The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms

European Archives of Psychiatry and Clinical Neuroscience

Volumn 262, Issue 3, 2012, Pages 193-197

  Mössner, Rainald ^a   Schuhmacher, Anna ^a   Wagner, Michael ^a   Lennertz, Leonhard ^a   Steinbrecher, Anja ^a   Quednow, Boris B ^a,b   Rujescu, Dan ^c   Rietschel, Marcella ^d   Maier, Wolfgang ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL OF PSYCHIATRY   (Switzerland)

^c UNIVERSITY OF MUNICH   (Germany)

^d CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

Pharmacogenetics; Positive symptoms; Schizophrenia

Indexed keywords

AMISULPRIDE; ARIPIPRAZOLE; BIFEPRUNOX; CLOZAPINE; ILOPERIDONE; OLANZAPINE; QUETIAPINE; RISPERIDONE; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZIPRASIDONE; ZNF804A PROTEIN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEGATIVE SYNDROME; OUTCOME ASSESSMENT; PHARMACOGENETICS; POSITIVE AND NEGATIVE SYNDROME SCALE; POSITIVE SYNDROME; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; TREATMENT RESPONSE;

ADULT; ANTIPSYCHOTIC AGENTS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MIDDLE AGED; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA; SEX FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84862862704     PISSN: 09401334     EISSN: 14338491     Source Type: Journal    
DOI: 10.1007/s00406-011-0235-1     Document Type: Article

References (16)

1. Arranz MJ, de Leon J (2007) Pharmacogenetics and pharmac-ogenomics of schizophrenia: a review of last decade of research. Mol Psychiatry 12:707-747 (Pubitemid 47172693)
2. Detera-Wadleigh SD, McMahon FJ (2006) G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis. Biol Psychiatry 60:106-114 (Pubitemid 44026593)
3. Donohoe G, Rose E, Frodl T, Morris D, Spoletini I, Adriano F, Bernardini S, Caltagirone C, Bossu P, Gill M, Corvin AP, Spalletta G (2010) ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia. Neuroimage 54:2132-2137
4. Esslinger C, Walter H, Kirsch P, Erk S, Schnell K, Arnold C, Haddad L, Mier D, Opitz von Boberfeld C, Raab K, Witt SH, Rietschel M, Cichon S, Meyer-Lindenberg A (2009) Neural mechanisms of a genome-wide supported psychosis variant. Science 324:605
5. Lencz T, Szeszko PR, DeRosse P, Burdick KE, Bromet EJ, Bilder RM, Malhotra AK (2010) A schizophrenia risk gene, ZNF804A, influences neuroanatomical and neurocognitive phenotypes. Neuropsychopharmacology 35:2284-2291
6. Maier W (2008) Common risk genes for affective and schizophrenic psychoses. Eur Arch Psychiatry Clin Neurosci 258 Suppl 2:37-40 (Pubitemid 351758759)
7. Mössner R, Maier W, Rujescu D (2009) Progress in locating the genetic causes of schizophrenia. Nervenarzt 80:6-11
8. Mössner R, Schuhmacher A, Kühn KU, Cvetanovska G, Rujescu D, Zill P, Quednow BB, Rietschel M, Wölwer W, Gaebel W, Wagner M, Maier W (2009) Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia. Pharmacogenet Genomics 19:91-94
9. Mössner R, Schuhmacher A, Wagner M, Quednow BB, Frommann I, Kühn KU, Schwab SG, Rietschel M, Falkai P, Wölwer W, Ruhrmann S, Bechdolf A, Gaebel W, Klosterkötter J, Maier W (2010) DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis. Eur Arch Psychiatry Clin Neurosci 260:209-215
10. O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Hartmann AM, Moller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Williams NM, Giegling I, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Gejman PV, Cichon S, Nothen MM, Gill M, Corvin A, Rujescu D, Kirov G, Owen MJ, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Cloninger CR (2008) Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 40:1053-1055
11. Reynolds GP, Arranz B, Templeman LA, Fertuzinhos S, San L (2006) Effect of 5-HT1A receptor gene polymorphism on negative and depressive symptom response to antipsychotic treatment of drug-naive psychotic patients. Am J Psychiatry 163:1826-1829 (Pubitemid 44522494)
12. Riley B, Thiselton D, Maher BS, Bigdeli T, Wormley B, McMichael GO, Fanous AH, Vladimirov V, O'Neill FA, Walsh D, Kendler KS (2010) Replication of association between schizophrenia and ZNF804A in the Irish case-control study of schizophrenia sample. Mol Psychiatry 15:29-37
13. Steinberg S, Mors O, Borglum AD, Gustafsson O, Werge T, Mortensen PB, Andreassen OA, Sigurdsson E, Thorgeirsson TE, Bottcher Y, Olason P, Ophoff RA, Cichon S, Gudjonsdottir IH, Pietilainen OP, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Athanasiu L, Suvisaari J, Lonnqvist J, Paunio T, Hartmann A, Jurgens G, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Breuer R, Moller HJ, Giegling I, Glenthoj B, Rasmussen HB, Mattheisen M, Bitter I, Rethelyi JM, Sigmundsson T, Fossdal R, Thorsteinsdottir U, Ruggeri M, Tosato S, Strengman E, Kiemeney LA, Melle I, Djurovic S, Abramova L, Kaleda V, Walshe M, Bramon E, Vassos E, Li T, Fraser G, Walker N, Toulopoulou T, Yoon J, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Jonsson EG, Terenius L, Agartz I, Petursson H, Nothen MM, Rietschel M, Peltonen L, Rujescu D, Collier DA, Stefansson H, St Clair D, Stefansson K (2011) Expanding the range of ZNF804A variants conferring risk of psychosis. Mol Psychiatry 16:59-66
14. Wang L, Fang C, Zhang A, Du J, Yu L, Ma J, Feng G, Xing QH, He L (2008) The -1,019 C/G polymorphism of the 5-HT1A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients. J Psychopharmacol 22:904-909
15. Williams HJ, Craddock N, Russo G, Hamshere ML, Moskvina V, Dwyer S, Smith RL, Green E, Grozeva D, Holmans P, Owen MJ, O'Donovan MC (2011) Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Hum Mol Genet 20:387-391
16. Williams HJ, Norton N, Dwyer S, Moskvina V, Nikolov I, Carroll L, Georgieva L, Williams NM, Morris DW, Quinn EM, Giegling I, Ikeda M, Wood J, Lencz T, Hultman C, Lichtenstein P, Thiselton D, Maher BS, Malhotra AK, Riley B, Kendler KS, Gill M, Sullivan P, Sklar P, Purcell S, Nimgaonkar VL, Kirov G, Holmans P, Corvin A, Rujescu D, Craddock N, Owen MJ, O'Donovan MC (2011) Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Mol Psychiatry 16:429-441