In vivo clearance and toxicity of monodisperse iron oxide nanocrystals

ACS Nano

Volumn 6, Issue 6, 2012, Pages 4947-4954

  Gu, Luo ^a   Fang, Ronnie H ^b   Sailor, Michael J ^a,c   Park, Ji Ho ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

bioclearance; biocompatibility; biodegradation; biodistribution; iron oxide nanoparticle

Indexed keywords

AQUEOUS PRECIPITATION; BIOCLEARANCE; BIODEGRADATION PRODUCTS; BIODISTRIBUTIONS; CELLULAR ENVIRONMENT; IN-VIVO; IRON OXIDE NANOCRYSTALS; IRON OXIDE NANOPARTICLE; MONODISPERSE; ORGANOMETALLIC PRECURSORS; POLY(ETHYLENE GLYCOL) CHAINS;

BIOCOMPATIBILITY; DECOMPOSITION; IRON OXIDES; MICROBIOLOGY; NANOCRYSTALS; OLEIC ACID; ORGANOMETALLICS; PHOSPHOLIPIDS; POLYETHYLENE GLYCOLS; SURFACE CHEMISTRY;

BIODEGRADATION;

FERRIC ION; FERRIC OXIDE; METAL NANOPARTICLE;

ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; MATERIALS TESTING; METABOLIC CLEARANCE RATE; MOUSE; TISSUE DISTRIBUTION;

ANIMALS; FERRIC COMPOUNDS; MATERIALS TESTING; METABOLIC CLEARANCE RATE; METAL NANOPARTICLES; MICE; ORGAN SPECIFICITY; TISSUE DISTRIBUTION;

EID: 84862848790     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn300456z     Document Type: Article

References (28)

1. Weissleder, R.; Bogdanov, A.; Neuwelt, E. A.; Papisov, M. Long-Circulating Iron Oxide for MR Imaging Adv. Drug Delivery Rev. 1995, 16, 321-334
2. Corot, C.; Robert, P.; Idée, J.-M.; Port, M. Recent Advances in Iron Oxide Nanocrystal Technology for Medical Imaging Adv. Drug Delivery Rev. 2006, 58, 1471-1504
3. Jun, Y. W.; Seo, J. W.; Cheon, A. Nanoscaling Laws of Magnetic Nanoparticles and Their Applicabilities in Biomedical Sciences Acc. Chem. Res. 2008, 41, 179-189
4. Ros, P. R.; Freeny, P. C.; Harms, S. E.; Seltzer, S. E.; Davis, P. L.; Chan, T. W.; Stillman, A. E.; Muroff, L. R.; Runge, V. M.; Nissenbaum, M. A. Hepatic MR Imaging with Ferumoxides: A Multicenter Clinical Trial of the Safety and Efficacy in the Detection of Focal Hepatic Lesions Radiology 1996, 196, 481-488
5. Hyeon, T.; Lee, S. S.; Park, J.; Chung, Y.; Na, H. B. Synthesis of Highly Crystalline and Monodisperse Maghemite Nanocrystallites without a Size-Selection Process J. Am. Chem. Soc. 2001, 123, 12798-12801
6. Sun, S.; Zeng, H. Size-Controlled Synthesis of Magnetite Nanoparticles J. Am. Chem. Soc. 2002, 124, 8204-8205
7. Park, J.; An, K.; Hwang, Y.; Park, J.-G.; Noh, H.-J.; Kim, J.-Y.; Park, J.-H.; Hwang, N.-M.; Hyeon, T. Ultra-Large-Scale Syntheses of Monodisperse Nanocrystals Nat. Mater. 2004, 3, 891-895
8. Park, J.; Lee, E.; Hwang, N. M.; Kang, M. S.; Kim, S. C.; Hwang, Y.; Park, J. G.; Noh, H. J.; Kini, J. Y.; Park, J. H. et al. One-Nanometer-Scale Size-Controlled Synthesis of Monodisperse Magnetic Iron Oxide Nanoparticles Angew. Chem., Int. Ed. 2005, 44, 2872-2877
9. Jun, Y. W.; Huh, Y. M.; Choi, J. S.; Lee, J. H.; Song, H. T.; Kim, S.; Yoon, S.; Kim, K. S.; Shin, J. S.; Suh, J. S. et al. Nanoscale Size Effect of Magnetic Nanocrystals and Their Utilization for Cancer Diagnosis via Magnetic Resonance Imaging J. Am. Chem. Soc. 2005, 127, 5732-5733
10. Park, J.-H.; Maltzahn, G. v.; Zhang, L.; Schwartz, M. P.; Ruoslahti, E.; Bhatia, S. N. Sailor, M. J., Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging Adv. Mater. 2008, 20, 1630-1635
11. 4 (M = Fe, Co, Mn) Nanoparticles J. Am. Chem. Soc. 2004, 126, 273-279
12. Lee, J. H.; Huh, Y. M.; Jun, Y.; Seo, J.; Jang, J.; Song, H. T.; Kim, S.; Cho, E. J.; Yoon, H. G.; Suh, J. S. et al. Artificially Engineered Magnetic Nanoparticles for Ultrasensitive Molecular Imaging Nat. Med. 2007, 13, 95-99
13. Yang, J.; Gunn, J.; Dave, S. R.; Zhang, M.; Wang, Y. A.; Gao, X. Ultrasensitive Detection and Molecular Imaging with Magnetic Nanoparticles Analyst 2008, 133, 154-160
14. Jain, T. K.; Reddy, M. K.; Morales, M. A.; Leslie-Pelecky, D. L.; Labhasetwar, V. Biodistribution, Clearance, and Biocompatibility of Iron Oxide Magnetic Nanoparticles in Rats Mol. Pharmaceutics 2008, 5, 316-327
15. Lee, P.-W.; Hsu, S.-H.; Wang, J.-J.; Tsai, J.-S.; Lin, K.-J.; Wey, S.-P.; Chen, F.-R.; Lai, C.-H.; Yen, T.-C.; Sung, H.-W. The Characteristics, Biodistribution, Magnetic Resonance Imaging and Biodegradability of Superparamagnetic Core-Shell Nanoparticles Biomaterials 2010, 31, 1316-1324
16. Dubertret, B.; Skourides, P.; Norris, D. J.; Noireaux, V.; Brivanlou, A. H.; Libchaber, A. In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles Science 2002, 298, 1759-1762
17. Park, J.-H.; von Maltzahn, G.; Ruoslahti, E.; Bhatia, S. N.; Sailor, M. J. Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery Angew. Chem., Int. Ed. 2008, 47, 7284-7288
18. Torchilin, V. P. Structure and Design of Polymeric Surfactant-Based Drug Delivery Systems J. Controlled Release 2001, 73, 137-172
19. Weissleder, R.; Stark, D. D.; Engelstad, B. L.; Bacon, B. A.; Compton, C. C.; White, D. L.; Jacobs, P.; Lewis, J. Superparamagnetic Iron Oxide: Pharmacokinetics and Toxicity Am. J. Roentgenol. 1989, 152, 167-173
20. Pouliquen, D.; Jeune, J. J. L.; Perdrisot, R.; Ermias, A.; Jallet, P. Iron Oxide Nanoparticles for Use as an MRI Contrast Agent: Pharmacokinetics and Metabolism Magn. Reson. Imaging 1991, 9, 275-283
21. Briley-Saebo, K.; Bjørnerud, A.; Grant, D.; Ahlstrom, H.; Berg, T.; Kindberg, G. M. Hepatic Cellular Distribution and Degradation of Iron Oxide Nanoparticles Following Single Intravenous Injection in Rats: Implications for Magnetic Resonance Imaging Cell Tissue Res. 2004, 316, 315-323
22. Levy, M.; Luciani, N.; Alloyeau, D.; Elgrabli, D.; Deveaux, V.; Pechoux, C.; Chat, S.; Wang, G.; Vats, N.; Gendron, F. et al. Long Term in Vivo Biotransformation of Iron Oxide Nanoparticles Biomaterials 2011, 32, 3988-3999
23. Na, H. B.; Lee, J. H.; An, K. J.; Park, Y. I.; Park, M.; Lee, I. S.; Nam, D. H.; Kim, S. T.; Kim, S. H.; Kim, S. W. et al. Development of a T-1 Contrast Agent for Magnetic Resonance Imaging Using MnO Nanoparticles Angew. Chem., Int. Ed. 2007, 46, 5397-5401
24. Perrault, S. D.; Walkey, C.; Jennings, T.; Fischer, H. C.; Chan, W. C. W. Mediating Tumor Homing Efficiency of Nanoparticles through Design Nano Lett. 2009, 2009, 1909-1915
25. Moghimi, S. M.; Hunter, A. C.; Murray, J. C. Long-Circulating and Target-Specific Nanoparticles: Theory to Practice Pharm. Rev 2001, 53, 283-318
26. Park, J.-H.; Maltzahn, G. v.; Zhang, L.; Derfus, A. M.; Simberg, D.; Harris, T. J.; Ruoslahti, E.; Bhatia, S. N.; Sailor, M. J. Systematic Surface Engineering of Magnetic Nanoworms for in Vivo Tumor Targeting Small 2009, 5, 694-700
27. Chena, Z. P.; Zhang, Y.; Zhang, S.; Xia, J. G.; Liu, J. W.; Xu, K.; Gua, N. Preparation and Characterization of Water-Soluble Monodisperse Magnetic Iron Oxide Nanoparticles via Surface Double-Exchange with DMSA. Colloids and Surfaces A: Physicochem Eng. Aspects 2008, 316, 210-216
28. Wunderbaldinger, P.; Josephson, L.; Weissleder, R. Tat Peptide Directs Enhanced Clearance and Hepatic Permeability of Magnetic Nanoparticles Bioconjugate Chem. 2002, 13, 264-268