Screening in frail older people: An ounce of prevention or a pound of trouble?

Journal of the American Geriatrics Society

Volumn 58, Issue 10, 2010, Pages 2016-2021

  Clarfield, A Mark ^a,b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Early diagnosis; Frail elderly; Screening; Secondary prevention

Indexed keywords

ABDOMINAL AORTA ANEURYSM; BREAST CANCER; CAROTID ARTERY OBSTRUCTION; COLON CANCER; COLONOSCOPY; COMORBIDITY; DEMENTIA; FRACTURE; FRAIL ELDERLY; GLAUCOMA; HUMAN; HYPERTENSION; LIFE EXPECTANCY; LUNG CANCER; OSTEOPOROSIS; POLYPHARMACY; PROSTATE CANCER; REVIEW; SCREENING; SECONDARY PREVENTION; SENESCENCE; SENSITIVITY AND SPECIFICITY; UTERINE CERVIX CANCER; VISUAL ACUITY; AGED; COGNITIVE DEFECT; INCIDENCE; MASS SCREENING; METHODOLOGY; ORGANIZATION AND MANAGEMENT; STATISTICS; UNITED STATES;

AGED; COGNITION DISORDERS; FRAIL ELDERLY; HUMANS; INCIDENCE; MASS SCREENING; SECONDARY PREVENTION; UNITED STATES;

EID: 78049385591     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2010.03070.x     Document Type: Review

References (47)

1. Han PKJ., Historical changes in the objectives of the periodic health exam. Ann Intern Med 1997; 127: 910 - 917.
2. Sackett DL., The arrogance of preventive medicine: Hormone replacement therapy. Can Med Assoc J 2002; 167: 363 - 364.
3. Laine C., Postmenopausal hormone replacement therapy: How could we have been so wrong? Ann Intern Med 2002; 137: 290.
4. Muir Gray JA., Evidence-Based Health Care and Public Health: How to Make Decisions About Health Services and Public Health. New York: Harcourt Brace & Co, 1997.
5. Esserman L, Shieh Y, Thompson I., Rethinking screening of breast cancer and prostate cancer. JAMA 2009; 302: 1685 - 1692.
6. US Preventive Services Task Force. Screening for prostate cancer: US Preventive Services Task Force recommendation statement. Ann Intern Med 2008; 149: 185 - 191.
7. US Preventive Services Task Force. Screening for colon cancer: US Preventive Services Task Force recommendation statement. Ann Intern Med 2008; 149: 627 - 637.
8. Clarfield AM, Friedman R., A survey of the age structure of "age-relevant" articles in four medical journals. J Am Geriatr Soc 1985; 33: 773 - 778.
9. Fried LP, Tangen CM, Walsten J, et al,. Frailty in older persons: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56A: M146 - M156.
10. Bergman H, Ferrucci L, Guralnik J, et al,. Frailty: An emerging research and clinical paradigm-issues and controversies. J Gerontol A Biol Sci Med Sci 2007; 62A: 721 - 737.
11. Stone JH., Incidentalomas-clinical correlation and translational science required. N Engl J Med 2006; 354: 2748 - 2749.
12. Shim JK, Russ AJ, Kaufman SR., Late-life cardiac interventions and the treatment imperative. PLoS Med 2008; 5: e7.
13. Kaufman SR, Shim JK, Russ AJ., Revisiting the biomedicalization of aging: Clinical trends and ethical challenges. Gerontologist 2004; 44: 731 - 738.
14. Gurwitz JH, Field TS, Harrold LS, et al,. Incidence and preventability of adverse drug events among older persons in the ambulatory setting. JAMA 2003; 289: 1107 - 1116.
15. Welch HG, Woloshin S, Schwartz LM, et al,. Overstating the evidence for lung cancer screening. The International Early Lung Cancer Action Program. (I-ELCAP). Arch Intern Med 2007; 167: 2289 - 2295.
16. McMurdo MET, Witham MD, Gillespie ND., Including older people in clinical research: Benefits shown in trials in younger people may not apply to older people. BMJ 2005; 331: 1036 - 1037.
17. Mangin D, Sweeney K, Heath I., Preventive health care in elderly people needs rethinking. BMJ 2007; 335: 285 - 287.
18. Moynihan R, Henry D., The fight against disease mongering: Generating knowledge for action. PLoS Med 2006; 3: 0425 - 0451.
19. Memory Screenings [on-line]. Available at Accessed September 2, 2009.
20. Screening for Dementia, Topic Page. June 2003. U.S. Preventive Services Task Force. Agency for Healthcare Research and Quality, Rockville, MD [on-line]. Available at Accessed on August 9, 2010.
21. Patterson C, Gass DA., Screening for cognitive decline in the elderly. Can J Neurol Sci 2001; 28 (suppl 1): 42 - 51.
22. Ashford JW, Borson S, O'Hara R, et al,. Should older adults be screened for dementia? Alzheimer Dementia 2006; 3: 75 - 80.
23. Raji MA, Yong-Fang K, Freeman JL, et al,. Effect of a dementia diagnosis on survival of older patients after a diagnosis of breast, colon or, prostate cancer. Arch Intern Med 2008; 168: 2033 - 2040.
24. Walter LC, Bertenthal D, Lindquist K, et al,. PSA screening among elderly men with limited life expectancies. JAMA 2006, 2336 - 2342.
25. Feightner JW., Screening for prostate cancer. In: Canadian Task Force on the Periodic Health Examination. Canadian Guide to Clinical Preventive Health Care. Ottawa: Health Canada, 1994, pp 812 - 823.
26. Andriole GL, Crawford ED, Grubb RL III, et al,. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med 2009; 360: 1310 - 1319.
27. Sirovich BE, Schwartz LM, Woloshin S., Screening men for prostate and colorectal cancer in the United States: Does practice reflect the evidence? JAMA 2003; 289: 1414 - 1420.
28. Tinetti ME, Bogardus ST, Agostini JV., Potential pitfalls of disease-specific guidelines for patients with multiple conditions. N Engl J Med 2004; 351: 2870 - 2874.
29. Lin OS, Kozarek RA, Schembre DB, et al,. Screening colonoscopy in very elderly patients: Prevalence of neoplasia and estimated impact on life expectancy. JAMA 2006; 295: 2357 - 2365.
30. Boyd CM, Darer J, Boult C, et al,. Clinical practice guidelines and quality of care of older patients multiple comorbid conditions. JAMA 2005; 294: 716 - 724.
31. Yarnall KSH, Pollak KI, Ostbye T, et al,. Primary care: Is there enough time for prevention? Am J Public Health 2003; 93: 635 - 641.
32. O'Malley PG, Greenland P., The promise of preventive interventions depends on robust health care delivery. Arch Intern Med 2007; 167: 532.
33. Welch HG., Informed choice in cancer screening. JAMA 2001; 285: 2776 - 2778.
34. Getz L, Sigurdsson JA, Hetlevik I., Is opportunistic disease prevention in the consultation ethically justifiable? BMJ 2003; 327: 498 - 500.
35. Jotkowitz AB, Clarfield AM, Faust G, et al,. Screening for carotid artery disease in the general public. Eur J Int Med 2005; 16: 34 - 36.
36. Khaw K-T, Wareham N, Bingham S, et al,. Combined impact of health behaviors and mortality in men and women: The EPIC-Norfolk Prospective Population Study. PLoS Med 2008; 5: e12do; DOI: 10.1371/journal.pmed 0050012.
37. Yates LB, Djousse L, Kurth T, et al,. Exceptional longevity in men: Modifiable risk factors associated with survival and function to 90 years. Arch Intern Med 2008; 168: 284 - 290.
38. Walter LC, Covinsky KE., Cancer screening in elderly patients: A framework for individualized decision making. JAMA 2001; 285: 2750 - 2756.
39. Braithwaite RS, Comato J, Chang CC, et al,. A framework for tailoring clinical guidelines to comorbidity at the point of care. Arch Intern Med 2007; 167: 2361 - 2365.
40. Pignone M., Weighing the benefits and downsides of prostate - specific antigen screening. Arch Intern Med 2009; 169: 1554 - 1555.
41. Williams BA, Lindquist K, Sudore RL, et al,. Screening mammography in older women: Effect of wealth and prognosis. Arch Intern Med 2008; 168: 514 - 520.
42. Goodwin JS., Geriatrics and the limits of modern medicine. N Engl J Med 1999; 340: 1283 - 1285.
43. Bramwell R, West H, Salmon P., Health professionals' and service users' interpretation of screening test results: Experimental study. BMJ 2006; 333: 284 - 286.
44. Kim LG, Scott AP, Ashton HA, et al,. A sustained mortality benefit from screening for abdominal aortic aneurysm. Ann Intern Med 2007; 148: 699 - 706.
45. Fairhead JF, Rothwell PM., Underinvestigation and undertreatment of carotid disease in elderly patients with transient ischemic attack and stroke: Comparative population-based study. BMJ 2006; 333: 325 - 327.
46. McCullough D., My Mother, Your Mother. Embracing "Slow Medicine" the Compassionate Approach to Caring for Your Aging Loved Ones. New York: Harper Collins, 2008.
47. Morens DM., Death of a president. N Engl J Med 1999; 341: 1845 - 1850.