Scavenging effect of Naoerkang on amyloid beta-peptide deposition in the hippocampus in a rat model of Alzheimer's disease

Chinese Journal of Integrative Medicine

Volumn 17, Issue 11, 2011, Pages 847-853

  Li, Xi ^a   Yuan, Hai Feng ^a   Quan, Qian Kun ^a   Wang, Jian Jun ^b   Wang, Ning Ning ^a   Li, Ming ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b FUZHOU GENERAL HOSPITAL   (China)

Author keywords

Alzheimer's disease; Amyloid beta peptide; Matrix metalloproteinase 9; Naoerkang; Rats

Indexed keywords

AMYLOID BETA PROTEIN; CHINESE DRUG; GELATINASE B; NAOERKANG; PIRACETAM; SODIUM CHLORIDE; UNCLASSIFIED DRUG; HERBACEOUS AGENT;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPAL CA1 REGION; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LEARNING; LEARNING DISORDER; MALE; MEMORY; MEMORY DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; DISEASE MODEL; ENZYMOLOGY; HIPPOCAMPUS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CA1 REGION, HIPPOCAMPAL; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MATRIX METALLOPROTEINASE 9; MEMORY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84862833134     PISSN: 16720415     EISSN: 19930402     Source Type: Journal    
DOI: 10.1007/s11655-011-0896-7     Document Type: Article

References (21)

1. Gallardo G, Schlüter OM, Südhof TC. A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides. Nat Neurosci 2008;11:301-308.
2. Huang RX, Liang XL, Liu ZL. Clinical neurology. Beijing: People's Medical Publishing House; 1998:505-506.
3. Yan P, Hu X, Song H, Yin K, Bateman RJ, Cirrito JR, et al. Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ. J Biol Chem 2006;281:24566-24574.
4. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001; 81:741-766.
5. Li X, Zhang XF, Qiao CL, Zhang ZY. Influence of Naoerkang on the intracerebral cholinesterase activity and neurons of mice with Alzheimer's disease. Chin J Clin Rehabil (Chin) 2003;7:4222-4223.
6. Li X, Wang JJ, Qiao CL, Nie DL. Effects of Naoerkang on learning and memory dysfunction in mouse. J Xi'an Jiaotong Univ (Med Sci, Chin) 1999;20:126-127.
7. Bao XM, Shu SY. The rat brain in stereotaxic coordinates. Beijing: People's Medical Publishing House; 1990:42.
8. Tian JZ, Xu Y, Shi J, Yin JX, Ji ZJ, Zhao ZW, et al. Effect of GETO extract on expression of growth-associated protein 43 in area CA1 of hippocampus in Alzheimer's disease model rats induced by Aβ42 peptide. Chin J Integr Med Cardio-/Cerebrovas Dis (Chin) 2007;5:217-219.
9. Li QM, Meng RS, Wei CX, Kan FJ, Huang QH. Effects of Naohuandan recipe on learning and memory abilities of SAM-P/8 mice and its role in anti-oxidation and antiapoptosis. J Chin Integr Med (Chin) 2006;4:48-51.
10. Du GH. Experimental pharmacology. Beijing: Peking Union Medical College Press; 2004:33.
11. Yang P. Beta-amyloid peptide and Alzheimer's disease. Med Recaptulate (Chin) 2001;7: 604-605.
12. Tanzi RE, Moir RD, Wagner SL. Clearance of Alzheimer's A beta peptide: the many roads to perdition. Neuron 2004;43:605-608.
13. Yong VW, Krekoski CA, Forsyth PA, Bell R, Edwards DR. Matrix metalloproteinases and diseases of the CNS. Trends Neurosci 1998;21:75-80.
14. Van den Steen PE, Dubois B, Nelissen I, Rudd PM, Dwek RA, Opdenakker G. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev Biochem Mol Biol 2002;37:375-536.
15. Zhang JT. Nootropic mechanisms of ginsenoside Rg1 - influence on neuronal plasticity and neurogenesis. Acta Pharm Sin (Chin) 2005;40:385-388.
16. Wang WX, Wang W, Chen KJ. Protective effect and mechanism of ginsenosides on central nerve system of animals. Chin J Integr Tradit West Med (Chin) 2005;25:89-93.
17. Shi RR, He LM, Hu YE, Weng SW, Cao YR, Yi NY. Regulation of milkvetch root on M-cholinergic receptors in the aged rats. J Tradit Chin Med (Chin) 1998;39:685-686.
18. Ji ZH, Yu XY, Zhang XL, Han H, Zhang W, Wang YF. Interventional effect of the water extract of Alpinia oxyphylla Miq. fruit on scopolamine-induced learning and memory impairements in rats. Chin J Clin Rehabi (Chin) 2005;8:120-122.
19. Yu ZL, Zhang GQ, Zhao HQ, Lu JF. Effect of puerariae isoflavone on memory in mice. J China Pharm Univ (Chin) 1997;28:350-353.
20. Zhang C, Wang SZ, Zuo PP, Cui X, Cai J. Effect of tetramethylpyrazine on learning,memory and cholinergic system in D-galactose-lesioned mice. Chin Acta Academiae Med Sinicae (Chin) 2003;25:553-556.
21. Cheng YM, Wang NY. Effect of borneol on the intercellular tight junction and pinocytosis vesicles in vitro bloodbrain barrier model. Chin J Integr Tradit West Med (Chin) 2004;24:632-634.