메뉴 건너뛰기




Volumn 292, Issue 6, 2007, Pages

Muc5b and Muc5ac are the major oligomeric mucins in equine airway mucus

Author keywords

Horses

Indexed keywords

DISULFIDE; GUANIDINE; MUCIN 5AC; MUCIN 5B; OLIGOMER; TRYPSIN;

EID: 34447521925     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00444.2006     Document Type: Article
Times cited : (25)

References (54)
  • 1
    • 0027320315 scopus 로고
    • Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization
    • Audie JP, Janin A, Porchet N, Copin MC, Gosselin B, Aubert JP. Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization. J Histochem Cytochem 41: 1479-1485, 1993.
    • (1993) J Histochem Cytochem , vol.41 , pp. 1479-1485
    • Audie, J.P.1    Janin, A.2    Porchet, N.3    Copin, M.C.4    Gosselin, B.5    Aubert, J.P.6
  • 2
    • 0033598483 scopus 로고    scopus 로고
    • Impact of injuries and disease on a cohort of two- and three-year-old thoroughbreds in training
    • Bailey CJ, Reid SW, Hodgson DR, Rose RJ. Impact of injuries and disease on a cohort of two- and three-year-old thoroughbreds in training. Vet Rec 145: 487-493, 1999.
    • (1999) Vet Rec , vol.145 , pp. 487-493
    • Bailey, C.J.1    Reid, S.W.2    Hodgson, D.R.3    Rose, R.J.4
  • 3
    • 33749328706 scopus 로고    scopus 로고
    • Persistent mucus accumulation-A consequence of delayed bronchial mucous cell apoptosis in RAO-affected horses?
    • Bartner LR, Robinson NE, Kiupel M, Tesfaigzi Y. Persistent mucus accumulation-A consequence of delayed bronchial mucous cell apoptosis in RAO-affected horses? Am J Physiol Lung Cell Mol Physiol 291: L602-L609, 2006.
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291
    • Bartner, L.R.1    Robinson, N.E.2    Kiupel, M.3    Tesfaigzi, Y.4
  • 4
    • 0032526260 scopus 로고    scopus 로고
    • Genomic organization of the 3′-region of the human MUC5AC mucin gene: Additional evidence for a common ancestral gene for the 11p15.5 mucin gene family
    • Buisine MP, Desseyn JL, Porchet N, Degand P, Laine A, Aubert JP. Genomic organization of the 3′-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family. Biochem J 332: 729-738, 1998.
    • (1998) Biochem J , vol.332 , pp. 729-738
    • Buisine, M.P.1    Desseyn, J.L.2    Porchet, N.3    Degand, P.4    Laine, A.5    Aubert, J.P.6
  • 5
    • 0030604852 scopus 로고    scopus 로고
    • Respiratory disease in thoroughbred horses in training: The relationships between disease and viruses, bacteria and environment
    • Burrell MH, Wood JL, Whitwell KE, Chanter N, Mackintosh ME, Mumford JA. Respiratory disease in thoroughbred horses in training: the relationships between disease and viruses, bacteria and environment. Vet Rec 139: 308-313, 1996.
    • (1996) Vet Rec , vol.139 , pp. 308-313
    • Burrell, M.H.1    Wood, J.L.2    Whitwell, K.E.3    Chanter, N.4    Mackintosh, M.E.5    Mumford, J.A.6
  • 6
    • 0024794309 scopus 로고
    • Structure and macromolecular properties of cervical mucus glycoproteins
    • Carlstedt I, Sheehan JK. Structure and macromolecular properties of cervical mucus glycoproteins. Symp Soc Exp Biol 43: 289-316, 1989.
    • (1989) Symp Soc Exp Biol , vol.43 , pp. 289-316
    • Carlstedt, I.1    Sheehan, J.K.2
  • 8
    • 0035883696 scopus 로고    scopus 로고
    • In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model
    • Chen Y, Zhao YH, Wu R. In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model. Am J Respir Crit Care Med 164: 1059-1066, 2001.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1059-1066
    • Chen, Y.1    Zhao, Y.H.2    Wu, R.3
  • 9
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 11
    • 0033406611 scopus 로고    scopus 로고
    • Identification of MUC5B, MUC5AC and small amounts of MUC2 mucins in cystic fibrosis airway secretions
    • Davies JR, Svitacheva N, Lannefors L, Kornfalt R, Carlstedt I. Identification of MUC5B, MUC5AC and small amounts of MUC2 mucins in cystic fibrosis airway secretions. Biochem J 344: 321-330, 1999.
    • (1999) Biochem J , vol.344 , pp. 321-330
    • Davies, J.R.1    Svitacheva, N.2    Lannefors, L.3    Kornfalt, R.4    Carlstedt, I.5
  • 13
    • 0031023179 scopus 로고    scopus 로고
    • Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p155 gene family
    • Desseyn JL, Guyonnet-Duperat V, Porchet N, Aubert JP, Laine A. Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p155 gene family. J Biol Chem 272: 3168-3178, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 3168-3178
    • Desseyn, J.L.1    Guyonnet-Duperat, V.2    Porchet, N.3    Aubert, J.P.4    Laine, A.5
  • 14
    • 0026757328 scopus 로고
    • Respiratory mucociliary clearance in the horse in health and disease, and its pharmaceutical modification
    • Dixon PM. Respiratory mucociliary clearance in the horse in health and disease, and its pharmaceutical modification. Vet Rec 131: 229-235, 1992.
    • (1992) Vet Rec , vol.131 , pp. 229-235
    • Dixon, P.M.1
  • 15
    • 0141924108 scopus 로고    scopus 로고
    • Excessive airway mucus in horses with pulmonary disease: Is it caused by mucus overproduction, decreased clearance or both?
    • Dixon PM, Pirie RS. Excessive airway mucus in horses with pulmonary disease: is it caused by mucus overproduction, decreased clearance or both? Equine Vet J 35: 222-223, 2003.
    • (2003) Equine Vet J , vol.35 , pp. 222-223
    • Dixon, P.M.1    Pirie, R.S.2
  • 16
    • 0029399057 scopus 로고
    • Equine pulmonary disease: A case control study of 300 referred cases. Part 3: ancillary diagnostic findings
    • Dixon PM, Railton DI, McGorum BC. Equine pulmonary disease: a case control study of 300 referred cases. Part 3: ancillary diagnostic findings. Equine Vet J 27: 428-435, 1995.
    • (1995) Equine Vet J , vol.27 , pp. 428-435
    • Dixon, P.M.1    Railton, D.I.2    McGorum, B.C.3
  • 17
    • 0035884708 scopus 로고    scopus 로고
    • Human mucin gene MUC5AC: Organization of its 5′-region and central repetitive region
    • Escande F, Aubert JP, Porchet N, Buisine MP. Human mucin gene MUC5AC: organization of its 5′-region and central repetitive region. Biochem J 358: 763-772, 2001.
    • (2001) Biochem J , vol.358 , pp. 763-772
    • Escande, F.1    Aubert, J.P.2    Porchet, N.3    Buisine, M.P.4
  • 18
    • 0036566430 scopus 로고    scopus 로고
    • The mouse Muc5b mucin gene: CDNA and genomic structures, chromosomal localization and expression
    • Escande F, Porchet N, Aubert JP, Buisine MP. The mouse Muc5b mucin gene: cDNA and genomic structures, chromosomal localization and expression. Biochem J 363: 589-598, 2002.
    • (2002) Biochem J , vol.363 , pp. 589-598
    • Escande, F.1    Porchet, N.2    Aubert, J.P.3    Buisine, M.P.4
  • 20
    • 0034263375 scopus 로고    scopus 로고
    • Tracheobronchial mucus viscoelasticity during environmental challenge in horses with recurrent airway obstruction
    • Gerber V, King M, Schneider DA, Robinson NE. Tracheobronchial mucus viscoelasticity during environmental challenge in horses with recurrent airway obstruction. Equine Vet J 32: 411-417, 2000.
    • (2000) Equine Vet J , vol.32 , pp. 411-417
    • Gerber, V.1    King, M.2    Schneider, D.A.3    Robinson, N.E.4
  • 21
    • 0141958559 scopus 로고    scopus 로고
    • Mucin genes in horse airways: MUC5AC, but not MUC2, may play a role in recurrent airway obstruction
    • Gerber V, Robinson NE, Venta RJ, Rawson J, Jefcoat AM, Hotchkiss JA. Mucin genes in horse airways: MUC5AC, but not MUC2, may play a role in recurrent airway obstruction. Equine Vet J 35: 252-257, 2003.
    • (2003) Equine Vet J , vol.35 , pp. 252-257
    • Gerber, V.1    Robinson, N.E.2    Venta, R.J.3    Rawson, J.4    Jefcoat, A.M.5    Hotchkiss, J.A.6
  • 22
    • 0024592945 scopus 로고
    • Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism
    • Gum JR, Byrd JC, Hicks JW, Toribara NW, Lamport DT, Kim YS. Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism. J Biol Chem 264: 6480-6487, 1989.
    • (1989) J Biol Chem , vol.264 , pp. 6480-6487
    • Gum, J.R.1    Byrd, J.C.2    Hicks, J.W.3    Toribara, N.W.4    Lamport, D.T.5    Kim, Y.S.6
  • 26
    • 0032849859 scopus 로고    scopus 로고
    • CAP3: A DNA sequence assembly program
    • Huang X, Madan A. CAP3: a DNA sequence assembly program. Genome Res 9: 868-877, 1999.
    • (1999) Genome Res , vol.9 , pp. 868-877
    • Huang, X.1    Madan, A.2
  • 30
    • 0036471129 scopus 로고    scopus 로고
    • Heterogeneity of airways mucus: Variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B
    • Kirkham S, Sheehan JK, Knight D, Richardson PS, Thornton DJ. Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Biochem J 361: 537-546, 2002.
    • (2002) Biochem J , vol.361 , pp. 537-546
    • Kirkham, S.1    Sheehan, J.K.2    Knight, D.3    Richardson, P.S.4    Thornton, D.J.5
  • 31
    • 0037093409 scopus 로고    scopus 로고
    • Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution
    • Nordman H, Davies JR, Lindell G, de Bolos C, Real F, Carlstedt I. Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. Biochem J 364: 191-200, 2002.
    • (2002) Biochem J , vol.364 , pp. 191-200
    • Nordman, H.1    Davies, J.R.2    Lindell, G.3    de Bolos, C.4    Real, F.5    Carlstedt, I.6
  • 33
    • 0022428690 scopus 로고
    • Epidemiological study of wastage among racehorses 1982 and 1983
    • Rossdale PD, Hopes R, Digby NJ, Offord K. Epidemiological study of wastage among racehorses 1982 and 1983. Vet Rec 116: 66-69, 1985.
    • (1985) Vet Rec , vol.116 , pp. 66-69
    • Rossdale, P.D.1    Hopes, R.2    Digby, N.J.3    Offord, K.4
  • 34
    • 0026024085 scopus 로고
    • Evidence for shared epitopes within the 'naked' protein domains of human mucus glycoproteins. A study performed by using polyclonal antibodies and electron microscopy
    • Sheehan JK, Boot-Handford RP, Chantler E, Carlstedt I, Thornton DJ. Evidence for shared epitopes within the 'naked' protein domains of human mucus glycoproteins. A study performed by using polyclonal antibodies and electron microscopy. Biochem J 274: 293-296, 1991.
    • (1991) Biochem J , vol.274 , pp. 293-296
    • Sheehan, J.K.1    Boot-Handford, R.P.2    Chantler, E.3    Carlstedt, I.4    Thornton, D.J.5
  • 35
    • 0034176225 scopus 로고    scopus 로고
    • Physical characterization of the MUC5AC mucin: A highly oligomeric glycoprotein whether isolated from cell culture or in vivo from respiratory mucous secretions
    • Sheehan JK, Brazeau C, Kutay S, Pigeon H, Kirkham S, Howard M, Thornton DJ. Physical characterization of the MUC5AC mucin: a highly oligomeric glycoprotein whether isolated from cell culture or in vivo from respiratory mucous secretions. Biochem J 347: 37-44, 2000.
    • (2000) Biochem J , vol.347 , pp. 37-44
    • Sheehan, J.K.1    Brazeau, C.2    Kutay, S.3    Pigeon, H.4    Kirkham, S.5    Howard, M.6    Thornton, D.J.7
  • 36
    • 0021335513 scopus 로고
    • Hydrodynamic properties of human cervicalmucus glycoproteins in 6M-guanidinium chloride
    • Sheehan JK, Carlstedt I. Hydrodynamic properties of human cervicalmucus glycoproteins in 6M-guanidinium chloride. Biochem J 217: 93-101, 1984.
    • (1984) Biochem J , vol.217 , pp. 93-101
    • Sheehan, J.K.1    Carlstedt, I.2
  • 37
    • 0023183253 scopus 로고
    • Size heterogeneity of human cervical mucus glycoproteins. Studies performed with rate-zonal centrifugation and laser light-scattering
    • Sheehan JK, Carlstedt I. Size heterogeneity of human cervical mucus glycoproteins. Studies performed with rate-zonal centrifugation and laser light-scattering. Biochem J 245: 757-762, 1987.
    • (1987) Biochem J , vol.245 , pp. 757-762
    • Sheehan, J.K.1    Carlstedt, I.2
  • 38
    • 0033105846 scopus 로고    scopus 로고
    • Physical characterization of a low-charge glycoform of the MUC5B mucin comprising the gel-phase of an asthmatic respiratory mucous plug
    • Sheehan JK, Howard M, Richardson PS, Longwill T, Thornton DJ. Physical characterization of a low-charge glycoform of the MUC5B mucin comprising the gel-phase of an asthmatic respiratory mucous plug. Biochem J 338: 507-513, 1999.
    • (1999) Biochem J , vol.338 , pp. 507-513
    • Sheehan, J.K.1    Howard, M.2    Richardson, P.S.3    Longwill, T.4    Thornton, D.J.5
  • 39
    • 0029611346 scopus 로고
    • Analysis of respiratory mucus glycoproteins in asthma: A detailed study from a patient who died in status asthmaticus
    • Sheehan JK, Richardson PS, Fung DC, Howard M, Thornton DJ. Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus. Am J Respir Cell Mol Biol 13: 748-756, 1995.
    • (1995) Am J Respir Cell Mol Biol , vol.13 , pp. 748-756
    • Sheehan, J.K.1    Richardson, P.S.2    Fung, D.C.3    Howard, M.4    Thornton, D.J.5
  • 40
    • 0025807914 scopus 로고
    • Mucin structure. The structure and heterogeneity of respiratory mucus glycoproteins
    • Sheehan JK, Thornton DJ, Somerville M, Carlstedt I. Mucin structure. The structure and heterogeneity of respiratory mucus glycoproteins. Am Rev Respir Dis 144: S4-S9, 1991.
    • (1991) Am Rev Respir Dis , vol.144
    • Sheehan, J.K.1    Thornton, D.J.2    Somerville, M.3    Carlstedt, I.4
  • 44
    • 0024461017 scopus 로고
    • Quantitation of mucus glycoproteins blotted onto nitrocellulose membranes
    • Thornton DJ, Holmes DF, Sheehan JK, Carlstedt I. Quantitation of mucus glycoproteins blotted onto nitrocellulose membranes. Anal Biochem 182: 160-164, 1989.
    • (1989) Anal Biochem , vol.182 , pp. 160-164
    • Thornton, D.J.1    Holmes, D.F.2    Sheehan, J.K.3    Carlstedt, I.4
  • 45
    • 0029000560 scopus 로고
    • Methods for separation and deglycosylation of mucin subunits
    • Thornton DJ, Howard M, Devine PL, Sheehan JK. Methods for separation and deglycosylation of mucin subunits. Anal Biochem 227: 162-167, 1995.
    • (1995) Anal Biochem , vol.227 , pp. 162-167
    • Thornton, D.J.1    Howard, M.2    Devine, P.L.3    Sheehan, J.K.4
  • 46
    • 0031003594 scopus 로고    scopus 로고
    • Identification of two glycoforms of the MUC5B mucin in human respiratory mucus. Evidence for a cysteine-rich sequence repeated within the molecule
    • Thornton DJ, Howard M, Khan N, Sheehan JK. Identification of two glycoforms of the MUC5B mucin in human respiratory mucus. Evidence for a cysteine-rich sequence repeated within the molecule. J Biol Chem 272: 9561-9566, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 9561-9566
    • Thornton, D.J.1    Howard, M.2    Khan, N.3    Sheehan, J.K.4
  • 47
    • 0033023581 scopus 로고    scopus 로고
    • Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product
    • Thornton DJ, Khan N, Mehrotra R, Howard M, Veerman E, Packer NH, Sheehan JK. Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product. Glycobiology 9: 293-302, 1999.
    • (1999) Glycobiology , vol.9 , pp. 293-302
    • Thornton, D.J.1    Khan, N.2    Mehrotra, R.3    Howard, M.4    Veerman, E.5    Packer, N.H.6    Sheehan, J.K.7
  • 48
    • 0025872645 scopus 로고
    • Heterogeneity of mucus glycoproteins from cystic fibrotic sputum. Are there different families of mucins?
    • Thornton DJ, Sheehan JK, Carlstedt I. Heterogeneity of mucus glycoproteins from cystic fibrotic sputum. Are there different families of mucins? Biochem J 276: 677-682, 1991.
    • (1991) Biochem J , vol.276 , pp. 677-682
    • Thornton, D.J.1    Sheehan, J.K.2    Carlstedt, I.3
  • 49
    • 0025802978 scopus 로고
    • Mucus glycoproteins from cystic fibrotic sputum. Macromolecular properties and structural 'architecture'
    • Thornton DJ, Sheehan JK, Lindgren H, Carlstedt I. Mucus glycoproteins from cystic fibrotic sputum. Macromolecular properties and structural 'architecture'. Biochem J 276: 667-675, 1991.
    • (1991) Biochem J , vol.276 , pp. 667-675
    • Thornton, D.J.1    Sheehan, J.K.2    Lindgren, H.3    Carlstedt, I.4
  • 52
    • 18544388777 scopus 로고    scopus 로고
    • Inflammatory airway disease, nasal discharge and respiratory infections in young British racehorses
    • Wood JL, Newton JR, Chanter N, Mumford JA. Inflammatory airway disease, nasal discharge and respiratory infections in young British racehorses. Equine Vet J 37: 236-242, 2005.
    • (2005) Equine Vet J , vol.37 , pp. 236-242
    • Wood, J.L.1    Newton, J.R.2    Chanter, N.3    Mumford, J.A.4
  • 53
    • 5844368173 scopus 로고
    • The scattering of light and the radial distribution function of high polymer solutions
    • Zimm BH. The scattering of light and the radial distribution function of high polymer solutions. J Chem Phys 1009-1116, 1948.
    • (1948) J Chem Phys , pp. 1009-1116
    • Zimm, B.H.1
  • 54
    • 0034129127 scopus 로고    scopus 로고
    • Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways
    • Zuhdi AM, Piazza FM, Selby DM, Letwin N, Huang L, Rose MC. Muc-5/5ac mucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am J Respir Cell Mol Biol 22: 253-260, 2000.
    • (2000) Am J Respir Cell Mol Biol , vol.22 , pp. 253-260
    • Zuhdi, A.M.1    Piazza, F.M.2    Selby, D.M.3    Letwin, N.4    Huang, L.5    Rose, M.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.