Proteins derived from latex of C. procera maintain coagulation homeostasis in septic mice and exhibit thrombin- and plasmin-like activities

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 385, Issue 5, 2012, Pages 455-463

  Ramos, Márcio V ^a   Viana, Carolina A ^a   Silva, Ayrles F B ^a   Freitas, Cléverson D T ^b   Figueiredo, Ingrid S T ^a   Oliveira, Raquel S B ^a   Alencar, Nylane M N ^a   Lima Filho, José V M ^c   Kumar, Vijay L ^d  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

^c UNIVERSIDADE FEDERAL RURAL DE PERNAMBUCO   (Brazil)

^d ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Blood coagulation; Calotropis procera; Cysteine protease; Latex; Sepsis

Indexed keywords

CALOTROPIS PROCERA EXTRACT; FIBRINOGEN; FIBRINOGEN AALPHA; FIBRINOGEN BBETA; FIBRINOGEN GAMMA; PLASMIN; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; FIBRIN CLOT; FIBRINOGENOLYSIS; FIBRINOLYSIS; HOMEOSTASIS; HUMAN; HYDROLYSIS; ION EXCHANGE CHROMATOGRAPHY; MALE; MOUSE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PROTEIN DEGRADATION; PROTHROMBIN TIME; SALMONELLOSIS; SEPSIS; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ANIMALS; BLOOD COAGULATION; CALOTROPIS; CYSTEINE PROTEASES; FIBRINOGEN; HEMOSTASIS; HUMANS; LATEX; MALE; MICE; PARTIAL THROMBOPLASTIN TIME; PLANT PROTEINS; PLATELET COUNT; PROTHROMBIN TIME; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM; SEPSIS;

EID: 84862874140     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-012-0733-3     Document Type: Article

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