Rutin ameliorates cyclophosphamide-induced reproductive toxicity in male rats

Toxicology International

Volumn 19, Issue 2, 2012, Pages 207-214

  Abarikwu, Sunny O ^a   Otuechere, C A ^a   Ekor, M ^a   Monwuba, K ^a   Osobu, D ^a  

^a REDEEMER S UNIVERSITY   (Nigeria)

Author keywords

Antioxidant system; Cyclophosphamide; Rats; Reproductive toxicity; Rutin; Sperms

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ACID PHOSPHATASE; ALKALINE PHOSPHATASE; CATALASE; CYCLOPHOSPHAMIDE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; IDITOL DEHYDROGENASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; RUTOSIDE; SUPEROXIDE DISMUTASE; TESTOSTERONE 17BETA DEHYDROGENASE;

ACID PHOSPHATASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; EPIDIDYMIS; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; NONHUMAN; RAT; REPRODUCTIVE TOXICITY; SEMINAL VESICLE; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS FUNCTION; WISTAR RAT;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84862988841     PISSN: 09716580     EISSN: 09765131     Source Type: Journal    
DOI: 10.4103/0971-6580.97224     Document Type: Article

References (46)

1. Howell ST, Shalet SM. Testicular function following chemotherapy. Hum Reprod Update 2001;7:363-9. (Pubitemid 32655321)
2. Meistrich ML. Hormonal stimulation of the recovery of spermatogenesis following chemo-or radiotherapy. APMIS 2008;106:37-45; discussion 45-6.
3. Lee S, Schmitt CA. Chemotherapy response and resistance. Curr Opin Genet Dev 2003;13:90-6. (Pubitemid 36143933)
4. Pandse S, Ginsburg E, Singh AK. Strategies for preservation of ovarian and testicular function after immunosuppression. Am J Kidney Dis 2004;43:772-81. (Pubitemid 38529614)
5. Das UB, Mallick M, Debnath JM, Ghosh D. Protective effect of ascorbic acid on cyclophosphamide-induced testicular gametogenic and androgenic disorders in male rats. Asian J Androl 2002;4:201-7.
6. Selvakumar E, Prahalathan C, Mythili Y, Varalakshmi P. Protective effect of dL-β-lipoic acid in cyclophosphamide induced oxidative injury in rat testis. Reprod Toxicol 2004;19:163-7. (Pubitemid 40288195)
7. Selvakumar E, Prahalathan C, Sudharsan PT, Varalakshmi P. Protective effect of lipoic acid on cyclophosphamide-induced testicular toxicity. Clin Chim Acta 2006;367:114-9.
8. Zhang YM. Protective effect of quercetin on aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells. Toxicol Sci 2005;88:545-50. (Pubitemid 41672162)
9. Rice-Evans C. Flavonoid antioxidants. Curr Med Chem 2001;8:797-807. (Pubitemid 32427907)
10. Cotelle N. Role of flavonoids in oxidative stress. Curr Top Med Chem 2001;1:569-90.
11. Hursting SD, Slaga TJ, Fischer SM, DiGiovani J, Phang JM. Mechanism-based cancer prevention approaches: targets, examples and the use of transgenic mice. J Natl Cancer Inst 1999;91:215-25. (Pubitemid 29090990)
12. Nakamura Y, Ishimitsu S, Tonogai Y. Effects of quercetin and rutin on serum and hepatic lipid concentrations, fecal steroid excretion and serum antioxidant properties. J Health Sci 2000;46:229-40.
13. Florek E, Ignatowicz E, Wrzosek J, Piekoszewski W. Effect of rutin on total antioxidant status of rats exposed to cigarette smoke. Pharmacol Rep 2005;57:84-9. (Pubitemid 40601545)
14. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric reaction. Anal Biochem 1979;95:351-8. (Pubitemid 9194347)
15. Misra HP, Fridovich I. The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972;247:3170-5.
16. Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972;47:389-94.
17. Habig WH, Pabst MJ, Jacob WB. Glutathione-s-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974;249:7130-9.
18. Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR. Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3, 4 bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 1974;11:151-69.
19. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973;179:588-90.
20. Staal GE, Visser J, Veeger C. Purification and properties of glutathione reductase of human erythrocytes. Biochim Biophys Acta 1969;185:39-48.
21. rd ed. Berlin: Verlag-Chemie; 1984. p. 92-106.
22. Principato GB, Asia MC, Talesa V, Rosi G, Giovannini E. Characterization of the soluble alkaline phosphatase from hepatopancreas of Squilla mantis L. Comp Bioch Physiol 1985;80:801-4.
23. Cabaud PC, Wroblewski F. Calorimetric measurement of lactate dehydrogenase activity of body fluids. J Clin Pathol 1958;30:234-6.
24. Gerlach U. Sorbitol dehydrogenase. In: Bergmeyer HU, Bergemeyer J, Grassi M, editors. Methods of enzymatic analysis. Berlin: Verlag Chemie; 1983. p. 112-7.
25. Bergmeyer HU. Beta-Hydroxy steroid dehydrogenase. In: Bergmeyer HU, editor. Methods of enzymatic analysis. New York: Academic Press; 1974. p. 447-89.
26. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951;193:265-75.
27. Abarikwu SO, Adesiyan AC, Oyeloja TO, Oyeyemi MO, Farombi EO. Changes in sperm characteristics and induction of oxidative stress in the testis and epididymis of experimental rats by a herbicide, atrazine. Arch Environ Contam Toxicol 2010;58:874-82.
28. Rezvanfar M, Sadrkhanlou R, Ahmadi A, Shojaei-Sadee H, Rezvanfar M, Mohammadirad A, et al. Protection of cyclophosphamide-induced toxicity in reproductive tract histology, sperm characteristics and DNA damage by an herbal source; evidence for role of free-radical toxic stress. Hum Exp Toxicol 2008;27:901-10.
29. Turk G, Çeribasi AO, Sakin F, Sönmez M, Atessahin A. Antiperoxidative and anti-apoptotic effects of lycopene and ellagic acid on cyclophosphamide-induced testicular lipid peroxidation and apoptosis. Reprod Fertil Dev 2010;22:587-96.
30. Ateşşahin A, Sahna E, Türk G, Ceribaşi AO, Yilmaz S, Yüce A, et al. Chemoprotective effect of melatonin against cisplatin-induced testicular toxicity in rats. J Pineal Res 2006;41:21-7. (Pubitemid 43980691)
31. Izawa H, Kohara M, Aizawa K, Suganuma H, Inakuma T, Watanabe G, et al. Alleviative effects of quercetin and onion on male reproductive toxicity induced by diesel exhaust particles. Biosci Biotechnol Biochem 2008;72:1235-41. (Pubitemid 351872496)
32. Selvakumar E, Prahalathan C, Sudharsan PT, Varalakshmi P. Protective effect of lipoic acid on cyclophosphamide-induced testicular toxicity. Clin Chim Acta 2006;367:114-9.
33. Gonzalez E, Rosello-Catafau J, Jawerbaum A, Sinner D, Pustovrh C, Vela J, et al. Pancreatic nitric oxide and oxygen free radicals in the early stages of streptozotoein-induced diabetes mellitus in the rat. Braz J Med Biol Res 2000;33:1335-42.
34. Pande M, Flora SJ. Lead induced oxidative damage and its response to combined administration of α-lipoic acid and succimers in rats. Toxicology 2002;177:187-96. (Pubitemid 34804306)
35. Zini A, Schlegel PN. Identification and characterization of antioxidant enzyme mRNAs in the rat epididymis. Int J Androl 1997;20:86-91. (Pubitemid 27390293)
36. Adesiyan AC, Oyejola TO, Abarikwu SO, Oyeyemi MO, Farombi EO. Selenium provides protection to the liver but not the reproductive organs in an atrazine-model of experimental toxicity. Exp Toxicol Pathol 2011;63:201-7.
37. Pigeolet E, Corbisier P, Houbion A, Lambert D, Michiels C, Raes M, et al. Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals. Mech Ageing Dev 1990;51:283-97. (Pubitemid 20041562)
38. Albina ML, Alonso V, Linares V, Belles M, Sirvent JJ, Domingo JL, et al. Effects of exposure to BDE-99 on oxidative status of liver and kidney in adult rats. Toxicology 2010;271:51-6.
39. Abarikwu SO, Farombi EO, Pant AB. Biflavanone-kolaviron protects human dopaminergic SH-SY5Y cells against atrazine induced toxic insult. Toxicol In Vitro 2011;25:848-58.
40. Sadik NA. Effects of Diallyl Sulfide and Zinc on Testicular Steroidogenesis in Cadmium-treated male rats. J Biochem Mol Toxicol 2008;22:345-53.
41. Erkkila K, Aito H, Aalto K, Pentikainen V, Dunkel L. Lactate inhibits germ cells apoptosis in the human testis. Mol Hum Reprod 2002;8:109-17. (Pubitemid 34144970)
42. Pant N, Srivastava SP. Testicular and spermatotoxic effects of quinalphos in rats. J Appl Toxicol 2003;23:271-4. (Pubitemid 36950297)
43. Akondi RB, Akula A, Challa SR. Protective Effects of Rutin and Naringin on Gentamycin Induced Testicular Oxidative Stress. Eur J Gen Med 2011;8:57-64.
44. Yang J, Guo J, Yuan J. In vitro antioxidant properties of rutin. LWT-Food Sci Technol 2008;41:1060-6. (Pubitemid 351374935)
45. Kostyuk VA, Potapovich AI. Anti radical and chelating effects in flavonoid protection against silica-induced cell injury. Arch Biochem Biophys 1998;355:43-8. (Pubitemid 28371150)
46. Diemer T, Allen JA, Hales KH, Hales DB. Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis. Endocrinology 2003;144:2882-91. (Pubitemid 36819890)