Mechanistic understanding of protein-silicone oil interactions

Pharmaceutical Research

Volumn 29, Issue 6, 2012, Pages 1689-1697

  Li, Jinjiang ^a   Pinnamaneni, Swathi ^a   Quan, Yong ^a   Jaiswal, Archana ^b   Andersson, Fredrik I ^c   Zhang, Xiaochun ^b  

^a BRISTOL MYERS SQUIBB   (United States)

^b Biolin Scientific Inc   (United States)

^c Biolin Scientific/Q Sense   (Sweden)

Author keywords

adsorption; aggregation; protein; silicone oil; syringes

Indexed keywords

ABATACEPT; BUFFER; POLOXAMER; POLYSORBATE 80; PROTEIN; SILICONE OIL; SURFACTANT;

ARTICLE; CONTROLLED STUDY; DESORPTION; DRUG ADSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; EQUILIBRIUM CONSTANT; GEL PERMEATION CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN INTERACTION; ROOM TEMPERATURE; SYRINGE; TIME;

ADSORPTION; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; DRUG STABILITY; IMMUNOCONJUGATES; KINETICS; MODELS, CHEMICAL; POLOXAMER; POLYSORBATES; PROTEIN CONFORMATION; PROTEIN DENATURATION; SILICONE OILS; SURFACE TENSION; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 84862825135     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0696-6     Document Type: Article

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