Asymmetric synthesis of the carbon-14-labeled selective glucocorticoid receptor modulator using cinchona alkaloid catalyzed addition of 6-bromoindole to ethyl trifluoropyruvate

Molecules

Volumn 17, Issue 6, 2012, Pages 6507-6518

  Sumiyoshi, Takaaki ^a   Urabe, Daisuke ^a   Tojo, Kengo ^a   Sakamoto, Masato ^a   Niidome, Kazumi ^a   Tsuboya, Norie ^a   Nakajima, Tomoko ^a   Tobe, Masanori ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Asymmetric synthesis; Cinchona alkaloid; Organocatalyst; Radioisotope labeled compound

Indexed keywords

(4 ((1 (2 (6 CYANO 1 (CYCLOHEXYLMETHYL) 1H INDOL 3 YL) 3,3,3 TRIFLUORO 2 HYDROXYPROPYL)PIPERIDIN 4 YL)OXY) 3 METHOXYPHENYL)ACETIC ACID; (4-((1-(2-(6-CYANO-1-(CYCLOHEXYLMETHYL)-1H-INDOL-3-YL)-3,3,3-TRIFLUORO-2-HYDROXYPROPYL)PIPERIDIN-4-YL)OXY)-3-METHOXYPHENYL)ACETIC ACID; 6 BROMOINDOLE; 6-BROMOINDOLE; CARBON; CINCHONA ALKALOID; DRUG DERIVATIVE; ETHYL TRIFLUOROPYRUVATE; GLUCOCORTICOID RECEPTOR; INDOLE DERIVATIVE; PIPERIDINE DERIVATIVE; PYRUVIC ACID;

ARTICLE; CATALYSIS; CHEMISTRY; DRUG ANTAGONISM; TEMPERATURE;

CARBON RADIOISOTOPES; CATALYSIS; CINCHONA ALKALOIDS; INDOLES; PIPERIDINES; PYRUVIC ACID; RECEPTORS, GLUCOCORTICOID; TEMPERATURE;

EID: 84862976166     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules17066507     Document Type: Article

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