α-Synuclein in the olfactory system of a mouse model of Parkinson's disease: Correlation with olfactory projections

Brain Structure and Function

Volumn 217, Issue 2, 2012, Pages 447-458

  Ubeda Bañon, Isabel ^a   Saiz Sanchez, Daniel ^a   De La Rosa Prieto, Carlos ^a   Martinez Marcos, Alino ^a  

^a UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

Author keywords

Synuclein; Anosmia; Olfactory deficit; Olfactory projections; Olfactory system; Parkinson's disease; Tract tracing; Transgenic mice

Indexed keywords

ALPHA SYNUCLEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; FEMALE; HOMOZYGOSITY; MALE; MOUSE; NONHUMAN; OLFACTORY BULB; OLFACTORY NUCLEUS; OLFACTORY PROJECTION; OLFACTORY SYSTEM; PARKINSON DISEASE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PYRIFORM CORTEX; SUBSTANTIA NIGRA; TRANSGENIC ANIMAL;

ALPHA-SYNUCLEIN; AMYGDALA; ANIMALS; CELL SURFACE EXTENSIONS; DISEASE MODELS, ANIMAL; ENTORHINAL CORTEX; FEMALE; MALE; MICE; MICE, TRANSGENIC; MUTATION; NEURAL PATHWAYS; OLFACTORY BULB; OLFACTORY PATHWAYS; PARKINSON DISEASE;

ANIMALIA; MUS MUSCULUS;

EID: 84862870053     PISSN: 18632653     EISSN: 18632661     Source Type: Journal    
DOI: 10.1007/s00429-011-0347-4     Document Type: Article

References (62)

1. Angot E et al (2010) Are synucleinopathies prion-like disorders? Lancet Neurol 9:1128-1138
2. Ansari KA, Johnson A (1975) Olfactory function in patients with Parkinson's disease. J Chronic Dis 28:493-497
3. Beach TG et al (2009) Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders. Acta Neuropathol 117:169-174
4. Benarroch EE (2010) Olfactory system: functional organization and involvement in neurodegenerative disease. Neurology 75:1104-1109
5. Braak H et al (2003a) Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 24:197-211
6. Braak H et al (2003b) Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm 110:517-536
7. Braak H et al (2006) Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett 396:67-72
8. Brundin P et al (2008) Research in motion: the enigma of Parkinson's disease pathology spread. Nat Rev Neurosci 9:741-745
9. Brunjes PC et al (2005) A field guide to the anterior olfactory nucleus (cortex). Brain Res Brain Res Rev 50:305-335
10. Constantinidis J, de Ajuriaguerra J (1970) Familial syndrome with parkinsonian tremor and anosmia and its therapy with L-dopa associated with a decarboxylase inhibitor. Therapeutique 46: 263-269
11. Daniel SE, Hawkes CH (1992) Preliminary diagnosis of Parkinson's disease by olfactory bulb pathology. Lancet 340:186
12. Davis BJ et al (1978) Efferents and centrifugal afferents of the main and accessory olfactory bulbs in the hamster. Brain Res Bull 3:59-72
13. Dawson T et al (2002) Animal models of PD: pieces of the same puzzle? Neuron 35:219-222
14. Deierborg T et al (2008) Emerging restorative treatments for Parkinson's disease. Prog Neurobiol 85:407-432
15. Del Tredici K et al (2002) Where does parkinson disease pathology begin in the brain? J Neuropathol Exp Neurol 61:413-426
16. Devor M (1976) Fiber trajectories of olfactory bulb efferents in the hamster. J Comp Neurol 166:31-47
17. Duda JE (2010) Olfactory system pathology as a model of Lewy neurodegenerative disease. J Neurol Sci 289:49-54
18. Fahn S (2008) The history of dopamine and levodopa in the treatment of Parkinson's disease. Mov Disord 23(Suppl 3):S497-S508
19. Fleming SM et al (2005) Genetic mouse models of parkinsonism: strengths and limitations. NeuroRx 2:495-503
20. Fleming SM et al (2008) Olfactory deficits in mice overexpressing human wildtype alpha-synuclein. Eur J Neurosci 28:247-256
21. Franklin KBJ, Paxinos G (2008) The mouse brain in stereotaxic coordinates. Elsevier, San Diego
22. Giasson BI et al (2002) Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alphasynuclein. Neuron 34:521-533
23. Gutierrez-Castellanos N et al (2010) Chemosensory function of the amygdala. Vitam Horm 83:165-196
24. Haehner A et al (2007) Olfactory loss may be a first sign of idiopathic Parkinson's disease. Mov Disord 22:839-842
25. Hawkes CH (2008) The prodromal phase of sporadic Parkinson's disease: does it exist and if so how long is it? Mov Disord 23:1799-1807
26. Hawkes CH, Shephard BC (1993) Selective anosmia in Parkinson's disease? Lancet 341:435-436
27. Hubbard PS et al (2007) Alpha-synuclein pathology in the olfactory pathways of dementia patients. J Anat 211:117-124
28. Katzenschlager R, Lees AJ (2004) Olfaction and Parkinson's syndromes: its role in differential diagnosis. Curr Opin Neurol 17:417-423
29. Kim YH et al (2011) Inducible dopaminergic glutathione depletion in an alpha-synuclein transgenic mouse model results in age-related olfactory dysfunction. Neuroscience 172:379-386
30. Kordower JH et al (2008) Transplanted dopaminergic neurons develop PD pathologic changes: a second case report. Mov Disord 23:2303-2306
31. Kranick SM, Duda JE (2008) Olfactory dysfunction in Parkinson's disease. Neurosignals 16:35-40
32. Lee MK et al (2002) Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53-Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A. 99:8968-8973
33. Lees AJ et al (2009) Parkinson's disease. Lancet 373:2055-2066
34. Lerner A, Bagic A (2008) Olfactory pathogenesis of idiopathic Parkinson disease revisited. Mov Disord 23:1076-1084
35. Li JY et al (2008) Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med 14:501-503
36. Marek K, Jennings D (2009) Can we image premotor Parkinson disease? Neurology 72:S21-S26
37. Martinez-Marcos A (2009) On the organization of olfactory and vomeronasal cortices. Prog Neurobiol 87:21-30
38. Martinez-Marcos A, Halpern M (2006) Efferent connections of the main olfactory bulb in the opossum (Monodelphis domestica): a characterization of the olfactory entorhinal cortex in a marsupial. Neurosci Lett 395:51-56
39. Morley JF, Duda JE (2010) Olfaction as a biomarker in Parkinson's disease. Biomark Med 4:661-670
40. Morley JF, Hurtig HI (2010) Current understanding and management of Parkinson disease: five new things. Neurology 75:S9-S15
41. Müller A et al (2002) Olfactory function in Parkinsonian syndromes. J Clin Neurosci 9:521-524
42. Pearce RK et al (1995) The anterior olfactory nucleus in Parkinson's disease. Mov Disord 10:283-287
43. Ponsen MM et al (2004) Idiopathic hyposmia as a preclinical sign of Parkinson's disease. Ann Neurol 56:173-181
44. Richfield EK et al (2002) Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Exp Neurol 175:35-48
45. Ross GW et al (2008) Association of olfactory dysfunction with risk for future Parkinson's disease. Ann Neurol 63:167-173
46. Saiz-Sanchez D et al (2010) Somatostatin, tau, and beta-amyloid within the anterior olfactory nucleus in Alzheimer disease. Exp Neurol 223:347-350
47. Saiz-Sanchez D et al (2010a) The human olfactory system: an anatomical and cytoarchitectonic study of the anterior olfactory nucleus. In: Flynn CE, Callaghan BR (eds) Neuroanatomy Research Advances, New York, p 171-182
48. Savica R et al (2010) When does Parkinson disease start? Arch Neurol 67:798-801
49. Sengoku R et al (2008) Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb. J Neuropathol Exp Neurol 67:1072-1083
50. Shipley MT, Adamek GD (1984) The connections of the mouse olfactory bulb: a study using orthograde and retrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase. Brain Res Bull 12:669-688
51. Siderowf A, Stern MB (2008) Premotor Parkinson's disease: clinical features, detection, and prospects for treatment. Ann Neurol 64(Suppl 2):S139-S147
52. Silveira-Moriyama L et al (2009) Regional differences in the severity of Lewy body pathology across the olfactory cortex. Neurosci Lett 453:77-80
53. Skeen LC, Hall WC (1977) Efferent projections of the main and the accessory olfactory bulb in the tree shrew (Tupaia glis). J Comp Neurol 172:1-35
54. Sommer B et al (2000) Mouse models of alpha-synucleinopathy and Lewy pathology. Exp Gerontol 35:1389-1403
55. Spillantini MG et al (1997) Alpha-synuclein in Lewy bodies. Nature 388:839-840
56. Tolosa E et al (2009) Diagnosis and the premotor phase of Parkinson disease. Neurology 72:S12-S20
57. Toulouse A, Sullivan AM (2008) Progress in Parkinson's diseasewhere do we stand? Prog Neurobiol 85:376-392
58. Ubeda-Banon I et al (2010a) Alpha-synucleinopathy in the human olfactory system in Parkinson's disease: involvement of calciumbinding protein-and substance P-positive cells. Acta Neuropathol 119:723-735
59. Ubeda-Banon I et al (2010b) Staging of alpha-synuclein in the olfactory bulb in a model of Parkinson's disease: cell types involved. Mov Disord 25:1701-1707
60. Ubeda-Banon I et al (2011) Cladistic analysis of olfactory and vomeronasal systems. Front Neuroanat 5:3
61. van der Putten H et al (2000) Neuropathology in mice expressing human alpha-synuclein. J Neurosci 20:6021-6029
62. Vidailhet M (2011) Movement disorders in 2010: Parkinson diseasesymptoms and treatments. Nat Rev Neurol 7:70-72