Neuropilin-1 is upregulated in Sjögren's syndrome and contributes to pathological neovascularization

Histochemistry and Cell Biology

Volumn 137, Issue 5, 2012, Pages 669-677

  Sisto, Margherita ^a   Lisi, Sabrina ^a   Lofrumento, Dario Domenico ^a   D'Amore, Massimo ^b   Ribatti, Domenico ^a  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b UNIVERSITY OF SALENTO   (Italy)

Author keywords

I kB Salivary gland; Neuropilin; NF B; Sj gren's syndrome

Indexed keywords

ANGIOGENIC FACTOR; I KAPPA B; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEUROPILIN 1; NEUTRALIZING ANTIBODY;

ADULT; AGED; ANTIANGIOGENIC ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG TARGETING; EPITHELIUM CELL; FEMALE; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MICROARRAY ANALYSIS; NEOVASCULARIZATION (PATHOLOGY); PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SALIVARY GLAND; SJOEGREN SYNDROME; UPREGULATION;

ADULT; AGED; EPITHELIAL CELLS; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; NEUROPILIN-1; SALIVARY GLANDS; SJOGREN'S SYNDROME;

EID: 84862905179     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-012-0910-y     Document Type: Article

References (20)

1. Carvalho JF, Blank M, Shoenfeld Y (2007) Vascular endothelial growth factor (VEGF) in autoimmune diseases. J Clin Immunol 27:246-256
2. kB. Natl Rev Mol Cell Biol 5:392-401
3. Cioikiewicz M, Kuryliszyn-Moskal A, Klimiuk PA (2010) Analysis of correlations between selected endothelial cell activation markers, disease activity, and nailfold capillaroscopy microvascular changes in systemic lupus erythematosus patients. Clin Rheumatol 29:175-180
4. Fassold A, Falk W, Anders S, Hirsch T, Mirsky VM, Straub RH (2009) Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic Wber repulsion and arthritis. Arthritis Rheum 60:2892-2901
5. Hayden MS, Ghosh S (2008) Shared principles in NF-kappaB signaling. Cell 132:344-362
6. Kapsogeorgou EK, Dimitriou ID, Abu-Helu RF, Moutsopoulos HM, Manoussakis MN (2001) Activation of epithelial and myoepithelial cells in the salivary glands of patients with Sjögren's syndrome: high expression of intercellular adhesion molecule-1 (ICAM.1) in biopsy specimens and cultured cells. Clin Exp Immunol 124:126-133
7. Kawamura H, Li X, Goishi K, van Meeteren LA, Jakobsson L, Cébe- Suarez S et al (2008) Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood 112:3638-3649
8. Koch S, Tugues S, Li X, Gualandi L, Claesson-Welsh L (2011) Signal transduction by vascular endothelial growth factor receptors. Biochem J 437:169-183
9. Kong JS, Yoo SA, Kim JW, Yang SP, Chae CB, Tarallo V et al (2010) Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis. Arthritis Rheum 62:179-190
10. Kurosaka D, Hirai K, Nishioka M, Miyamoto Y, Yoshida K, Noda K et al (2010) Clinical signiWcance of serum levels of vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in patients with rheumatoid arthritis. J Rheumatol 376:1121-1128
11. Lisi S, Sisto M, Lofrumento DD, Cucci L, Frassanito MA, Mitolo V, D'Amore M (2010) Pro-inXammatory role of Anti-Ro/SSA autoantibodies through the activation of Furin-TACE-amphiregulin axis. J Autoimmun 35:160-170
12. Maruotti N, Cantatore FP, Crivellato E, Vacca A, Ribatti D (2006) Angiogenesis in rheumatoid arthritis. Histol Histopathol 21:557-566
13. Munoz-Chapuli R, Quesada AR, Angel Medina M (2004) Angiogenesis and signal transduction in endothelial cells. Cell Mol Life Sci 61:2224-2243
14. Ono M (2008) Molecular links between tumor angiogenesis and inXammation: inXammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy. Cancer Sci 99:1501-1506
15. Roman-Blas JA, Jimenez SA (2006) NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthr Cartil 14:839-848
16. Sakamoto K, Maeda S, Hikiba Y, Nakagawa H, Hayakawa Y, Shibata W et al (2009) Constitutive NF-kappaB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth. Clin Cancer Res 15:2248-2258
17. Seabrook TJ, Littlewood-Evans A, Brinkmann V, Pöllinger B, Schnell C, Hiestand PC (2010) Angiogenesis is present in experimental autoimmune encephalomyelitis and pro-angiogenic factors are increased in multiple sclerosis lesions. J NeuroinXammation 22:95
18. kB activation in Sjögren's syndrome. Histochem Cell Biol 135:615-625
19. Vadasz Z, Attias D, Kessel A, Toubi E (2010) Neuropilins and semaphorins- from angiogenesis to autoimmunity. Autoimmun Rev 9:825-829
20. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH (2002) ClassiWcation criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. European Study Group on ClassiWcation Criteria for Sjögren's Syndrome. Ann Rheum Dis 61:554-558