Individual and dyadic barriers to a pharmacotherapeutic treatment of hypoactive sexual desire disorders: Results and implications from a small-scale study with bupropion

Journal of Sex and Marital Therapy

Volumn 38, Issue 4, 2012, Pages 325-348

  Hartmann, Uwe H ^a   Rüffer Hesse, Claudia ^a   Krüger, Tillmann H C ^a   Philippsohn, Susanne ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; DOPAMINE UPTAKE INHIBITOR;

ADULT; AROUSAL; ARTICLE; CASE REPORT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED RELEASE FORMULATION; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMAN; MALE; MARRIAGE; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; ORGASM; PATIENT ATTITUDE; PSYCHOLOGIC TEST; PSYCHOLOGICAL ASPECT; PSYCHOSEXUAL DISORDER; PSYCHOTHERAPY; QUESTIONNAIRE; SINGLE BLIND PROCEDURE; SOCIAL SUPPORT; TREATMENT OUTCOME;

ADULT; AROUSAL; BUPROPION; COMBINED MODALITY THERAPY; DELAYED-ACTION PREPARATIONS; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INTERVIEW, PSYCHOLOGICAL; MALE; MARRIAGE; MIDDLE AGED; ORGASM; PATIENT ACCEPTANCE OF HEALTH CARE; PSYCHOTHERAPY; QUESTIONNAIRES; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL; SINGLE-BLIND METHOD; SOCIAL SUPPORT; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84862862892     PISSN: 0092623X     EISSN: 15210715     Source Type: Journal    
DOI: 10.1080/0092623X.2011.606495     Document Type: Review

References (59)

1. Althof, S. E. (2007). It was the best of times; it was the worst of times. Journal of Sex & Marital Therapy, 33, 399-403. (Pubitemid 47221479)
2. Althof, S. E., Leiblum, S. R., Chevret-Measson, M., Hartmann, U., Levine, S. B., McCabe, M., . . . Wylie, K. (2005). Psychological and Interpersonal dimensions of sexual function and dysfunction. Journal of Sexual Medicine, 2, 793-800. (Pubitemid 41727392)
3. Anonymous. (2009). Testosterone patches for female sexual dysfunction. Drug and Therapeutics Bulletin, 47, 30-34.
4. Balon, R. (2007). Is medicalization and dichotomization of sexology the answer? A commentary. Journal of Sex & Marital Therapy, 33, 405-409. (Pubitemid 47221478)
5. Bancroft, J. (2002). The medicalization of female sexual dysfunction: The need for caution. Archives of Sexual Behavior, 31, 451-455. (Pubitemid 38471090)
6. Bancroft, J. (2009). Human sexuality and its disorders (3rd ed.). Edinburgh, England: Churchill Livingstone.
7. Bancroft, J., Loftus, J., & Long, J. S. (2003). Distress about sex: A national survey of women in heterosexual relationships. Archives of Sexual Behavior, 32, 193-208. (Pubitemid 38090835)
8. Bartlik, B., Kaplan, P., Kaminetsky, J., Roentsch, G., & Goldberg, J. (1999). Medications with the potential to enhance sexual responsivity in women. Psychiatric Annals, 29, 46-52.
9. Borkenau, P., & Ostendorf, F. (1993). Ein fragebogen zur erfassung f̈unf robuster pers̈onlichkeitsfaktoren [A questionnaire to assess five robust personality factors]. Diagnostica, 37, 29-41.
10. Borkenau, P., & Ostendorf, F. (2008). NEO-FFI (2nd ed.). G̈ottingen, Germany: Hogrefe.
11. Chambles, D., Sanderson, W. C., Shoham, V., Bennett Johnson, S., Pope, K. S., Crits-Christoph, P., . . . McCurry, S. (1996). An update on empirically validated treatments. Clinical Psychologist, 49, 5-18.
12. Clayton, A. H. (2007). Extended-release bupropion: An antidepressant with a broad spectrum of therapeutic activity? Expert Opinion Pharmacotherapy, 8, 457-466. (Pubitemid 46416414)
13. Clayton, A. H., Croft, H. A., Horrigan, J. P., Wightman, D. S., Krishen, A., Richard, N. E., & Modell, J. G. (2006). Bupropion extended release compared with escitalopram: Effects on sexual functioning and antidepressant efficacy in 2 randomized, double-blind, placebo-controlled studies. Journal of Clinical Psychiatry, 67, 736-746. (Pubitemid 43946180)
14. Clayton, A. H., Dennerstein, L., Fisher, W. A., Kingsberg, S. A., Perelman, M. A., & Pyke, R. E. (2010). Standards for clinical trials in sexual dysfunction in women: Research designs and outcomes assessment. Journal of Sexual Medicine, 7, 541-560.
15. Clayton, A. H., McGarvey, E. L., Abouesh, A. I., & Pinkerton, R. G. (2001). Substitution of an SSRI with bupropion sustained release following SSRI-induced sexual dysfunction. Journal of Clinical Psychiatry, 62, 185-190. (Pubitemid 32270093)
16. Coleman, C. C., King, B. R., Bolden-Watson, C., Book, M. J., Segraves, R. T., Ascher, N., . . . Metz, A. (2001). A placebo-controlled comparison of the effects on sexual functioning of bupropion sustained release and fluoxetine. Clinical Therapy, 23, 1040-1058. (Pubitemid 32709626)
17. Conaglen, H., O'Connor, E., McCabe, M. P., & Conaglen, J. V. (2009). How interviews expand on FSFI questionnaire responses: A mixed-methods investigation of coexisting sexual dysfunction in female partners of men with erectile dysfunction. Journal of Sexual Medicine, 6(Suppl. 5), 408.
18. Costa, P. T., & McCrae, R. R. (1989). The NEO PI/FFI manual supplement. Odessa, FL: Psychological Assessment Resources.
19. Costa, P. T., & McCrae, R. R. (1992). Revised NEO Personality Inventory (NEO PI-R) and NEO Five- actory Inventory. Professional Manual. Odessa, FL: Psychological Assessment Resources.
20. De Amicis, L. ., Goldberg, D. C., LoPiccolo, J., Friedman, J., & Davies, L. (1985). Clinical follow-up of couples treated for sexual dysfunction. Archives of Sexual Behavior, 14, 467-489. (Pubitemid 16210911)
21. Deneke, F. W., & Hilgenstock, B. (1989). Das narziβmusinventar: Handbuch [A narcissism inventory: Handbook]. Bern, Germany: Huber.
22. Derogatis, L. R. (1977). SCL-90-R, Administration, Scoring & Procedures Manual-I for the R(evised) Version. Baltimore, MD: Johns Hopkins University School of Medicine.
23. Fagan, P. (2007). Sex therapy and research: A view from health services research. Journal of Sex & Marital Therapy, 33, 427-432. (Pubitemid 47221484)
24. Franke, G. H. (2002). SCL-90-R. Symptom-Checkliste von L. R. Derogatis-Deutsche Version-2. Auflage [Symptom-checklist by L. R. Derogatis-German version-2nd ed.]. G̈ottingen, Germany: Beltz Test GmbH.
25. Gardner, E. A., & Johnston, J. A. (1985). Bupropion: An antidepressant without sexual pathophysiological action. Journal of Clinical Psychopharmacology, 5, 24-29. (Pubitemid 15126297)
26. GlaxoSmithKline. (2010). Zyban prescribing information. Retrieved from http://us.gsk.com/products/assets/us-zyban.pdf
27. Hahlweg, K. (1988). PFB Partnership Questionnaire. In M. Hersen & A. S. Bellack (Eds.), Dictionary of behavioral assessment techniques (pp. 192-198). New York, NY: Pergamon Press.
28. Hart, G., & Wellings, K. (2002). Sexual behavior and its medicalization: In sickness and in health. British Medical Journal, 324, 896-900. (Pubitemid 34303946)
29. Hartmann, U. (2002). Psychologische diagnostik und sexualanamnese [Psychological evaluation and sexual history]. In C. G. Stief, U. Hartmann, M. C. Truss, & U. Jonas (Eds.), Zeitgem̈aβe therapie Der erektilen dysfunktion [Current treatment of erectile dysfunction] (2nd ed.). Berlin, Germany: Springer.
30. Hartmann, U., Heiser, K., R̈uffer-Hesse, C., & Kloth, G. (2002). Female sexual desire disorders: Subtypes, classification, personality factors and new directions for treatment. World Journal of Urology 2002, 20, 79-88.
31. Hartmann, U., Philippsohn, S., Heiser, K., & R̈uffer-Hesse, C. (2004). Low sexual desire in midlife and older women: Personality factors, psychosocial development, present sexuality. Menopause, 11, 726-740.
32. Hautzinger, M., & Bailer, M. (1993). Allgemeine Depressions Skala-ADS [General depression scale]. Weinheim, Germany: Beltz.
33. Hawton, K. (1986). Long-Term outcome of sex therapy. Behavioral Research and Therapy, 24, 665-675. (Pubitemid 17213221)
34. Hayes, R. D., Dennerstein, L., Bennett, C. M., Sidat, M., Gurrin, L. C., & Fairley, C. K. (2008). Risk factors for female sexual dysfunction in the general population: Exploring factors associated with low sexual function and sexual distress. Journal of Sexual Medicine, 5, 1681-1693. (Pubitemid 352044424)
35. Heiman, J., & Meston, C. (1997). Empirically validated treatment for sexual dysfunction. In R. Rosen (Ed.), Annual review of sex research (Vol. VIII, pp. 148-194). Mount Vernon, Iowa: Society for the Scientific Study of Sex.
36. Holmberg, D., Blair, K. L., & Phillips, M. (2010). Women's sexual satisfaction as a predictor of well-being in same-sex versus mixed-sex relationships. Journal of Sex Research, 47, 1-11.
37. Kennedy, S. H., Fulton, K. A., Bagby, R. M., Greene, A. L., Cohen, N. L., & Rafi-Tari, S. (2006). Sexual function during bupropion or paroxetine treatment of major depressive disorder. Canadian Journal of Psychiatry, 51, 234-242.
38. Kennedy, S. H., McCann, S. M., Masellis, M., McIntyre, R. S., Raskin, J., McKay, G., & Baker, G. B. (2002). Combining bupropion SR with venlafaxine, paroxetine, or fluoxetine: A preliminary report on pharmacokinetic, therapeutic, and sexual dysfunction effects. Journal of Clinical Psychiatry, 63, 181-186. (Pubitemid 34407075)
39. Levine, S. B. (2007). Commentary on David Rowland's "Will medical solutions to sexual problems make sexological care and science obsolete?" Journal of Sex & Marital Therapy, 33, 449-453. (Pubitemid 47224835)
40. Leiblum, S. R., Koochaki, P. E., Rodenberg, C. A., Barton, I. P., & Rosen, R. C. (2006). Hypoactive sexual desire disorder in postmenopausal women: US results from the Women's International Study of Health and Sexuality (WISHeS). Menopause, 13, 46-56.
41. Mathias, C., Cardeal Mendes, C. M., Ponde De Sena, E., Dias De Moraes, E., Bastos, C., Braghiroli, M. I., . . . del Giglio, A. (2006). An open-label, fixed-dose study of bupropion effect on sexual function scores in women treated for breast cancer. Annals of Oncology, 17, 1792-1796. (Pubitemid 44884054)
42. Mazer, N. A., Leiblum, S. R., & Rosen, R. C. (2000). The Brief Index of Sexual Functioning for Women (BISF-W): A new scoring algorithm and comparison of normative and surgically menopausal populations. Menopause, 7, 350-363.
43. Modell, J. G., May, R. S., & Katholi, C. R. (2000). Effect of bupropion-SR on orgasmic dysfunction in nondepressed subjects: A pilot study. Journal of Sex & Marital Therapy, 26, 231-240. (Pubitemid 30439825)
44. Moynihan, R. (2003). The making of disease: Female sexual dysfunction. British Medical Journal, 326, 45-47. (Pubitemid 36110722)
45. Moynihan, R. (2005). The marketing of a disease: Female sexual dysfunction. British Medical Journal, 330, 192-194.
46. Nijland, E., Davis, S., Laan, E., & Weijmar Schultz, W. (2006). Female sexual satisfaction and pharmaceutical intervention: A critical review of the drug intervention studies in female sexual dysfunction. Journal of Sexual Medicine, 3, 763-777. (Pubitemid 44269533)
47. O'Carroll, R. (1991). Sexual desire disorders: A review of controlled treatment studies. The Journal of Sex Research, 28, 607-624.
48. Philippsohn, S., & Hartmann, U. (2009). Determinants of sexual satisfaction in a sample of German women. Journal of Sexual Medicine, 6, 1001-1010.
49. Pukall, C. F., & Reissing, E. (2007). The demise of sexological science is not imminent in the face of sexual medicine. Journal of Sex & Marital Therapy, 33, 455-459.
50. Radloff, L. S. (1977). The CES-D Scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 3, 385-401.
51. Riley, A. (2007). Commentary on Rowland's article. Journal of Sex & Marital Thearpy, 33, 461-466.
52. Rosen, R., Brown, C., Heiman, J., Leiblum, S., Shabsigh, R., Ferguson, D., & D'Agostino, R. (2000). The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function. Journal of Sex & Marital Therapy, 26, 191-208. (Pubitemid 30194541)
53. Rowland, D. L. (2007). Will medical solutions to sexual problems make sexological care and science obsolete? Journal of Sex & Marital Therapy, 33, 385-397. (Pubitemid 47221480)
54. Schindler, L., Hahlweg, K., & Revenstorf, D. (1998). Partnerschaftsprobleme: Diagnose und therapie [Marital problems: Diagnosis and therapy]. Berlin, Germany: Springer.
55. Segraves, R. T., Clayton, A., Croft, H., Wolf, A., & Warnock, J. (2004). Bupropion sustained release for the treatment of hypoactive sexual desire disorder in premenopausal women. Journal of Clinical Psychopharmacology, 24, 339-342. (Pubitemid 38658043)
56. Segraves, R. T., Croft, H., Kavoussi, R., Ascher, J. A., Batey, S. R., Foster, V. J., . . . . Metz, A. (2001). Bupropion sustained release (SR) for the treatment of hypoactive sexual desire disorder (HSDD) in nondepressed women. Journal of Sex & Marital Therapy, 27, 303-316. (Pubitemid 32374402)
57. Taylor, J. F., Rosen, R. C., & Leiblum, S. R. (1994). Self-report assessment of female sexual function: Psychometric evaluation of the Brief Index of Sexual Functioning for Women. Archives of Sexual Behavior, 23, 627-643. (Pubitemid 24378588)
58. Trudel, G., Marchand, A., Ravart, M., Aubin, S., Turgeo, L., & Fortier, P. (2001). The effect of a cognitive behavioral group treatment program on hypoactive sexual desire in women. Sexual and Relationship Therapy, 16, 145-164. (Pubitemid 32529606)
59. Wagner, G., & Kaplan, H. S. (1993). The new injection treatment for impotence. New York, NY: Brunner/Mazel.