An implantable, focal brain cooling device suppresses nociceptive pain in rats

Neuroscience Research

Volumn 66, Issue 4, 2010, Pages 402-405

  Fujioka, Hiroshi ^a,c   Fujii, Masami ^a,c   Koizumi, Hiroyasu ^a   Imoto, Hirochika ^a,c   Nomura, Sadahiro ^a,c   Saito, Takashi ^a   Yamakawa, Takeshi ^b,c   Suzuki, Michiyasu ^a,b  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

^c Consortium of Advanced Epilepsy Treatment ^*  (Japan)

Author keywords

Brain cooling; Nociceptive pain; Rats; Sensorimotor cortex; Thermal neuromodulation

Indexed keywords

ARTICLE; CLINICAL EFFECTIVENESS; COOLING; CRYOTHERAPY; ELECTROCARDIOGRAM; EXPERIMENTAL TEST; FOCAL BRAIN COOLING DEVICE; HOT PLATE TEST; MEDICAL INSTRUMENTATION; NEUROMODULATION; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; SENSORIMOTOR CORTEX; SENSORIMOTOR FUNCTION; SYNAPTIC TRANSMISSION; TEMPERATURE; THERMAL WITHDRAWAL TEST; TREATMENT RESPONSE;

ANIMALS; ELECTRICAL EQUIPMENT AND SUPPLIES; HYPOTHERMIA, INDUCED; MALE; MOTOR CORTEX; PAIN; PAIN MEASUREMENT; RATS; RATS, WISTAR; SOMATOSENSORY CORTEX;

EID: 77049116231     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2009.12.014     Document Type: Article

References (21)

1. Barth T.M., Jones T.A., and Schallert T. Functional subdivisions of the rat somatic sensorimotor cortex. Behav. Brain Res. 39 (1990) 73-95
2. Brinkman J., Colebatch J.G., Porter R., and York D.H. Responses of precentral cells during cooling of post-central cortex in conscious monkeys. J. Physiol. (Lond.) 368 (1985) 611-625
3. Chang C., and Shyu B.-C. A fMRI study of brain activations during non-noxious and noxious electrical stimulation of the sciatic nerve of rats. Brain Res. 897 (2001) 71-81
4. Fay T. Early experiences with local and generalized refrigeration of the human brain. J. Neurosurg. 16 (1959) 239-259
5. Fregni F., Freedman S., and Pascual-Leone A. Recent advances in the treatment of chronic pain with non-invasive brain stimulation techniques. Lancet Neurol. 6 (2007) 188-199
6. Hall R.D., and Lindholm E.P. Organization of motor and somatosensory neocortex in the albino rat. Brain Res. 66 (1974) 23-38
7. Hitchcock E.R. Hypothermic subarachnoid irrigation for intractable pain. Lancet 1 (1967) 1133-1135
8. Imoto H., Fujii M., Uchiyama J., Fujisawa H., Nakano K., Kunitsugu I., Nomura S., Saito T., and Suzuki M. Use of a Peltier chip with a newly devised local brain-cooling system for neocortical seizures in the rat. J. Neurosurg. 104 (2006) 150-156
9. Karkar K.M., Garcia P.A., Bateman L.M., Smyth M.D., Barbaro N.M., and Berger M. Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold. Epilepsia 43 (2002) 932-935
10. Kenshalo D.R., Iwata K., Sholas M., and Thomas D.A. Response properties and organization of nociceptive neurons in area 1 of monkey primary somatosensory cortex. J. Neurophysiol. 84 (2000) 719-729
11. Lamour Y., Willer J.C., and Guibaud G. Rat somatosensory (SmI) cortex: I. Characteristics of neuronal responses to noxious stimulation and comparison with responses to non-noxious stimulation. Exp. Brain Res. 49 (1983) 35-45
12. Lamour Y., Guibaud G., and Willer J.C. Rat somatosensory (SmI) cortex: II. Laminar and columnar organization of noxious and non-noxious inputs. Exp. Brain Res. 49 (1983) 46-54
13. Okada Y. The effects of mild and deep hypothermia on the neuronal activity and energy metabolism in brain slices in vitro. In: Hayashi N., Bullock R., Dietrich D.W., Maekawa T., and Tamura A. (Eds). Hypothermia for Acute Brain Damage (2004), Springer 208-214
14. Oku T., Fujii M., Tanaka N., Imoto H., Uchiyama J., Oka F., Kunitsugu I., Fujioka H., Nomura S., Kajiwara K., Fujisawa H., Kato S., Saito T., and Suzuki M. The influence of focal brain cooling on neurophysiopathology: validation for clinical application. J. Neurosurg. 110 (2009) 1209-1217
15. Saitoh Y., Shibata M., Hirano S., Hirata M., Mashimo T., and Yoshimine T. Motor cortex stimulation for central and peripheral deafferentation pain. Report of eight cases. J. Neurosurg. 92 (2000) 150-155
16. Savitz M.H., and Malis L.I. Intractable pain treated with intrathecal isotonic iced saline. J. Neurol. Neurosurg. Psychiatry 36 (1973) 417-420
17. Soblosky J.S., Matthews M.A., Davidson J.F., Tabor S.L., and Carey M.E. Traumatic brain injury of the forelimb and hindlimb sensorimotor areas in the rats: physiological, histological and behavioral correlates. Behav. Brain Res. 79 (1996) 79-92
18. Tanaka N., Fujii M., Imoto H., Uchiyama J., Nakano K., Nomura S., Fujisawa H., Kunitsugu I., Saito T., and Suzuki M. Effective suppression of hippocampal seizures in rats by direct hippocampal cooling with a Peltier chip. J. Neurosurg. 108 (2008) 791-797
19. Tani N., Saitoh Y., Hirata M., Kato A., and Yoshimine T. Bilateral cortical stimulation for deafferentation pain after spinal cord injury. J. Neurosurg. 101 (2004) 687-689
20. Yang X.-F., Kennedy B.R., Lomber S.G., Schmidt R.E., and Rothman S.M. Cooling produces minimal neuropathology in neocortex and hippocampus. Neurobiol. Dis. 23 (2006) 637-643
21. Volgushev M., Vidyasagar T.R., Chistiakova M., and Eysel U.T. Synaptic transmission in the neocortex during reversible cooling. Neuroscience 98 (2000) 9-22