NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination

Journal of Neuroscience

Volumn 32, Issue 25, 2012, Pages 8696-8702

  Kheirbek, Mazen A ^a,b   Tannenholz, Lindsay ^a,b   Hen, René ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLECORTIN; KI 67 ANTIGEN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NESTIN; YELLOW FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DENDRITE; DENTATE GYRUS; ELECTROPHYSIOLOGY; FEEDING BEHAVIOR; FORCED SWIMMING TEST; GRANULE CELL; IMMUNOHISTOCHEMISTRY; MALE; MAZE TEST; MOUSE; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OPEN FIELD BEHAVIOR; PERCEPTIVE DISCRIMINATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANXIETY; CELL SURVIVAL; CONDITIONING (PSYCHOLOGY); DENTATE GYRUS; DISCRIMINATION (PSYCHOLOGY); FEAR; FEEDING BEHAVIOR; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; MICE; MOTOR ACTIVITY; NERVE NET; NERVE TISSUE PROTEINS; NEUROGENESIS; NEURONAL PLASTICITY; NEURONS; PATCH-CLAMP TECHNIQUES; RECEPTORS, N-METHYL-D-ASPARTATE; RECOGNITION (PSYCHOLOGY); SWIMMING;

EID: 84862898508     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1692-12.2012     Document Type: Article

References (26)

1. Altman J, Das GD (1965) Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol 124: 319-335.
2. Clelland CD, Choi M, Romberg C, Clemenson GD Jr, Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA, Gage FH, Bussey TJ (2009) A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 325:210-213.
3. Cull-Candy SG, Leszkiewicz DN (2004) Role of distinct NMDA receptor subtypes at central synapses. Sci STKE 2004:re16.
4. David DJ, Samuels BA, Rainer Q, Wang JW, Marsteller D, Mendez I, Drew M, Craig DA, Guiard BP, Guilloux JP, Artymyshyn RP, Gardier AM, Gerald C, Antonijevic IA, Leonardo ED, Hen R (2009) Neurogenesisdependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron 62:479-493.
5. Denny CA, Burghardt NS, Schachter DM, Hen R, Drew MR (2012) 4- to 6-week-old adult-born hippocampal neurons influence noveltyevoked exploration and contextual fear conditioning. Hippocampus 22:1188-1201.
6. Dranovsky A, Picchini AM, Moadel T, Sisti AC, Yamada A, Kimura S, Leonardo ED, Hen R (2011) Experience dictates stem cell fate in the adult hippocampus. Neuron 70:908-923.
7. Dulawa SC, Holick KA, Gundersen B, Hen R (2004) Effects of chronic fluoxetine in animal models of anxiety and depression. Neuropsychopharmacology 29:1321-1330.
8. Espinosa JS, Wheeler DG, Tsien RW, Luo L (2009) Uncoupling dendrite growth and patterning: single-cell knockout analysis of NMDA receptor 2B. Neuron 62:205-217.
9. Ge S, Goh EL, Sailor KA, Kitabatake Y, Ming GL, Song H (2006) GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature 439:589-593.
10. Ge S, Yang CH, Hsu KS, Ming GL, Song H (2007) A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron 54:559-566.
11. Hunsaker MR, Rosenberg JS, Kesner RP (2008) The role of the dentate gyrus, CA3a,b, and CA3c for detecting spatial and environmental novelty. Hippocampus 18:1064-1073.
12. Imayoshi I, Sakamoto M, Ohtsuka T, Takao K, Miyakawa T, Yamaguchi M, Mori K, Ikeda T, Itohara S, Kageyama R (2008) Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci 11:1153-1161.
13. Jessberger S, Clark RE, Broadbent NJ, Clemenson GD Jr, Consiglio A, Lie DC, Squire LR, Gage FH (2009) Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem 16:147-154.
14. McNaughton BL (1980) Evidence for two physiologically distinct perforant pathways to the fascia dentata. Brain Res 199:1-19.
15. Nakashiba T, Cushman JD, Pelkey KA, Renaudineau S, Buhl DL, McHugh TJ, Rodriguez Barrera V, Chittajallu R, Iwamoto KS, McBain CJ, Fanselow MS, Tonegawa S (2012) Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. Cell 149:188-201.
16. Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, Hen R (2011a) Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472:466-470.
17. Sahay A, Wilson DA, Hen R (2011b) Pattern separation: a common function for new neurons in hippocampus and olfactory bulb. Neuron 70:582-588.
18. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805-809.
19. Saxe MD, Battaglia F, Wang JW, Malleret G, David DJ, Monckton JE, Garcia AD, Sofroniew MV, Kandel ER, Santarelli L, Hen R, Drew MR (2006) Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc Natl Acad Sci U S A 103:17501-17506.
20. Snyder JS, Kee N, Wojtowicz JM (2001) Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus. J Neurophysiol 85:2423-2431.
21. Tashiro A, Sandler VM, Toni N, Zhao C, Gage FH (2006) NMDA-receptormediated, cell-specific integration of new neurons in adult dentate gyrus. Nature 442:929-933.
22. Toni N, Laplagne DA, Zhao C, Lombardi G, Ribak CE, Gage FH, Schinder AF (2008) Neurons born in the adult dentate gyrus form functional synapses with target cells. Nat Neurosci 11:901-907.
23. von Engelhardt J, Doganci B, Jensen V, Hvalby Ø, Göngrich C, Taylor A, Barkus C, Sanderson DJ, Rawlins JN, Seeburg PH, Bannerman DM, Monyer H (2008) Contribution of hippocampal and extra-hippocampal NR2Bcontaining NMDA receptors to performance on spatial learning tasks. Neuron 60:846-860.
24. Winters BD, Bussey TJ (2005) Transient inactivation of perirhinal cortex disrupts encoding, retrieval, and consolidation of object recognition memory. J Neurosci 25:52-61.
25. Winters BD, Forwood SE, Cowell RA, Saksida LM, Bussey TJ (2004) Double dissociation between the effects of peri-postrhinal cortex and hippocampal lesions on tests of object recognition and spatial memory: heterogeneity of function within the temporal lobe. J Neurosci 24:5901-5908.
26. Zhao C, Deng W, Gage FH (2008) Mechanisms and functional implications of adult neurogenesis. Cell 132:645-660.