Requirement for Pak3 in Rac1-induced organization of actin and myosin during Drosophila larval wound healing

FEBS Letters

Volumn 586, Issue 6, 2012, Pages 772-777

  Baek, Seung Hee ^a   Cho, Hae Weon ^a   Kwon, Young Chang ^a   Lee, Ji Hyun ^a   Kim, Moon Jong ^a   Lee, Hyangkyu ^a   Choe, Kwang Min ^a  

^a Yonsei University   (South Korea)

Author keywords

Actin cable; Cell migration; Cell polarization; Chemotaxis; Wound repair

Indexed keywords

F ACTIN; MYOSIN; P21 ACTIVATED KINASE 3; RAC1 PROTEIN;

ACTIN MYOSIN INTERACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; EPIDERMIS; IN VIVO STUDY; LARVAL STAGE; NONHUMAN; PHENOTYPE; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; WOUND CLOSURE; WOUND HEALING;

ACTINS; ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EPIDERMIS; LARVA; MYOSINS; P21-ACTIVATED KINASES; RAC1 GTP-BINDING PROTEIN; RECOMBINANT FUSION PROTEINS; WOUND HEALING;

EID: 84862829679     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.01.061     Document Type: Article

References (38)

1. Rorth, P. (2009) Collective cell migration. Annu. Rev. Cell Dev. Biol. 25, 407-429.
2. Martin, P. (1997) Wound healing-aiming for perfect skin regeneration. Science 276, 75-81.
3. Singer, A.J. and Clark, R.A. (1999) Cutaneous wound healing. N. Engl. J. Med. 341, 738-746. (Pubitemid 29407375)
4. Martin, P. and Lewis, J. (1992) Actin cables and epidermal movement in embryonic wound healing. Nature 360, 179-183.
5. Bement, W.M., Forscher, P. and Mooseker, M.S. (1993) A novel cytoskeletal structure involved in purse string wound closure and cell polarity maintenance. J. Cell Biol. 121, 565-578. (Pubitemid 23131268)
6. Galko, M.J. and Krasnow, M.A. (2004) Cellular and genetic analysis of wound healing in Drosophila larvae. PLoS Biol. 2, E239.
7. Kwon, Y.C., Baek, S.H., Lee, H. and Choe, K.M. (2010) Nonmuscle myosin II localization is regulated by JNK during Drosophila larval wound healing. Biochem. Biophys. Res. Commun. 393, 656-661.
8. Martin, P. and Parkhurst, S.M. (2004) Parallels between tissue repair and embryo morphogenesis. Development 131, 3021-3034. (Pubitemid 39077428)
9. Fukata, M., Nakagawa, M. and Kaibuchi, K. (2003) Roles of Rho-family GTPases in cell polarisation and directional migration. Curr. Opin. Cell Biol. 15, 590-597. (Pubitemid 37176968)
10. Wood, W., Jacinto, A., Grose, R., Woolner, S., Gale, J., Wilson, C. and Martin, P. (2002) Wound healing recapitulates morphogenesis in Drosophila embryos. Nat. Cell Biol. 4, 907-912. (Pubitemid 35331367)
11. Baek, S.H., Kwon, Y.C., Lee, H. and Choe, K.M. (2010) Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healing. Biochem. Biophys. Res. Commun. 394, 488-492.
12. Zeitlinger, J. and Bohmann, D. (1999) Thorax closure in Drosophila: involvement of Fos and the JNK pathway. Development 126, 3947-3956. (Pubitemid 29440491)
13. Pastor-Pareja, J.C., Grawe, F., Martin-Blanco, E. and Garcia-Bellido, A. (2004) Invasive cell behavior during Drosophila imaginal disc eversion is mediated by the JNK signaling cascade. Dev. Cell 7, 387-399. (Pubitemid 39232974)
14. Sluss, H.K., Han, Z., Barrett, T., Goberdhan, D.C., Wilson, C., Davis, R.J. and Ip, Y.T. (1996) A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev. 10, 2745-2758. (Pubitemid 26384494)
15. Manser, E., Leung, T., Salihuddin, H., Zhao, Z.S. and Lim, L. (1994) A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367, 40-46. (Pubitemid 24038530)
16. Ng, J. and Luo, L. (2004) Rho GTPases regulate axon growth through convergent and divergent signaling pathways. Neuron 44, 779-793. (Pubitemid 39575632)
17. Conder, R., Yu, H., Ricos, M., Hing, H., Chia, W., Lim, L. and Harden, N. (2004) DPak is required for integrity of the leading edge cytoskeleton during Drosophila dorsal closure but does not signal through the JNK cascade. Dev. Biol. 276, 378-390. (Pubitemid 39592401)
18. Allen, J.D. et al. (2009) P21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood 113, 2695-2705.
19. Van den Broeke, C., Radu, M., Deruelle, M., Nauwynck, H., Hofmann, C., Jaffer, Z.M., Chernoff, J. and Favoreel, H.W. (2009) Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases. Proc. Natl. Acad. Sci. USA 106, 8707-8712.
20. Huang, W., Zhou, Z., Asrar, S., Henkelman, M., Xie, W. and Jia, Z. (2010). PAK1/3 Control Brain Size through Coordinating Neuronal Complexity and Synaptic Properties. Mol. Cell Biol. 31, 388-403.
21. Qu, J. et al. (2003) PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol. Cell Biol. 23, 7122-7133. (Pubitemid 37210995)
22. Conder, R., Yu, H., Zahedi, B. and Harden, N. (2007) The serine/threonine kinase dPak is required for polarized assembly of F-actin bundles and apical-basal polarity in the Drosophila follicular epithelium. Dev. Biol. 305, 470-482. (Pubitemid 46686617)
23. Bokoch, G.M. (2003) Biology of the p21-activated kinases. Annu. Rev. Biochem. 72, 743-781.
24. Hing, H., Xiao, J., Harden, N., Lim, L. and Zipursky, S.L. (1999) Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell 97, 853-863. (Pubitemid 29375045)
25. Parnas, D., Haghighi, A.P., Fetter, R.D., Kim, S.W. and Goodman, C.S. (2001) Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix. Neuron 32, 415-424. (Pubitemid 33082043)
26. Ang, L.H., Kim, J., Stepensky, V. and Hing, H. (2003) Dock and Pak regulate olfactory axon pathfinding in Drosophila. Development 130, 1307-1316. (Pubitemid 36410779)
27. Newsome, T.P., Schmidt, S., Dietzl, G., Keleman, K., Asling, B., Debant, A. and Dickson, B.J. (2000) Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila. Cell 101, 283-294.
28. Bahri, S. et al. (2010) The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation. Development 137, 2023-2032.
29. Mentzel, B. and Raabe, T. (2005) Phylogenetic and structural analysis of the Drosophila melanogaster p21-activated kinase DmPAK3. Gene 349, 25-33.
30. Fan, X., Labrador, J.P., Hing, H. and Bashaw, G.J. (2003) Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline. Neuron 40, 113-127. (Pubitemid 37222467)
31. Franke, J.D., Montague, R.A. and Kiehart, D.P. (2005) Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure. Curr. Biol. 15, 2208-2221. (Pubitemid 41790614)
32. Choe, K.M., Prakash, S., Bright, A. and Clandinin, T.R. (2006) Liprin-alpha is required for photoreceptor target selection in Drosophila. Proc. Natl. Acad. Sci. USA 103, 11601-11606. (Pubitemid 44182498)
33. Rasse, T.M. et al. (2005) Glutamate receptor dynamics organizing synapse formation in vivo. Nat. Neurosci. 8, 898-905.
34. Sells, M.A., Pfaff, A. and Chernoff, J. (2000) Temporal and spatial distribution of activated Pak1 in fibroblasts. J. Cell Biol. 151, 1449-1458.
35. Adam, L., Vadlamudi, R., Kondapaka, S.B., Chernoff, J., Mendelsohn, J. and Kumar, R. (1998) Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. J. Biol. Chem. 273, 28238-28246. (Pubitemid 28496122)
36. Woolner, S., Jacinto, A. and Martin, P. (2005) The small GTPase Rac plays multiple roles in epithelial sheet fusion-dynamic studies of Drosophila dorsal closure. Dev. Biol. 282, 163-173. (Pubitemid 40779935)
37. Zegers, M. (2008) Roles of P21-activated kinases and associated proteins in epithelial wound healing. Int. Rev. Cell Mol. Biol. 267, 253-298.
38. Harden, N., Lee, J., Loh, H.Y., Ong, Y.M., Tan, I., Leung, T., Manser, E. and Lim, L. (1996) A Drosophila homolog of the Rac- and Cdc42-activated serine/ threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures. Mol. Cell Biol. 16, 1896-1908. (Pubitemid 26123710)