Correlation between eosinophil count and methacholine challenge test in asymptomatic subjects

Journal of Asthma

Volumn 49, Issue 4, 2012, Pages 336-341

  Schwartz, Nofrat ^a   Grossman, Alon ^b,c   Levy, Yuval ^b   Schwarz, Yehuda ^d  

^a Surgeon General Office Headquarters   (Israel)

^b ISRAELI AIR FORCE   (Israel)

^c RABIN MEDICAL CENTER   (Israel)

^d TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

asthma; diagnosis; eosinophilm; ethacholine

Indexed keywords

METHACHOLINE;

ADULT; ARTICLE; ASTHMA; CHILDHOOD DISEASE; DISEASE SEVERITY; EOSINOPHIL COUNT; FEMALE; HUMAN; MALE; NEUTROPHIL COUNT; PROVOCATION TEST; RESPIRATORY TRACT ALLERGY; SPIROMETRY; WHEEZING;

ADOLESCENT; ASTHMA; BIOLOGICAL MARKERS; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTOR AGENTS; EOSINOPHILS; FEMALE; HUMANS; LEUKOCYTE COUNT; MALE; METHACHOLINE CHLORIDE; NEUTROPHILS; RESPIRATORY FUNCTION TESTS; RETROSPECTIVE STUDIES;

EID: 84863004783     PISSN: 02770903     EISSN: 15324303     Source Type: Journal    
DOI: 10.3109/02770903.2012.672613     Document Type: Article

References (30)

1. Seaton A, Godden DJ, Brown K. Increase in asthma: a more toxic environment or a more susceptible population? Thorax 1994; 49:171-174. (Pubitemid 24115452)
2. Bousquet J, Chanez P, Jean Bousquet, M.D., Ph.D., Pascal Chanez, M.D., Jean Yves Lacoste, M.D., Gilbert Barnéon, M.D., Nouchine Ghavanian, Ph.D., Ingrid Enander, Ph.D., Per Venge, M.D., Staffan Ahlstedt, M.D., Joelle Simony-Lafontaine, M.D., Philippe Godard, M.D., and François-Bernard Michel, M.D. Eosinophilic inflammation in asthma. N Engl J Med 1990; 323:1033-1039.
3. Larsen GL. Asthma in children. N Engl J Med 1992; 326:1540-1545.
4. Cockcroft DW. Direct challenge tests: airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 2010; 138(2): 18s-24s.
5. Frigas E, Gleich GJ. The eosinophil and the pathophysiology of asthma. J Allergy Clin Immunol 1986; 77:527-537. (Pubitemid 16101438)
6. Wardlaw AJ, Dunnette, Gleich GJ, Collins JV, Kay AB. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis 1988; 137:62-69. (Pubitemid 18032827)
7. Kim CK, Choi J, Callaway Z, Iijima K, Volcheck G, Kita H. Increases in airway eosinophilia and a th1 cytokine during the chronic asymptomatic phase of asthma. Respir Med 2010; 104(10):1436-43.
8. Foresi A, Leone C, Pelucchi A, Mastropasqua B, Chetta A, D'Ippolito R, Marazzini L, Olivieri D. Eosinophils, mast cells, and basophils in induced sputum from patients with seasonal allergic rhinitis and perennial asthma: Relationship to methacholine responsiveness. J Allergy Clin Immunol 1997; 100:58-64. (Pubitemid 27328532)
9. Horn BR, Robin ED, Theodore J, Van Kessel A. Total Eosinophil Counts in the Management of Bronchial Asthma. N Engl J Med 1975; 292:1152-1155.
10. Schwarz YA, Erel J, Davidson B, Caine Y, Baum GL. An algorithm for pulmonary screening of military pilots in Israel. Chest 1997; 111 (4):916-921. (Pubitemid 27171461)
11. Wongtim S, Mogmud S, Chareonlap P, Phanuphak P. Standardization of Methacholine Inhalation Challenge by a Reservoir Method. Asian Pacific Journal of Allergy and Immunology 1994; 12:131-136.
12. Boulet LP. Asymptomatic airway hyperresponsiveness.A curiosity or an opportunity to prevent asthma? Am J Respir Crit Care Med 2003; 167:371-378.
13. Laprise C, Laviolette M, Boutet M, Boulet LP. Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodelling. Eur Respir J 1999; 14:63-73. (Pubitemid 29411236)
14. Yoo Y, Choung JT, Yu J, Kim do K, Choi SH, Koh YY. Comparison of percentage fall in FVC at the provocative concentration of methacholine causing a 20%fall in FEV1 between patients with asymptomatic bronchial hyperresponsiveness and mild asthma. Chest 2007; 132(1):106-111. (Pubitemid 47068210)
15. van den Nieuwenhof L, Schermer T, Heijdra Y, Bottema B, Akkermans R, Folgering H, van Weel C. Are asymptomatic airway hyperresponsiveness and allergy risk factors for asthma? A longitudinal study. Eur Respir J 2008; 32(1):70-76.
16. Laprise C, Boulet LP. Asymptomatic airway hyperresponsiveness: a three-year follow-up. Am J Respir Crit Care Med 1997; 156:403-409. (Pubitemid 27351971)
17. Zhong NS, Chen RC, Yang MO, Wu ZY, Zheng JP, Li YF. Is asymptomatic bronchial hyperresponsiveness an indication of potential asthma? A two year follow up of young students with bronchial hyperresponsiveness. Chest 1992; 102:1104-1109.
18. Pin I, Siroux V, Ferran J, Bakouboula P, Bresson JL, Demoly P, Castaldi MH, Cracowski JL, Gormand F, Just J, Le Moual N, Mainprice B, Morange S, Nadif R, Matran R, Oryszczyn MP, Ramadour M, Ravault C, Scheinmann P, Vervloet D, Kauffmann F. 12 year follow up of the Epidemiological study on the genetics and environment of asthma (EGEA) - asthma incidence: preliminary results. Eur Respir J 2006; 28:238s.
19. Gilbert R, Auchincloss JH. Post-test probability of asthma following methacholine challenge. Chest 1990; 97:562-565. (Pubitemid 20095569)
20. Schwartz J, Schindler C, Zemp E, Perruchoud AP, Zellweger JP, Wüthrich B, Leuenberger P, Ackermann-Liebrich U. Predictors of methacholine responsiveness in a general population. Chest 2002; 122: 812-820.
21. Louis R, Sele J, Henket M, Cataldo D, Bettiol J, Seiden L, Bartsch P. Sputum eosinophil count in a large population of patients with mild to moderate steroid-naïve asthma: distribution and relationship with methacholine bronchial hyperresponsiveness. Allergy 2002; 57(10):907-912.
22. Quaedvlieg V, Sele J, Henket M, Louis R. Association between asthma control and bronchial hyperresponsiveness and airway inflammation: a cross-sectional study in daily practice. Clin Exp Allergy 2009; 39 (12):1822-1829.
23. Jatakanon A, Lim S, Kharitonov SA, Chung KF, Barnes PJ. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax 1998; 53(2):91-95. (Pubitemid 28212132)
24. Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, Wardlaw AJ, Pavord ID. Asthma exacerbations and sputum eosinophil counts: a randomized controlled trial. Lancet 2002; 360 (9347):1715-1721. (Pubitemid 35447900)
25. Cohen RM, Grant W, Lieberman P, Potter W, Golden E, Crawford LV, Herrod H, Yoo TJ. The use of methacholine inhalation, methacholine skin testing, distilled water inhalation challenge, and eosinophil counts in the evaluation of patients presenting with cough and/or nonwheezing dyspnea. Ann Allergy 1986; 56:308-312. (Pubitemid 16102115)
26. Pizzichini E, Pizzichini MM, Efthimiadis A, Dolovich J, Hargreave FE. Measuring airway inflammation in asthma: eosinophils and eosinophilic cationic protein in induced sputum compared with peripheral blood. J Allergy Clin Immunol 1997; 99:539-544. (Pubitemid 27173093)
27. Taylor KJ, Luksza AR. Peripheral blood eosinophil counts and bronchial responsiveness. Thorax 1987; 42:452-456. (Pubitemid 17080666)
28. Annema JT, Sparrow D, O'Connor GT, Rijcken B, Koeter GH, Postma DS, Weiss ST. Chronic respiratory symptoms and airway responsiveness to methacholine are associated with eosinophilia in older men: the Normative Aging Study. Eur Respir J 1995; 8:62-69.
29. Rasmussen F, Taylor DR, Flannery EM, Cowan JO, Greene JM, Herbison GP, Sears MR. Outcome in adulthood of asymptomatic airway hyperresponsiveness in childhood: a longitudinal population study. Pediatr Pulmonol 2002; 34(3):164-171. (Pubitemid 34971068)
30. Just J, Gouvis-Echraghi R, Rouve S, Wanin S, Moreau D, Annesi Maesano I. Two novel severe asthma phenotypes identified during childhood using a clustering approach. Eur Respir J 2012.