NUDT6, the FGF-2's antisense gene, showed associations with fat deposition related traits in pigs

Molecular Biology Reports

Volumn 39, Issue 4, 2012, Pages 4119-4126

  Sun, Ling ^a   Yu, Shaobo ^a   Wang, Hongyang ^a   Fan, Bin ^a   Liu, Bang ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

Author keywords

Association analysis; Express profile; FGF 2; NUDT6; Pig; Variant transcript

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; COMPLEMENTARY RNA; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2;

3' UNTRANSLATED REGION; ANIMAL GENETICS; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC ASSOCIATION; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; LIPID STORAGE; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOSIDE DIPHOSPHATE LINKED MOIETY X TYPE MOTIF 6 GENE; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SWINE; ANIMAL; BREEDING; CHINA; CHROMOSOME; DNA SEQUENCE; EXON; GENE EXPRESSION REGULATION; GENETICS; GENOME; GENOTYPE; MEAT; METABOLISM; OBESITY; POLYMERASE CHAIN REACTION; QUANTITATIVE TRAIT; RADIATION HYBRID MAPPING; RAT; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; STANDARD; TIME;

RATTUS; SUIDAE; SUS;

ADIPOSITY; ANIMALS; BREEDING; CHINA; CHROMOSOMES, MAMMALIAN; EXONS; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; GENOME; GENOTYPE; MEAT; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; QUANTITATIVE TRAIT, HERITABLE; RADIATION HYBRID MAPPING; RATS; RNA, ANTISENSE; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; SUS SCROFA; TIME FACTORS;

EID: 84862999256     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-1194-3     Document Type: Article

References (29)

1. Asa SL, Ramyar L, Murphy PR, Li AW, Ezzat S (2001) The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. Mol Endocrinol 15:589-599
2. Baguma-Nibasheka M, Li AW, Osman MS, Geldenhuys L, Casson AG, Too CK, Murphy PR (2005) Coexpression and regulation of the FGF-2 and FGF antisense genes in leukemic cells. Leuk Res 29:423-433
3. Burrus LW, Zuber ME, Lueddecke BA, Olwin BB (1992) Identification of a cysteine-rich receptor for fibroblast growth factors. Mol Cell Biol 12:5600-5609
4. Cai W, Casey DS, Dekkers JC (2008) Selection response and genetic parameters for residual feed intake in Yorkshire swine. J Anim Sci 86:287-298
5. Fedorov YV, Rosenthal RS, Olwin BB (2001) Oncogenic Rasinduced proliferation requires autocrine fibroblast growth factor 2 signaling in skeletal muscle cells. J Cell Biol 152:1301-1305
6. Friesel R, Brown SA (1992) Spatially restricted expression of fibroblast growth factor receptor-2 during Xenopus development. Development 116:1051-1058
7. Han JK (1997) Expression of the fibroblast growth factor-2 gene during chick development. Mol Cells 7:208-213
8. He XP, Xu XW, Zhao SH, Fan B, Yu M, Zhu MJ, Li CC, Peng ZZ, Liu B (2009) Investigation of Lpin1 as a candidate gene for fat deposition in pigs. Mol Biol Rep 36:1175-1180
9. Hu ZL, Reecy JM (2007) Animal QTLdb: Beyond a repository. A public platform for QTL comparisons and integration with diverse types of structural genomic information. Mamm Genome 18:1-4
10. Kakudo N, Shimotsuma A, Kusumoto K (2007) Fibroblast growth factor-2 stimulates adipogenic differentiation of human adipose-derived stem cells. Biochem Biophys Res Commun 359: 239-244
11. Kimelman D, Kirschner MW (1989) An antisense messenger RNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes. Cell 59:9
12. Kimura T, Noda M, Sugihara H, Kashima K, Hattori T (1999) Expression of fibroblast growth factor-2 transcripts in the healing of acetic acid-induced gastric ulcers. APMIS 107:767-772
13. Knee R, Li AW, Murphy PR (1997) Characterization and tissuespecific expression of the rat basic fibroblast growth factor antisense mRNA and protein. Proc Natl Acad Sci USA 94: 4943-4947
14. Knee R, Murphy PR (1997) Regulation of gene expression by natural antisense RNA transcripts. Neurochem Int 31:379-392
15. Lee SY, Lim J, Khang G, Son Y, Choung PH, Kang SS, Chun SY, Shin HI, Kim SY, Park EK (2009) Enhanced ex vivo expansion of human adipose tissue-derived mesenchymal stromal cells by fibroblast growth factor-2 and dexamethasone. Tissue Eng Part A 15:2491-2499
16. Leung HY, Gullick WJ, Lemoine NR (1994) Expression and functional activity of fibroblast growth factors and their receptors in human pancreatic cancer. Int J Cancer 59:667-675
17. Li AW, Murphy PR (2000) Expression of alternatively spliced FGF-2 antisense RNA transcripts in the central nervous system: Regulation of FGF-2 mRNA translation. Mol Cell Endocrinol 170:233-242
18. Li AW, Too CK, Murphy PR (1996) The basic fibroblast growth factor (FGF-2) antisense RNA (GFG) is translated into a MutTrelated protein in vivo. Biochem Biophys Res Commun 223: 19-23
19. McFarland DC, Liu X, Velleman SG, Zeng C, Coy CS, Pesall JE (2003) Variation in fibroblast growth factor response and heparan sulfate proteoglycan production in satellite cell populations. Comp Biochem Physiol C Toxicol Pharmacol 134:341-351
20. McFarland DC, Pesall JE (2008) Phospho-MAPK as a marker of myogenic satellite cell responsiveness to growth factors. Comp Biochem Physiol B Biochem Mol Biol 149:463-467
21. Milan D, Hawken R, Cabau C, Leroux S, Genet C, Lahbib Y, Tosser G, Robic A, Hatey F, Alexander L et al (2000) IMpRH server: An RH mapping server available on the Web. Bioinformatics 16:558-559
22. Mitchell P, Steenstrup T, Hannon K (1999) Expression of fibroblast growth factor family during postnatal skeletal muscle hypertrophy. J Appl Physiol 86:313-319
23. Sugi Y, Lough J (1995) Activin-A and FGF-2 mimic the inductive effects of anterior endoderm on terminal cardiac myogenesis in vitro. Dev Biol 168:567-574
24. Xiao L, Sobue T, Esliger A, Kronenberg MS, Coffin JD, Doetschman T, Hurley MM (2010) Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells. Bone 47:360-370
25. Xu X, Xing S, Du ZQ, Rothschild MF, Yerle M, Liu B (2008) Porcine TEF1 and RTEF1: Molecular characterization and association analyses with growth traits. Comp Biochem Physiol 150: 447-453
26. Yamada T, Kawakami S, Nakanishi N (2010) Fat depot-specific differences in angiogenic growth factor gene expression and its relation to adipocyte size in cattle. J Vet Med Sci 72:991-997
27. Yerle M, Pinton P, Robic A, Alfonso A, Palvadeau Y, Delcros C, Hawken R, Alexander L, Beattie C, Schook L et al (1998) Construction of a whole-genome radiation hybrid panel for highresolution gene mapping in pigs. Cytogenet Cell Genet 82: 182-188
28. Zhang SC, Barclay C, Alexander LA, Geldenhuys L, Porter GA, Casson AG, Murphy PR (2007) Alternative splicing of the FGF antisense gene: Differential subcellular localization in human tissues and esophageal adenocarcinoma. J Mol Med 85:1215-1228
29. Zhang SC, MacDonald KA, Baguma-Nibasheka M, Geldenhuys L, Casson AG, Murphy PR (2008) Alternative splicing and differential subcellular localization of the rat FGF antisense gene product. BMC Mol Biol 9:10