, 1935-1941 (2000).
    • (2000) Biochemistry , vol.39 , pp. 1935-1941
    • Goetz, D.H.1    Willie, S.T.2    Armen, R.S.3    Bratt, T.4    Borregaard, N.5    Strong, R.K.6
  • 39
    • 0032876327 scopus 로고    scopus 로고
    • Interactions between neutrophil gelatinase-associated lipocalin and natural lipophilic ligands
    • Bratt T, Ohlson S, Borregaard N. Interactions between neutrophil gelatinase-associated lipocalin and natural lipophilic ligands. Biochim. Biophys. Acta 1472, 262-269 (1999).
    • (1999) Biochim. Biophys. Acta , vol.1472 , pp. 262-269
    • Bratt, T.1    Ohlson, S.2    Borregaard, N.3
  • 40
    • 0034684233 scopus 로고    scopus 로고
    • Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse
    • Kjeldsen L, Cowland JB, Borregaard N. Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse. Biochim. Biophys. Acta 1482, 272-283 (2000).
    • (2000) Biochim. Biophys. Acta , vol.1482 , pp. 272-283
    • Kjeldsen, L.1    Cowland, J.B.2    Borregaard, N.3
  • 41
    • 0034684168 scopus 로고    scopus 로고
    • The lipocalin protein family: Structural and sequence overview
    • Flower DR, North AC, Sansom CE. The lipocalin protein family: structural and sequence overview. Biochim. Biophys. Acta 1482, 9-24 (2000).
    • (2000) Biochim. Biophys. Acta , vol.1482 , pp. 9-24
    • Flower, D.R.1    North, A.C.2    Sansom, C.E.3
  • 42
    • 0029894116 scopus 로고    scopus 로고
    • Demonstration of a glycoprotein derived from the 24p3 gene in mouse uterine luminal fluid
    • Chu ST, Huang HL, Chen JM, Chen YH. Demonstration of a glycoprotein derived from the 24p3 gene in mouse uterine luminal fluid. Biochem. J. 316 (Pt 2), 545-550 (1996).
    • (1996) Biochem. J , vol.316 , Issue.PART 2 , pp. 545-550
    • Chu, S.T.1    Huang, H.L.2    Chen, J.M.3    Chen, Y.H.4
  • 43
    • 0344132583 scopus 로고    scopus 로고
    • Glycosylation of natural human neutrophil gelatinase B and neutrophil gelatinase B-associated lipocalin
    • Rudd PM, Mattu TS, Masure S et al. Glycosylation of natural human neutrophil gelatinase B and neutrophil gelatinase B-associated lipocalin. Biochemistry 38, 13937-13950 (1999).
    • (1999) Biochemistry , vol.38 , pp. 13937-13950
    • Rudd, P.M.1    Mattu, T.S.2    Masure, S.3
  • 44
    • 0024320333 scopus 로고
    • SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism
    • Hraba-Renevey S, Turler H, Kress M, Salomon C, Weil R. SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism. Oncogene 4, 601-608 (1989).
    • (1989) Oncogene , vol.4 , pp. 601-608
    • Hraba-Renevey, S.1    Turler, H.2    Kress, M.3    Salomon, C.4    Weil, R.5
  • 45
    • 11144314814 scopus 로고    scopus 로고
    • Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
    • Flo TH, Smith KD, Sato S et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432, 917-921 (2004).
    • (2004) Nature , vol.432 , pp. 917-921
    • Flo, T.H.1    Smith, K.D.2    Sato, S.3
  • 46
    • 33750795321 scopus 로고    scopus 로고
    • The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2
    • Fischbach MA, Lin H, Zhou L et al. The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc. Natl Acad. Sci. USA 103, 16502-16507 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 16502-16507
    • Fischbach, M.A.1    Lin, H.2    Zhou, L.3
  • 47
    • 20044395425 scopus 로고    scopus 로고
    • Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    • Mori K, Lee HT, Rapoport D et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J. Clin. Invest. 115, 610-621 (2005).
    • (2005) J. Clin. Invest , vol.115 , pp. 610-621
    • Mori, K.1    Lee, H.T.2    Rapoport, D.3
  • 48
    • 32444442757 scopus 로고    scopus 로고
    • Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury
    • Berger T, Togawa A, Duncan GS et al. Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc. Natl Acad. Sci. USA 103, 1834-1839 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 1834-1839
    • Berger, T.1    Togawa, A.2    Duncan, G.S.3
  • 49
    • 33748094845 scopus 로고    scopus 로고
    • Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair
    • Playford RJ, Belo A, Poulsom R et al. Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair. Gastroenterology 131, 809-817 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 809-817
    • Playford, R.J.1    Belo, A.2    Poulsom, R.3
  • 50
    • 0037616349 scopus 로고    scopus 로고
    • Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886
    • Tong Z, Wu X, Kehrer JP, Increased expression of the lipocalin 24p3 as an apoptotic mechanism for MK886. Biochem. J. 372, 203-210 (2003).
    • (2003) Biochem. J , vol.372 , pp. 203-210
    • Tong, Z.1    Wu, X.2    Kehrer, J.P.3
  • 51
  • 52
    • 12744272449 scopus 로고    scopus 로고
    • The endocytic receptor megatin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake
    • Hvidberg V, Jacobsen C, Strong RK, Cowland JB, Moestrup SK, Borregaard N. The endocytic receptor megatin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett. 579, 773-777 (2005).
    • (2005) FEBS Lett , vol.579 , pp. 773-777
    • Hvidberg, V.1    Jacobsen, C.2    Strong, R.K.3    Cowland, J.B.4    Moestrup, S.K.5    Borregaard, N.6
  • 53
    • 29244492306 scopus 로고    scopus 로고
    • A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake
    • Devireddy LR, Gazin C, Zhu X, Green MR. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 123, 1293-1305 (2005).
    • (2005) Cell , vol.123 , pp. 1293-1305
    • Devireddy, L.R.1    Gazin, C.2    Zhu, X.3    Green, M.R.4
  • 54
    • 0346996867 scopus 로고    scopus 로고
    • Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 β, but not by TNF-α
    • Cowland JB, Sorensen OE, Sehested M, Borregaard N. Neutrophil gelatinase-associated lipocalin is up-regulated in human epithelial cells by IL-1 β, but not by TNF-α. J. Immunol. 171, 6630-6639 (2003).
    • (2003) J. Immunol , vol.171 , pp. 6630-6639
    • Cowland, J.B.1    Sorensen, O.E.2    Sehested, M.3    Borregaard, N.4
  • 55
    • 0027198001 scopus 로고
    • Identification by microsequencing of lipopolysaccharide-induced proteins secreted by mouse macrophages
    • Meheus LA, Fransen LM, Raymackers JG et al. Identification by microsequencing of lipopolysaccharide-induced proteins secreted by mouse macrophages. J. Immunol. 151, 1535-1547 (1993).
    • (1993) J. Immunol , vol.151 , pp. 1535-1547
    • Meheus, L.A.1    Fransen, L.M.2    Raymackers, J.G.3
  • 56
    • 0038014072 scopus 로고    scopus 로고
    • Macrophage-induced rat mesangial cell expression of the 24p3-like protein α-2-microglobulin-related protein
    • Pawluczyk IZ, Furness PN, Harris KP. Macrophage-induced rat mesangial cell expression of the 24p3-like protein α-2-microglobulin-related protein. Biochim. Biophys. Acta 1645, 218-227 (2003).
    • (2003) Biochim. Biophys. Acta , vol.1645 , pp. 218-227
    • Pawluczyk, I.Z.1    Furness, P.N.2    Harris, K.P.3
  • 57
    • 33745385110 scopus 로고    scopus 로고
    • Effects of dexamethazone on LPS-induced activation and migration of mouse dendritic cells revealed by a genome-wide transcriptional analysis
    • Vizzardelli C, Pavelka N, Luchini A et al. Effects of dexamethazone on LPS-induced activation and migration of mouse dendritic cells revealed by a genome-wide transcriptional analysis. Eur. J. Immunol. 36, 1504-1515 (2006).
    • (2006) Eur. J. Immunol , vol.36 , pp. 1504-1515
    • Vizzardelli, C.1    Pavelka, N.2    Luchini, A.3
  • 58
    • 34547893117 scopus 로고    scopus 로고
    • Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-κB
    • Bu DX, Hemdahl AL, Gabrielsen A et al. Induction of neutrophil gelatinase-associated lipocalin in vascular injury via activation of nuclear factor-κB. Am. J. Pathol. 169, 2245-2253 (2006).
    • (2006) Am. J. Pathol , vol.169 , pp. 2245-2253
    • Bu, D.X.1    Hemdahl, A.L.2    Gabrielsen, A.3
  • 59
    • 33646006080 scopus 로고    scopus 로고
    • IL-1β-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IκB-ζ
    • Cowland JB, Muta T, Borregaard N. IL-1β-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IκB-ζ. J. Immunol. 176, 5559-5566 (2006).
    • (2006) J. Immunol , vol.176 , pp. 5559-5566
    • Cowland, J.B.1    Muta, T.2    Borregaard, N.3
  • 60
    • 30144442455 scopus 로고    scopus 로고
    • Toll-like receptor 2-dependent and -independent activation of macrophages by group B streptococci
    • Draper DW, Bethea HN, He YW. Toll-like receptor 2-dependent and -independent activation of macrophages by group B streptococci. Immunol. Lett. 102, 202-214 (2006).
    • (2006) Immunol. Lett , vol.102 , pp. 202-214
    • Draper, D.W.1    Bethea, H.N.2    He, Y.W.3
  • 61
    • 0031754132 scopus 로고    scopus 로고
    • Increasing levels of leukocyte-derived inflammatory mediators in plasma and cAMP in platelets during fbilow-up after acute cerebral ischemia
    • Anwaar I, Gottsater A. Ohlsson K, Mattiasson I, Lindgarde F. Increasing levels of leukocyte-derived inflammatory mediators in plasma and cAMP in platelets during fbilow-up after acute cerebral ischemia. Cerebrovasc. Dis. 8, 310-317 (1998).
    • (1998) Cerebrovasc. Dis , vol.8 , pp. 310-317
    • Anwaar, I.1    Gottsater, A.2    Ohlsson, K.3    Mattiasson, I.4    Lindgarde, F.5
  • 62
    • 0033974568 scopus 로고    scopus 로고
    • Leukocyte activation: Relation to cardiovascular mortality after cerebrovascular ischemia
    • Falke P, Elneihoum AM, Ohlsson K. Leukocyte activation: relation to cardiovascular mortality after cerebrovascular ischemia. Cerebrovasc. Dis. 10, 97-101 (2000).
    • (2000) Cerebrovasc. Dis , vol.10 , pp. 97-101
    • Falke, P.1    Elneihoum, A.M.2    Ohlsson, K.3
  • 63
    • 20144388328 scopus 로고    scopus 로고
    • Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    • Mishra J, Dent C, Tarabishi R et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365, 1231-1238 (2005).
    • (2005) Lancet , vol.365 , pp. 1231-1238
    • Mishra, J.1    Dent, C.2    Tarabishi, R.3
  • 64
    • 34447642181 scopus 로고    scopus 로고
    • Detection of subclinical tubular injury after renal transplantation: Comparison of urine protein analysis with allograft histopathology
    • Schaub S, Mayr M, Honger G et al. Detection of subclinical tubular injury after renal transplantation: comparison of urine protein analysis with allograft histopathology. Transplantation 84, 104-112 (2007).
    • (2007) Transplantation , vol.84 , pp. 104-112
    • Schaub, S.1    Mayr, M.2    Honger, G.3
  • 65
    • 33745108383 scopus 로고    scopus 로고
    • Urinary neutrophil gelatinase-associated lipocalcin in D+HUS: A novel marker of renal injury
    • Trachtman H, Christen E, Cnaan A et al. Urinary neutrophil gelatinase-associated lipocalcin in D+HUS: a novel marker of renal injury. Pediatr. Nephrol. 21, 989-994 (2006).
    • (2006) Pediatr. Nephrol , vol.21 , pp. 989-994
    • Trachtman, H.1    Christen, E.2    Cnaan, A.3
  • 66
    • 0029115795 scopus 로고
    • Identification of a new acute phase protein
    • Liu Q, Nilsen-Hamilton, M. Identification of a new acute phase protein. J. Biol. Chem. 270, 22565-22570 (1995).
    • (1995) J. Biol. Chem , vol.270 , pp. 22565-22570
    • Liu, Q.1    Nilsen-Hamilton, M.2
  • 67
    • 0034684232 scopus 로고    scopus 로고
    • Lipocalins as biochemical markers of disease
    • Xu S, Venge P. Lipocalins as biochemical markers of disease. Biochim. Biophys. Acta 1482, 298-307 (2000).
    • (2000) Biochim. Biophys. Acta , vol.1482 , pp. 298-307
    • Xu, S.1    Venge, P.2
  • 68
    • 14244256520 scopus 로고    scopus 로고
    • Cytokines link osteoblasts and inflammation: Microarray analysis of interleukin-17- and TNF-α-induced genes in bone cells
    • Shen F, Ruddy MJ, Plamondon P, Gaffen SL. Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-α-induced genes in bone cells. J. Leukoc. Biol. 77, 388-399 (2005).
    • (2005) J. Leukoc. Biol , vol.77 , pp. 388-399
    • Shen, F.1    Ruddy, M.J.2    Plamondon, P.3    Gaffen, S.L.4
  • 69
    • 33947594501 scopus 로고    scopus 로고
    • Lipocalin-2 regulates the inflammatory response during ischemia and reperfusion of the transplanted heart
    • Aigner F, Maier HT, Schwelberger HG et al. Lipocalin-2 regulates the inflammatory response during ischemia and reperfusion of the transplanted heart. Am. J. Transplant. 7, 779-788 (2007).
    • (2007) Am. J. Transplant , vol.7 , pp. 779-788
    • Aigner, F.1    Maier, H.T.2    Schwelberger, H.G.3
  • 70
    • 33644829033 scopus 로고    scopus 로고
    • Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction
    • Hemdahl AL, Gabrielsen A, Zhu C et al. Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction. Arterioscler Thromb. Vasc. Biol. 26, 136-142 (2006).
    • (2006) Arterioscler Thromb. Vasc. Biol , vol.26 , pp. 136-142
    • Hemdahl, A.L.1    Gabrielsen, A.2    Zhu, C.3
  • 71
    • 3042560032 scopus 로고    scopus 로고
    • Characterization of apoM in normal and genetically modified mice
    • Faber K, Axler O, Dahlback B, Nielsen LB. Characterization of apoM in normal and genetically modified mice. J. Lipid Res. 45, 1272-1278 (2004).
    • (2004) J. Lipid Res , vol.45 , pp. 1272-1278
    • Faber, K.1    Axler, O.2    Dahlback, B.3    Nielsen, L.B.4
  • 72
    • 0035813187 scopus 로고    scopus 로고
    • The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL
    • Yan L, Borregaard N, Kjeldsen L, Moses MA. The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL. J. Biol. Chem. 276, 37258-37265 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 37258-37265
    • Yan, L.1    Borregaard, N.2    Kjeldsen, L.3    Moses, M.A.4
  • 73
    • 0029762478 scopus 로고    scopus 로고
    • Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases
    • Elneihoum AM, Falke P, Axelsson L, Lundberg E, Lindgarde F, Ohlsson K. Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases. Stroke 27, 1734-1738 (1996).
    • (1996) Stroke , vol.27 , pp. 1734-1738
    • Elneihoum, A.M.1    Falke, P.2    Axelsson, L.3    Lundberg, E.4    Lindgarde, F.5    Ohlsson, K.6
  • 76
    • 0036491539 scopus 로고    scopus 로고
    • A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes
    • Kratchmarova I, Kalume DE, Blagoev B et al. A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes. Mol Cell Proteomics 1, 213-222 (2002).
    • (2002) Mol Cell Proteomics , vol.1 , pp. 213-222
    • Kratchmarova, I.1    Kalume, D.E.2    Blagoev, B.3
  • 77
    • 33645214765 scopus 로고    scopus 로고
    • PKBα is required for adipose differentiation of mouse embryonic fibroblasts
    • Baudry A, Yang ZZ, Hemmings BA. PKBα is required for adipose differentiation of mouse embryonic fibroblasts. J. Cell. Sci. 119, 889-897 (2006).
    • (2006) J. Cell. Sci , vol.119 , pp. 889-897
    • Baudry, A.1    Yang, Z.Z.2    Hemmings, B.A.3
  • 78
    • 33845973764 scopus 로고    scopus 로고
    • Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans
    • Wang Y, Lam KS, Kraegen EW et al. Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clin. Chem. 53, 34-41 (2007).
    • (2007) Clin. Chem , vol.53 , pp. 34-41
    • Wang, Y.1    Lam, K.S.2    Kraegen, E.W.3
  • 79
    • 34948856953 scopus 로고    scopus 로고
    • The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance
    • Yan QW, Yang Q, Mody N et al. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes 56(10), 2533-2540 (2007).
    • (2007) Diabetes , vol.56 , Issue.10 , pp. 2533-2540
    • Yan, Q.W.1    Yang, Q.2    Mody, N.3
  • 80
    • 23244465337 scopus 로고    scopus 로고
    • Identification of neutrophil gelatinase-associated lipocalin (NGAL) as a discriminatory marker of the hepatocyte-secreted protein response to IL-1β: A proteomic analysis
    • Jayaraman A, Roberts KA, Yoon J et al. Identification of neutrophil gelatinase-associated lipocalin (NGAL) as a discriminatory marker of the hepatocyte-secreted protein response to IL-1β: a proteomic analysis. Biotechnol. Bioeng. 91, 502-515 (2005).
    • (2005) Biotechnol. Bioeng , vol.91 , pp. 502-515
    • Jayaraman, A.1    Roberts, K.A.2    Yoon, J.3
  • 81
    • 0023620236 scopus 로고
    • The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships
    • Sweetser DA, Birkenmeier EH, Klisak IJ et al. The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships. J. Biol. Chem. 262, 16060-16071 (1987).
    • (1987) J. Biol. Chem , vol.262 , pp. 16060-16071
    • Sweetser, D.A.1    Birkenmeier, E.H.2    Klisak, I.J.3
  • 82
    • 0036212621 scopus 로고    scopus 로고
    • Cytoplasmic fatty acid-binding proteins: Emerging roles in metabolism and atherosclerosis
    • Boord JB, Fazio S, Linton MF. Cytoplasmic fatty acid-binding proteins: emerging roles in metabolism and atherosclerosis. Curr. Opin. Lipidol. 13, 141-147 (2002).
    • (2002) Curr. Opin. Lipidol , vol.13 , pp. 141-147
    • Boord, J.B.1    Fazio, S.2    Linton, M.F.3
  • 83
    • 0030837971 scopus 로고    scopus 로고
    • Intracellular lipid-binding proteins and their genes
    • Bernlohr DA Simpson MA, Hertzel AV et al. Intracellular lipid-binding proteins and their genes. Annu. Rev. Nutr. 17, 277-303 (1997).
    • (1997) Annu. Rev. Nutr , vol.17 , pp. 277-303
    • Bernlohr DA Simpson, M.A.1    Hertzel, A.V.2
  • 84
    • 0029790266 scopus 로고    scopus 로고
    • The lipocalin protein family: Structure and function
    • Flower DR. The lipocalin protein family: structure and function. Biochem. J. 318(Pt 1), 1-14 (1996).
    • (1996) Biochem. J , vol.318 , Issue.PART 1 , pp. 1-14
    • Flower, D.R.1
  • 85
    • 0031713954 scopus 로고    scopus 로고
    • Palmitate transport and fatty acid transporters in red and white muscles
    • Bonen A, Luiken JJ, Liu S et al. Palmitate transport and fatty acid transporters in red and white muscles. Am. J. Physiol. 275, E471-E478 (1998).
    • (1998) Am. J. Physiol , vol.275
    • Bonen, A.1    Luiken, J.J.2    Liu, S.3
  • 86
    • 0034785683 scopus 로고    scopus 로고
    • Common mechanisms of monoacylglycerol and fatty acid uptake by human intestinal Caco-2 cells
    • Ho SY, Storch J. Common mechanisms of monoacylglycerol and fatty acid uptake by human intestinal Caco-2 cells. Am. J. Physiol. Cell. Physiol. 281, C1106-1117 (2001).
    • (2001) Am. J. Physiol. Cell. Physiol , vol.281
    • SY, H.1    Storch, J.2
  • 87
    • 4444296764 scopus 로고    scopus 로고
    • Fatty acid binding proteins - the evolutionary crossroads of inflammatory and metabolic responses
    • Makowski L, Hotamisligil GS. Fatty acid binding proteins - the evolutionary crossroads of inflammatory and metabolic responses. J. Nutr. 134, S2464-S2468 (2004).
    • (2004) J. Nutr , vol.134
    • Makowski, L.1    Hotamisligil, G.S.2
  • 88
    • 20144363950 scopus 로고    scopus 로고
    • Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of murine macrophages by Toll-like receptor agonists
    • Kazemi MR, McDonald CM, Shigenaga JK, Grunfeld C, Feingold KR. Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of murine macrophages by Toll-like receptor agonists. Arterioscler. Thromb. Vasc. Biol. 25, 1220-1224 (2005).
    • (2005) Arterioscler. Thromb. Vasc. Biol , vol.25 , pp. 1220-1224
    • Kazemi, M.R.1    McDonald, C.M.2    Shigenaga, J.K.3    Grunfeld, C.4    Feingold, K.R.5
  • 89
    • 0033516723 scopus 로고    scopus 로고
    • PPAR activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes
    • Pelton PD, Zhou L, Demarest KT, Burris TP. PPAR activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes. Biochem. Biophys. Res. Commun. 261, 456-458 (1999).
    • (1999) Biochem. Biophys. Res. Commun , vol.261 , pp. 456-458
    • Pelton, P.D.1    Zhou, L.2    Demarest, K.T.3    Burris, T.P.4
  • 90
    • 0023676229 scopus 로고
    • Purification of murine adipocyte lipid-binding protein. Characterization as a fatty acid- and retinoic acid-binding protein
    • Matarese V, Bernlohr DA. Purification of murine adipocyte lipid-binding protein. Characterization as a fatty acid- and retinoic acid-binding protein. J. Biol. Chem. 263, 14544-14551 (1988).
    • (1988) J. Biol. Chem , vol.263 , pp. 14544-14551
    • Matarese, V.1    Bernlohr, D.A.2
  • 92
    • 0032946226 scopus 로고    scopus 로고
    • Biochemical and biophysical analysis of the intracellular lipid binding proteins of adipocytes
    • Simpson MA, LiCata VJ, Ribarik Coe N, Bernlohr DA. Biochemical and biophysical analysis of the intracellular lipid binding proteins of adipocytes. Mol. Cell. Biochem. 192, 33-40 (1999).
    • (1999) Mol. Cell. Biochem , vol.192 , pp. 33-40
    • Simpson, M.A.1    LiCata, V.J.2    Ribarik Coe, N.3    Bernlohr, D.A.4
  • 93
    • 0025951065 scopus 로고
    • Regulation of adipose cell differentiation. I. Fatty acids are inducers of the aP2 gene expression
    • Amri EZ, Bertrand B, Ailhaud G, Grimaldi P. Regulation of adipose cell differentiation. I. Fatty acids are inducers of the aP2 gene expression. J. Lipid Res. 32, 1449-1456 (1991).
    • (1991) J. Lipid Res , vol.32 , pp. 1449-1456
    • Amri, E.Z.1    Bertrand, B.2    Ailhaud, G.3    Grimaldi, P.4
  • 94
    • 0026739556 scopus 로고
    • Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms
    • Distel RJ, Robinson GS, Spiegelman BM. Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms. J. Biol. Chem. 267, 5937-5941 (1992).
    • (1992) J. Biol. Chem , vol.267 , pp. 5937-5941
    • Distel, R.J.1    Robinson, G.S.2    Spiegelman, B.M.3
  • 95
    • 0036709899 scopus 로고    scopus 로고
    • Is there a single mechanism for fatty acid regulation of gene transcription?
    • Duplus E, Forest C. Is there a single mechanism for fatty acid regulation of gene transcription? Biochem. Pharmacol. 64, 893-901 (2002).
    • (2002) Biochem. Pharmacol , vol.64 , pp. 893-901
    • Duplus, E.1    Forest, C.2
  • 96
    • 3242733220 scopus 로고    scopus 로고
    • Functional analysis of peroxisome-prolifefator-responsive element motifs in genes of fatty acid-binding proteins
    • Schachtrup C, Emmler T, Bleck B, Sandqvist A, Spener E Functional analysis of peroxisome-prolifefator-responsive element motifs in genes of fatty acid-binding proteins. Biochem. J. 382, 239-245 (2004).
    • (2004) Biochem. J , vol.382 , pp. 239-245
    • Schachtrup, C.1    Emmler, T.2    Bleck, B.3    Sandqvist, A.4    Spener, E.5
  • 97
    • 7244232742 scopus 로고    scopus 로고
    • Regulating the balance between peroxisome proliferator-activated receptor γ and β-catenin signaling during adipogenesis. A glycogen synthase kinase 3β phosphorylation-defective mutant of β-catenin inhibits expression of a subset of adipogenic genes
    • Liu J, Farmer SR. Regulating the balance between peroxisome proliferator-activated receptor γ and β-catenin signaling during adipogenesis. A glycogen synthase kinase 3β phosphorylation-defective mutant of β-catenin inhibits expression of a subset of adipogenic genes. J. Biol. Chem. 279, 45020-45027 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 45020-45027
    • Liu, J.1    Farmer, S.R.2
  • 98
    • 0032895839 scopus 로고    scopus 로고
    • Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels
    • Coe NR, Simpson MA, Bernlohr DA. Targeted disruption of the adipocyte lipid-binding protein (aP2 protein) gene impairs fat cell lipolysis and increases cellular fatty acid levels. J. Lipid Res. 40, 967-972 (1999).
    • (1999) J. Lipid Res , vol.40 , pp. 967-972
    • Coe, N.R.1    Simpson, M.A.2    Bernlohr, D.A.3
  • 100
    • 0033545915 scopus 로고    scopus 로고
    • Interaction of rat hormone-sensitive lipase with adipocyte lipid-binding protein
    • Shen WJ, Sridhar K, Bernlohr DA, Kraemer FB. Interaction of rat hormone-sensitive lipase with adipocyte lipid-binding protein. Proc. Natl Acad. Sci. USA 96, 5528-5532 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 5528-5532
    • Shen, W.J.1    Sridhar, K.2    Bernlohr, D.A.3    Kraemer, F.B.4
  • 101
    • 0035966072 scopus 로고    scopus 로고
    • Characterization of the functional interaction of adipocyte lipid-binding protein with hormone-sensitive lipase
    • Shen WJ, Liang Y, Hong R et al. Characterization of the functional interaction of adipocyte lipid-binding protein with hormone-sensitive lipase. J. Biol. Chem. 276, 49443-49448 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 49443-49448
    • Shen, W.J.1    Liang, Y.2    Hong, R.3
  • 102
    • 33746572217 scopus 로고    scopus 로고
    • Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophages
    • Fu Y, Luo L, Luo N, Garvey WT. Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophages. Atherosclerosis 188, 102-111 (2006).
    • (2006) Atherosclerosis , vol.188 , pp. 102-111
    • Fu, Y.1    Luo, L.2    Luo, N.3    Garvey, W.T.4
  • 103
    • 0029847504 scopus 로고    scopus 로고
    • Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
    • Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274, 1377-1379 (1996).
    • (1996) Science , vol.274 , pp. 1377-1379
    • Hotamisligil, G.S.1    Johnson, R.S.2    Distel, R.J.3    Ellis, R.4    Papaioannou, V.E.5    Spiegelman, B.M.6
  • 105
    • 0027293808 scopus 로고
    • Tumor-specific overexpression of a novel keratinocyte lipid-binding protein. Identification and characterization of a cloned sequence activated during multistage carcinogenesis in mouse skin
    • Krieg R Feil S, Furstenberger G, Bowden GT. Tumor-specific overexpression of a novel keratinocyte lipid-binding protein. Identification and characterization of a cloned sequence activated during multistage carcinogenesis in mouse skin. J. Biol. Chem. 268, 17362-17369 (1993).
    • (1993) J. Biol. Chem , vol.268 , pp. 17362-17369
    • Krieg, R.1    Feil, S.2    Furstenberger, G.3    Bowden, G.T.4
  • 106
    • 18244363982 scopus 로고    scopus 로고
    • Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes
    • Maeda K, Cao H, Kono K et al. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. 1, 107-119 (2005).
    • (2005) Cell Metab , vol.1 , pp. 107-119
    • Maeda, K.1    Cao, H.2    Kono, K.3
  • 107
    • 34249727188 scopus 로고    scopus 로고
    • Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP)
    • Sulsky R, Magnin DR, Huang Y et al. Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg. Med. Chem. Lett. 17, 3511-3515 (2007).
    • (2007) Bioorg. Med. Chem. Lett , vol.17 , pp. 3511-3515
    • Sulsky, R.1    Magnin, D.R.2    Huang, Y.3
  • 108
    • 34250904186 scopus 로고    scopus 로고
    • Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
    • Furuhashi M, Tuncman G, Gorgun CZ et al. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 447, 959-965 (2007).
    • (2007) Nature , vol.447 , pp. 959-965
    • Furuhashi, M.1    Tuncman, G.2    Gorgun, C.Z.3
  • 109
    • 0034959752 scopus 로고    scopus 로고
    • Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
    • Makowski L, Boord JB, Maeda K et al. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat. Med. 7, 699-705 (2001).
    • (2001) Nat. Med , vol.7 , pp. 699-705
    • Makowski, L.1    Boord, J.B.2    Maeda, K.3
  • 110
    • 0036790535 scopus 로고    scopus 로고
    • Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia
    • Boord JB, Maeda K, Makowski L et al. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 22, 1686-1691 (2002).
    • (2002) Arterioscler. Thromb. Vasc. Biol , vol.22 , pp. 1686-1691
    • Boord, J.B.1    Maeda, K.2    Makowski, L.3
  • 111
    • 4544298808 scopus 로고    scopus 로고
    • Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice
    • Boord JB, Maeda K, Makowski L et al. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation 110, 1492-1498 (2004).
    • (2004) Circulation , vol.110 , pp. 1492-1498
    • Boord, J.B.1    Maeda, K.2    Makowski, L.3
  • 112
    • 0035656183 scopus 로고    scopus 로고
    • Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice
    • Layne MD, Patel A, Chen YH et al. Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J. 15, 2733-2735 (2001).
    • (2001) FASEB J , vol.15 , pp. 2733-2735
    • Layne, M.D.1    Patel, A.2    Chen, Y.H.3
  • 113
    • 0034524387 scopus 로고    scopus 로고
    • Oxidized LDL induces the expression of ALBP/aP2 mRNA and protein in human THP-1 macrophages
    • Fu Y, Luo N, Lopes-Virella MF. Oxidized LDL induces the expression of ALBP/aP2 mRNA and protein in human THP-1 macrophages. J. Lipid Res. 41, 2017-2023 (2000).
    • (2000) J. Lipid Res , vol.41 , pp. 2017-2023
    • Fu, Y.1    Luo, N.2    Lopes-Virella, M.F.3
  • 114
    • 1942521017 scopus 로고    scopus 로고
    • Atorvastatin reduces CD68, FABP4, and HBP expression in oxLDL-treated human macrophages
    • Llaverias G, Noe V, Penuelas S et al. Atorvastatin reduces CD68, FABP4, and HBP expression in oxLDL-treated human macrophages. Biochem. Biophys. Res. Commun. 318, 265-274 (2004).
    • (2004) Biochem. Biophys. Res. Commun , vol.318 , pp. 265-274
    • Llaverias, G.1    Noe, V.2    Penuelas, S.3
  • 115
    • 0036890095 scopus 로고    scopus 로고
    • The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages
    • Fu Y, Luo N, Lopes-Virella MF, Garvey WT. The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages. Atherosclerosis 165, 259-269 (2002).
    • (2002) Atherosclerosis , vol.165 , pp. 259-269
    • Fu, Y.1    Luo, N.2    Lopes-Virella, M.F.3    Garvey, W.T.4
  • 116
    • 16844379483 scopus 로고    scopus 로고
    • The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor γ and IκB kinase activities
    • Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS. The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor γ and IκB kinase activities. J. Mol. Chem. 280, 12888-12895 (2005).
    • (2005) J. Mol. Chem , vol.280 , pp. 12888-12895
    • Makowski, L.1    Brittingham, K.C.2    Reynolds, J.M.3    Suttles, J.4    Hotamisligil, G.S.5
  • 117
    • 33746758322 scopus 로고    scopus 로고
    • The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation
    • Shum BO, Mackay CR, Gorgun CZ et al. The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. J. Clin. Invest. 116, 2183-2192 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 2183-2192
    • Shum, B.O.1    Mackay, C.R.2    Gorgun, C.Z.3
  • 118
    • 34250896099 scopus 로고    scopus 로고
    • Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis
    • Reynolds JM, Liu Q, Brittingham KC et al. Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis. J. Immunol. 179, 313-321 (2007).
    • (2007) J. Immunol , vol.179 , pp. 313-321
    • Reynolds, J.M.1    Liu, Q.2    Brittingham, K.C.3
  • 119
    • 33644545704 scopus 로고    scopus 로고
    • Adipocyte fatty acid binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome
    • Xu A, Wang Y, Xu JY et al. Adipocyte fatty acid binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clin. Chem. 52, 405-413 (2006).
    • (2006) Clin. Chem , vol.52 , pp. 405-413
    • Xu, A.1    Wang, Y.2    Xu, J.Y.3
  • 120
    • 33747031136 scopus 로고    scopus 로고
    • Adipocyte fatty acid binding protein in a Caucasian population: A new marker of metabolic syndrome?
    • Stejskal D, Karpisek M. Adipocyte fatty acid binding protein in a Caucasian population: a new marker of metabolic syndrome? Eur. J. Clin. Invest. 36, 621-625 (2006).
    • (2006) Eur. J. Clin. Invest , vol.36 , pp. 621-625
    • Stejskal, D.1    Karpisek, M.2
  • 121
    • 34547764734 scopus 로고    scopus 로고
    • Adipocyte fatty acid-binding protein is associated with markers of obesity, but is an unlikely link between obesity, insulin resistance, and hyperandrogenism in polycystic ovary syndrome women
    • Mohlig M, Weickert MO, Ghadamgadai E et al. Adipocyte fatty acid-binding protein is associated with markers of obesity, but is an unlikely link between obesity, insulin resistance, and hyperandrogenism in polycystic ovary syndrome women. Eur. J. Endocrinol. 157, 195-200 (2007).
    • (2007) Eur. J. Endocrinol , vol.157 , pp. 195-200
    • Mohlig, M.1    Weickert, M.O.2    Ghadamgadai, E.3
  • 122
    • 34547916094 scopus 로고    scopus 로고
    • Plasma adipocyte and epidermal fatty acid binding protein is reduced after weight loss in obesity
    • Haider DG, Schindler K, Bohdjalian A et al. Plasma adipocyte and epidermal fatty acid binding protein is reduced after weight loss in obesity. Diabetes Obes. Metab. 9, 761-763 (2007).
    • (2007) Diabetes Obes. Metab , vol.9 , pp. 761-763
    • Haider, D.G.1    Schindler, K.2    Bohdjalian, A.3
  • 123
    • 34247472138 scopus 로고    scopus 로고
    • Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: A 5-year prospective study
    • Xu A, Tso AW, Cheting BM et al. Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation 115, 1537-1543 (2007).
    • (2007) Circulation , vol.115 , pp. 1537-1543
    • Xu, A.1    Tso, A.W.2    Cheting, B.M.3
  • 124
    • 35148875083 scopus 로고    scopus 로고
    • Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of Type 2 diabetes - a 10-year prospective study in Chinese
    • Tso AW, Xu A, Sham PC et al. Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of Type 2 diabetes - a 10-year prospective study in Chinese. Diabetes Care 30(10), 2667-2672 (2007).
    • (2007) Diabetes Care , vol.30 , Issue.10 , pp. 2667-2672
    • Tso, A.W.1    Xu, A.2    Sham, P.C.3
  • 125
    • 34547612970 scopus 로고    scopus 로고
    • Serum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosis
    • Yeung DC, Xu A, Cheung CW et al. Serum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 27, 1796-1802 (2007).
    • (2007) Arterioscler. Thromb. Vasc. Biol , vol.27 , pp. 1796-1802
    • Yeung, D.C.1    Xu, A.2    Cheung, C.W.3
  • 126
    • 0038651815 scopus 로고    scopus 로고
    • Elevated C-reactive protein in high-risk asymptomatic individuals is strongly associated with the metabolic syndrome
    • Mora S, Blumenthal RS, Yanek LR et al. Elevated C-reactive protein in high-risk asymptomatic individuals is strongly associated with the metabolic syndrome. J. Am. Coll. Cardiol. 41, A292 (2003).
    • (2003) J. Am. Coll. Cardiol , vol.41
    • Mora, S.1    Blumenthal, R.S.2    Yanek, L.R.3
  • 127
    • 17844396206 scopus 로고    scopus 로고
    • Adiponectin inhibits LPS-induced NF-κB activation and IL-6 production and increases PPAR2 expression in adipocytes
    • Ajuwon KM, Spurlock ME. Adiponectin inhibits LPS-induced NF-κB activation and IL-6 production and increases PPAR2 expression in adipocytes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R1220-R1225 (2005).
    • (2005) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.288
    • Ajuwon, K.M.1    Spurlock, M.E.2
  • 128
    • 33646417610 scopus 로고    scopus 로고
    • Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice
    • Hertzel A, Smith L, Berg A et al. Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice. Am. J. Physiol. Endocrinol. Metab. 290, E814-E823 (2006).
    • (2006) Am. J. Physiol. Endocrinol. Metab , vol.290
    • Hertzel, A.1    Smith, L.2    Berg, A.3
  • 129
    • 1842610797 scopus 로고    scopus 로고
    • Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor interactively influence insulin sensitivity and body composition in males
    • Damcott CM, Moffett SP, Feingold E et al. Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor interactively influence insulin sensitivity and body composition in males. Metabolism 53, 303-309 (2004).
    • (2004) Metabolism , vol.53 , pp. 303-309
    • Damcott, C.M.1    Moffett, S.P.2    Feingold, E.3
  • 130
    • 33646493482 scopus 로고    scopus 로고
    • A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, Type 2 diabetes, and cardiovascular disease
    • Tuncman G, Erbay E, Hom X et al. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, Type 2 diabetes, and cardiovascular disease. Proc. Natl Acad. Sci. USA 103, 6970-6975 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 6970-6975
    • Tuncman, G.1    Erbay, E.2    Hom, X.3
  • 131
    • 22944434929 scopus 로고    scopus 로고
    • Serum retinol binding protein 4 contributes to insulin resistance in obesity and Type 2 diabetes
    • Yang Q, Graham TE, Mody N et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and Type 2 diabetes. Nature 436, 356-362 (2005).
    • (2005) Nature , vol.436 , pp. 356-362
    • Yang, Q.1    Graham, T.E.2    Mody, N.3
  • 132
    • 33745095399 scopus 로고    scopus 로고
    • Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects
    • Graham TE, Yang Q, Bluher M et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N. Engl. J. Med. 354, 2552-2563 (2006).
    • (2006) N. Engl. J. Med , vol.354 , pp. 2552-2563
    • Graham, T.E.1    Yang, Q.2    Bluher, M.3


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