SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2522-2526

A novel 3,4-dihydropyrimidin-2(1H)-one: HIV-1 replication inhibitors with improved metabolic stability

(23) Kim, Junwon a Ok, Taedong a Park, Changmin a So, Wonyoung a Jo, Mina a Kim, Youngmi a Seo, Minjung a Lee, Doohyun a Jo, Suyeon a Ko, Yoonae a Choi, Inhee a Park, Youngsam b Yoon, Jaewan b Ju, Moon Kyeong b Ahn, Jiye b Kim, Junghwan b Han, Sung Jun b Kim, Tae Hee b,c Cechetto, Jonathan b Nam, Jiyoun b more..

a Institute Pasteur Korea (South Korea)

b Institut Pasteur Korea (South Korea)

c Yonsei University (South Korea)

Author keywords

3,4 Dihydropyrimidin 2(1H) one; Biginelli reaction; Bioisostere; HIV; Inhibitor

Indexed keywords

3,4 DIHYDROPYRIMIDIN 2(1H) ONE; ANTIRETROVIRUS AGENT; DIHYDROPYRIDINE DERIVATIVE; IMIDAZOLE; INTEGRASE INHIBITOR; LACTONE; PROTEINASE INHIBITOR; SCAFFOLD PROTEIN; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; ENANTIOMER; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; NONHUMAN; VIRUS REPLICATION;

ANIMALS; CELL LINE, TUMOR; DRUG STABILITY; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MICROSOMES, LIVER; MODELS, MOLECULAR; NEVIRAPINE; PYRIMIDINONES; RATS; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84862830799 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.01.133 Document Type: Article

Times cited : (58)

References (26)

1
- 68449083305
- H. Xu, and M. Lv Curr. Pharm. Des. 15 2009 2120
- (2009) Curr. Pharm. Des. , vol.15 , pp. 2120
- Xu, H.¹ Lv, M.²

2
- 77249134151
- references cited therein
- Y. Mehellou, and E. De Clercq J. Med. Chem. 53 2010 521 and references cited therein
- (2010) J. Med. Chem. , vol.53 , pp. 521
- Mehellou, Y.¹ De Clercq, E.²

3
- 0033673684
- B. Brenner, M.A. Wainberg, H. Salomon, D. Rouleau, A. Dascal, B. Spira, R.P. Sekaly, B. Conway, and J.P. Routy Int. J. Antimicrob. Agents 16 2000 429
- (2000) Int. J. Antimicrob. Agents , vol.16 , pp. 429
- Brenner, B.¹ Wainberg, M.A.² Salomon, H.³ Rouleau, D.⁴ Dascal, A.⁵ Spira, B.⁶ Sekaly, R.P.⁷ Conway, B.⁸ Routy, J.P.⁹

4
- 0033914449
- A. Si-Mohamed, M. Kazatchkine, I. Heard, C. Goujon, T. Prazuck, G. Aymard, G. Cessot, Y.H. Kuo, M.C. Bernard, B. Diquet, J.E. Malkin, L. Gutmann, and L. Belec J. Infect. Dis. 182 2000 112
- (2000) J. Infect. Dis. , vol.182 , pp. 112
- Si-Mohamed, A.¹ Kazatchkine, M.² Heard, I.³ Goujon, C.⁴ Prazuck, T.⁵ Aymard, G.⁶ Cessot, G.⁷ Kuo, Y.H.⁸ Bernard, M.C.⁹ Diquet, B.¹⁰ Malkin, J.E.¹¹ Gutmann, L.¹² Belec, L.¹³

5
- 67649101424
- S. Kiertiburanakul, and S. Sungkanuparph Curr. HIV Res. 7 2009 273
- (2009) Curr. HIV Res. , vol.7 , pp. 273
- Kiertiburanakul, S.¹ Sungkanuparph, S.²

6
- 25844523876
- A.M.J. Wensing, D.A. van de Vijver, and G. Angarano J. Infect. Dis. 192 2005 1501
- (2005) J. Infect. Dis. , vol.192 , pp. 1501
- Wensing, A.M.J.¹ Van De Vijver, D.A.² Angarano, G.³

7
- 84862803229
- J. Kim, C. Park, T. Ok, W. So, M. Jo, M. Seo, Y. Kim, J.-H. Sohn, Y. Park, M.K. Ju, J. Kim, S.-J. Han, T.-H. Kim, J. Cechetto, J. Nam, P. Sommer, and Z. No Bioorg. Med. Chem. Lett. 22 2012 2119
- (2012) Bioorg. Med. Chem. Lett. , vol.22 , pp. 2119
- Kim, J.¹ Park, C.² Ok, T.³ So, W.⁴ Jo, M.⁵ Seo, M.⁶ Kim, Y.⁷ Sohn, J.-H.⁸ Park, Y.⁹ Ju, M.K.¹⁰ Kim, J.¹¹ Han, S.-J.¹² Kim, T.-H.¹³ Cechetto, J.¹⁴ Nam, J.¹⁵ Sommer, P.¹⁶ No, Z.¹⁷

8
- 0043199389
- G. Sabitha, G.S.K.K. Reddy, K.B. Reddy, and J.S. Yadav Tetrahedron Lett. 44 2003 6497
- (2003) Tetrahedron Lett. , vol.44 , pp. 6497
- Sabitha, G.¹ Reddy, G.S.K.K.² Reddy, K.B.³ Yadav, J.S.⁴

9
- 0141549304
- C.O. Kappe, R. Perez, T. Beryozkina, O.I. Zbruyev, and W. Haas J. Comb. Chem. 4 2002 501
- (2002) J. Comb. Chem. , vol.4 , pp. 501
- Kappe, C.O.¹ Perez, R.² Beryozkina, T.³ Zbruyev, O.I.⁴ Haas, W.⁵

10
- 0001743806
- C.R. Holmquist, and E.J. Roskamp J. Org. Chem. 54 1989 3258
- (1989) J. Org. Chem. , vol.54 , pp. 3258
- Holmquist, C.R.¹ Roskamp, E.J.²

11
- 0034814917
- D.J. Kopecky, and S.D. Rychnovsky J. Am. Chem. Soc. 123 2001 8420
- (2001) J. Am. Chem. Soc. , vol.123 , pp. 8420
- Kopecky, D.J.¹ Rychnovsky, S.D.²

12
- 0020858731
- K. Steliou, and M.A. Poupart J. Am. Chem. Soc. 105 1983 7130
- (1983) J. Am. Chem. Soc. , vol.105 , pp. 7130
- Steliou, K.¹ Poupart, M.A.²

13
- 33846630858
- D. Menche, F. Arikan, J. Li, and S. Rudolph Org. Lett. 9 2007 267
- (2007) Org. Lett. , vol.9 , pp. 267
- Menche, D.¹ Arikan, F.² Li, J.³ Rudolph, S.⁴

14
- 3042741556
- D.B. Dess, and J.C. Martin J. Am. Chem. Soc. 113 1991 7277
- (1991) J. Am. Chem. Soc. , vol.113 , pp. 7277
- Dess, D.B.¹ Martin, J.C.²

15
- 0025995750
- A. Burger Prog. Drug Res. 37 1991 287
- (1991) Prog. Drug Res. , vol.37 , pp. 287
- Burger, A.¹

16
- 0006908514
- C.W. Thornber Chem. Soc. Rev. 8 1979 563
- (1979) Chem. Soc. Rev. , vol.8 , pp. 563
- Thornber, C.W.¹

17
- 77956715838
- C.A. Lipinski Annu. Rep. Med. Chem. 21 1986 283
- (1986) Annu. Rep. Med. Chem. , vol.21 , pp. 283
- Lipinski, C.A.¹

18
- 7744243992
- G.A. Patani, and E.J. La Voie Chem. Rev. 96 1996 3147
- (1996) Chem. Rev. , vol.96 , pp. 3147
- Patani, G.A.¹ La Voie, E.J.²

19
- 36148959779
- X. Chen, and W. Wang Annu. Rep. Med. Chem. 38 2003 333
- (2003) Annu. Rep. Med. Chem. , vol.38 , pp. 333
- Chen, X.¹ Wang, W.²

20
- 79955419410
- N.A. Meanwell J. Med. Chem. 54 2011 2529
- (2011) J. Med. Chem. , vol.54 , pp. 2529
- Meanwell, N.A.¹

21
- 74849094116
- R. Epple, C. Cow, Y.P. Xie, M. Azimioara, R. Russo, X. Wang, J. Wityak, D.S. Karanewsky, T. Tuntland, V.T.B. Nguyen-Tran, C.C. Ngo, D. Huang, E. Saez, T. Spalding, A. Gerken, M. Iskandar, H.M. Seidel, and S.S. Tian J. Med. Chem. 53 2010 77
- (2010) J. Med. Chem. , vol.53 , pp. 77
- Epple, R.¹ Cow, C.² Xie, Y.P.³ Azimioara, M.⁴ Russo, R.⁵ Wang, X.⁶ Wityak, J.⁷ Karanewsky, D.S.⁸ Tuntland, T.⁹ Nguyen-Tran, V.T.B.¹⁰ Ngo, C.C.¹¹ Huang, D.¹² Saez, E.¹³ Spalding, T.¹⁴ Gerken, A.¹⁵ Iskandar, M.¹⁶ Seidel, H.M.¹⁷ Tian, S.S.¹⁸

22
- 0019813187
- W.J. Hammar, and M.A. Rustad J. Heterocycl. Chem. 18 1981 885
- (1981) J. Heterocycl. Chem. , vol.18 , pp. 885
- Hammar, W.J.¹ Rustad, M.A.²

23
- 0033565015
- D.A. Evans, V.J. Cee, T.E. Smith, and K.J. Santiago Org. Lett. 1 1999 87
- (1999) Org. Lett. , vol.1 , pp. 87
- Evans, D.A.¹ Cee, V.J.² Smith, T.E.³ Santiago, K.J.⁴

24
- 7244226607
- 2. Fluorescence intensities were the determined using a multilabel plate reader (Victor3; PerkinElmer, Inc.; USA). And see: P. Sommer, J.P. Vartanian, M. Wachsmuth, M. Henry, D. Guetard, and S. Wain-Hobson J. Mol. Biol. 344 2004 11
- (2004) J. Mol. Biol. , vol.344 , pp. 11
- Sommer, P.¹ Vartanian, J.P.² Wachsmuth, M.³ Henry, M.⁴ Guetard, D.⁵ Wain-Hobson, S.⁶

25
- 84986512474
- B.R. Brooks, R.E. Bruccoleri, B.D. Olafson, D.J. States, S. Swaminathan, and M. Karplus J. Comput. Chem. 4 1983 187 217
- (1983) J. Comput. Chem. , vol.4 , pp. 187-217
- Brooks, B.R.¹ Bruccoleri, R.E.² Olafson, B.D.³ States, D.J.⁴ Swaminathan, S.⁵ Karplus, M.⁶

26
- 84862824815
- Discovery Studio, version 3.1; Accelrys Inc.: San Diego, CA
- Discovery Studio, version 3.1; Accelrys Inc.: San Diego, CA.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.