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Volumn 41, Issue 1, 2012, Pages 169-178

Silencing of IKKε using siRNA inhibits proliferation and invasion of glioma cells in vitro and in vivo

Author keywords

Glioma; IKK ; Invasion; Proliferation

Indexed keywords

BETA TUBULIN; CYCLIN D1; CYCLINE; GELATINASE A; GELATINASE B; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HISTONE; I KAPPA B ALPHA; I KAPPA B KINASE EPSILON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYC PROTEIN; PROTEIN BCL 2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; VASCULOTROPIN;

EID: 84862893179     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1452     Document Type: Article
Times cited : (23)

References (40)
  • 1
    • 0029992897 scopus 로고    scopus 로고
    • Molecular genetics and molecular biology advances in brain tumors
    • James CD and Olson JJ: Molecular genetics and molecular biology advances in brain tumors. Curr Opin Oncol 8: 188-195, 1996. (Pubitemid 26200552)
    • (1996) Current Opinion in Oncology , vol.8 , Issue.3 , pp. 188-195
    • James, C.D.1    Olson, J.J.2
  • 2
    • 0028913665 scopus 로고
    • Molecular genetics of human glioma
    • Westermark B and Nister M: Molecular genetics of human glioma. Curr Opin Oncol 7: 220-225, 1995.
    • (1995) Curr Opin Oncol , vol.7 , pp. 220-225
    • Westermark, B.1    Nister, M.2
  • 6
    • 0033623848 scopus 로고    scopus 로고
    • IKK is part of a novel PMA-inducible I (kappa) B kinase complex
    • Peters RT, Liao SM and Maniatis T: IKK is part of a novel PMA-inducible I (kappa) B kinase complex. Mol Cell 5: 513-522, 2000.
    • (2000) Mol Cell , vol.5 , pp. 513-522
    • Peters, R.T.1    Liao, S.M.2    Maniatis, T.3
  • 7
    • 18644380436 scopus 로고    scopus 로고
    • Regulation of c-Jun phosphorylation by the IkappaB kinase-ε complex in fibroblast-like synoviocytes
    • Sweeney SE, Hammaker D, Boyle DL and Firestein GS: Regulation of c-Jun phosphorylation by the IκB kinase-ε complex in fibroblast-like synoviocytes. J Immunol 174: 6424-6430, 2005. (Pubitemid 40663836)
    • (2005) Journal of Immunology , vol.174 , Issue.10 , pp. 6424-6430
    • Sweeney, S.E.1    Hammaker, D.2    Boyle, D.L.3    Firestein, G.S.4
  • 8
    • 29244439558 scopus 로고    scopus 로고
    • Inducible IkappaB kinase/IkappaB kinase ε expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells
    • DOI 10.1158/0008-5472.CAN-05-1602
    • Eddy SF, Guo S, Demicco EG, et al: Inducible IκB kinase/IκB kinase ε expression is induced by CK2 and promotes aberrant nuclear factor-κB activation in breast cancer cells. Cancer Res 65: 11375-11383, 2005. (Pubitemid 41823949)
    • (2005) Cancer Research , vol.65 , Issue.24 , pp. 11375-11383
    • Eddy, S.F.1    Guo, S.2    Demicco, E.G.3    Romieu-Mourez, R.4    Landesman-Bollag, E.5    Seldin, D.C.6    Sonenshein, G.E.7
  • 9
    • 33748756170 scopus 로고    scopus 로고
    • IKK-i/IKKε controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation
    • DOI 10.1074/jbc.M603133200
    • Adli M and Baldwin AS: IKK-i/IKKε controls constitutive, cancer cell-associated NF-κB activity via regulation of Ser-536 p65/RelA phosphorylation. J Biol Chem 281: 26976-26984, 2006. (Pubitemid 44401726)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.37 , pp. 26976-26984
    • Adli, M.1    Baldwin, A.S.2
  • 11
    • 67649969188 scopus 로고    scopus 로고
    • Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer
    • Guo JP, Shu SK, He L, et al: Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer. Am J Pathol 175: 324-333, 2009.
    • (2009) Am J Pathol , vol.175 , pp. 324-333
    • Guo, J.P.1    Shu, S.K.2    He, L.3
  • 12
    • 65449163494 scopus 로고    scopus 로고
    • Over-expression of IκB-kinase-ε(IKKε/IKKi) induces secretion of inflammatory cytokines in prostate cancer cell lines
    • Péant B, Diallo JS, Dufour F, et al: Over-expression of IκB-kinase-ε(IKKε/IKKi) induces secretion of inflammatory cytokines in prostate cancer cell lines. Prostate 69: 706-718, 2009.
    • (2009) Prostate , vol.69 , pp. 706-718
    • Péant, B.1    Diallo, J.S.2    Dufour, F.3
  • 14
    • 78650625252 scopus 로고    scopus 로고
    • IKBKE is over-expressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF-kappaB
    • Guan H, Zhang H, Cai J, et al: IKBKE is over-expressed in glioma and contributes to resistance of glioma cells to apoptosis via activating NF-kappaB. J Pathol 223: 436-445, 2011.
    • (2011) J Pathol , vol.223 , pp. 436-445
    • Guan, H.1    Zhang, H.2    Cai, J.3
  • 15
    • 8544283079 scopus 로고    scopus 로고
    • Endogenous inhibitors of nuclear factor-kappaB, an opportunity for cancer control
    • Chen F: Endogenous inhibitors of nuclear factor-kappaB, an opportunity for cancer control. Cancer Res 64: 8135-8138, 2004.
    • (2004) Cancer Res , vol.64 , pp. 8135-8138
    • Chen, F.1
  • 17
    • 37549004392 scopus 로고    scopus 로고
    • Nuclear factor-kappaB activation: From bench to bedside
    • Maywood
    • Sethi G, Sung B and Aggarwal BB: Nuclear factor-kappaB activation: from bench to bedside. Exp Biol Med (Maywood) 233: 21-31, 2008.
    • (2008) Exp Biol Med , vol.233 , pp. 21-31
    • Sethi, G.1    Sung, B.2    Aggarwal, B.B.3
  • 19
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp R, Hegi ME, Mason WP, et al: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10: 459-466, 2009.
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3
  • 20
    • 78650866392 scopus 로고    scopus 로고
    • Silencing of the IKKε gene by siRNA inhibits invasiveness and growth of breast cancer cells
    • Qin B and Cheng K: Silencing of the IKKε gene by siRNA inhibits invasiveness and growth of breast cancer cells. Breast Cancer Res 12: R74, 2010.
    • (2010) Breast Cancer Res , vol.12
    • Qin, B.1    Cheng, K.2
  • 21
    • 0035896513 scopus 로고    scopus 로고
    • ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation
    • Pearson G, English JM, White MA and Cobb MH: ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation. J Biol Chem 276: 7927-7931, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 7927-7931
    • Pearson, G.1    English, J.M.2    White, M.A.3    Cobb, M.H.4
  • 22
    • 20444419344 scopus 로고    scopus 로고
    • Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance
    • DOI 10.1038/ncb1258
    • MacKeigan JP, Murphy LO and Blenis J: Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol 7: 591-600, 2005. (Pubitemid 40796982)
    • (2005) Nature Cell Biology , vol.7 , Issue.6 , pp. 591-600
    • MacKeigan, J.P.1    Murphy, L.O.2    Blenis, J.3
  • 23
    • 0001003612 scopus 로고    scopus 로고
    • Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members
    • DOI 10.1073/pnas.94.23.12401
    • Hsu SY, Kaipia A, McGee E, Lomeli M and Hsueh AJ: Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc Natl Acad Sci USA 94: 12401-12406, 1997. (Pubitemid 27492540)
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , Issue.23 , pp. 12401-12406
    • Hsu, S.Y.1    Kaipia, A.2    McGee, E.3    Lomeli, M.4    Hsueh, A.J.W.5
  • 24
    • 0036488589 scopus 로고    scopus 로고
    • Role of integrins in cell invasion and migration
    • Hood JD and Cheresh DA: Role of integrins in cell invasion and migration. Nat Rev Cancer 2: 91-100, 2002. (Pubitemid 37328796)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.2 , pp. 91-100
    • Hood, J.D.1    Cheresh, D.A.2
  • 25
    • 0033766009 scopus 로고    scopus 로고
    • Molecular events implicated in brain tumor angiogenesis and invasion
    • Zagzag D, Friedlander DR, Margolis B, et al: Molecular events implicated in brain tumor angiogenesis and invasion. Pediatr Neurosurg 33: 49-55, 2000.
    • (2000) Pediatr Neurosurg , vol.33 , pp. 49-55
    • Zagzag, D.1    Friedlander, D.R.2    Margolis, B.3
  • 26
    • 38349124180 scopus 로고    scopus 로고
    • Identification of a novel blocker of IkappaBalpha kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-kappaB
    • Sung B, Pandey MK, Nakajima Y, et al: Identification of a novel blocker of IkappaBalpha kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-kappaB. Mol Cancer Ther 7: 191-201, 2008.
    • (2008) Mol Cancer Ther , vol.7 , pp. 191-201
    • Sung, B.1    Pandey, M.K.2    Nakajima, Y.3
  • 27
    • 34548763142 scopus 로고    scopus 로고
    • Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model
    • DOI 10.1158/0008-5472.CAN-07-0801
    • Lee TK, Poon RT, Wo JY, et al: Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model. Cancer Res 67: 8800-8809, 2007. (Pubitemid 47437456)
    • (2007) Cancer Research , vol.67 , Issue.18 , pp. 8800-8809
    • Lee, T.K.1    Poon, R.T.P.2    Wo, J.Y.3    Ma, S.4    Guan, X.-Y.5    Myers, J.N.6    Altevogt, P.7    Yuen, A.P.W.8
  • 28
    • 34247274248 scopus 로고    scopus 로고
    • Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin
    • DOI 10.1038/nature05656, PII NATURE05656
    • Luo JL, Tan W, Ricono JM, et al: Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature 446: 690-694, 2007. (Pubitemid 46606879)
    • (2007) Nature , vol.446 , Issue.7136 , pp. 690-694
    • Luo, J.-L.1    Tan, W.2    Ricono, J.M.3    Korchynskyi, O.4    Zhang, M.5    Gonias, S.L.6    Cheresh, D.A.7    Karin, M.8
  • 30
    • 34250898562 scopus 로고    scopus 로고
    • NF-kappaB as a potential molecular target for cancer therapy
    • Lee CH, Jeon YT, Kim SH and Song YS: NF-kappaB as a potential molecular target for cancer therapy. Biofactors 29: 19-35, 2007. (Pubitemid 46985299)
    • (2007) BioFactors , vol.29 , Issue.1 , pp. 19-35
    • Lee, C.H.1    Jeon, Y.-T.2    Kim, S.-H.3    Song, Y.-S.4
  • 31
    • 43749098070 scopus 로고    scopus 로고
    • NF-kappaB and cancer-identifying targets and mechanisms
    • Naugler WE and Karin M: NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev 18: 19-26, 2008.
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 19-26
    • Naugler, W.E.1    Karin, M.2
  • 33
    • 52549098089 scopus 로고    scopus 로고
    • In vitro and in vivo study of cell growth inhibition of simvastatin on chronic myelogenous leukemia cells
    • Yang YC, Huang WF and Chuan LM, et al: In vitro and in vivo study of cell growth inhibition of simvastatin on chronic myelogenous leukemia cells. Chemotherapy 54: 438-446, 2008.
    • (2008) Chemotherapy , vol.54 , pp. 438-446
    • Yang, Y.C.1    Huang, W.F.2    Chuan, L.M.3
  • 38
    • 33646576169 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tumor metastasis
    • DOI 10.1007/s10555-006-7886-9, Metalloproteinases and Cancer
    • Deryugina EI and Quigley JP: Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25: 9-34, 2006. (Pubitemid 43723979)
    • (2006) Cancer and Metastasis Reviews , vol.25 , Issue.1 , pp. 9-34
    • Deryugina, E.I.1    Quigley, J.P.2
  • 39
    • 0033015706 scopus 로고    scopus 로고
    • Transcriptional up-regulation of matrix metalloproteinase-9 expression during spontaneous epithelial to neuroblast phenotype conversion by SK-N-SH neuroblastoma cells, involved in enhanced invasivity, depends upon GT-box and nuclear factor kappaB elements
    • Farina AR, Tacconelli A, Vacca A, Maroder M, Gulino A and Mackay AR: Transcriptional up-regulation of matrix metalloproteinase-9 expression during spontaneous epithelial to neuroblast phenotype conversion by SK-N-SH neuroblastoma cells, involved in enhanced invasivity, depends upon GT-box and nuclear factor kappaB elements. Cell Growth Differ 10: 353-367, 1999. (Pubitemid 29242601)
    • (1999) Cell Growth and Differentiation , vol.10 , Issue.5 , pp. 353-367
    • Farina, A.R.1    Tacconelli, A.2    Vacca, A.3    Maroder, M.4    Gulino, A.5    Mackay, A.R.6
  • 40
    • 0035156633 scopus 로고    scopus 로고
    • TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-kappaB mediated induction of MT1-MMP
    • Han YP, Tuan TL, Wu H, Hughes M and Garner WL: TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP. J Cell Sci 114: 131-139, 2001. (Pubitemid 32118063)
    • (2001) Journal of Cell Science , vol.114 , Issue.1 , pp. 131-139
    • Han, Y.-P.1    Tuan, T.-L.2    Wu, H.3    Hughes, M.4    Garner, W.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.