The studies of phase equilibria and efficiency assessment for self-emulsifying lipid-based formulations

AAPS PharmSciTech

Volumn 13, Issue 2, 2012, Pages 522-533

  Shahba, Ahmad Abdul Wahhab ^a   Mohsin, Kazi ^a   Alanazi, Fars Kaed ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

droplet size analysis; lipid based drug delivery systems; phase diagram study; self emulsification assessment; self emulsifying formulations

Indexed keywords

ACYLGLYCEROL; ARACHIS OIL; FAT DROPLET; LIPID; LIPOSOME; MEDIUM CHAIN ACYLGLYCEROL; SOYBEAN OIL; SURFACTANT;

AQUEOUS SOLUTION; ARTICLE; DILUTION; DISPERSION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; EMULSION; EQUILIBRIUM CONSTANT; GEL; HYDROPHILICITY; LIPOPHILICITY; PARTICLE SIZE; PHYSICAL PHASE; PRIORITY JOURNAL; SOLUBILIZATION; TURBIDITY;

CHEMISTRY, PHARMACEUTICAL; EMULSIONS; EXCIPIENTS; GLYCEROL; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPIDS; OLEIC ACID; PARTICLE SIZE; PHASE TRANSITION; SOLUBILITY; SOLVENTS; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL; TRIGLYCERIDES; WATER;

EID: 84862882347     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-012-9773-8     Document Type: Article

References (24)

1. A Rai G Tiwari R Tiwari 2010 Self-emulsifying drug delivery system: an approach to enhance solubility Syst Rev Pharm 1 133 140 10.4103/0975-8453.75055
2. CJH Porter NL Trevaskis WN Charman 2007 Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs Nat Rev Drug Discov 6 231 248 17330072 10.1038/nrd2197 1:CAS:528:DC%2BD2sXit12rsbY%3D (Pubitemid 46344627)
3. MA Rahman R Harwansh MA Mirza S Hussain A Hussain 2011 Oral lipid based drug delivery system (LBDDS): formulation, characterization and application: a review Curr Drug Deliv 8 330 345 21453264 10.2174/156720111795767906 1:CAS:528:DC%2BC3MXot1Cmtb0%3D
4. K Kohli S Chopra D Dhar S Arora RK Khar 2010 Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability Drug Discov Today 15 958 965 20727418 10.1016/j.drudis.2010.08.007 1:CAS:528:DC%2BC3cXhsVWmsrfL
5. RN Gursoy S Benita 2004 Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs Biomed Pharmacother 58 173 182 15082340 10.1016/j.biopha.2004.02.001 (Pubitemid 38479922)
6. T Gershanik S Benita 2000 Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs Eur J Pharm Biopharm 50 179 188 10840200 10.1016/S0939-6411(00)00089-8 1:CAS:528:DC%2BD3cXjslyisrk%3D (Pubitemid 30326696)
7. CW Pouton 1997 Formulation of self-emulsifying drug delivery systems Adv Drug Del Rev 25 47 58 10.1016/S0169-409X(96)00490-5 1:CAS:528:DyaK2sXhtlOqsrc%3D (Pubitemid 27107790)
8. CW Pouton 1985 Self-emulsifying drug delivery systems: assessment of the efficiency of emulsification Int J Pharm 27 335 348 10.1016/0378-5173(85)90081-X 1:CAS:528:DyaL28XhtlGqt74%3D (Pubitemid 16218683)
9. CW Pouton 2000 Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and "self-microemulsifying" drug delivery systems Eur J Pharm Sci 11 S93 S98 11033431 10.1016/S0928-0987(00) 00167-6 1:CAS:528:DC%2BD3cXntF2gur4%3D
10. CW Pouton 2006 Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system Eur J Pharm Sci 29 278 287 16815001 10.1016/j.ejps.2006.04.016 1:CAS:528:DC%2BD28XhtFentrrM (Pubitemid 44740131)
11. C Porter C Pouton J Cuine W Charman 2008 Enhancing intestinal drug solubilisation using lipid-based delivery systems Adv Drug Del Rev 60 673 691 10.1016/j.addr.2007.10.014 1:CAS:528:DC%2BD1cXitVOmsr4%3D
12. DQM Craig SA Barker D Banning SW Booth 1995 An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy Int J Pharm 114 103 110 10.1016/0378-5173(94)00222-Q 1:CAS:528:DyaK2MXivVKrtrk%3D (Pubitemid 24377034)
13. TR Kommuru B Gurley MA Khan IK Reddy 2001 Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment Int J Pharm 212 233 246 11165081 10.1016/S0378-5173(00)00614-1 1:CAS:528:DC%2BD3MXmvFKktQ%3D%3D (Pubitemid 32119449)
14. V Nekkanti P Karatgi R Prabhu R Pillai 2010 Solid self-microemulsifying formulation for candesartan cilexetil AAPS PharmSciTech 11 9 17 20013081 10.1208/s12249-009-9347-6 1:CAS:528:DC%2BC3cXovFaiu70%3D
15. H Thakkar J Nangesh M Parmar D Patel 2011 Formulation and characterization of lipid-based drug delivery system of raloxifene-microemulsion and self-microemulsifying drug delivery system J Pharm Bioallied Sci 3 3 442 448 21966167 10.4103/0975-7406.84463 1:CAS:528:DC%2BC3MXhsVSjtbzK
16. AA Date MS Nagarsenker 2007 Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil Int J Pharm 329 166 172 17010543 10.1016/j.ijpharm.2006.08.038 1:CAS:528:DC%2BD28XhtlCmtLjN (Pubitemid 44937527)
17. GA Kossena WN Charman BJ Boyd DE Dunstan CJ Porter 2004 Probing drug solubilization patterns in the gastrointestinal tract after administration of lipid-based delivery systems: a phase diagram approach J Pharm Sci 93 332 348 14705191 10.1002/jps.10554 1:CAS:528:DC%2BD2cXhsFagu7k%3D (Pubitemid 38174256)
18. K Mohsin MA Long CW Pouton 2009 Design of lipid-based formulations for oral administration of poorly water-soluble drugs: precipitation of drug after dispersion of formulations in aqueous solution J Pharm Sci 98 3582 3595 19130605 10.1002/jps.21659 1:CAS:528:DC%2BD1MXhtVKhsr7K
19. BK Kang JS Lee SK Chon SY Jeong SH Yuk G Khang, et al. 2004 Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs Int J Pharm 274 65 73 15072783 10.1016/j.ijpharm.2003.12.028 1:CAS:528:DC%2BD2cXivFGlu7g%3D (Pubitemid 38457007)
20. E Atef AA Belmonte 2008 Formulation and in vitro and in vivo characterization of a phenytoin self-emulsifying drug delivery system (SEDDS) Eur J Pharm Sci 35 257 263 18706499 10.1016/j.ejps.2008.07.004 1:CAS:528:DC%2BD1cXht1Klt7vN
21. Wakerly MG, Pouton CW, Meakin BJ, Morton FS. Self-emulsification of vegetable oil-nonionic surfactant mixtures. In: Scamehorn JF, editor. Phenomena in mixed surfactant systems. Washington: American Chemical Society; 1986. p. 242-55.
22. SA Charman WN Charman MC Rogge TD Wilson FJ Dutko CW Pouton 1992 Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound Pharm Res 9 87 93 1589415 10.1023/A:1018987928936 1:CAS:528:DyaK38XptFaluw%3D%3D
23. NH Shah MT Carvajal CI Patel MH Infeld AW Malick 1994 Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs Int J Pharm 106 15 23 10.1016/0378-5173(94)90271-2 1:CAS:528:DyaK2cXjtlSqu74%3D (Pubitemid 24110060)
24. CW Pouton CJ Porter 2008 Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies Adv Drug Deliv Rev 60 625 637 18068260 10.1016/j.addr.2007.10.010 1:CAS:528:DC%2BD1cXitVOnu7s%3D