JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27Kip1 phosphorylation

Cancer Letters

Volumn 314, Issue 2, 2012, Pages 198-205

  Kim, Hyeonjung ^a   Jung, Oisun ^a   Kang, Minkyung ^a   Lee, Mi Sook ^a   Jeong, Doyoung ^a   Ryu, Jihye ^a   Ko, Youra ^a   Choi, Yoon Ju ^a   Lee, Jung Weon ^a  

^a Seoul National University   (South Korea)

Author keywords

Adherence Junction; JNK; TM4SF5

Indexed keywords

CELL ADHESION MOLECULE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PROTEIN KINASE B; REGULATOR PROTEIN; SERINE; STRESS ACTIVATED PROTEIN KINASE; TRANSMEMBRANE 4 L SIX FAMILY MEMBER 5 PROTEIN; UNCLASSIFIED DRUG; CDKN1B PROTEIN, HUMAN; MEMBRANE PROTEIN; TM4SF5 PROTEIN, HUMAN;

ARTICLE; CELL ADHESION; CELL STRUCTURE; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE;

CELL ADHESION; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P27; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; PHOSPHORYLATION;

EID: 84862832985     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.09.030     Document Type: Article

References (33)

1. J.P. Thiery, Cell adhesion in cancer, C. R. Phys. 4 (2003) 289-304.
2. T.J. Harris, U. Tepass, Adherens junctions: from molecules to morphogenesis, Nat. Rev. Mol. Cell Biol. 11 (2010) 502-514.
3. V. Maruthamuthu, Y. Aratyn-Schaus, M.L. Gardel, Conserved F-actin dynamics and force transmission at cell adhesions, Curr. Opin. Cell Biol. 22 (2010) 583-588.
4. M. Guarino, B. Rubino, G. Ballabio, The role of epithelial- mesenchymal transition in cancer pathology, Pathology 39 (2007) 305-318.
5. M.D. Wright, J. Ni, G.B. Rudy, The L6 membrane proteins - a new four-transmembrane superfamily, Protein Sci. 9 (2000) 1594-1600.
6. F. Muller-Pillasch, C. Wallrapp, U. Lacher, H. Friess, M. Buchler, G. Adler, T.M. Gress, Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer, Gene 208 (1998) 25-30.
7. S.A. Lee, S.Y. Lee, I.H. Cho, M.A. Oh, E.S. Kang, Y.B. Kim, W.D. Seo, S. Choi, J.O. Nam, M. Tamamori-Adachi, S. Kitajima, S.K. Ye, S. Kim, Y.J. Hwang, I.S. Kim, K.H. Park, J.W. Lee, Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma, J. Clin. Invest. 118 (2008) 1354-1366.
8. C.S. Stipp, T.V. Kolesnikova, M.E. Hemler, Functional domains in tetraspanin proteins, Trends Biochem. Sci. 28 (2003) 106-112.
9. S.A. Lee, K.H. Park, J.W. Lee, Modulation of signaling between TM4SF5 and integrins in tumor microenvironment, Front. Biosci. 16 (2011) 1752-1758.
10. M. Boehm, T. Yoshimoto, M.F. Crook, S. Nallamshetty, A. True, G.J. Nabel, E.G. Nabel, A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression, EMBO J. 21 (2002) 3390-3401.
11. S. Sato, N. Fujita, T. Tsuruo, Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3, J. Biol. Chem. 277 (2002) 39360-39367.
12. M. Ciaparrone, H. Yamamoto, Y. Yao, A. Sgambato, G. Cattoretti, N. Tomita, T. Monden, H. Rotterdam, I.B. Weinstein, Localization and expression of p27KIP1 in multistage colorectal carcinogenesis, Cancer Res. 58 (1998) 114-122.
13. S.P. Singh, J. Lipman, H. Goldman, F.H. Ellis Jr., L. Aizenman, M.G. Cangi, S. Signoretti, D.S. Chiaur, M. Pagano, M. Loda, Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma, Cancer Res. 58 (1998) 1730-1735.
14. G. Baldassarre, B. Belletti, P. Bruni, A. Boccia, F. Trapasso, F. Pentimalli, M.V. Barone, G. Chiappetta, M.T. Vento, S. Spiezia, A. Fusco, G. Viglietto, Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells, J. Clin. Invest. 104 (1999) 865-874.
15. S.Y. Lee, Y.T. Kim, M.S. Lee, Y.B. Kim, E. Chung, S. Kim, J.W. Lee, Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment, Exp. Cell Res. 312 (2006) 2983-2999.
16. E.S. Kang, D. Han, J. Park, T.K. Kwak, M.A. Oh, S.A. Lee, S. Choi, Z.Y. Park, Y. Kim, J.W. Lee, O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells, Exp. Cell Res. 314 (2008) 2238-2248.
17. J.W. Lee, R.L. Juliano, Alpha5beta1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol 3-kinase and protein kinase B-dependent pathway, Mol. Biol. Cell 11 (2000) 1973-1987.
18. H. Kim, M. Kang, S.A. Lee, T.K. Kwak, O. Jung, H.J. Lee, S.H. Kim, J.W. Lee, TM4SF5 accelerates G1/S phase progression via cytosolic p27(Kip1) expression and RhoA activity, Biochim. Biophys. Acta 1803 (2010) 975-982.
19. S.A. Lee, T.Y. Kim, T.K. Kwak, H. Kim, S. Kim, H.J. Lee, S.H. Kim, K.H. Park, H.J. Kim, M. Cho, J.W. Lee, Transmembrane 4 L six family member 5 (TM4SF5) enhances migration and invasion of hepatocytes for effective metastasis, J. Cell. Biochem. 111 (2010) 59-66.
20. K. Mielke, Growth-arrest-dependent expression and phosphorylation of p27kip at serine10 is mediated by the JNK pathway in C6 glioma cells, Mol. Cell. Neurosci. 38 (2008) 301- 311.
21. N. Fujita, S. Sato, K. Katayama, T. Tsuruo, Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization, J. Biol. Chem. 277 (2002) 28706-28713.
22. N. Fujita, S. Sato, T. Tsuruo, Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization, J. Biol. Chem. 278 (2003) 49254- 49260.
23. J. Liang, J. Zubovitz, T. Petrocelli, R. Kotchetkov, M.K. Connor, K. Han, J.H. Lee, S. Ciarallo, C. Catzavelos, R. Beniston, E. Franssen, J.M. Slingerland, PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest, Nat. Med. 8 (2002) 1153- 1160.
24. T. Sekimoto, M. Fukumoto, Y. Yoneda, 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1), EMBO J. 23 (2004) 1934-1942.
25. S.J. Grille, A. Bellacosa, J. Upson, A.J. Klein-Szanto, F. van Roy, W. Lee-Kwon, M. Donowitz, P.N. Tsichlis, L. Larue, The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines, Cancer Res. 63 (2003) 2172-2178.
26. K. Hemavathy, S.I. Ashraf, Y.T. Ip, Snail/slug family of repressors: slowly going into the fast lane of development and cancer, Gene 257 (2000) 1-12.
27. V. Bolos, J.M. Gasent, S. Lopez-Tarruella, E. Grande, The dual kinase complex FAK-Src as a promising therapeutic target in cancer, Onco. Targets Ther. 3 (2010) 83-97.
28. B.C. Willis, Z. Borok, TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease, Am. J. Physiol. Lung Cell Mol. Physiol. 293 (2007) L525-534.
29. M.H. Lee, H.Y. Yang, Negative regulators of cyclin-dependent kinases and their roles in cancers, Cell. Mol. Life Sci. 58 (2001) 1907-1922.
30. I.M. Chu, L. Hengst, J.M. Slingerland, The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy, Nat. Rev. Cancer 8 (2008) 253-267.
31. A. Besson, M. Gurian-West, A. Schmidt, A. Hall, J.M. Roberts, P27Kip1 modulates cell migration through the regulation of RhoA activation, Genes Dev. 18 (2004) 862-876.
32. A. Besson, S.F. Dowdy, J.M. Roberts, CDK inhibitors: cell cycle regulators and beyond, Dev. Cell 14 (2008) 159-169.
33. C.F. Welsh, K. Roovers, J. Villanueva, Y. Liu, M.A. Schwartz, R.K. Assoian, Timing of cyclin D1 expression within G1 phase is controlled by Rho, Nat. Cell Biol. 3 (2001) 950-957.