Prolactin and autoimmunity: Hyperprolactinemia correlates with serositis and anemia in SLE patients

Clinical Reviews in Allergy and Immunology

Volumn 42, Issue 2, 2012, Pages 189-198

  Orbach, Hedi ^a   Zandman Goddard, Gisele ^a,d   Boaz, Mona ^a,d   Agmon Levin, Nancy ^b,d   Amital, Howard ^c,d   Szekanecz, Zoltan ^e   Szucs, Gabriella ^e   Rovensky, Josef ^f   Kiss, Emese ^g   Doria, Andrea ^h   Ghirardello, Anna ^h   Gomez Arbesu, Jesus ⁱ   Stojanovich, Ljudmila ^j   Ingegnoli, Francesca ^k   Meroni, Pier Luigi ^k   Rozman, Blaz' ^l   Blank, Miri ^b,d   Shoenfeld, Yehuda ^b,d  

^a WOLFSON MEDICAL CENTER   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c MEIR MEDICAL CENTER   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

^e UNIVERSITY OF DEBRECEN   (Hungary)

^f NATIONAL INSTITUTE OF RHEUMATIC DISEASES   (Slovakia)

^g National Institute of Rheumatology Budapest   (Hungary)

^h UNIVERSITY OF PADOVA   (Italy)

ⁱ HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^j Bezhanijska Kosa University Medical Center   (Serbia)

^k UNIVERSITY OF MILAN   (Italy)

^l University Clinical Center Lubljiana   (Slovenia)

more..

Author keywords

Anemia Proteinuria; Autoimmune thyroid disease; Disease activity; Multiple sclerosis; Prolactin; Rheumatoid arthritis; Serositis; Sj gren's syndrome; Systemic lupus erythematosus; Systemic sclerosis

Indexed keywords

ANTIMALARIAL AGENT; BROMOCRIPTINE; CABERGOLINE; CORTICOSTEROID; DOPAMINE RECEPTOR STIMULATING AGENT; METHYLPREDNISOLONE; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISONE; PROLACTIN; QUINAGOLIDE;

ADD ON THERAPY; ADOLESCENT; ADULT; AGED; ALLERGIC ENCEPHALOMYELITIS; ANEMIA; BLOOD SAMPLING; COHORT ANALYSIS; CONSENSUS; DISEASE ACTIVITY; DRUG MECHANISM; FEMALE; HASHIMOTO DISEASE; HUMAN; HYPERPROLACTINEMIA; IMMUNOASSAY; INFLAMMATION; LABORATORY TEST; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PERITONITIS; PLEURISY; POLYSEROSITIS; PROLACTIN BLOOD LEVEL; PROLACTINOMA; PROTEINURIA; REVIEW; RHEUMATOID ARTHRITIS; SCORING SYSTEM; SEROLOGY; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS;

ADOLESCENT; ADULT; AGED; ANEMIA; AUTOIMMUNITY; DOPAMINE AGONISTS; FEMALE; HUMANS; HYPERPROLACTINEMIA; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; PROLACTIN; SEROSITIS; YOUNG ADULT;

EID: 84862873239     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-011-8256-0     Document Type: Review

References (106)

1. De Schepper J, Schiettecatte J, Velkeniers B et al (2003) Clinical and biological characterization of macroprolactinemia with and without prolactin-IgG complexes. Eur J Endocrinol 149:201-207 (Pubitemid 37120992)
2. Freeman ME, Kanyicska B, Lerant A, Nagy G (2000) Prolactin: structure, function, and regulation of secretion. Physiol Rev 80:1523-1631
3. Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev 19:225-258
4. Chikanza IC (1999) Prolactin and neuroimmunomodulation: in vitro and in vivo observations. Ann NY Acad Sci 876:119-130 (Pubitemid 29352116)
5. Serri O, Chik CL, Ur E, Ezzat S (2003) Diagnosis and management of hyperprolactinemia. Can MedAssoc J 169:575-581 (Pubitemid 37174600)
6. Jara LJ, Medina G, Saavedra MA, Vera-Lastra O, Navarro C (2011) Prolactin and autoimmunity Clin Rev Allergy Immunol 40:50-59
7. Adamson AD, Friedrichsen S, Semprini S et al (2008) Human prolactin gene promoter regulation by estrogen: convergence with tumor necrosis factor-alpha signaling. Endocrinology 149:687-694 (Pubitemid 351159349)
8. Vera-Lastra O, Jara LJ, Espinoza RL (2002) Prolactin and autoimmunity. Autoimmun Rev 1:360-364 (Pubitemid 38340249)
9. Walker SE, Jacobson JD (2000) Roles of prolactin and gonadotropin- releasing hormone in rheumatic diseases. Rheum Dis Clin North Am 26:713-736
10. Thoreau E, Petridou B, Kelly PA, Djiane J, Mornon JP (1991) Structural symmetry of the extracellular domain of the cytokine/ growth hormone/prolactin receptor family and interferon recep-tors revealed by hydrophobic cluster analysis. FEBS Lett 282:26-31
11. Ben-Jonathan N, Mershon JL, Allen DL, Steinmetz RW (1996) Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects. Endocr Rev 17:639-669 (Pubitemid 26425260)
12. Peeva E, Zouali M (2005) Spotlight on the role of hormonal factors in the emergence of autoreactive B-lymphocytes. Immu-nol Lett 101:123-143 (Pubitemid 41368071)
13. Saha S, Gonzalez J, Rosenfeld G, Keiser H, Peeva E (2009) Prolactin alters the mechanisms of B cell tolerance induction. Arthritis Rheum 60:1743-1752
14. Athreya BH, Pletcher J, Zulian F, Weiner DB, Williams WV (1993) Subset-specific effects of sex hormones and pituitary gonadotropins on human lymphocyte proliferation in vitro. Clin Immunol Immunopathol 66:201-211 (Pubitemid 23075973)
15. Sousa GM, Olivera RC, Perelra MM, Paraná R, Sousa-Atta ML, Atta AM (2010) Autoimmunity in hepatitis C virus carriers: involvement of ferritin and prolactin. Autoimmun Rev (in press)
16. Jara LJ, Benitez G, Medina G (2008) Prolactin, dendritic cells, and systemic lupus erythematosus. Autoimmun Rev 7:251-255
17. Lahat N, Miller A, Shtiller R, Toubi E (1993) Differential effects of prolactin upon activation and differentiation of human B lymphocytes. J Neuroimmunol 47:35-40 (Pubitemid 23274633)
18. Orbach H, Shoenfeld Y (2007) Hyperprolactinemia and autoim-mune diseases. Autoimmun Rev 6:537-542
19. Cejkova P, Fojtikova M, Cerna M (2009) Immunomudulatory role of prolactin in diabetes mellitus. Autoimmun Rev 9:23-27
20. Jara LJ, Gomez-Sanchez C, Silveira LH, Martinez-Osuna P, Vasey FB, Espinoza LR (1992) Hyperprolactinemia in systemic lupus erythematosus: association with disease activity Am J Med Sci 303:222-226
21. Allen SH, Sharp GC, Wang G et al (1996) Prolactin levels and antinuclear antibody profiles in women tested for connective tissue disease. Lupus 5:30-37 (Pubitemid 26072426)
22. Buskila D, Lorber M, Neumann L, Flusser D, Shoenfeld Y (1996) No correlation between prolactin levels and clinical activity in patients with systemic lupus erythematosus. J Rheumatol 23:629-632 (Pubitemid 26139634)
23. Alvarez-Nemegyei J, Cobarrubias-Cobos A, Escalante-Triay F et al (1998) Bromocriptine in systemic lupus erythematosus: a double-blind, randomized, placebo-controlled study. Lupus 7:414-419 (Pubitemid 28410188)
24. Szyper-Kravitz M, Zandman-Goddard G, Lahita RG, Shoenfeld Y (2005) The neuroendocrine-immune interactions in systemic lupus erythematosus: a basis for understanding disease patho-genesis and complexity Rheum Dis Clin North Am 31:161-175 (Pubitemid 40082060)
25. Leanos-Miranda A, Cardenas-Mondragon G (2006) Serum free prolactin concentrations in patients with systemic lupus eryth-ematosus are associated with lupus activity Rheumatology 45:97-101 (Pubitemid 43033883)
26. Rezaieyazdi Z, Hesamifard A (2006) Correlation between serum prolactin levels and lupus activity. Rheumatol Int 26:1036-1039 (Pubitemid 44394509)
27. El Miedany YM, Ahmed I, Moustafa H, El Baddini M (2004) Hyperprolactinemia in Sjogren's syndrome: a patient subset or a disease manifestation? Joint Bone Spine 71:203-208 (Pubitemid 38739130)
28. Peeva E (2011) Reproductive immunology: a focus on the role of female sex hormones and other gender-related factors. Clin Rev Allergy Immunol 40:1-7
29. Blank M, Krause I, Buskila D et al (1995) Bromocriptine immunomodulation of experimental SLE and primary antiphos-pholipid syndrome via induction of nonspecific T suppressor cells. Cell Immunol 162:114-122
30. Peeva E, Grimaldi C, Spatz L, Diamond B (2000) Bromocriptine restores tolerance in estrogen-treated mice. J Clin Invest 106:1373-1379
31. Walker SE (2001) Bromocriptine treatment of systemic lupus erythematosus. Lupus 10:762-768 (Pubitemid 33048800)
32. McMurray RW, Weidensaul D, Allen SH, Walker SE (1995) Efficacy of bromocriptine in an open label therapeutic trial for systemic lupus erythematosus. J Rheumatol 22:2084-2091
33. Jara LJ, Cruz-Cruz P, Saavedra MA et al (2007) Bromocriptine during pregnancy in systemic lupus erythematosus. A pilot clinical trial. Ann NY Acad Sci 1110:297-304 (Pubitemid 350043018)
34. Hrycek A, Pochopien-Kenig G, Cieszka J (2007) Selected acute phase proteins and interleukin-6 in systemic lupus erythematosus patients treated with low doses of quinagolide. Autoimmunity 40:217-222 (Pubitemid 46680975)
35. Fojtíková M, Tomasová Studýnková J, Filková M et al (2010) Elevated prolactin levels in patients with rheumatoid arthritis: association with disease activity and structural damage. Clin Exp Rheumatol 28:849-854
36. Olsen NJ, Kovacs WJ (2002) Hormones, pregnancy, and rheumatoid arthritis. J Gend-SpecifMed 5:28-37 (Pubitemid 35469409)
37. Brennan P, Ollier B, Worthington J, Hajeer A, Silman A (1996) Are both genetic and reproductive associations with rheumatoid arthritis linked to prolactin? Lancet 348:106-109
38. Jorgensen C, Bressot N, Bologna C, Sany J (1995) Dysregula-tion of the hypothalamo-pituitary axis in rheumatoid arthritis. J Rheumatol 22:1829-1833
39. Templ E, Koeller M, Riedl M, Wagner O, Graninger W, Luger A (1996) Anterior pituitary function in patients with newly diagnosed rheumatoid arthritis. Br J Rheumatol 35:350-356
40. Zoli A, Lizzio MM, Ferlisi EM et al (2002) ACTH, cortisol and prolactin in active rheumatoid arthritis. Clin Rheumatol 21:289-293
41. Eijsbouts AM, van den Hoogen FH, Laan RF, Sweep CG, Hermus AR, van de Putte LB (2005) Decreased prolactin response to hypoglycaemia in patients with rheumatoid arthritis: correlation with disease activity. Ann Rheum Dis 64:433-437 (Pubitemid 40283055)
42. Rovensky J, Imrich R, Malis F et al (2004) Prolactin and growth hormone responses to hypoglycemia in patients with rheumatoid arthritis and ankylosing spondylitis. J Rheumatol 31:2418-2421 (Pubitemid 39603091)
43. Kullich WC, Klein G (1998) High levels of macrophage inflammatory protein-1alpha correlate with prolactin in female patients with active rheumatoid arthritis. Clin Rheumatol 17:263-264 (Pubitemid 28346385)
44. Nagafuchi H, Suzuki N, Kaneko A, Asai T, Sakane T (1999) Prolactin locally produced by synovium infiltrating T lympho-cytes induces excessive synovial cell functions in patients with rheumatoid arthritis. J Rheumatol 26:1890-1900 (Pubitemid 30007054)
45. Cutolo M, Balleari E, Giusti M, Monachesi M, Accardo S (1986) Sex hormone status in women suffering from rheumatoid arthritis. JRheumatol 13:1019-1023 (Pubitemid 17027649)
46. Gutierrez MA, Garcia ME, Rodriguez JA, Mardonez G, Jacobelli S, Rivero S (1999) Hypothalamic-pituitary-adrenal axis function in patients with active rheumatoid arthritis: a controlled study using insulin hypoglycemia stress test and prolactin stimulation. J Rheumatol 26:277-281 (Pubitemid 29066728)
47. Ram S, Blumberg D, Newton P, Anderson NR, Gama R (2004) Raised serum prolactin in rheumatoid arthritis: genuine or laboratory artefact? Rheumatol (Oxford) 43:1272-1274
48. Seriolo B, Ferretti V, Sulli A, Fasciolo D, Cutolo M (2002) Serum prolactin concentrations in male patients with rheumatoid arthritis. Ann NY Acad Sci 966:258-262 (Pubitemid 34729183)
49. Mateo L, Nolla JM, Bonnin MR, Navarro MA, Roig-Escofet D (1998) High serum prolactin levels in men with rheumatoid arthritis. Rheumatol 25:2077-2082 (Pubitemid 28505851)
50. Orbach H, Zandman-Goddard G, Amital H et al (2007) Novel biomarkers in autoimmune diseases: prolactin, ferritin, vitamin D, and TPA levels in autoimmune diseases. Ann NY Acad Sci 1109:385-400 (Pubitemid 47511381)
51. Dougados M, Duchesne L, Amor B (1988) Bromocriptine and cyclosporin A combination therapy in rheumatoid arthritis. Arthritis Rheum 31:1333-1334
52. Marguerie C, David J, So A, Walport M (1990) A pilot study comparing bromocriptine with D-penicillamine in the treatment of rheumatoid arthritis. Br J Rheumatol 29(suppl 2):3
53. Mader R (1997) Bromocriptine for refractory rheumatoid arthritis. Harefuah 133:527-529
54. Figueroa F, Carrion F, Martinez M, Rivero S, Mamani I (1997) Bromocriptine induces immunological changes related to disease parameters in rheumatoid arthritis. Br J Rheumatol 36:1022-1027
55. Eijsbouts A, van den Joogen F, Laan R, Hermus A, Sweep F, van de Putte L (1999) Treatment of rheumatoid arthritis with the dopamine agonist quinagolide. J Rheumatol 26:2284-2285 (Pubitemid 29487038)
56. Erb N, Pace A, Delamere J, Kitas G (2001) Control of unremitting rheumatoid arthritis by the prolactin antagonist cabergoline. Rheumatology 40:237-239 (Pubitemid 32229654)
57. Riskind PN, Massacesi L, Doolittle TH, Hauser SL (1991) The role of prolactin in autoimmune demyelination: suppression of experimental allergic encephalomyelitis by bromocriptine. Ann Neurol 29:542-527
58. Dijkstra CD, van der Voort ER, De Groot CJ et al (1994) Therapeutic effect of the D2-dopamine agonist bromocriptine on acute and relapsing experimental allergic encephalomyelitis. Psychoneuroendocrinology 19:135-142
59. Kira J, Harada M, Yamaguchi Y, Shida N, Goto I (1991) Hyperprolactinemia in multiple sclerosis. J Neurol Sci 102:61-66
60. Azar ST, Yamout B (1999) Prolactin secretion is increased in patients with multiple sclerosis. Endocrin Res 25:207-214 (Pubitemid 29269400)
61. Zych-Twardowska E, Wajgt A (1999) Serum prolactin and sex hormone concentrations in patients withmultiple sclerosis. Med Sci Monit 5:216-220 (Pubitemid 29262220)
62. Yamasaki K, Horiuchi I, Minohara M et al (2000) Hyper-prolactinemia in optico-spinal multiple sclerosis. Intern Med 39:296-299
63. Safarinejad MR (2008) Evaluation of endocrine profile, hypo-thalamic-pituitary-testis axis and semen quality in multiple sclerosis. JNeuroendocrinol 20:1368-1375
64. Markianos M, Koutsis G, Evangelopoulos ME, Mandellos D, Sfagos C (2010) Serum and cerebrospinal fluid prolactin levels in male and female patients with clinically-isolated syndrome or relapsing-remitting multiple sclerosis. J Neuroendocrinol 22:503-508
65. Da Costa R, Szyper-Kravitz M, Szekanecz Z et al. (2011) Ferritin and prolactin levels in multiple sclerosis. Isr Med Assoc J (in press)
66. Nociti V, Frisullo G, Tartaglione T et al (2010) Multiple sclerosis attacks triggered by hyperprolactinemia. J Neurooncol 98: 407-409
67. RederAT LMT (1993) Serum prolactin levels in active multiple sclerosis and during cyclosporin treatment. J Neurol Sci 117:192-196
68. Wei T, Lightman SL (1997) The neuroendocrine axis in patients with multiple sclerosis. Brain 120:1067-1076 (Pubitemid 27259555)
69. Heesen C, Gold SM, Bruhn M, Mönch A, Schulz KH (2002) Prolactin stimulation in multiple sclerosis-an indicator of disease subtypes and activity? Endocr Res 28:9-18 (Pubitemid 34693134)
70. Harirchian MH, Sahralan MA, Shirani A (2006) Serum prolactin level in patients with multiple sclerosis: a case control study. Med Sci Monit 12:177-180
71. Bissay V, De Klippelm N, Herroelenm L et al (1994) Bromocriptine therapy in multiple sclerosis: an open label pilot study. Clin Neuropharmacol 17:473-476 (Pubitemid 24294475)
72. Then Bergh F, Kuemple T, Schumann E et al (2006) Monthly i.v. methylprednisolone in relapsing remitting MS-reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations. BMC Neurol 23:19
73. Steen VD (1999) Pregnancy in women with systemic sclerosis. Obstet Gynecol 94:15-20 (Pubitemid 29284419)
74. Hilty C, Brühlmann P, Sprott H et al (2000) Altered diurnal rhythm of prolactin in systemic sclerosis. J Rheumatol 27: 2160-2165
75. Shahin AA, Abdoh S, Abdelrazik M (2002) Prolactin and thyroid hormones in patients with systemic sclerosis: corre-lations with disease manifestations and activity. Z Rheumatol 61:703-709 (Pubitemid 36131884)
76. Czuwara-Ladykowska J, Sicinska J, Olszewska M, Uhrynowska-Tyszkiewicz I, Rudnicka L (2006) Prolactin synthesis by lymphocytes from patients with systemic sclerosis. Biomed Pharmacother 60:152-155 (Pubitemid 43870418)
77. La Montagna G, Baruffo A, Pasquali D, Bellastella A, Tirri G, Sinisi AA (2001) Assessment ofpituitary gonadotropin release to gonadotropin releasing hormone/thyroid-stimulating hormone stimulation in women with systemic sclerosis. Rheumatol (Oxford) 40:310-314
78. Vera-Lastra O, Jara LJ, Medina G et al (2006) Functional hyperprolactinemia and hypophyseal microadenoma in systemic sclerosis. J Rheumatol 33:1108-1112 (Pubitemid 43825460)
79. Straub RH, Zeuner M, Lock G, Schölmerich J, Lang B (1997) High prolactin and low dehydroepiandrosterone sulphate ser-umlevels in patients with severe systemic sclerosis. Br J Rheumatol 36:426-432
80. Buskila D, Berezin M, Gur H et al (1995) Autoantibody profile in the sera of women with hyperprolactinemia. J Autoimmun 8:415-424
81. Haga HJ, Rygh T (1999) The prevalence of hyperprolactinemia in patients with primary Sjögren's syndrome. J Rheumatol 26:1291-1295 (Pubitemid 29268080)
82. Gutiérrez MA, Anaya JM, Scopelitis E, Citera G, Silveira L, Espinoza LR (1994) Hyperprolactinaemia in primary Sjögren's syndrome. Ann Rheum Dis 53:425
83. Steinfeld S, Rommes S, François C et al (2000) Big prolactin 60 kDa is overexpressed in salivary glandular epithelial cells from patients with Sjögren's syndrome. Lab Invest 80:239-247 (Pubitemid 30120976)
84. Johnson EO, Moutsopoulos HM (2000) Neuroendocrine mani-festationsin Sjögren's syndrome. Relation to the neurobiology of stress. Ann NY Acad Sci 917:797-808
85. Legakis I, Petroyianni V, Saramantis A, Tolis G (2001) Elevated prolactin to cortisol ratio and polyclonal autoimmune activation in Hashimoto's thyroiditis. Horm Metab Res 33:585-589 (Pubitemid 33015960)
86. Notsu K, Ito Y Furuya H, Ohguni S, Kato Y (1997) Incidence of hyperprolactinemia in patients with Hashimoto's thyroiditis. Endocr J 44:89-94 (Pubitemid 27150165)
87. Poyraz BC, Aksoy C, Balc?o?lu I (2008) Increased incidence of autoimmune thyroiditis in patients with antipsychotic-induced hyperprolactinemia. Europ Neuropsychopharmacol 18:667-672
88. Ward MM, Marx AS, Barry NN (2000) Comparison of the validity and sensitivity to change of 5 activity indices in systemic lupus erythematosus. J Rheumatol 27:664-670 (Pubitemid 30151343)
89. Jacobi AM, Rohde W, Ventz M, Riemekasten G, Burmester GR, Hiepe F (2001) Enhanced serum prolactin (PRL) in patients with systemic lupus erythematosus: PRL levels are related to the disease activity. Lupus 10:554-561 (Pubitemid 32777652)
90. Leaños-Miranda A, Pascoe-Lira D, Chávez-Rueda KA, Blanco-Favela F (2001) Antiprolactin autoantibodies in systemic lupus erythematosus: frequency and correlation with prolactinemia and disease activity. J Rheumatol 28:1546-1553 (Pubitemid 32660626)
91. Paciliom M, Mgliaresim S, Melim R, Ambrosonem L, Bigliardom B, Di Carlo R (2001) Elevatedbioactive prolactin levels in systemic lupus erythematosus-association with disease activity. J Rheumatol 28:2216-2221 (Pubitemid 32947865)
92. Shabanova SS, Ananieva LP, Alekberova ZS, Guzov II (2008) Ovarian function and disease activity in patients with systemic lupus erythematosus. Clin Exp Rheumatol 26:436-441 (Pubitemid 352003212)
93. McMurray R, Keisler D, Kanuckel K, Izui S, Walker SE (1991) Prolactin influences autoimmune disease activity in the female B/W mouse. J Immunol 147:3780-3787
94. McMurray R, Keisler D, Izui S, Walker SE (1994) Hyper-prolactinemia in male NZB/NZW (B/W) F1 mice: accelerated autoimmune disease with normal circulating testosterone. Clin Immunol Immunopathol 71:338-343 (Pubitemid 24190235)
95. Rovenský J, Juránková E, Rauová L et al (1997) Relationship between endocrine, immune, and clinical variables in patients with systemic lupus erythematosus. J Rheumatol 24:2330-2334 (Pubitemid 28005131)
96. Ferreira C, Paes M, Gouveia A, Ferreira E, Padua F, Fiuza T (1998) Plasma homovanillic acid and prolactin in systemic lupus erythematosus. Lupus 7:392-397 (Pubitemid 28410184)
97. Jimena P, Aguirre MA, Lopez-Curbelo A, de Andres M, Garcia-Courtay C, Cuadrado MJ (1998) Prolactin levels in patient with systemic lupus erythematosus: a case controlled study. Lupus 7:383-386 (Pubitemid 28410182)
98. Blanco-Favela F, Quintal-Alvarez G, Leanos-Miranda A (1999) Association between prolactin and disease activity in systemic lupus erythematosus. Influence of statistical power. J Rheumatol 26:55-59 (Pubitemid 29051395)
99. Leanos-Miranda A, Chavez-Rueda KA, Blanco-Favela F (2001) Biologic activity and plasma clearance of prolactin-IgG complex in patients with systemic lupus erythematosus. Arthritis Rheum 44:866-875 (Pubitemid 32319779)
100. Leanos A, Pascoe D, Fraga A, Blanco-Favela F (1998) Anti-prolactin autoantibodies in systemic lupus erythematosus patients with associated hyperprolactinemia. Lupus 7:398-403 (Pubitemid 28410185)
101. Jara LJ, Vera-Lastra O, Miranda JM, Alcala M, Alvarez-Nemegyei J (2001) Prolactin in human systemic lupus eryth-ematosus. Lupus 10:748-756 (Pubitemid 33041668)
102. Jara LJ, Irigoyen L, de Ortiz MJ, Zazueta B, Bravo G, Espinoza LR (1998) Prolactin and interleukin-6 in neuropsychiatric lupus erythematosus. Clin Rheumatol 17:110-114 (Pubitemid 28253167)
103. Zoli A, Ferlisi EM, Pompa A et al (1999) Basal and after-stimuli test for prolactinemia in systemic lupus erythematosus. Ann NY Acad Sci 876:155-158 (Pubitemid 29352121)
104. Rastin M, Hatef MR, Tabasi N, Sheikh AM, Abbasi J, Mahmoudi M (2007) Sex hormones and peripheral white blood cell subsets in systemic lupus erythematosus patients. Iran J Immunol 4:110-115 (Pubitemid 46983401)
105. Praprotnik S, Agmon-Levin N, Porat-Katz BS et al (2010) Prolactin's role in the pathogenesis of the antiphospholipid syndrome. Lupus 19:1515-1519
106. Alarcón-Segovia D (2001) The future oftreatment for systemic lupus erythematosus. Isr Med Assoc J 3:127-130