Anti-inflammatory effect of the latex from Calotropis procera in three different experimental models: Peritonitis, paw edema and hemorrhagic cystitis

Planta Medica

Volumn 70, Issue 12, 2004, Pages 1144-1149

  Alencar, N M N ^a   Figueiredo, I S T ^a   Vale, M R ^a   Bitencurt, F S ^a   Oliveira, J S ^a   Ribeiro, R A ^a   Ramos, M V ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Asclepiadaceae; Calotropis procera; Inflammation; Iphosphamide; Latex; Mesna; Proteins

Indexed keywords

CALOTROPIS PROCERA EXTRACT; CARRAGEENAN; DEXTRAN; DRUG METABOLITE; HOLOXANE; IFOSFAMIDE; MESNA; RUBBER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALOTROPIS; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HEMORRHAGIC CYSTITIS; IN VIVO STUDY; LEUKOCYTE MIGRATION; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PAW EDEMA; PERITONITIS; PROTEIN ANALYSIS; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALOTROPIS; CARRAGEENAN; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; INJECTIONS, INTRAVENOUS; LATEX; MALE; PERITONITIS; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; URINARY BLADDER DISEASES;

ANIMALIA; APOCYNACEAE; CALOTROPIS PROCERA;

EID: 11944271152     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-835842     Document Type: Article

References (20)

1. Shukla OP, Krishna-Murti CR. Properties and partial purification of a bacteriolytic enzyme from the latex of Calotropis procera. J Sci Industr Res 1961; 20: 109-12
2. Arhsini MI, Bousaid M, Lazrer HB, Jana M, Amarouch H. Evaluation of antifungal and molluscicidal properties of extracts of Calotropis procera. Fitoterapia 1997; 78: 371-3
3. Sharma P, Sharma JD. Evaluation of in vitro schizontocidal activity of plant parts of Calotropis procera - an ethnobotanical approach. J Ethnopharmacol 1999; 68: 83-95
4. Morsy TA, Rahem MA, Allam KA. Control of Musa domestica third instar larvae by the latex of Calotropis procera. J Egypt Soc Parasitol 2001; 31: 107-10
5. Dewan S, Sangraula H, Kimar VL. Preliminary studies on the analgesic activity of the latex of Calotropis procera. J Ethnopharmacol 2000; 73: 307-11
6. Rasik AM, Raghubir R, Gupta A, Shukla A, Dubey MP, Srivastava S et al. Healing potential of Calotropis procera on dermal wounds in Guinea pigs. J Ethnopharmacol 1999; 68: 261-6
7. Kumar S, Dewan H, Sangraula H, Kumar VL. Anti-diarrhoeal activity of the latex of Calotropis procera. J Ethnopharmacol 2001; 76: 115-8
8. Seiber JN, Nelson CJ, Lee SM. Cardenolides in the latex and leaves of seven Asclepias species and Calotropis procera. Phytochemistry 1982; 9: 2343-8
9. Olea RSG, Oliveira AV, Silveira LMS, Silveira ER. Organic carbonate from Calotropis procera leaves. Fitoterapia 2002; 73: 263-5
10. Kumar DV, Jagannadham M.V. Procerain, a stable cysteine protease from the latex of Calotropis procera. Phytochemistry 2003; 62: 1057-71
11. Trejo SA, Lopes LM, Cimino CV, Caffini NO, Natalucci CL. Purification and characterization of a new plant endopeptidase isolated from latex of Asclepia fruticosa L. (Asclepiadaceae). J Prot Chem 2001; 20: 469-77
12. Majumder PK, Kumar VL. Anti-inflammatory activity of fractions of the latex of Calotropis procera in carrageenin induced rat paw edema. Phytotherapy Res 1997; 11: 166-7
13. Howarb-Jones N. A CIOMS ethical code for animal experimentation. WHO Chron 1985; 39: 51-6
14. Laemmli UK. Cleavage of structural proteins during the assembly of the bacteriophage T4. Nature 1970; 227: 680-5
15. Alencar NMN, Teixeira EH, Assreuy AMS, Cavada BS, Flores CA, Ribeiro RA. Leguminous lectins as tools for studying the role of sugar residues in leukocyte recruitment. Mediators Inflamm 1999; 8: 107-13
16. Landucci ECT, Antunes E, Donato JL, Faro R, Hyslop S, Marangoni S et al. Inhibition of carrageenin-induced rat paw edema by crotapotin, a polypeptide complexed with phospholipase A2. Br J Phamacol 1995; 114: 578-83
17. Gomes TN, Santos CC, Souza-Filho MVP, Cunha FQ, Ribeiro RA. Participation of TNF and IL-1 in the pathogenesis of cyclophosphamide-induced cystitis. Braz J Med Biol Res 1995; 28; 1103-8
18. Gray KJ, Engelmann UH, Johnson EH, Fishman IJ. Evaluation of misoprostol cytoprotection of the bladder with cyclophosphamide (cytoxan) therapy. J Urol 1986; 136: 497-500
19. Lo TN, Almeida AP, Beaven MA. Dextran and carrageenin evoke different inflammatory response in rat with respect to composition of infiltrates and effect of indomethacin. J Pharmacol Exp Ther 1982; 221: 261-7
20. Philips FS, Sternberg SS, Cronin AP, Vidal PM. Cyclophosphamide and urinary bladder toxicity. Cancer Res 1961; 21: 1577-89