Altered tight junctions and fence function in NRK-52E cells induced by aristolochic acid

Human and Experimental Toxicology

Volumn 31, Issue 1, 2012, Pages 32-41

  Liu, Mei ^a   Yang, Xiao ^a   Fan, Jinjin ^a   Zhang, Rui ^a   Wu, Jun ^a   Zeng, Youjia ^a   Nie, Jing ^a   Yu, Xueqing ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

apoptosis; aristolochic acid; renal epithelial cell line; tight junctions

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ARISTOLOCHIC ACID; PROTEIN ZO1; SCAFFOLD PROTEIN; UVOMORULIN;

APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; KIDNEY EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TIGHT JUNCTION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; ARISTOLOCHIC ACIDS; CADHERINS; CARRIER PROTEINS; CELL LINE; CELL SURVIVAL; KIDNEY; MEMBRANE PROTEINS; PHOSPHOPROTEINS; RATS; TIGHT JUNCTIONS;

EID: 84862970568     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327111407645     Document Type: Article

References (29)

1. Ioset JR, Raoelison GE, Hostettmann K. Detection of aristolochic acid in Chinese phytomedicines and dietary supplements used as slimming regimens. Food Chem Toxicol. 2003 ; 41: 29-36 (Pubitemid 35346770)
2. Vanherweghem JL, Depierreux M, Tielemans C, et al. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet. 1993 ; 341: 387-391 (Pubitemid 23048140)
3. Bamias G, Boletis J. Balkan nephropathy: evolution of our knowledge. Am J Kidney Dis. 2008 ; 52: 606-616
4. Cosyns JP. Aristolochic acid and 'Chinese Herbs Nephropathy': a review of the evidence to date. Drug Saf. 2003 ; 26: 33-48
5. Mucsi I, Rosivall L. Epithelial-mesenchymal transition in renal tubular cells in the pathogenesis of progressive tubulo-interstitial fibrosis. Acta Physiol Hung. 2007 ; 94: 117-131
6. Pozdzik AA, Salmon IJ, Nortier JL, et al. Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation. Kidney Int. 2008 ; 73: 595-607 (Pubitemid 351264108)
7. Yang L, Li X, Wang H. Possible mechanisms explaining the tendency towards interstitial fibrosis in aristolochic acid-induced acute tubular necrosis. Nephrol Dial Transplant. 2007 ; 22: 445-456 (Pubitemid 46189888)
8. Pozdzik AA, Salmon IJ, Nortier JL, et al. Patterns of interstitial inflammation during the evolution of renal injury in experimental aristolochic acid nephropathy. Nephrol Dial Transplant. 2008 ; 23: 2480-2491
9. Balkovetz DF. Opening Pandora's box in the tight junction. J Am Soc Nephrol. 2007 ; 18: 1624-1625 (Pubitemid 46870295)
10. Anderson JM, Van Itallie CM. Tight junctions and the molecular basis for regulation of paracellular permeability. Am J Physiol Gastrointest Liver Physiol. 1995 ; 269: G467 - G475
11. Zeisberg M, Kalluri R. The role of epithelial-to-mesenchymal transition in renal brosis. J Mol Med. 2004 ; 82: 175-181 (Pubitemid 38392167)
12. Zhang M, Lee CH, Phillips A, et al. Polarity of response to transforming growth factor-beta1 in proximal tubular epithelial cells is regulated by beta-catenin. J Biol Chem. 2007 ; 282: 28639-28647 (Pubitemid 47606061)
13. Martin-Martin N, Ryan G, Ryan MP, et al. Sirolimus and cyclosporine A alter barrier function in renal proximal tubular cells through stimulation of ERK 1/2 signaling and claudin-1 expression. Am J Physiol Renal Physiol. 2010 ; 298: F672 - F682
14. Mossman BT. In vitro approaches for determining mechanisms of toxicity and carcinogenicity by asbestos in the gastrointestinal and respiratory tracts. Environ Health Perspect. 1983 ; 53: 155-161 (Pubitemid 14162054)
15. Okada T, Narai A, Shimizu M, et al. Assessment of the marine toxins by monitoring the integrity of human intestinal Caco-2 cell monolayer. Toxicol In Vitro. 2000 ; 14: 219-226 (Pubitemid 30235119)
16. Zhang L, Li J, Jiang Z, et al. Inhibition of aquaporin-1 expression by RNAi protects against aristolochic acid I-induced apoptosis in human proximal tubular epithelial (HK-2) cells. Biochem Biophys Res Commun. 2011 ; 405: 68-73
17. Liu Q, Wang Q, Yang X, et al. Differential cytotoxic effects of denitroaristolochic acid II and aristolochic acids on renal epithelial cells. Toxicol Lett. 2009 ; 184: 5-12
18. Mullin JM, Skrovanek SM, Valenzano MC. Modification of tight junction structure and permeability by nutritional means. Ann N Y Acad Sci. 2009 ; 1165: 99-112
19. Kiely B, Feldman G, Ryan MP. Modulation of renal epithelial barrier function by mitogens-activated protein kinases (MAPKs): mechanism of cyclosporine A-induced increase in transepithelial resistance. Kidney Int. 2003 ; 63: 908-916 (Pubitemid 36315568)
20. Kwon O, Nelson WJ, Myers BD, et al. Backleak, tight junctions, and cell- cell adhesion in postischemic injury to the renal allograft. J Clin Invest. 1998 ; 101: 2054-2064 (Pubitemid 28244089)
21. Nilsson M, Dahlman T, Westermark K, et al. Transforming growth factor-beta promotes epidermal growth factor-induced thyroid cell migration and follicle neoformation in collagen gel separable from cell proliferation. Exp Cell Res. 1995 ; 220: 257-265
22. Suzuki T, Hara H. Quercetin enhances intestinal barrier function through the assembly of zonula occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. J Nutr. 2009 ; 139: 965-974
23. Ooshio T, Fujita N, Takai Y. Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions. J Cell Sci. 2007 ; 12: 2352-2365 (Pubitemid 47225939)
24. Liu Y. Epithelial to mesenchymal transition in renal brogenesis: pathologic signicance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol. 2004 ; 15: 1-12 (Pubitemid 38020692)
25. Gopalakrishnan S, Hallett MA. Marrs JA, et al. aPKC-PAR complex dysfunction and tight junction disassembly in renal epithelial cells during ATP depletion. Am J Physiol Cell Physiol. 2007 ; 292: C1094 - C1102 (Pubitemid 46440413)
26. Mellman I, Nelso WJ. Coordinated protein sorting, targeting and distribution in polarized cells. Nat Rev Mol Cell Biol. 2008 ; 9: 833-845
27. Blanco D, Vicent S, Montuenga LM, et al. Altered expression of adhesion molecules and epithelial-mesenchymal transition in silica-induced rat lung carcinogenesis. Lab Invest. 2004 ; 84: 999-1012 (Pubitemid 39025035)
28. Yang J, Liu Y. Dissection of key events in tubular epithelial to myobroblast transition and its implications in renal interstitial brosis. Am J Pathol. 2001 ; 159: 1465-1475 (Pubitemid 32947976)
29. Iwano M, Neilson EG. Mechanisms of tubulointerstitial brosis. Curr Opin Nephrol Hypertens. 2004 ; 13: 279-284