Hypoglycemic and hypolipidemic activities of MT-α-glucan and its effect on immune function of diabetic mice

Carbohydrate Polymers

Volumn 89, Issue 1, 2012, Pages 245-250

  Lei, Hong ^a   Guo, Shuzhen ^a   Han, Juncheng ^a   Wang, Qin ^a   Zhang, Xiaoxiang ^a   Wu, Wutong ^b  

^a HEFEI UNIVERSITY OF TECHNOLOGY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Glucan; Grifola frondosa; Hypoglycemic; Hypolipidemic; Immune function; Polysaccharide

Indexed keywords

DIABETES MELLITUS; DIABETIC MICE; FREE FATTY ACID; FRUIT BODY; GRIFOLA FRONDOSA; HIGH-FAT-DIET; HYPOGLYCEMIC; HYPOLIPIDEMIC; HYPOLIPIDEMIC EFFECT; IMMUNE FUNCTION; PANCREATIC ISLET; PLASMA GLUCOSE; SERUM INSULIN; SPLENOCYTES; STREPTOZOTOCIN; TREATMENT GROUP; ULTRASTRUCTURAL CHANGES;

GLUCOSE; ISOMERS; MACROPHAGES; POLYSACCHARIDES;

MAMMALS;

GRIFOLA FRONDOSA; MUS;

ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; GLUCAN; GLUCOSE BLOOD LEVEL; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTERLEUKIN 1; INTERLEUKIN 2; LIPID; NITRIC OXIDE; NOS2 PROTEIN, MOUSE;

ANALYSIS; ANIMAL; BLOOD; C57BL MOUSE; CELL PROLIFERATION; CYTOLOGY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; FRUITING BODY; GLUCOSE BLOOD LEVEL; GRIFOLA; IMMUNOLOGY; LIPID DIET; MACROPHAGE; MALE; METABOLISM; PANCREAS ISLET BETA CELL; PATHOLOGY; SPLEEN;

ANIMALS; BLOOD GLUCOSE; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; FRUITING BODIES, FUNGAL; GLUCANS; GRIFOLA; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; INTERLEUKIN-1; INTERLEUKIN-2; LIPIDS; MACROPHAGES; MALE; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; SPLEEN;

EID: 84862819762     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2012.03.003     Document Type: Article

References (22)

1. H. Andras, B. Gyongyi, O. Laszlo, B. Tamas, and K. Gyorgy Comparison of the cytotoxic effects of receptor tyrosine kinase inhibitors on macrophage functions; possible side effects in the immune defense Immunology Letters 107 2006 169 175
2. R.A. Defronzo, R.C. Bondonna, and E. Ferranini Pathogenesis of NIDDM: A balanced overview Diabetes Care 15 1992 318 337
3. A.C. Dimitry, V.V. Natalia, and A.C. Pavel The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies Immunology Letters 118 2008 1 5
4. K. Hirotada, K. Noriko, and N. Hiroaki Activities of polysaccharides obtained from Grifola frondosa on insulin-dependent diabetes mellitus induced by streptozotocin in mice Mycoscience 41 2000 473 480
5. A. Inoue, N. Kodoma, and N. Nanba Effect of maitake (Grifola frondosa) D-fraction on the control of the T lymph node Th-1/Th-2 proportion Chemical and Pharmaceutical Bulletin 25 2002 536 540
6. H.P. Ji, H.K. Ji, and H.K. Won Association of the endothelial nitric oxide synthase (ecNOS) gene polymorphism with carotidatherosclerosis in type 2 diabetes Diabetes Research and Clinical Practice 72 2006 322 327
7. K. Kubo Anti-hyperliposis effect of maitake fruit body (Grifola frondosa) Biological and Pharmaceutical Bulletin 20 1997 781 785
8. K. Kubo Anti-diabetic activity present in the fruit body of Grifola frondosa (maitake) Biological and Pharmaceutical Bulletin 17 1994 1106 1110
9. K. Kubo, and H. Nanba Modification of cellular immune responses in experimental autoimmune hepatitis in mice by maitake (Grifola frondosa) Mycoscience 39 1998 351 360
10. H. Lei, X. Ma, and W.T. Wu Antidiabetic effect of a α-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice Journal of Pharmacy and Pharmacology 59 2007 575 582
11. X.W. Liu, X.D. Chen, and W.T. Wu Separation, purification and characterization of polysaccharide from Grifola frondosa Pharmaceutical Biotechnology 3 2005 175 178
12. J. Luo, J. Quan, T. Joyce, K. Christina, S. Cynthia, and H. Richard Nongenetic mouse models of non-insulin-dependent diabetes mellitus Metabolism: Clinical and Experimental 47 1998 663 668
13. M.A. Malek, and A. Mohammad Nitric oxide involvement in pancreatic β cell apoptosis by glibenclamide Nitric Oxide 14 2006 39 44
14. H. Nanba, N. Kodama, D. Schar, and D. Turner Effects of maitake (Grifola frondosa) glucan in HIV-infected patients Mycoscience 41 2000 293 295
15. J.M. Olefsky, and J. Nolan Insulin resistance and non-insulin dependent diabetes mellitus: Cellular and molecular mechanisms American Journal of Clinical Nutrition 61 1995 980 986
16. V. Ooi Hepatoprotective effect of some edible mushroom Phytotherapy Research 6 1996 536 538
17. L. Philippe, K. Ulrich, B. Nenad, J. Dominik, and M. Beat Diminished production of nitric oxide synthase cofactor tetrahydrobiopterin by rosiglitazone in adipocytes Biochemical Pharmacology 65 2003 593 598
18. L.J. Rosenwasser Biologic activities of IL-1 and its role in human disease Journal of Allergy and Clinical Immunology 102 1998 344 350
19. Y.L. Ruth, S. Carlos, and M.E. Gershwin The regulatory, inflammatory, and T cell programming roles of interleukin-2 (IL-2) Journal of Autoimmunity 31 2008 7 12
20. I.K. Song, S.K. Kap, J.S. Seok, S.K. Myung, Y.K. Dae, and L.K. Sun Anti-inflammatory effect of Ulmus davidiana Planch (Ulmaceae) on collagen-induced inflammation in rats Environmental Toxicology and Pharmacology 23 2007 102 110
21. L. Thorvaldson, M. Holstad, and S. Sandler Cytokine release by murine spleen cells following multiple low dose streptozotocin-induced diabetes and treatment with a TNFa transcriptional inhibitor International Immunopharmacology 3 2003 1609 1617
22. J.T. Xie, and Y.P. Zhou Ginseng beery reduces blood glucose and body weight in db/db mice Phytomedicine 9 2002 254 258