Ion yields for some salts in MALDI: Mechanism for the gas-phase ion formation from preformed ions

Journal of the American Society for Mass Spectrometry

Volumn 23, Issue 1, 2012, Pages 162-170

  Moon, Jeong Hee ^a   Shin, Young Sik ^b   Bae, Yong Jin ^b   Kim, Myung Soo ^b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Ion formation mechanism; Ion pair; Ion yield; MALDI; Preformed ion

Indexed keywords

1-BUTYL-3-METHYL-IMIDAZOLIUM HEXAFLUOROPHOSPHATE; ANALYTE CONCENTRATION; ANALYTES; CONCENTRATION DEPENDENCE; COUNTER ANIONS; CYANO-4-HYDROXYCINNAMIC ACIDS; GASPHASE; IDEAL SYSTEMS; ION EMISSIONS; ION FORMATION; ION PAIR; ION PAIR FORMATION; ION PAIRS; ION YIELD; ION YIELDS; MALDI; MATRIX; MATRIX-ASSISTED LASER DESORPTION IONIZATION; ROOM TEMPERATURE IONIC LIQUIDS; SALT CONCENTRATION; SOLID SAMPLES; TRIHEXYLTETRADECYLPHOSPHONIUM;

CHLORINE COMPOUNDS; DESORPTION; IONIC LIQUIDS; IONIZATION OF GASES; POSITIVE IONS;

SALTS;

1 BUTYL 3 METHYLIMIDAZOLIUM HEXAFLUOROPHOSPHATE; ALPHA CYANO 4 HYDROCINNAMIC ACID; ANION; BENZYLTRIPHENYLPHOSPHONIUM SALT; CATION; HYDROCINNAMIC ACID DERIVATIVE; IONIC LIQUID; PEPTIDE; PHOSPHINE DERIVATIVE; PROTEIN; TRIHEXYLTETRADECYLPHOSPHONIUM BIS(2,4,4 TRIMETHYLPENTYL)PHOSPHINATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL PARAMETERS; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GAS; ION YIELD; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; SOLID;

COUMARIC ACIDS; IMIDAZOLES; IONIC LIQUIDS; IONS; MODELS, CHEMICAL; SALTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84862973588     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-011-0278-6     Document Type: Article

References (29)

1. Hillenkamp, F., Peter-Katalinić, J.: MALDI MS. A Practical Guide to Instrumentation, Methods and Applications. Wiley-VCH, Weinheim (2007)
2. Cole, R.B.: Electrospray and MALDI Mass Spectrometry. Fundamentals, Instrumentation, Practicalities, and Biological Applications, 2nd edn. Wiley, Hoboken (2010)
3. Dreisewerd, K.: The desorption process in MALDI. Chem. Rev. 103, 395-425 (2003)
4. Zenobi, R., Knochenmuss, R.: Ion formation in MALDI mass spectrometry. Mass Spectrom. Rev. 17, 337-366 (1998) (Pubitemid 128628191)
5. Knochenmuss, R., Stortelder, A., Breuker, K., Zenobi, R.: Secondary ion-molecule reactions in matrix-assisted laser desorption/ionization. J. Mass Spectrom. 35, 1237-1245 (2000)
6. Breuker, K., Knochenmuss, R., Zhang, J., Storteler, A., Zenobi, R.: Thermodynamic control of final ion distributions in MALDI: In-plume proton transfer reactions. Int. J. Mass Spectrom. 226, 211-222 (2003)
7. Knochenmuss, R., Zenobi, R.: MALDI ionization: The role of in-plume processes. Chem. Rev. 103, 441-452 (2003)
8. Knochenmuss, R.: Ion formation mechanisms in UV-MALDI. Analyst 131, 966-986 (2006) (Pubitemid 44313637)
9. Karas, M., Glückmann, M., Schäfer, J.: Ionization in matrix-assisted laser desorption/ionization: Singly charged molecular ions are the lucky survivors. J. Mass Spectrom. 35, 1-12 (2000) (Pubitemid 30060147)
10. Karas, M., Krüger, R.: Ion formation in MALDI: The cluster ionization mechanism. Chem. Rev. 103, 427-439 (2003)
11. Jaskolla, T.W., Karas, M.: Compelling evidence for lucky survivor and gas phase protonation: The unified MALDI analyte protonation mechanism. J. Am. Soc. Mass Spectrom. 22(6), 976-988 (2011)
12. Ens, W., Mao, Y., Mayer, F., Standing, K.G.: Properties of matrix-assisted laser desorption. Measurements with a time-to-digital converter. Rapid Commun. Mass Spectrom. 5(3), 117-123 (1991)
13. Mowry, C.D., Johnston, M.V.: Simultaneous detection of ions and neutrals produced by matrix-assisted laser desorption. Rapid Commun. Mass Spectrom. 7, 569-575 (1993)
14. Quist, A.P., Huth-Fehre, T., Sundqvist, B.U.R.: Total yield measurements in matrix-assisted laser desorption using a quartz crystal microbalance. Rapid Commun. Mass Spectrom. 8, 149-154 (1994)
15. Puretzky, A.A., Geohegan, D.B.: Gas-phase diagnostics and LIF-imaging of 3-hydroxypicolinic acid MALDI-matrix plumes. Chem. Phys. Lett. 286, 425-432 (1998) (Pubitemid 128181172)
16. Yoon, S.H., Kim, M.S.: Development of a time-resolved method for photodissociation mechanistic study of protonated peptides: Use of a voltage-floated cell in a tandem time-of-flight mass spectrometer. J. Am. Soc. Mass Spectrom. 18, 1729-1739 (2007) (Pubitemid 47419341)
17. n ) time-of-flight mass spectrometry. Bull. Korean Chem. Soc. 31(1), 92-99 (2010)
18. Yoon, S.H., Moon, J.H., Kim, M.S.: Changes in dissociation efficiency and kinetics of peptide ions induced by basic residues and their mechanistic implication. J. Am. Soc. Mass Spectrom. 22, 214-220 (2011)
19. Moon, J.H., Yoon, S.H., Kim, M.S.: Temperature of peptide ions generated by matrix-assisted laser desorption ionization and their kinetic parameters. J. Phys. Chem. B 113, 2071-2076 (2009)
20. Beavis, R.C., Chait, B.T.: Factors affecting the ultraviolet laser desorption of proteins. Rapid Commun. Mass Spectrom. 3(7), 233-237 (1989)
21. Westman, A., Brinkmalm, G., Barofsky, D.F.: MALDI induced saturation effects in chevron microchannel plate detectors. Int. J. Mass Spectrom. Ion Processes 169/170, 79-87 (1997) (Pubitemid 127737162)
22. Frankevich, V., Knochenmuss, R., Zenobi, R.: The origin of electrons in MALDI and their use for sympathetic cooling of negative ions in FTICR. Int. J. Mass Spectrom. 220, 11-19 (2002)
23. Knochenmuss, R.: Photoionization pathways and free electrons in UV-MALDI. Anal. Chem. 76, 3179-3184 (2004) (Pubitemid 38715712)
24. McCombie, G., Knochenmuss, R.: Enhanced MALDI ionization efficiency at the metal-matrix interface: Practical and mechanistic consequences of sample thickness and preparation method. J. Am. Soc. Mass Spectrom. 17, 737-745 (2006) (Pubitemid 44389567)
25. Armstrong, D.W., Zhang, L., He, L., Gross, M.L.: Ionic liquids as matrixes for matrix-assisted laser desorption/ionization mass spectrometry. Anal. Chem. 73, 3679-3686 (2001) (Pubitemid 32867301)
26. Knochenmuss, R., Zhigilei, L.V.: What determines MALDI ion yields? A molecular dynamics study of ion mechanisms. Anal. Bioanal. Chem (2011). doi: 10.1007/s00216-011-5194-x
27. Spengler, B.: Post-source decay analysis in matrix-assisted laser desorption/ionization mass spectrometry of biomolecules. J. Mass Spectrom. 32, 1019-1036 (1997) (Pubitemid 27454247)
28. Yoon, S.H., Moon, J.H., Kim, M.S.: A comparative study of in- and post-source decays of peptides and preformed ions in matrix-assisted laser desorption ionization time-of-flight mass spectrometry: Effective temperature and matrix effect. J. Am. Soc. Mass Spectrom. 21, 1876-1883 (2010)
29. Bae, Y.J., Moon, J.H., Kim, M.S.: Expansion cooling in the matrix plume is under-recognized in MALDI mass spectrometry. J. Am. Soc. Mass Spectrom. 22, 1070-1078 (2011)