Histone deacetylases 2 and 9 are coexpressed and nuclear localized in human molar odontoblasts in vivo

Histochemistry and Cell Biology

Volumn 137, Issue 5, 2012, Pages 697-702

  Klinz, Franz J ^a   Korkmaz, Yüksel ^b   Bloch, Wilhelm ^c   Raab, Wolfgang H M ^b   Addicks, Klaus ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

Author keywords

Epigenetics; HDAC2; HDAC9; Histone deacetylase; Human molar; Human odontoblast

Indexed keywords

DNA; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 4; HISTONE DEACETYLASE 9; UNCLASSIFIED DRUG; HDAC2 PROTEIN, HUMAN; HDAC9 PROTEIN, HUMAN; REPRESSOR PROTEIN;

ADULT; ARTICLE; CELL DIFFERENTIATION; CELL NUCLEUS; CELL TYPE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA DETERMINATION; ENZYME LOCALIZATION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOLAR TOOTH; ODONTOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; BIOSYNTHESIS; CHEMISTRY; CYTOLOGY; METABOLISM; NORMAL HUMAN; YOUNG ADULT;

ORYCTOLAGUS CUNICULUS;

ADULT; CELL NUCLEUS; HEALTHY VOLUNTEERS; HISTONE DEACETYLASE 2; HISTONE DEACETYLASES; HUMANS; IMMUNOHISTOCHEMISTRY; MOLAR; ODONTOBLASTS; REPRESSOR PROTEINS; YOUNG ADULT;

EID: 84862835992     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-012-0920-9     Document Type: Article

References (19)

1. About I, Laurent-Maquin D, Lendahl U, Mitsiadis TA (2000) Nestin expression in embryonic and adult human teeth under normal and pathological conditions. Am J Pathol 157:287-295
2. Chatterjee TK, Idelman G, Blanco V, Blomkalns AL, Piegore MG Jr, Weintraub DS et al (2011) Histone deacetylase 9 is a negative regulator of adipogenic diVerentiation. J Biol Chem 286:27836-27847
3. Chen YH, Yeh FL, Yeh SP, Ma HT, Hung SC, Hung MC et al (2011) Myocyte enhancer factor-2 interacting transcriptional repressor (MITR) is a switch that promotes osteogenesis and inhibits adipogenesis of mesenchymal stem cells by inactivating peroxisome proliferator-activated receptor gamma-2. J Biol Chem 286: 10671-10680
4. Choo MK, Yeo H, Zayzafoon M (2009) NFATc1 mediates HDACdependent transcriptional repression of osteocalcin expression during osteoblast diVerentiation. Bone 45:579-589
5. Duncan HF, Smith AJ, Fleming GJ, Cooper PR (2011) HDACi: cellular eVects, opportunities for restorative dentistry. J Dent Res 90:1377-1388
6. Haberland M, Montgomery RL, Olson EN (2009) The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 10:32-42
7. Jensen ED, Gopalakrishnan R, Westendorf JJ (2010) Regulation of gene expression in osteoblasts. Biofactors 36:25-32
8. Klinz FJ, Herberg N, Arnhold S, Addicks K, Bloch W (2007) PhosphoeNOS Ser-1176 is associated with the nucleoli and the Golgi complex in C6 rat glioma cells. Neurosci Lett 421:224-228
9. Komori T (2011) Signaling networks in RUNX2-dependent bone development. J Cell Biochem 112:750-755
10. Korkmaz Y, Lang H, Beikler T, Cho B, Behrends S, Bloch W et al (2011) Irreversible inXammation is associated with decreased levels of the alpha1-, beta1-, and alpha2-subunits of sGC in human odontoblasts. J Dent Res 90:517-522
11. Lee HW, Suh JH, Kim AY, Lee YS, Park SY, Kim JB (2006) Histone deacetylase 1-mediated histone modiWcation regulates osteoblast diVerentiation. Mol Endocrinol 20:2432-2443
12. Lin M, Li L, Liu C, Liu H, He F, Yan F et al (2011) Wnt5a regulates growth, patterning, and odontoblast diVerentiation of developing mouse tooth. Dev Dyn 240:432-440
13. McGee-Lawrence ME, Westendorf JJ (2011) Histone deacetylases in skeletal development and bone mass maintenance. Gene 474:1-11
14. Muralidhar SA, Ramakrishnan V, Kalra IS, Li W, Pace BS (2011) Histone deacetylase 9 activates gamma-globin gene expression in primary erythroid cells. J Biol Chem 286:2343-2353
15. Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M et al (2003) The histone deacetylase 9 gene encodes multiple protein isoforms. J Biol Chem 278:16059-16072
16. Takami Y, Nakayama T (2000) N-terminal region, C-terminal region, nuclear export signal, and deacetylation activity of histone deacetylase- 3 are essential for the viability of the DT40 chicken B cell line. J Biol Chem 275:16191-16201
17. Yang XJ, Seto E (2003) Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression. Curr Opin Genet Dev 13:143-153
18. Yang XJ, Seto E (2008) The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol 9:206-218
19. Yang WM, Tsai SC, Wen YD, Fejer G, Seto E (2002) Functional domains of histone deacetylase-3. J Biol Chem 277:9447-9454