CDR4 is the major contributor to azole resistance among four Pdr5p-like ABC transporters in Neurospora crassa

Fungal Biology

Volumn 116, Issue 7, 2012, Pages 848-854

  Zhang, Yu ^a,b   Zhang, Zhenying ^a   Zhang, Xinyu ^a   Zhang, Hanxing ^a   Sun, Xianyun ^a   Hu, Chengcheng ^a,b   Li, Shaojie ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

ABC transporter; Antifungal drug resistance; Filamentous fungi; Pdr5p

Indexed keywords

ABC TRANSPORTER; ANTIFUNGAL AGENT; FLUCONAZOLE; FUNGAL PROTEIN; ITRACONAZOLE; KETOCONAZOLE;

ANTIBIOTIC RESISTANCE; FUNGUS; GENE EXPRESSION; HOMOLOGY; MOLECULAR ANALYSIS; ORGANIC NITROGEN COMPOUND; PHYLOGENETICS; PHYLOGENY; PROTEIN;

ANTIFUNGAL RESISTANCE; ARTICLE; DRUG EFFECT; GENE INACTIVATION; GENETICS; METABOLISM; MICROBIOLOGICAL EXAMINATION; NEUROSPORA CRASSA; PHYLOGENY; SEQUENCE HOMOLOGY;

ANTIFUNGAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; DRUG RESISTANCE, FUNGAL; FLUCONAZOLE; FUNGAL PROTEINS; GENE KNOCKOUT TECHNIQUES; ITRACONAZOLE; KETOCONAZOLE; MICROBIAL SENSITIVITY TESTS; NEUROSPORA CRASSA; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID;

CANDIDA; FUNGI; NEUROSPORA CRASSA; SACCHAROMYCES CEREVISIAE;

EID: 84863004654     PISSN: 18786146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.funbio.2012.05.002     Document Type: Article

References (28)

1. Agarwal A.K., Rogers P.D., Baerson S.R., Jacob M.R., Barker K.S., Cleary J.D., Walker L.A., Nagle D.G., Clark A.M. Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae. The Journal of Biological Chemistry 2003, 278:34998-35015.
2. Andrade A.C., Del Sorbo G., Van Nistelrooy J.G.M., De Waard M.A. The ABC transporter AtrB from Aspergillus nidulans mediates resistance to all major classes of fungicides and some natural toxic compounds. Microbiology 2000, 146:1987-1997.
3. Da Silva Ferreira M.E., Malavazi I., Savoldi M., Brakhage A.A., Goldman M.H., Kim H.S., Nierman W.C., Goldman G.H. Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole. Current Genetics 2006, 50:32-44.
4. Del Sorbo G., Andrade A.C., Van Nistelrooy J.G.M., Van Kan J.A.L., Balzi E., De Waard M.A. Multidrug resistance in Aspergillus nidulans involves novel ATP-binding cassette transporters. Molecular and General Genetics 1997, 254:417-426.
5. Hayashi K., Schoonbeek H., De Waard M.A. Expression of the ABC transporter BcatrD from Botrytis cinerea reduces sensitivity to sterol demethylation inhibitor fungicides. Pesticide Biochemistry and Physiology 2002, 73:110-121.
6. Hernaez M.L., Gil C., Pla J., Nombela C. Induced expression of the Candida albicans multidrug resistance gene CDR1 in response to fluconazole and other antifungals. Yeast 1998, 14:517-526.
7. Kolaczkowski M., Van der Rest M., Cybularz-Kolaczkowska A., Soumillion J.P., Konings W.N., Goffeau A. Anticancer Drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p. The Journal of Biological Chemistry 1996, 271:31543-31548.
8. Lee Y., Yamamoto K., Hamamoto H., Nakaune R., Hibi T. A novel ABC transporter gene ABC2 involved in multidrug susceptibility but not pathogenicity in rice blast fungus, Magnaporthe grisea. Pesticide Biochemistry and Physiology 2005, 81:13-23.
9. Leppert G., McDewitt R., Falco S.C., Van Dyk T., Ficke M., Golin J. Cloning by gene amplification of two loci conferring multiple drug resistance in Saccharomyces. Genetics 1990, 125:13-20.
10. Liu T.T., Lee R.E., Barker K.S., Wei L., Homayouni R., Rogers P.D. Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans. Antimicrobial Agents and Chemotherapy 2005, 49:2226-2236.
11. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
12. Nakaune R., Adachi K., Nawata O., Tomiyama M., Akutsu K., Hibi T. A novel ATP-binding cassette transporter involved in multidrug resistance in the phytopathogenic fungus Penicillium digitatum. Applied and Environmental Microbiology 1998, 64:3983-3988.
13. Nakaune R., Hamamoto H., Imada J., Akutsu K., Hibi T. A novel ABC transporter gene, PMR5, is involved in multidrug resistance in the phytopathogenic fungus Penicillium digitatum. Molecular Genetics and Genomics 2002, 267:179-185.
14. Niimi M., Niimi K., Takano Y., Holmes A.R., Fischer F.J., Uehara Y., Cannon R.D. Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance. Journal of Antimicrobial Chemotherapy 2004, 54(6):999-1006.
15. Prasad R., De Wergifosse P., Goffeau A., Balzi E. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. Current Genetics 1995, 27:320-329.
16. Sanglard D., Kuchler K., Ischer F., Pagani J.L., Monod M., Bille J. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrobial Agents and Chemotherapy 1995, 39:2378-2386.
17. Sanglard D., Ischer F., Monod M., Bille J. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 1997, 143:405-416.
18. Schoonbeek H., Del Sorbo G., De Waard M.A. The ABC transporter BcatrB affects the susceptibility of Botrytis cinerea to the phytoalexin resveratrol and the fungicide fenpiclonil. Molecular Plant-Microbe Interactions 2001, 14:562-571.
19. Schuetzer-Muehlbauer M., Willinger B., Egner R., Ecker G., Kuchler K. Reversal of antifungal resistance mediated by ABC efflux pumps from Candida albicans functionally expressed in yeast. International Journal of Antimicrobial Agents 2003, 22:291-300.
20. Skov J., Lemmens M., Giese H. Role of a Fusarium culmorum ABC transporter (FcABC1) during infection of wheat and barley. Physiological and Molecular Plant Pathology 2004, 64:245-254.
21. Slaven J.W., Anderson M.J., Sanglard D., Dixon G.K., Bille J., Roberts I.S., Denning D.W. Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate. Fungal Genetics and Biology 2002, 36:199-206.
22. Swofford D.L. PAUP*. Phylogenetic Analysis Using Parsimony (* and Other Methods) 2003, Version 4 (Sunderland, Massachusetts: Sinauer Associates).
23. Urban M., Bhargava T., Hamer J.E. An ATP-driven efflux pump is a novel pathogenicity factor in rice blast disease. EMBO Journal 1999, 18:512-521.
24. Vermeulen T., Schoonbeek H., De Waard M.A. The ABC transporter BcatrB from Botrytis cinerea is a determinant of the activity of the phenylpyrrole fungicide fludioxonil. Pest Management Science 2001, 57:393-402.
25. Vogel H.J. A convenient growth medium for Neurospora (medium N). Microbial Genetics Bulletin 1956, 13:42-43.
26. White T.C. Increased mRNA Levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrobial Agents and Chemotherapy 1997, 41:1482-1487.
27. Zwiers L.H., De Waard M.A. Characterization of the ABC transporter genes Mgatr1 and Mgatr2 from the wheat pathogen Mycosphaerella graminicola. Fungal Genetics and Biology 2000, 30:115-125.
28. Zwiers L.H., Stergiopoulos I.C., Gielkens M.M., Goodall S.D., De Waard M.A. ABC transporters of the wheat pathogen Mycosphaerella graminicola function as protectants against biotic and xenobiotic toxic compounds. Molecular Genetics and Genomics 2003, 269:499-507.