Influence of the interaction between the adiponectin G276T polymorphism and body mass index on lipid levels in healthy children

Molecular Biology Reports

Volumn 39, Issue 4, 2012, Pages 4831-4835

  Riestra, Pía ^a   García Anguita, Alicia ^a   Lasunción, Miguel A ^b   Mangas, Alipio ^c   De Oya, Manuel ^a   Garcés, Carmen ^a  

^a Instituto de Investigación Sanitaria Fundación Jiménez Díaz   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF CÁDIZ   (Spain)

Author keywords

Adiponectin polymorphisms; BMI; Children; Lipid levels

Indexed keywords

ADIPONECTIN; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; ADIPOQ PROTEIN, HUMAN;

ADIPONECTIN GENE; ADOLESCENT; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CHILD; CHOLESTEROL BILE LEVEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DNA POLYMORPHISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE; GENE FREQUENCY; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; MALE; MOLECULAR INTERACTION; OBESITY; SCHOOL CHILD; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; BLOOD; GENETICS; HEALTH; REGRESSION ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPONECTIN; ADOLESCENT; BODY MASS INDEX; CHILD; FEMALE; GENOTYPE; HEALTH; HUMANS; LIPIDS; MALE; OVERWEIGHT; POLYMORPHISM, SINGLE NUCLEOTIDE; REGRESSION ANALYSIS;

EID: 84862997807     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-1276-2     Document Type: Article

References (25)

1. Han SH, Sakuma I, Shin EK et al (2009) Antiatherosclerotic and anti-insulin resistance effects of adiponectin: basic and clinical studies. Prog Cardiovasc Dis 52:126-140
2. Chandran M, Phillips SA, Ciaraldi T et al (2003) Adiponectin: More than just another fat cell hormone? Diabetes Care 26:2442-2450
3. Weyer C, Funahashi T, Tanaka S et al (2001) Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930-1935
4. Matsubara M, Maruoka S, Katayose S (2002) Decreased plasma adiponectin concentrations in women with dyslipidemia. J Clin Endocrinol Metab 87:2764-2769
5. Kazumi T, Kawaguchi A, Hirano T et al (2004) Serum adiponectin is associated with high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein particle size in young healthy men. Metabolism 53:589-593
6. Gu HF (2009) Biomarkers of adiponectin: Plasma protein variation and genomic DNA polymorphisms. Biomarker Insights 4:123-133
7. Yu Z, Han S, Cao X, et al. (2011) Genetic polymorphisms in adipokine genes and the risk of obesity: A systematic review and meta-Analysis. Obesity. doi:10.1038/oby.2011.148
8. Hara K, Boutin P, Mori Y et al (2002) Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 51:536-540
9. Menzaghi C, Trischitta V, Doria A (2007) Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. Diabetes 56:1198-1209
10. Han LY, Wu QH, Jiao ML et al (2011) Associations between single-nucleotide polymorphisms (?45T[G, ?276G[T, 11377C[G, -11391 G[A) of adiponectin gene and type 2 diabetes mellitus: A systematic review and meta-Analysis. Diabetologia 54:2303-2314
11. Jang Y, Lee JH, Chae JS et al (2005) Association of the 276G->T polymorphism of the adiponectin gene with cardiovascular disease risk factors in nondiabetic Koreans. Am J Clin Nutr 82:760-767
12. Mackevics V, Heid IM, Wagner SA et al (2006) The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians. Eur J Hum Genet 14:349-356
13. Qi L, Li T, Rimm E et al (2005) The 276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic men. Diabetes 54:1607-1610
14. Mousavinasab F, Tähtinen T, Jokelainen J et al (2006) Common polymorphisms (single-nucleotide polymorphisms SNP ? 45 and SNP ? 276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men. Mol Genet Metab 87:147-151
15. Jang Y, Lee JH, Kim OY et al (2006) The SNP276G[T polymorphism in the adiponectin (ACDC) gene is more strongly associated with insulin resistance and cardiovascular disease risk than SNP45T>G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin. Metabolism 55:59-66
16. Bouatia-Naji N, Meyre D, Lobbens S et al (2006) ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes 55:545-550
17. Cieslak J, Skorczyk A, Stachowiak M et al (2011) Polymorphisms in 50-flanking regions of genes encoding adiponectin, leptin and resistin are not associated with obesity of polish children and adolescents. Mol Biol Rep 38:1793-1798
18. Petrone A, Zavarella S, Caiazzo A et al (2006) The promoter region of the adiponectin gene is a determinant in modulating insulin sensitivity in childhood obesity. Obesity 14:1498-1504
19. Rasmussen-Torvik LJ, Pankow JS, Jacobs DR Jr et al (2009) The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. Hum Genet 125:21-28
20. Johansson LE, Danielsson P, Norgren S et al (2009) Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity. Int J Pediatr Obes 4:119-125
21. Riestra P, García-Anguita A, Schoppen S et al (2010) Sex-specific association between leptin receptor polymorphisms and leptin levels and BMI in healthy adolescents. Acta Paediatr 99(10):1527-1530
22. Cole TJ, Bellizi MC, Flegal KM et al (2000) Establishing a standard definition for child overweight and obesity worldwide: International survey. BMJ 320:1240-1243
23. Matthews DR, Hosker JP, Rudenski AS et al (1985) Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
24. Menzaghi C, Ercolino T, Di Paola R et al (2002) A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 51:2306-2312
25. Li LL, Kang XL, Ran XJ et al (2007) Associations between 45T/G polymorphism of the adiponectin gene and plasma adiponectin levels with type 2 diabetes. Clin Exp Pharmacol Physiol 34:1287-1290