Sex hormones and cardiac arrest in long QT syndrome: Does progesterone represent a potential new antiarrhythmic therapy?

Heart Rhythm

Volumn 9, Issue 7, 2012, Pages 1150-1152

  Odening, Katja E ^a,b   Choi, Bum Rak ^a   Koren, Gideon ^a  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

17ALPHA ESTRADIOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL L TYPE; ESTROGEN RECEPTOR; GESTAGEN; GLUCOCORTICOID RECEPTOR; GONADORELIN; LUTEINIZING HORMONE; MEDROXYPROGESTERONE ACETATE; ORAL CONTRACEPTIVE AGENT; POTASSIUM CHANNEL HERG; PROGESTERONE;

CARDIOVASCULAR RISK; DISEASE ASSOCIATION; DISEASE MODEL; HEART ARREST; HEART VENTRICLE ARRHYTHMIA; HUMAN; INCIDENCE; LONG QT SYNDROME; NOTE; PHENOTYPE; POLYMORPHIC VENTRICULAR TACHYCARDIA; PREGNANCY; PRIORITY JOURNAL; QT PROLONGATION; RABBIT; RANDOMIZED CONTROLLED TRIAL (TOPIC); SUDDEN DEATH;

EID: 84862898110     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2012.02.028     Document Type: Editorial

References (16)

1. Zareba W, Moss AJ, Locati EH, et al; International Long QT Syndrome Registry. Modulating effects of age and gender on the clinical course of long QT syndrome by genotype. J Am Coll Cardiol 2003;42:103-109. (Pubitemid 36760769)
2. Sauer AJ, Moss AJ, McNitt S, et al. Long QT syndrome in adults. J Am Coll Cardiol 2007;49:329-337. (Pubitemid 46097383)
3. Seth R, Moss AJ, McNitt S, et al. Long QT syndrome and pregnancy. J Am Coll Cardiol 2007;49:1092-1098. (Pubitemid 46349501)
4. Khositseth A, Tester DJ, Will ML, Bell CM, Ackerman MJ. Identification of a common genetic substrate underlying postpartum cardiac events in congenital long QT syndrome. Heart Rhythm 2004;1:60-64. (Pubitemid 38647252)
5. Rashba EJ, Zareba W, Moss AJ, et al LQTS Investigators. Influence of pregnancy on the risk for cardiac events in patients with hereditary long QT syndrome. Circulation 1998;97:451-456. (Pubitemid 28090216)
6. Brunner M, Peng X, Liu GX, et al. Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome. J Clin Invest 2008;118:2246-2259. (Pubitemid 351872342)
7. Odening KE, Hyder O, Chaves L, et al. Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization. Am J Physiol Heart Circ Physiol 2008;295:H2264-H2272.
8. Odening KE, Choi B-R, Liu GX, et al. Estradiol promotes sudden cardiac death in transgenic long-QT type 2 rabbits while progesterone is protective. Heart Rhythm 2012;9:823-832.
9. Forbes TR. Systemic levels of plasma progesterone during pregnancy in women and monkeys. Endocrinology 1951;49:218-224.
10. Moss AJ. Sex hormones and ventricular tachyarrhythmias in LQTS: new insights regarding antiarrhythmic therapy. Heart Rhythm Jan 20, 2012. [Epub ahead of print].
11. Giudicessi JR, Brost BC, Traynor KD, Ackerman MJ. Potential depot medroxyprogesterone acetate-triggered torsades de pointes in a case of congenital type 2 long QT syndrome. Heart Rhythm 2012;9:1143-1147.
12. Hermsmeyer RK, Thompson TL, Pohost GM, Kaski JC. Cardiovascular effects of medroxyprogesterone acetate and progesterone: a case of mistaken identity? Nat Clin Pract Cardiovasc Med 2008;5:387-395. (Pubitemid 351935572)
13. Holtorf K. The bioidentical hormone debate: are bioidentical hormones (estradiol, estriol, and progesterone) safer or more efficacious than commonly used synthetic versions in hormone replacement therapy? Postgrad Med 2009;121: 73-85.
14. Bernstein P, Pohost G. Progesterone, progestins, and the heart. Rev Cardiovasc Med 2010;11:228-236.
15. Africander D, Verhoog N, Hapgood JP. Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception. Steroids 2011; 76:636-652.
16. McNeilly AS, Tay CC, Glasier A. Physiological mechanisms underlying lactational amenorrhea. Ann N Y Acad Sci 1994;709:145-155. (Pubitemid 24123326)