Greater percent-free testosterone is associated with high-grade prostate cancer in men undergoing prostate biopsy

Urology

Volumn 80, Issue 1, 2012, Pages 162-168

  Albisinni, Simone ^a   De Nunzio, Cosimo ^a   Tubaro, Andrea ^a   Barry, William T ^b   Banez, Lionel L ^b   Freedland, Stephen J ^b,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTATE SPECIFIC ANTIGEN; TESTOSTERONE;

ADULT; AGED; ARTICLE; CANCER RISK; DIGITAL RECTAL EXAMINATION; DISEASE ASSOCIATION; GLEASON SCORE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; ORGAN SIZE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTATE; PROSTATE BIOPSY; PROSTATE CANCER; TESTOSTERONE BLOOD LEVEL;

EID: 84862976882     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2012.01.068     Document Type: Article

References (30)

1. A. Tubaro Testosterone and prostate cancer Eur Urol 51 2007 293 295 (Pubitemid 44937807)
2. C. Huggins, C.V. Hodges Studies on prostatic cancer - I The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate Cancer Res 1 1941 293 297
3. A.W. Roddam, N.E. Allen, P. Appleby Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies J Natl Cancer Inst 100 2008 170 183 (Pubitemid 351480553)
4. J. Morote, J. Planas, C. Ramirez Evaluation of the serum testosterone to prostate-specific antigen ratio as a predictor of prostate cancer risk BJU Int 105 2010 481 484
5. J.K. Parsons, H.B. Carter, E.A. Platz Serum testosterone and the risk of prostate cancer: potential implications for testosterone therapy Cancer Epidemiol Biomarkers Prev 14 2005 2257 2260 (Pubitemid 41603276)
6. A.B. Porcaro, A. Petrozziello, M. Romano Investigative clinical study on prostate cancer Part III: exploring total PSA and free testosterone distributions and linear correlations in groups and subgroups of operated prostate cancer patients according to the total PSA/FT ratio Urol Int 85 2010 406 409
7. S.J. Freedland, L.L. Bañez, L.L. Sun Obese men have higher-grade and larger tumors: an analysis of the duke prostate center database Prostate Cancer Prostatic Dis 12 2009 259 263
8. J.M. Amatruda, S.M. Harman, G. Pourmotabbed Depressed plasma testosterone and fractional binding of testosterone in obese males J Clin Endocrinol Metab 47 1978 268 271 (Pubitemid 8393519)
9. S.M. Harman, E.J. Metter, J.D. Tobin Longitudinal effects of aging on serum total and free testosterone levels in healthy men Baltimore longitudinal study of aging J Clin Endocrinol Metab 86 2001 724 731 (Pubitemid 32207487)
10. S.J. Freedland, W.B. Isaacs, E.A. Platz Prostate size and risk of high-grade, advanced prostate cancer and biochemical progression after radical prostatectomy: a search database study J Clin Oncol 23 2005 7546 7554 (Pubitemid 46291818)
11. A.A. Caire, L. Sun, B.D. Lack Predicting non-organ-confined prostate cancer in men diagnosed after 2000 Prostate Cancer Prostatic Dis 13 2010 248 251
12. P. Stattin, S. Lumme, L. Tenkanen High levels of circulating testosterone are not associated with increased prostate cancer risk: a pooled prospective study Int J Cancer 108 2004 418 424 (Pubitemid 37549608)
13. T. Imamoto, H. Suzuki, M. Yano Does presence of prostate cancer affect serum testosterone levels in clinically localized prostate cancer patients? Prostate Cancer Prostatic Dis 12 2009 78 82
14. J.C. Massengill, L. Sun, J.W. Moul Pretreatment total testosterone level predicts pathological stage in patients with localized prostate cancer treated with radical prostatectomy J Urol 169 2003 1670 1675 (Pubitemid 36443468)
15. C. Teloken, C.T. Da Ros, F. Caraver Low serum testosterone levels are associated with positive surgical margins in radical retropubic prostatectomy: hypogonadism represents bad prognosis in prostate cancer J Urol 174 2005 2178 2180 (Pubitemid 41611769)
16. M. Yano, T. Imamoto, H. Suzuki The clinical potential of pretreatment serum testosterone level to improve the efficiency of prostate cancer screening Eur Urol 51 2007 375 380 (Pubitemid 44937808)
17. T. Imamoto, H. Suzuki, S. Fukasawa Pretreatment serum testosterone level as a predictive factor of pathological stage in localized prostate cancer patients treated with radical prostatectomy Eur Urol 47 2005 308 312 (Pubitemid 40248848)
18. R.S. Swerdloff, C. Wang Androgens and the ageing male Best Pract Res Clin Endocrinol Metab 18 2004 349 362 (Pubitemid 38992416)
19. J. Jayachandran, L.L. Bañez, W.J. Aronson Obesity as a predictor of adverse outcome across black and white race: results from the shared equal access regional Cancer Hospital (SEARCH) database Cancer 115 2009 5263 5271
20. V.E. Quarmby, W.G. Yarbrough, D.B. Lubahn Autologous down-regulation of androgen receptor messenger ribonucleic acid Mol Endocrinol 4 1990 22 28
21. N. Papadopoulou, I. Charalampopoulos, V. Anagnostopoulou Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells Mol Cancer 7 2008 88
22. L.S. Marks, N.A. Mazer, E. Mostaghel Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial JAMA 296 2006 2351 2361 (Pubitemid 44749363)
23. E.A. Mostaghel, S.T. Page, D.W. Lin Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer Cancer Res 67 2007 5033 5041 (Pubitemid 46910214)
24. Z. Hyde, L. Flicker, O.P. Almeida Low free testosterone predicts frailty in older men: the health in men study J Clin Endocrinol Metab 95 2010 3165 3172
25. G. Vanbillemont, V. Bogaert, D. De Bacquer Polymorphisms of the SHBG gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly men Clin Endocrinol Oxf 70 2009 303 310
26. S.K. Singh, R. Goyal, D.D. Pratyush Is hypoandrogenemia a component of metabolic syndrome in males? Exp Clin Endocrinol Diabetes 119 2011 30 35
27. S. Dhindsa, S. Prabhakar, M. Sethi Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes J Clin Endocrinol Metab 89 2004 5462 5468 (Pubitemid 39518427)
28. G. Corona, M. Monami, G. Rastrelli Type 2 diabetes mellitus and testosterone: a meta-analysis study Int J Androl 34 2011 528 540
29. E.A. Atchison, G. Gridley, J.D. Carreon Risk of cancer in a large cohort of U.S. veterans with diabetes Int J Cancer 128 2011 635 643
30. S.A. Moreno, A. Shyam, A. Morgentaler Comparison of free testosterone results by analog radioimmunoassay and calculated free testosterone in an ambulatory clinical population J Sex Med 7 2010 1948 1953