Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosis

European Respiratory Journal

Volumn 39, Issue 2, 2012, Pages 352-358

  Lee, J S ^a   Song, J W ^b   Wolters, P J ^a   Elicker, B M ^a   King, T E ^a   Kim, D S ^b   Collard, H R ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Asan Medical Center   (South Korea)

^c NONE   (United States)

Author keywords

Acute lung injury; Aspiration; Gastro oesophageal reflux; Idiopathic pulmonary fibrosis

Indexed keywords

PEPSIN A; PREDNISONE;

ACUTE EXACERBATION; ADULT; AGE; AGED; ARTICLE; ASPIRATION; BODY MASS; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE MARKER; DISEASE SEVERITY; DRUG USE; EOSINOPHIL COUNT; ERYTHROCYTE COUNT; FEMALE; FIBROSING ALVEOLITIS; FORCED VITAL CAPACITY; GASTROESOPHAGEAL REFLUX; GENDER; HIATUS HERNIA; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HOSPITAL BASED CASE CONTROL STUDY; HUMAN; INTUBATION; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; NEUTROPHIL COUNT; PREVALENCE; PRIORITY JOURNAL; SMOKING; SURVIVAL TIME; TOTAL LUNG CAPACITY;

EID: 84863012828     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00050911     Document Type: Article

References (26)

1. Raghu G, Weycker D, Edelsberg J, et al. Incidence and prevalence of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2006; 174: 810-816. (Pubitemid 44511663)
2. Bjoraker JA, Ryu JH., Edwin MK, et al. Prognostic significance of histopathologic subsets in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1998; 157: 199-203. (Pubitemid 28071283)
3. King TE Jr, Tooze JA, Schwarz MI, et al. Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival model. Am J Respir Crit Care Med 2001; 164: 1171-1181. (Pubitemid 33052246)
4. Collard HR, Moore BB, Flaherty KR, et al. Acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2007; 176: 636-643. (Pubitemid 47503070)
5. Kim DS, Park JH, Park BK, et al. Acute exacerbation of idiopathic pulmonary fibrosis: frequency and clinical features. Eur Respir J 2006; 27: 143-150. (Pubitemid 43092678)
6. Travis WD, Colby TV, Koss MN, et al. Lipoid pneumonia and chronic fibrosis. In: King DW, ed. Non-Neoplastic Disorders of the Lower Respiratory Tract. Washington, American Registry of Pathology and the Armed Forces Institute of Pathology, 2002; pp. 187-196.
7. Lee JS, Collard HR, Raghu G, et al. Does chronic microaspiration cause idiopathic pulmonary fibrosis?Am J Med 2010; 123: 304-311.
8. Tobin RW, Pope CE 2nd., Pellegrini CA, et al. Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1998; 158: 1804-1808. (Pubitemid 29008818)
9. Sweet MP, Patti MG, Leard LE, et al. Gastroesophageal reflux in patients with idiopathic pulmonary fibrosis referred for lung transplantation. J Thorac Cardiovasc Surg 2007; 133: 1078-1084. (Pubitemid 46435907)
10. Raghu G, Freudenberger TD, Yang S, et al. High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis. Eur Respir J 2006; 27: 136-142. (Pubitemid 43092677)
11. Pellegrini CA, DeMeester TR, Johnson LF, et al. Gastroesophageal reflux and pulmonary aspiration: incidence, functional abnormality, and results of surgical therapy. Surgery 1979; 86: 110-119. (Pubitemid 10211211)
12. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000; 342: 1334-1349. (Pubitemid 30408719)
13. Ward C, Forrest IA, Brownlee IA, et al. Pepsin like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts. Thorax 2005; 60: 872-874. (Pubitemid 41475218)
14. Blondeau K, Mertens V, Vanaudenaerde BA, et al. Gastro-oesophageal reflux and gastric aspiration in lung transplant patients with or without chronic rejection. Eur Respir J 2008; 31: 707-713.
15. Farrell S, McMaster C, Gibson D, et al. Pepsin in bronchoalveolar lavage fluid: a specific and sensitive method of diagnosing gastrooesophageal reflux-related pulmonary aspiration. J Pediatr Surg 2006; 41: 289-293. (Pubitemid 43233840)
16. Starosta V, Kitz R, Hartl D, et al. Bronchoalveolar pepsin, bile acids, oxidation, and inflammation in children with gastroesophageal reflux disease. Chest 2007; 132: 1557-1564. (Pubitemid 350156013)
17. Metheny NA, Chang YH, Ye JS, et al. Pepsin as a marker for pulmonary aspiration. Am J Crit Care 2002; 11: 150-154.
18. Stovold R, Forrest IA, Corris PA, et al. Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection. Am J Respir Crit Care Med 2007; 175: 1298-1303. (Pubitemid 46905756)
19. American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. Am J Respir Crit Care Med 2000; 161: 646-664.
20. Kim DS, Jeon YG, Shim TS, et al. The value of interleukin-12 as an activity marker of pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2000; 17: 271-276.
21. Akira M, Hamada H, Sakatani M, et al. CT findings during phase of accelerated deterioration in patients with idiopathic pulmonary fibrosis. AJR Am J Roentgenol 1997; 168: 79-83. (Pubitemid 27014751)
22. Patti MG, Goldberg HI, Arcerito M, et al. Hiatal hernia size affects lower esophageal sphincter function, esophageal acid exposure, and the degree of mucosal injury. Am J Surg 1996; 171: 182-186. (Pubitemid 26028216)
23. Raghu G, Yang ST, Spada C, et al. Sole treatment of acid gastroesophageal reflux in idiopathic pulmonary fibrosis: a case series. Chest 2006; 129: 794-800.
24. Linden PA, Gilbert RJ, Yeap BY, et al. Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation. J Thorac Cardiovasc Surg 2006; 131: 438-446. (Pubitemid 43121569)
25. Kinder BW, Brown KK, Schwarz MI, et al. Baseline BAL neutrophilia predicts early mortality in idiopathic pulmonary fibrosis. Chest 2008; 133: 226-232.
26. Ufberg JW, Bushra JS, Patel D, et al. A new pepsin assay to detect pulmonary aspiration of gastric contents among newly intubated patients. Am J Emerg Med 2004; 22: 612-614. (Pubitemid 40143249)