Pentachlorophenol decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells

Journal of Applied Toxicology

Volumn 32, Issue 8, 2012, Pages 627-634

  Hurd, Tasia ^a   Walker, Jasmine ^a   Whalen, Margaret M ^a  

^a TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

Binding function; CD16; CD56; NK cells; Pentachlorophenol

Indexed keywords

CD16 ANTIGEN; CD18 ANTIGEN; CD2 ANTIGEN; CD56 ANTIGEN; CELL SURFACE PROTEIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PENTACHLOROPHENOL;

ARTICLE; CELL ADHESION; CONCENTRATION (PARAMETERS); CYTOLYSIS; EXPOSURE; FEMALE; FLOW CYTOMETRY; HISTOGRAM; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; NATURAL KILLER CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION;

CELL SURVIVAL; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; K562 CELLS; KILLER CELLS, NATURAL; MALE; MEMBRANE PROTEINS; PENTACHLOROPHENOL; PESTICIDES;

EID: 84862857082     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1781     Document Type: Article

References (33)

1. Agency for Toxic Substances and Disease Registry. 2001. Toxicological Profile for Pentachlorophenol. Update. US Department of Health and Human Services, Public Health Service: Atlanta, GA.
2. Atuma SS, Okor DI. 1985. Gas chromatographic determination of pentachlorophenol in human blood and urine. Bull. Environ. Contam. Toxicol. 35: 406-410.
3. 1+ subset. J. Allergy Clin. Immunol. 85: 453-459.
4. Biron CA, Byron KS, Sullivan JL. 1989. Severe herpes virus in an adolescent without natural killer cells. New Engl. J. Med. 320: 1731-1735.
5. Centers for Disease Control and Prevention. 2005. Third National Report on Human Exposure to Environmental Chemicals.
6. Cirelli DP. 1978. Patterns of pentachlorophenol usage in the United States of America - an overview. In Pentachlorophenol, Chemistry, Pharmacology, And Environmental Toxicology, Rao KR (ed.). Plenum Press: New York; 13-18.
7. Cline RE, Hill RH Jr, Phillips DL, Needham LL. 1989. Pentachlorophenol measurements in body fluids of people in log homes and workplaces. Arch. Environ. Contam. Toxicol. 18: 475-481.
8. Cohn BA, Wolff MS, Cirillo PM, Sholtz RI. 2007. DDT and breast cancer in young women: new data on the significance of age at exposure. Environ. Health Perspect. 115: 406-414.
9. Demers PA, Davies HW, Friesen MC, Hertzman C, Ostry A, Hershler R, Teschke K. 2006. Cancer and occupational exposure to pentachlorophenol and tetrachlorophenol (Canada). Cancer Causes Control 17: 749-758.
10. Eskenazi B, Chevier J, Rosas LG, Anderson HA, Bornman MS, Bouwman H, Chen A, Cohn BA, deJager C, Henshel DS, Leipzig F, Leipzig JS, Lorenz EC, Snedeker SM, Stapleton D. 2009. The Pine River Statement: human health consequences of DDT use. Environ. Health Perspec. 117: 1359-1367.
11. Fleisher G, Koven N, Kamiya H, Henle W. 1982. A non-X-linked syndrome with susceptibility to severe Epstein-Bar virus infections. J. Pediatr. 100: 727-730.
12. Fulton A, Heppner G, Roi L, Howard L, Russo J, Brennan M. 1984. Ralationship of natural killer cytotoxicity to clinical and biochemical parameters of primary human breast cancer. Breast Cancer Res. Treat. 4: 109-116.
13. Hinkson NC, Whalen MM. 2010. Hexabromocyclododecane decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells. J. Appl. Toxicol. 30: 302-309 PMCID: PMC2876233
14. Hurd T, Whalen MM. 2011. Tetrabromobisphenol A decreases cell-surface protein expression in human natural killer cells. J. Immunooxicol. 8: 219-227.
15. Jones RD, Winter DP, Cooper AJ. 1986. Absorption study of pentachlorophenol in persons working with wood preservatives. Hum. Toxicol. 5: 189-194.
16. Kibakaya EC, Stephen K, Whalen MM. 2009. Tetrabromobisphenol A has immunosuppressive effects on human natural killer cells. J. Immunotoxicol. 6: 285-292.
17. Lotzova E. 1993. Definition and function of natural killer cells. Nat. Immunol. 12: 177-193.
18. Mandelboim O, Malik P, Davis DM, Jo CH, Boyson JE. 1999. Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity. Proc. Natl Acad. Sci. USA 96: 5640-5644.
19. Nitta T, Yagita H, Sato K, Okomura K. 1989. Involvement of CD56 (NKH-1/Leu-19 antigen) as an adhesion molecule in natural killer-target cell interaction. J. Exp. Med. 170: 1757-1761.
20. Nnodu U, Whalen MM. 2008. Pentachlorophenol decreases ATP levels in human natural killer cells. J. Appl. Toxicol. 28: 1016-1020.
21. Odman-Ghazi SO, Hatcher F, Whalen MM. 2003. Expression of functionally relevant cell surface markers in dibutyltin-exposed human natural killer cells. Chemico-Biol. Interact. 146: 1-18.
22. Reed A, Dzon L, Loganathan BG, Whalen MM. 2004. Immunomodulation of human natural killer cell cytotoxic function by organochlorine pesticides. Hum. Exp. Toxicol. 23: 463-471.
23. Svensson BG, Hallberg T, Nilsson A, Schütz A, Hagmar L. 1994. Parameters of immunological competence in subjects with high consumption of fish contaminated with persistent organochlorine compounds. Int. Arch. Occup. Environ. Health 65: 351-358.
24. Taylor TR, Whalen MM. 2011. Effects of ziram on tumor-cell-binding capacity, cell-surface marker expression, and ATP levels of human natural killer cells. Cell Biol. Toxicol. 21: 577-584.
25. Taylor TR, Tucker T, Whalen MM. 2005. Persistent inhibition of human natural killer cell function by ziram and pentachlorophenol. Environ. Toxicol. 20: 418-424.
26. Thornton JW, McCally M, Houlihan J. 2002. Biomonitoring of industrial pollutants: health and policy implications of the chemical body burden. Public Health Rep. 117: 315-323. Available from:
27. Uhl S, Schmid P, Schlatter C. 1986. Pharmacokinetics of pentachlorophenol in man. Arch. Toxicol. 58: 182-186.
28. US Environmental Protection Agency. 2001. Restricted use product file, 25 October.
29. Vivier E, Nunes JA, Vely F. 2004. Natural killer cell signaling pathways. Science 306: 1517-1519.
30. Whalen MM, Doshi RN, Bankhurst AD. 1992. Effects of pertussis toxin treatment on human natural killer cell function. Immunology 76: 402-407.
31. Whalen MM, Green SA, Loganathan BG. 2002a. Brief butyltin exposure induces irreversible inhibition of the cytotoxic function on human natural killer cells, in vitro. Environ. Res. 88: 19-29.
32. Whalen MM, Ghazi S, Loganathan BG, Hatcher F. 2002b. Expression of CD16, CD18 and CD56 in tributyltin-exposed human natural killer cells. Chemico-Biol. Interact. 139: 159-176.
33. Whalen MM, Loganathan BG, Yamashita N, Saito T. 2003. Immunomodulation of human natural killer cell cytotoxic function by triazine and carbamate pesticides. Chemico-Biol. Interact. 145: 311-319.