Quantitative monitoring of corticosteroids in cosmetic products manufactured in Korea using LC-MS/MS

Forensic Science International

Volumn 220, Issue 1-3, 2012, Pages

  Nam, Yun Sik ^a,b   Kwon, Il Keun ^b   Lee, Yeonhee ^a   Lee, Kang Bong ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

Betamethasone; Cosmetic products; Dexamethasone and triamcinolone acetonide; Hydrocortisone; LC MS MS; Prednisolone

Indexed keywords

BETAMETHASONE; CORTICOSTEROID; COSMETIC; HYDROCORTISONE; PREDNISOLONE; TRIAMCINOLONE ACETONIDE;

ARTICLE; CONTROLLED STUDY; CREAM; DRUG MANUFACTURE; DRUG MARKETING; DRUG MONITORING; DRUG STRUCTURE; DRUG SURVEILLANCE PROGRAM; EMULSION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LOTION; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOUTH KOREA; STRUCTURE ANALYSIS; VALIDATION STUDY;

EID: 84862821327     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2011.12.011     Document Type: Article

References (29)

1. Pozo O.J., Ventura R., Monfort N., Segura J., Delbeke F.T. Evaluation of different scan methods for the urinary detection of corticosteroid metabolites by liquid chromatography tandem mass spectrometry. J. Mass Spectrom. 2009, 44:929-944.
2. Schoepe S., Schäcke H., May E., Asadullah K. Glucocorticoid therapy-induced skin atrophy. Exp. Dermatol. 2006, 15:406-420.
3. Zöller N.N., Kippenberger S., Thaçi D., Mewes K., Spiegel M., Sättler A., Schultz M., Bereiter-Hahn J., Kaufmann R., Bernd A. Evaluation of beneficial and adverse effects of glucocorticoids on a newly developed full-thickness skin model. Toxicol. In Vitro 2008, 22:747-759.
4. Tokunaga H., Kimura T., Kawamura J. Determination of glucocorticoids by liquid chromatography. III. Application to ointments and a cream containing cortisone acetate, dexamethasone acetate, fluorometholone and betamethasone valerate. Chem. Pharm. Bull. 1984, 32:4012-4016.
5. Feldman S.R., Yentzer B.A. Topical clobetasol propionate in the treatment of psoriasis: a review of newer formulations. Am. J. Clin. Dermatol. 2009, 10:397-406.
6. http://www.wada-ama.org/rtecontent/document/2008_list_en.pdf.
7. http://en.wikipedia.org/wiki/corticosteroid.
8. Meulenberg P.M., Ross H.A., Swinkels L.M., Benraad T.J. The effect of oral contraceptives on plasma-free and salivary cortisol and cortisone. Clin. Chim. Acta 1987, 165:379-385.
9. AbuRuz S., Millership J., Heaney L., McElnay J. Simple liquid chromatography method for the rapid simultaneous determination of prednisolone and cortisol in plasma and urine using hydrophilic lipophilic balanced solid phase extraction cartridges. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2003, 798:193-201.
10. Gaudiano M.C., Lucente D., Antoniella E., Bertocchi P., Muleri N., Manna L., Bartolomei M., Alimonti S., Valvo L., Rodomonte A.L. For export only medicines come back to Europe: a RP-LC method for the screening of six glucocorticoids in illegal and counterfeit anti-inflammatory and lightening creams. J. Pharm. Biomed. Anal. 2010, 53:158-164.
11. Nam Y.S., Kwon I.K., Lee K.-B. Monitoring of clobetasol propionate and betamethasone dipropionate as undeclared steroids in cosmetic products manufactured in Korea. Forensic Sci. Int. 2011, 210:144-148.
12. Slominski A., Wortsman J., Foecking M.F., Shackleton C., Gomez-sanchez C., Szczesniewski A. Gas chromatograpy/mass spectrometry characterization of corticosteroid metabolism in human immortalized keratinocytes. J. Invest. Dermat. 2002, 118:310-315.
13. Luo Y., Uboh C.E., Soma L.R., Guan F.Y., Rudy J.A., Tsang D.S. Simultaneous analysis of twenty-one glucocorticoids in equine plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2005, 19:1245-1256.
14. Reddy I.M., Beotra A., Jain S., Ahi S. A simple and rapid ESI-LC-MS/MS method for simultaneous screening of doping agents in urine samples. Indian J. Pharmacol. 2009, 49:80-86.
15. VieiraMde L., Singh R.P., Derendorf H. Simultaneous HPLC analysis of triamcinolone acetonide and budesonide in microdialysate and rat plasma: application to a pharmacokinetic study. J. Chromatogr. B 2010, 878:2967-2973.
16. Samtani M.N., Jusko W.J. Quantification of dexamethasone and corticosterone in rat biofluids and fetal tissue using highly sensitive analytical method: assay validation and application to a pharmacokinetic study. Biomed. Chromatogr. 2007, 21:585-597.
17. Touber M.E., van Engelen M.C., Georgakopoulus C., van Rhijn J.A., Nielen M.W. Multi-detection of corticosteroids in sports doping and veterinary control using high-resolution liquid chromatography/time-of-flight mass spectrometry. Anal. Chim. Acta 2007, 586:137-146.
18. Frerichs V.A., Tornatore K.M. Determination of the glucocorticoids prednisone, prednisolone, dexamethasone, and cortisol in human serum using liquid chromatography coupled to tandem mass spectrometry. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2004, 802:329-338.
19. Gao L., Chiou W.J., Camp H.S., Burns D.J., Cheng X. Quantitative measurements of corticosteroids in ex vivo samples using on-line SPE-LC/MS/MS. J. Chromatogr. B 2009, 877:303-310.
20. Ronquist-Nii Y., Edlund P.O. Determination of corticosteroids in tissue samples by liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal. 2005, 37:341-350.
21. http://www.uam.es/personal_pas/txrf/MU5.pdf.
22. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm070107.pdf.
23. Antignac J.P., LeBizec B., Monteau F., Poulain F., André F. Collision-induced dissociation of corticosteroids in electrospray tandem mass spectrometry and development of a screening method by high performance liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2000, 14:33-39.
24. http://www.wada-ama.org/rtecontent/document/criteria_1_2.pdf.
25. Vonaparti A., Lyris E., Panderi I., Koupparis M., Georgakopoulos C. Direct injection LC/ESI-MS horse urine analysis for the quantification and identification of the threshold substances for doping control. I. Determination of hydrocortisone. J. Mass Spectrom. 2008, 43:1255-1264.
26. Antignac J.P., LeBizec B., Monteau F., Andre F. Differentiation of betamethasone and dexamethasone using liquid chromatography/positive electrospray tandem mass spectrometry and multivariate statistical analysis. J. Mass Spectrom. 2002, 37:69-75.
27. DeWasch K., DeBrabander H.F., M.Van deWiele, Vercammen J., Courtheyn D., Impens S. Differentiation between dexamethasone and betamethasone in a mixture using multiple mass spectrometry. J. Chromatogr. A 2001, 926:79-86.
28. Van DenHauwe O., Perez J.C., Claereboudt J., VanPeteghem C. Simultaneous determination of betamethasone and dexamethasone residues in bovine liver by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2001, 15:857-861.
29. Prednisolone levels in four cosmetic cream samples containing prednisolone were 0.76, 0.77, 0.80 and 0.94μg/g and triamcinolone acetonide levels in nine cosmetic cream samples were 11.5, 15.3, 18.0, 19.7, 32.0, 40.1, 49.6, 158.5 and 272.0μg/g. Other corticosteroids were not monitored.