Compartmental hollow fiber capillary membrane-based bioreactor technology for in vitro studies on red blood cell lineage direction of hematopoietic stem cells

Tissue Engineering - Part C: Methods

Volumn 18, Issue 2, 2012, Pages 133-142

  Housler, Greggory J ^a,b   Miki, Toshio ^a   Schmelzer, Eva ^a   Pekor, Christopher ^a   Zhang, Xiaokui ^c   Kang, Lin ^c   Voskinarian Berse, Vanessa ^c   Abbot, Stewart ^c   Zeilinger, Katrin ^d   Gerlach, Jörg C ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c CELGENE CORPORATION   (United States)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; BIOCONVERSION; BIOREACTORS; BLOOD; CARBON DIOXIDE; CARBON FIBERS; CELL PROLIFERATION; CONTINUOUS CELL CULTURE; CYTOLOGY; EXPANSION; INNOVATION; MAGNETIC SEPARATION; MICROFILTRATION; OXYGENATION; THREE DIMENSIONAL;

BLOOD TRANSFUSION; CELL EXPANSION; CLINICAL APPLICATION; CONTINUOUS PRODUCTION; CORD BLOOD; CULTURE MEDIUM; CULTURE SYSTEMS; HEMATOPOIETIC STEM CELLS; HIGH DEMAND; HOLLOW FIBER; HOLLOW FIBER MEMBRANES; IN-VITRO; LABORATORY SCALE; MICRO-FILTRATION MEMBRANES; PROGENITOR CELL; RED BLOOD CELL; SCALED-DOWN VERSIONS; SEEDING DENSITY; SEMI-CONTINUOUS; THREE-DIMENSIONAL (3D);

STEM CELLS;

ACRYLIC ACID RESIN; GLUCOSE; LACTIC ACID; MEMBRANE ANTIGEN;

ARTICLE; ARTIFICIAL MEMBRANE; BIOREACTOR; BIOSYNTHESIS; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CELL SURVIVAL; CHEMISTRY; CULTURE TECHNIQUE; CYTOLOGY; ERYTHROCYTE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HEMATOPOIETIC STEM CELL; HUMAN; INSTRUMENTATION; METABOLISM; METHODOLOGY; PERFUSION; STAINING; TIME; ULTRASTRUCTURE;

ACRYLIC RESINS; ANTIGENS, SURFACE; BIOREACTORS; CELL COUNT; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINEAGE; CELL SURVIVAL; CELLS, CULTURED; ERYTHROCYTES; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GLUCOSE; HEMATOPOIETIC STEM CELLS; HUMANS; LACTIC ACID; MEMBRANES, ARTIFICIAL; PERFUSION; STAINING AND LABELING; TIME FACTORS;

EID: 84862909080     PISSN: 19373384     EISSN: 19373392     Source Type: Journal    
DOI: 10.1089/ten.tec.2011.0305     Document Type: Article

References (31)

1. Bersch, C. The give and take of blood banking. Medical Laboratory Observer [on-line]. March 2010. Available at http://www.mlo-online.com/
2. Yap, C., Lau, L., Krishnaswamy, M., Gaskell, M., and Yii, M. Age of transfused red cells and early outcomes after cardiac surgery. Ann Thorac Surg 86. 554, 2008.
3. Kirouac, D.C., and Zandstra, P.W. The systematic production of cells for cell therapies. Cell Stem Cell 3, 369, 2008.
4. Noll, T., Jelonek, N., Schmidt, S., Biselli, M., and Wandrey, C. Cultivation of hematopoietic stem and progenitor cells: biochemical engineering aspects. Adv Biochem Eng Biotechnol 74, 111, 2002.
5. Kowalczyk, M., Waldron, K., Kresnowati, P., and Danquah, M.K. Review: process challenges relating to hematopoietic stem cell culture in bioreactors. J. Ind Microbiol Biotechnol 38, 761, 2011.
6. Dahlberg, A., Delaney, C., and Bernstein, I.D. Ex vivo expansion of human hematopoietic stem and progenitor cells. Blood 117, 6083, 2011.
7. Panoskaltsis, N., Mantalaris, A., and Wu, J.H.D., Engineering a mimicry of bone marrow tissue ex vivo. J Biosc Bioeng 100, 28, 2005.
8. Koller, M.R. Manchel, I., Palsson, M.A., Maher, R.J., and Palsson, B.O. Different measures of human hematopoietic cell culture performance are optimized under vastly different conditions. Biotechnol Bioeng 50, 505, 1996.
9. Zimring, J.C., Spitalnik, S.L., Roback, J.D., and Hillyer, C.D. Transfusion-induced autoantibodies and differential immunogenicity of blood group antigens: a novel hypothesis. Tranfusion 47, 2189, 2007.
10. Douay, L., and Andreu, G. Ex vivo production of Human red blood cells from hematopoietic stem cells: what is the future in transfusion. Transfus Med Rev 21, 2007.
11. Giarratana, M.C., Kobari, L., Lapillonne, H., Chalmers, D., Kiger, L., Cynober, T., Marden, M.C., Wajcman, H., and Douay, L. Ex vivo generation of fullymature human red blood cells fromhematopoietic stemcells.Nat Biotechnol 23, 69, 2005.
12. Douay, L. From stem cells to red blood cells in vitro: "the 12 labors of Hercules." Clin Lab Med 30, 391, 2010.
13. Douay, L., Lapillonne, H., and Turhan, A.G., Stem cells-a source of adult red blood cells for transfusion purposes: present and future. Crit Care Clin 25, 383, 2009.
14. Peng, C., and Palsson, B. Determination of specific oxygen uptake rates in human hematopoietic culture and implication for bioreactor design. Ann Biomed Eng 24, 373, 1996.
15. Cabrita, G., Ferreira, B.S., Lobato da Silva, C., Goncalves, R., Almeida-Porada, G., and Cabral, J. Hematopoietic stem cells: from the bone to the bioreactor. Trends Biotechnol 21, 233, 2003.
16. Koller, M.R., Bender, J.G., Papoutsakis, E.T., and Miller, W.M. Beneficial effects of reduced oxygen tension and perfusion in long-term hematopoietic cultures. Ann N Y Acad Sc 665, 105, 1992.
17. Abbot, S. The three "R"s of Blood transfusion in 2020: routine, reliable and robust. Clin Lab Med 30, 405, 2010.
18. Gerlach, J.C., Encke, J., Hole, O., Müller, C., Ryan, C.J., and Neuhaus, P. Bioreactor for a larger scale hepatocyte in vitro perfusion. Transplantation 58, 984, 1994.
19. Gerlach, J.C., Mutig, K., Sauer, I.M., Schrade, P., Efimova, E., Mieder, T., Naumann, G., Grunwald, A., Pless, G., Mas, A., Bachmann, S., Neuhaus, P., and Zeilinger, K. Use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors: a morphologic study. Transplantation 76, 781, 2003.
20. Schmelzer, E., Mutig, K., Schrade, P., Bachmann, S., Gerlach, J.C., and Zeilinger, K. Effect of human patient plasma ex vivo treatment on gene expression and progenitor cell activation of primary human liver cells in multi-compartment 3d perfusion bioreactors for extracorporeal liver support. Biotech Bioeng 103, 817, 2009.
21. Zeilinger, K., Holland, G., Sauer, I.M., Efimova, E., Kardassis, D., Obermayer, N., Liu, M., Neuhaus, P., and Gerlach, J.C. Time course of primary liver cell reorganization in threedimensional high-density bioreactors for extracorporeal liver support: an immunohistochemical and ultrastructural study. Tissue Eng 10, 1113, 2004.
22. Gerlach, J.C., Zeilinger, K., Grebe, A., Puhl, G., Pless, G., Sauer, I., Grunwald, A., Schnoy, N., Muller, C., and Neuhaus, P. Recovery of preservation-injured primary human hepatocytes and nonparenchymal cells to tissue like structures in large-scale bioreactors for liver support: an initial transmission electron microscopy study. J Invest Surg 16, 83, 2003.
23. Pless, G., Steffen, I., Zeilinger, K., Sauer, I.M., Katenz, E., Kehr, D.C., Roth,S.,Mieder,T.,Schwartlander,R.,Müller,C., Wegner, B., Hout, M.S., and Gerlach, J.C. Evaluation of primary human liver cells in bioreactor cultures for extracorporeal liver support on the basis of urea production. Artif Organs 9, 686, 2006.
24. Neildez-Nguyen TM, Wajcman H, Marden MC, Bensidhoum M,Moncollin V, GiarratanaMC, Kobari L, ThierryD, Douay L. Human erythroid cells produced ex vivo at large scale differentiate into red blood cells in vivo.Nat Biotechnol 20, 467, 2002.
25. Sussman, N.L., and Kelly, J.H. Improved liver function following treatment with an extracorporeal liver assist device. Artif Organs 17, 27, 1993.
26. Watanabe, F.D., Mullon, C.J., Hewitt, W.R., Arkadopoulos, N., Kahaku, E., Eguchi, S., Khalili, T., Arnaout, W., Shackleton, C.R., Rozga, J., Solomon, B., and Demetriou, A. A clinical experience with a bioartificial liver in the treatment of severe liver failure. a phase i clinical trial. Ann Surg 225, 484, 1997.
27. Xu, A.S.L., Luntz T.L., Macdonalds, J.M., Kubota, H., Hsu, E., London,R.E., and Reid, L.M. Lineage and biology and liver. In: Lanza RP, Langer R, Vacanti J (eds). Principles of Tissue Engineering. San Diego CA: Academic Press, 1999, pp. 559-598.
28. Hay, P.D., Veitich, A.R., Smith M.D., Cousins, R.B., and Gaylor, J.D. Oxygen transfer in a diffusion-limited hollow fiber bioartificial liver. Artif Organs 24, 278, 2000.
29. Collins, P.C., Nielsen, L.K., Patel, P.E., Papoutsakis, T., and Miller, W.M. Characterization of hematopoietic cell expansion, oxygen uptake, and glycolysis in a controlled, stirredtank bioreactor system. Biotechnol Prog 14, 466, 1998.
30. Koller, M.R., Manchel, I., Newsom, B.S., Palsson, M.A., and Palsson, B.O. Bioreactor expansion of human bone marrow: comparison of unprocessed, density-separated, and cd34-enriched cells. J Hematother 4, 159, 1995.
31. Liu, Y., Liu, T., Fan, X., Ma, X., and Cui, Z. Ex vivo expansion of hematopoietic stem cells derived from umbilical cord blood in rotating wall vessel. J Biotechnol 124, 592, 2006.