Pharmacokinetics and the effect of application site on a novel, long-acting transdermal fentanyl solution in healthy laboratory Beagles

Journal of Veterinary Pharmacology and Therapeutics

Volumn 35, Issue SUPPL.2, 2012, Pages 27-33

  Freise, K J ^a   Newbound, G C ^a   Tudan, C ^b   Clark, T P ^a  

^a Nexcyon Pharmaceuticals Inc   (United States)

^b BioAccurate Enterprises Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FENTANYL;

AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG HALF LIFE; FEMALE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; STEADY STATE;

ABSORPTION; ADMINISTRATION, CUTANEOUS; ANALGESICS, OPIOID; ANIMALS; AREA UNDER CURVE; DELAYED-ACTION PREPARATIONS; DOGS; FEMALE; FENTANYL; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; PILOT PROJECTS; SOLUTIONS; THERAPEUTIC EQUIVALENCY;

EID: 84862877395     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2012.01411.x     Document Type: Article

References (19)

1. Allen, D.G. & Monteiro-Riviere, N.A. (1999) Alteration of cytokeratin expression following transdermal lidocaine hydrochloride iontophoresis. Pharmaceutical Research, 16, 1487-1490.
2. FDA-CVM (2002) Guidance for Industry: Bioequivalence Guidance. Rockville, MD.
3. Feldmann, R.J. & Maibach, H.I. (1967) Regional variation in percutaneous penetration of 14C cortisol in man. Journal of Investigative Dermatology, 48, 181-183.
4. Freise, K.J., Savides, M.C., Riggs, K.L., Owens, J.G., Newbound, G.C. & Clark, T.P. (2012) Pharmacokinetics and dose selection of a novel, long-acting transdermal fentanyl solution in healthy laboratory Beagles. Journal of Veterinary Pharmacology and Therapeutics, 35(Suppl. 2), 21-26.
5. Gourlay, G.K., Kowalski, S.R., Plummer, J.L., Cousins, M.J. & Armstrong, P.J. (1988) Fentanyl blood concentration-analgesic response relationship in the treatment of postoperative pain. Anesthesia and Analgesia, 67, 329-337.
6. Hofmeister, E.H. & Egger, C.M. (2004) Transdermal fentanyl patches in small animals. Journal of the American Animal Hospital Association, 40, 468-478.
7. Kyles, A.E., Papich, M. & Hardie, E.M. (1996) Disposition of transdermally administered fentanyl in dogs. American Journal of Veterinary Research, 57, 715-719.
8. Magnusson, B.M., Walters, K.A. & Roberts, M.S. (2001) Veterinary drug delivery: potential for skin penetration enhancement. Advanced Drug Delivery Reviews, 50, 205-227.
9. Monteiro-Riviere, N.A. (1990) Altered epidermal morphology secondary to lidocaine iontophoresis: in vivo and in vitro studies in porcine skin. Fundamental and Applied Toxicology, 15, 174-185.
10. Monteiro-Riviere, N.A., Bristol, D.G., Manning, T.O., Rogers, R.A. & Riviere, J.E. (1990) Interspecies and interregional analysis of the comparative histologic thickness and laser Doppler blood flow measurements at five cutaneous sites in nine species. Journal of Investigative Dermatology, 95, 582-586.
11. Mukhtar, H. (1992) Pharmacology of the Skin. CRC Press, Boca Ratonm, FL.
12. Murphy, M.R., Hug, C.C. Jr & McClain, D.A. (1983) Dose-independent pharmacokinetics of fentanyl. Anesthesiology, 59, 537-540.
13. Pascoe, P.J. (2000) Opioid analgesics. The Veterinary Clinics of North America. Small Animal Practice, 30, 757-772.
14. Plumb, D.C. (2008) Plumb's Veterinary Drug Handbook. Blackwell Publishing, Ames, IA.
15. Riviere, J.E., Monteiro-Riviere, N.A. & Inman, A.O. (1992) Determination of lidocaine concentrations in skin after transdermal iontophoresis: effects of vasoactive drugs. Pharmaceutical Research, 9, 211-214.
16. Sano, T., Nishimura, R., Kanazawa, H., Igarashi, E., Nagata, Y., Mochizuki, M. & Sasaki, N. (2006) Pharmacokinetics of fentanyl after single intravenous injection and constant rate infusion in dogs. Veterinary Anaesthesia and Analgesia, 33, 266-273.
17. Savides, M.C., Pohland, R.C., Wilkie, D.A., Abbott, J.A., Newbound, G.C., Freise, K.J. & Clark, T.P. (2012) The margin of safety of a single application of transdermal fentanyl solution when administered at multiples of the therapeutic dose to laboratory dogs. Journal of Veterinary Pharmacology and Therapeutics, 35(Suppl. 2), 35-43.
18. Smith, F.M., Scott, R.C. & Foster, J.R. (1990). An interspecies comparison of skin structure (hair follicle area s determined by a novel technique) and skin permeability. In Skin Pharmacology and Toxicology. Eds Galli, C.L., Hensby, C.N. & Marinovich, M. pp. 299-305. Plenum, New York.
19. Veng-Pedersen, P. (2001) Noncompartmentally-based pharmacokinetic modeling. Advanced Drug Delivery Reviews, 48, 265-300.