Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating bone morphogenetic protein 4

Journal of Neuropathology and Experimental Neurology

Volumn 71, Issue 7, 2012, Pages 640-653

  Reid, Mary V ^a   Murray, Kaitlin A ^a   Marsh, Eric D ^a,c   Golden, Jeffrey A ^a,c   Simmons, Rebecca A ^a,c   Grinspan, Judith B ^a,b,c  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b Pathology and Laboratory Medicine   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Bone morphogenetic protein; Intrauterine growth retardation; Myelin; Oligodendrocytes; Oxidative stress; Periventricular white matter injury

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; NOGGIN; OXIDIZING AGENT;

ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; BEHAVIOR DISORDER; BRAIN DEVELOPMENT; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; DEMYELINATION; DISEASE MODEL; EMBRYO; FEMALE; FETUS GROWTH; GROWTH RETARDATION; IN VITRO STUDY; IN VIVO STUDY; INFORMATION PROCESSING; INTRACELLULAR SIGNALING; INTRAUTERINE GROWTH RETARDATION; MYELINATION; NERVE CELL CULTURE; NEURAL STEM CELL; NONHUMAN; OLIGODENDROGLIA; OXIDATIVE STRESS; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUP (RODENT); RAT; STATISTICAL SIGNIFICANCE; UPREGULATION; UTERINE ARTERY;

ALDEHYDES; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; BRAIN; CELL DEATH; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; FETAL GROWTH RETARDATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HAND STRENGTH; IN SITU NICK-END LABELING; MALE; MICE; MICE, KNOCKOUT; MYELIN SHEATH; NERVE GROWTH FACTOR; NERVE TISSUE PROTEINS; NEURONS; OXIDATIVE STRESS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; UP-REGULATION;

EID: 84862901718     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e31825cfa81     Document Type: Article

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