Estimated clinical benefit of protecting neurogenesis in the developing brain during radiation therapy for pediatric medulloblastoma

Neuro-Oncology

Volumn 14, Issue 7, 2012, Pages 882-889

  Blomstrand, Malin ^a,b   Patrik Brodin, N ^c,d   Munck Af Rosenschld, Per ^c   Vogelius, Ivan R ^c   Snchez Merino, Gaspar ^d   Kiil Berthlesen, Anne ^c,e   Blomgren, Klas ^b,f,g   Lannering, Birgitta ^g   Bentzen, Søren M ^c,h   Bjrk Eriksson, Thomas ⁱ  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c Rigshospitalet   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e HOSPITAL TXAGORRITXU   (Spain)

^f KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^g QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

^h UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

ⁱ LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

CNS; medulloblastoma; neurocognitive sparing; radiotherapy; risk modeling

Indexed keywords

ARTICLE; BRAIN RADIATION; CANCER RADIOTHERAPY; CHILD; HIGH RISK POPULATION; HIPPOCAMPUS; HUMAN; INTENSITY MODULATED RADIATION THERAPY; MEDULLOBLASTOMA; MEMORY DISORDER; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; PRESCHOOL CHILD; RADIATION DOSE; SCHOOL CHILD; SUBVENTRICULAR ZONE;

BRAIN; CEREBELLAR NEOPLASMS; CHILD; CRANIAL IRRADIATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MEDULLOBLASTOMA; NEUROGENESIS; ORGANS AT RISK; PROGNOSIS; PROTONS; RADIATION INJURIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, INTENSITY-MODULATED; RETROSPECTIVE STUDIES; TUMOR BURDEN;

EID: 84862892950     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nos120     Document Type: Article

References (40)

1. Fossati P, Ricardi U, Orecchia R. Pediatric medulloblastoma: toxicity of current treatment and potential role of protontherapy. Cancer Treat Rev. 2009;35(1):79-96.
2. Danoff BF, Cowchock FS, Marquette C, Mulgrew L, Kramer S. Assessment of the long-term effects of primary radiation therapy for brain tumors in children. Cancer. 1982;49(8):1580-1586. (Pubitemid 12146942)
3. Mulhern RK, Palmer SL, Merchant TE, et al. Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma. J Clin Oncol. 2005;23(24):5511-5519.
4. Abayomi OK. Pathogenesis of irradiation-induced cognitive dysfunction. Acta Oncol. 1996;35(6):659-663. (Pubitemid 26366721)
5. Khong PL, Leung LH, Fung AS, et al. White matter anisotropy in posttreatment childhood cancer survivors: preliminary evidence of association with neurocognitive function. J Clin Oncol. 2006;24(6):884-890. (Pubitemid 46638840)
6. Palmer SL, Reddick WE, Glass JO, Gajjar A, Goloubeva O, Mulhern RK. Decline in corpus callosum volume among pediatric patients with medulloblastoma: longitudinal MR imaging study. AJNR Am J Neuroradiol. 2002;23(7):1088-1094.
7. Nagel BJ, Palmer SL, Reddick WE, et al. Abnormal hippocampal development in children with medulloblastoma treated with risk-adapted irradiation. AJNR Am J Neuroradiol. 2004;25(9):1575-1582. (Pubitemid 44383613)
8. Palmer TD, Takahashi J, Gage FH. The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci. 1997;8(6): 389-404. (Pubitemid 127796477)
9. Eriksson PS, Perfilieva E, Bjork-Eriksson T, et al. Neurogenesis in the adult human hippocampus. Nat Med. 1998;4(11):1313-1317. (Pubitemid 28512114)
10. Luskin MB. Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron. 1993;11(1):173-189. (Pubitemid 23222544)
11. Doetsch F, Garcia-Verdugo JM, Alvarez-Buylla A. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J Neurosci. 1997;17(13): 5046-5061. (Pubitemid 27263818)
12. Hellstrom NA, Bjork-Eriksson T, Blomgren K, Kuhn HG. Differential recovery of neural stem cells in the subventricular zone and dentate gyrus after ionizing radiation. Stem Cells. 2009;27(3):634-641.
13. Andres-Mach M, Rola R, Fike JR. Radiation effects on neural precursor cells in the dentate gyrus. Cell Tissue Res. 2008;331(1):251-262. (Pubitemid 350265490)
14. Fukuda A, Fukuda H, Swanpalmer J, et al. Age-dependent sensitivity of the developing brain to irradiation is correlated with the number and vulnerability of progenitor cells. J Neurochem. 2005;92(3): 569-584. (Pubitemid 40189460)
15. Mizumatsu S, Monje ML, Morhardt DR, Rola R, Palmer TD, Fike JR. Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res. 2003;63(14):4021-4027. (Pubitemid 36917922)
16. Tada E, Parent JM, Lowenstein DH, Fike JR. X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience. 2000;99(1):33-41. (Pubitemid 30495550)
17. Naylor AS, Bull C, Nilsson MK, et al. Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain. Proc Natl Acad Sci USA. 2008;105(38):14632-14637.
18. Georg Kuhn H, Blomgren K. Developmental dysregulation of adult neurogenesis. Eur J Neurosci. 2011;33(6):1115-1122.
19. Monje ML, Mizumatsu S, Fike JR, Palmer TD. Irradiation induces neural precursor-cell dysfunction. Nat Med. 2002;8(9):955-962. (Pubitemid 35033699)
20. Shors TJ, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E. Neurogenesis in the adult is involved in the formation of trace memories. Nature. 2001;410(6826):372-376. (Pubitemid 32246054)
21. Acharya MM, Christie LA, Lan ML, et al. Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci USA. 2009;106(45): 19150-19155.
22. Silber JH, Radcliffe J, Peckham V, et al. Whole-brain irradiation and decline in intelligence: the influence of dose and age on IQ score. J Clin Oncol. 1992;10(9):1390-1396. (Pubitemid 23059921)
23. Mulhern RK, Kepner JL, Thomas PR, Armstrong FD, Friedman HS, Kun LE. Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation: a Pediatric Oncology Group study. J Clin Oncol. 1998;16(5):1723-1728.
24. Kieffer-Renaux V, Viguier D, Raquin MA, et al. Therapeutic schedules influence the pattern of intellectual decline after irradiation of posterior fossa tumors. Pediatr Blood Cancer. 2005;45(6):814-819. (Pubitemid 41416492)
25. Grill J, Renaux VK, Bulteau C, et al. Long-term intellectual outcome in children with posterior fossa tumors according to radiation doses and volumes. Int J Radiat Oncol Biol Phys. 1999;45(1):137-145. (Pubitemid 29380085)
26. Jalali R, Mallick I, Dutta D, et al. Factors influencing neurocognitive outcomes in young patients with benign and low-grade brain tumors treated with stereotactic conformal radiotherapy. Int J Radiat Oncol Biol Phys. 2010;77(4):974-979.
27. Armstrong GT, Jain N, Liu W, et al. Region-specific radiotherapy and neuropsychological outcomes in adult survivors of childhood CNS malignancies. Neuro Oncol. 2010;12(11):1173-1186.
28. Markakis EA, Gage FH. Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. J Comp Neurol. 1999;406(4):449-460. (Pubitemid 29144933)
29. Mulhern RK, Merchant TE, Gajjar A, Reddick WE, Kun LE. Late neurocognitive sequelae in survivors of brain tumours in childhood. Lancet Oncol. 2004;5(7):399-408. (Pubitemid 38878043)
30. Lannering B, Marky I, Lundberg A, Olsson E. Long-term sequelae after pediatric brain tumors: their effect on disability and quality of life. Med Pediatr Oncol. 1990;18(4):304-310. (Pubitemid 20219924)
31. Armstrong GT, Liu Q, Yasui Y, et al. Long-term outcomes among adult survivors of childhood central nervous system malignancies in the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2009;101(13): 946-958.
32. Hall P, Adami HO, Trichopoulos D, et al. Effect of low doses of ionising radiation in infancy on cognitive function in adulthood: Swedish population based cohort study. BMJ. 2004;328(7430):19.
33. Ron E, Modan B, Floro S, Harkedar I, Gurewitz R. Mental function following scalp irradiation during childhood. Am J Epidemiol. 1982;116(1):149-160. (Pubitemid 12087731)
34. Armstrong GT. Long-term survivors of childhood central nervous system malignancies: the experience of the Childhood Cancer Survivor Study. Eur J Paediatr Neurol. 2010;14(4):298-303.
35. Ellenberg L, Liu Q, Gioia G, et al. Neurocognitive status in long-term survivors of childhood CNS malignancies: a report from the Childhood Cancer Survivor Study. Neuropsychology. 2009;23(6):705-717.
36. Boman KK, Lindblad F, Hjern A. Long-term outcomes of childhood cancer survivors in Sweden: a population-based study of education, employment, and income. Cancer. 2010;116(5):1385-1391.
37. Baillieux H, De Smet HJ, Paquier PF, De Deyn PP, Marien P. Cerebellar neurocognition: insights into the bottom of the brain. Clin Neurol Neurosurg. 2008;110(8):763-773.
38. Redmond KJ, Achanta P, Grossman SA, et al. A radiotherapy technique to limit dose to neural progenitor cell niches without compromising tumor coverage. J Neurooncol. 2011;104(2):579-587.
39. Newhauser WD, Fontenot JD, Mahajan A, et al. The risk of developing a second cancer after receiving craniospinal proton irradiation. Phys Med Biol. 2009;54(8):2277-2291.
40. Merchant TE, Hua CH, Shukla H, Ying X, Nill S, Oelfke U. Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relation-ship to cognitive function. Pediatr Blood Cancer. 2008;51(1):110-117. (Pubitemid 351717400)