Remyelination is altered by bone morphogenic protein signaling in demyelinated lesions

Journal of Neuroscience

Volumn 31, Issue 12, 2011, Pages 4504-4510

  Sabo, Jennifer K ^a   Aumann, Tim D ^a   Merlo, Daniel ^a   Kilpatrick, Trevor J ^a   Cate, Holly S ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; NOGGIN; ANTIMETABOLITE; BONE MORPHOGENETIC PROTEIN; BROXURIDINE; CARRIER PROTEIN; CHELATING AGENT; CUPRIZONE; NOGGIN PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL DENSITY; CELL PROLIFERATION; CONTROLLED STUDY; CORPUS CALLOSUM; DEMYELINATION; FEMALE; IN VIVO STUDY; MICROGLIA; MOUSE; NERVE FIBER; NERVE REGENERATION; NEURAL STEM CELL; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; REMYELINIZATION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL COUNT; CHEMICALLY INDUCED; DEMYELINATING DISEASE; DIAGNOSTIC USE; ELECTRON MICROSCOPY; GENETICS; GLIA; MYELIN SHEATH; PATHOLOGY; PHYSIOLOGY; STEM CELL;

ANIMALS; ANTIMETABOLITES; ASTROCYTES; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEINS; BROMODEOXYURIDINE; CARRIER PROTEINS; CELL COUNT; CHELATING AGENTS; CORPUS CALLOSUM; CUPRIZONE; DEMYELINATING DISEASES; FEMALE; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; MYELIN SHEATH; NEUROGLIA; OLIGODENDROGLIA; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 79953011587     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5859-10.2011     Document Type: Article

References (22)

1. Ara J, See J, Mamontov P, Hahn A, Bannerman P, Pleasure D, Grinspan JB (2008) Bone morphogenetic proteins 4, 6, and 7 are up-regulated in mouse spinal cord during experimental autoimmune encephalomyelitis. J Neurosci Res 86:125-135.
2. Barnett MH, Prineas JW (2004) Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion. Ann Neurol 55:458-468. (Pubitemid 38391962)
3. Cate HS, Sabo JK, Merlo D, Kemper D, Aumann TD, Robinson J, Merson TD, Emery B, Perreau VM, Kilpatrick TJ (2010) Modulation of bone morphogenic protein signalling alters numbers of astrocytes and oligodendroglia in the subventricular zone during cuprizone-induced demyelination. J Neurochem 115:11-22.
4. Deininger M, Meyermann R, Schluesener H (1995) Detection of two transforming growth factor-beta-related morphogens, bone morphogenetic proteins-4 and-5, in RNA of multiple sclerosis and Creutzfeldt-Jakob disease lesions. Acta Neuropathol 90:76-79.
5. Grinspan JB, Edell E, Carpio DF, Beesley JS, Lavy L, Pleasure D, Golden JA (2000) Stage-specific effects of bone morphogenetic proteins on the oligodendrocyte lineage. J Neurobiol 43:1-17. (Pubitemid 30191176)
6. Irvine KA, Blakemore WF (2008) Remyelination protects axons from demyelination-associated axon degeneration. Brain 131:1464-1477. (Pubitemid 351806463)
7. Izrael M, Zhang P, Kaufman R, Shinder V, Ella R, Amit M, Itskovitz-Eldor J, Chebath J, Revel M (2007) Human oligodendrocytes derived from embryonic stem cells: effect of noggin on phenotypic differentiation in vitro and on myelination in vivo. Mol Cell Neurosci 34:310-323. (Pubitemid 46330036)
8. Jablonska B, Aguirre A, Raymond M, Szabo G, Kitabatake Y, Sailor KA, Ming GL, Song H, Gallo V (2010) Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination. Nat Neurosci 13:541-550.
9. Kondo T, Raff MC (2004) A role for Noggin in the development of oligodendrocyte precursor cells. Dev Biol 267:242-251. (Pubitemid 38234747)
10. Kuhlmann T, Miron V, Cui Q, Wegner C, Antel J, Brúck W (2008) Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 131:1749-1758. (Pubitemid 351957453)
11. Mason JL, Jones JJ, Taniike M, Morell P, Suzuki K, Matsushima GK (2000) Mature oligodendrocyte apoptosis precedes IGF-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/ remyelination. J Neurosci Res 61:251-262. (Pubitemid 30620056)
12. Massagué J (1998) TGF-β signal transduction. Annu Rev Biochem 67:753-791.
13. Piccolo S, Sasai Y, Lu B, De Robertis EM (1996) Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of Chordin to BMP4. Cell 86:589-598.
14. Rivers LE, Young KM, Rizzi M, Jamen F, Psachoulia K, Wade A, Kessaris N, Richardson WD (2008) PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice. Nat Neurosci 11:1392-1401.
15. Sabo JK, Kilpatrick TJ, Cate HS (2009) Effects of bone morphogenic proteins on neural precursor cells and regulation during central nervous system injury. Neurosignals 17:255-264.
16. Selvamurugan N, Kwok S, Vasilov A, Jefcoat SC, Partridge NC (2007) Effects of BMP-2and pulsed electromagnetic field (PEMF) on rat primary osteoblastic cell proliferation and gene expression. J Orthop Res 25:1213-1220. (Pubitemid 47365295)
17. Sim FJ, Lang JK, Waldau B, Roy NS, Schwartz TE, Pilcher WH, Chandross KJ, Natesan S, Merrill JE, Goldman SA (2006) Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation. Ann Neurol 59:763-779. (Pubitemid 43673154)
18. Stidworthy MF, Genoud S, Suter U, Mantei N, Franklin RJ (2003) Quantifying the early stages of remyelination following cuprizone-induced demyelination. Brain Pathol 13:329-339. (Pubitemid 36975823)
19. Watanabe M, Sakurai Y, Ichinose T, Aikawa Y, Kotani M, Itoh K (2006) Monoclonal antibody Rip specifically recognizes 2′,3′-cyclic nucleotide 3′-phosphodiesterase in oligodendrocytes. J Neurosci Res 84:525-533. (Pubitemid 44196693)
20. Wolswijk G (1998) Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells. J Neurosci 18:601-609.
21. Zawadzka M, Rivers LE, Fancy SP, Zhao C, Tripathi R, Jamen F, Young K, Goncharevich A, Pohl H, Rizzi M, Rowitch DH, Kessaris N, Suter U, Richardson WD, Franklin RJ (2010) CNS-resident glial progenitor/ stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. Cell Stem Cell 6:578-590.
22. Zhao C, Fancy SP, Magy L, Urwin JE, Franklin RJ (2005) Stem cells, progenitors and myelin repair. J Anat 207:251-258. (Pubitemid 41301000)