An open-label, fixed-dose study of bupropion effect on sexual function scores in women treated for breast cancer

Annals of Oncology

Volumn 17, Issue 12, 2006, Pages 1792-1796

  Mathias, Clarissa ^a,e   Cardeal Mendes, C M ^b   Ponde de Sena E ^b   Dias de Moraes, E ^a   Bastos, C ^a   Braghiroli, M I ^b   Nunez G ^b   Athanazio, R ^b   Alban, L ^b   Moore, H C F ^c   del Giglio, A ^d  

^a Sociedade de Oncologia da Bahia   (Brazil)

^b FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^c LERNER RESEARCH INSTITUTE   (United States)

^d Universitário São Camilo   (Brazil)

^e NONE   (Brazil)

Author keywords

Antineoplastic agents; Breast neoplasms; Bupropion; Hormonal therapy; Libido; Sexual behavior

Indexed keywords

AMFEBUTAMONE; ANTINEOPLASTIC AGENT; AROMATASE INHIBITOR; TAMOXIFEN;

ADULT; ARTICLE; BECK DEPRESSION INVENTORY; BREAST CANCER; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION LOSS; DRUG EFFICACY; DRUG SAFETY; EXCITABILITY; FEMALE; HORMONAL THERAPY; HUMAN; INSOMNIA; LIBIDO; ORGASM; PRIORITY JOURNAL; QUALITY OF LIFE; SEXUAL DYSFUNCTION; TREMOR;

EID: 33845367643     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdl304     Document Type: Article

References (31)

1. Ganz PA, Desmond KA, Leedham B et al. Quality of life in long-term, disease-free survivors of breast cancer: A follow-up study. J Natl Cancer Inst 2002; 94(1): 39-49.
2. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet 2005; 365(9472): 1665-1666.
3. Schover LR, Yetman RJ, Tuason LJ et al. Partial mastectomy and breast reconstruction. A comparison of their effects on psychosocial adjustment, body image, and sexuality. Cancer 1995; 75(1): 54-64.
4. Young-McCaughan S. Sexual functioning in women with breast cancer after treatment with adjuvant therapy. Cancer Nurs 1996; 19(4): 308-319.
5. Mortimer JE, Boucher L, Baty J et al. Effect of tamoxifen on sexual functioning in patients with breast cancer. J Clin Oncol 1999; 17(5): 1488-1492.
6. Steginga S, Occhipinti S, Wilson K, Dunn J. Domains of distress: The experience of breast cancer in Australia. Oncol Nurs Forum 1998; 25(6): 1063-1070.
7. Stead M. Sexual dysfunction after treatment for gyneaecologic and breast malignancies. Curr Opin Obstet. Gynecol 2003; 15: 57-61.
8. Broeckel JA, Thors CL, Jacobsen PB et al. Sexual functioning in long-term breast cancer survivors treated with adjuvant chemotherapy. Breast Canc Res Treat 2002, 241-248.
9. Schain WS. The sexual and intimate consequences of breast cancer treatment. CA Cancer J Clin 1988; 38(3): 154-161.
10. Knobf MT. Physical and psychologic distress associated with adjuvant chemotherapy in women with breast cancer. J Clin Oncol 1986; 4(5): 678-684.
11. Segraves RT, Kavoussi R, Hughes AR et al. Evaluation of sexual functioning in depressed outpatients: A double-blind comparison of sustained-release bupropion and sertraline treatment. J Clin Psychopharmacol 2000; 20(2): 122-128.
12. Gardner EA, Johnston JA. Bupropion - an antidepressant without sexual pathophysiological action. J Clin Psychopharmacol 1985; 5(1): 24-29.
13. Crenshaw TL, Goldberg JP, Stern WC. Pharmacologic modification of psychosexual dysfunction. J Sex Marital Ther 1987; 13(4): 239-252.
14. Masand PS, Ashton AK, Gupta S, Frank B. Sustained-release bupropion for selective serotonin reuptake inhibitor-induced sexual dysfunction: A randomized, double-blind, placebo-controlled, parallel-group study. Am J Psychiatry 2001; 158(5): 805-807.
15. Labbate LA, Grimes JB, Hines A, Pollack MH. Bupropion treatment of serotonin reuptake antidepressant-associated sexual dysfunction. Ann Clin Psychiatry 1997; 9(4): 241-245.
16. Segraves RT, Clayton A, Croft H et al. Bupropion sustained release for the treatment of hypoactive sexual desire disorder in premenopausal women. J Clin Psychopharmacol 2004; 24(3): 339-342.
17. Labbate LA, Grimes JB, Hines A, Pollack MH. Bupropion treatment of seratonin reuptake antidepressant-associated sexual dysfunction. Ann Clin Psychiatry 1997; 9(4): 241-245.
18. Meston CM, Frohlich PF. The neurobiology of sexual function. Arch Gen Psychiatry 2000; 57(11): 1012-1030.
19. Rowland DL, Myers L, Culver A, Davidson JM. Bupropion and sexual function: A placebo-controlled prospective study on diabetic men with erectile dysfunction. J Clin Psychopharmacol 1997; 17(5): 350-357.
20. McGahuey CA, Gelenberg AJ, Laukes CA et al. The Arizona Sexual Experience Scale (ASEX): Reliability and validity. J Sex Marital Ther 2000; 26(1): 25-40.
21. Mathias C, Athanazio RA, Braghiroli MI et al. Uso da Escala de Experiência Sexual do Arizona (ASEX) na avaliação de disfunção sexual em pacientes oncológicos brasileiros. J Bras Psiquiatr 2005; 54(3): 216-220.
22. Beck AT, Steer RA. Internal consistencies of the original and revised Beck Depression Inventory. J Clin Psychol 1984; 40(6): 1365-1367.
23. Andrade L, Gorenstein C, Vieira-Filho AH et al. Psychometric properties of the Portuguese version of the State-Trait Anxiety Inventory applied to college students: Factor analysis and relation to the Beck Depression Inventory. Braz J Med Biol Res 2001; 34(3): 367-374.
24. Aaronson NK, Ahmedzai S, Bergman B et al. The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993; 85(5): 365-376.
25. Soares HP, Zatta SM, Bezerra AS et al. Aplicação dos Questionários de Qualidade de Vida "FLIE" e "EORTC QLQ C-30" para pacientes oncológicos em tratamento quimioterápico: Estudo piloto da Disciplina de Oncologia e Hematología da Faculdade de Medicina da Fundação ABC. Revista da Sociedade Brasileira de Cancerologia 2001; 15: 19.
26. StataCorp 2003. Stata Statistical Software: Release 8. College Station, TX: StataCorp LP.
27. Rosner B. Fundamentals of biostatistics. Belmont (CA): Duxbury Press; 1995.
28. Crenshaw TL, Goldberg PJ. Bupropion in sexual pharmacology. In: Crenshaw TL, Goldberg PJ, (eds). Drugs that affect sexual functioning. New York: Norton and Co; 1996. pp. 389-408.
29. Croft H, Settle E Jr, Houser T et al. A placebo-controlled comparison of the antidepressant efficacy and effects on sexual functioning of sustained-release bupropion and sertraline. Clin Ther 1999; 21(4): 643-658.
30. Gitlin MJ, Suri R, Altshuler L et al. Bupropion-sustained release as a treatment for SSRI-induced sexual side effects. J Sex Marital Ther 2002; 28(2): 131-138.
31. Moss EL, Simpson JS, Pelletir G, Forsyth P. An open-label study of the effects of bupropion SR on fatigue, depression and quality of life of mixed-site cancer patients and their partners. Psychooncology 2005; 25.