5-aminoimidazole-4-carboxyamide ribonucleoside induces G 1/S arrest and nanog downregulation via p53 and enhances erythroid differentiation

Stem Cells

Volumn 30, Issue 2, 2012, Pages 140-149

  Chae, Hee Don ^a   Lee, Man Ryul ^a   Broxmeyer, Hal E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AICAR; Erythroid; Mouse embryonic stem cells; Nanog; P53; Proliferation

Indexed keywords

5 AMINOIMIDAZOLE 4 CARBOXYAMIDE RIBONUCLEOSIDE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEUKEMIA INHIBITORY FACTOR; MESSENGER RNA; PROTEIN P21; PROTEIN P53; RIBONUCLEOSIDE DERIVATIVE; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; DOWN REGULATION; EMBRYO; EMBRYONIC STEM CELL; ENERGY METABOLISM; ERYTHROID CELL; HOMEOSTASIS; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ADENYLATE KINASE; AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; ANTIGENS, CD15; ANTIGENS, DIFFERENTIATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; EMBRYOID BODIES; EMBRYONIC STEM CELLS; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME ACTIVATORS; ERYTHROID CELLS; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; MICE; RIBONUCLEOSIDES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84862907953     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.778     Document Type: Article

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