Evaluation of collagen alteration after topical photodynamic therapy (PDT) using second harmonic generation (SHG) microscopy - in vivo study in a mouse model

Photodiagnosis and Photodynamic Therapy

Volumn 9, Issue 2, 2012, Pages 164-169

  Lv, Ting ^a   Huang, Zu Fang ^b   Wang, Hong Wei ^a   Lin, Ju Qiang ^b   Chen, Guan Nan ^b   Chen, Xi Wen ^b   Chen, Rong ^b   Huang, Zheng ^b,c,d   Wang, Xiu Li ^a  

^a Shanghai Skin Disease Hospital   (China)

^b FUJIAN NORMAL UNIVERSITY   (China)

^c UNIVERSITY OF COLORADO   (United States)

^d DEPARTMENT OF MEDICINE   (United States)

Author keywords

5 ALA; Collagen; Photodynamic therapy; Second harmonic generation; Skin rejuvenation

Indexed keywords

AMINOLEVULINIC ACID; COLLAGEN; COLLAGEN FIBER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CUTANEOUS PARAMETERS; DENSITY; FEMALE; HAIR GROWTH; HISTOLOGY; HISTOPATHOLOGY; IN VIVO STUDY; MICROSCOPY; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; REJUVENATION; SECOND HARMONIC GENERATION MICROSCOPY; SKIN COLOR; SKIN DEFECT; SKIN STRUCTURE; SKIN SURFACE; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; AMINO ACIDS, NEUTRAL; ANIMALS; COLLAGEN; FEMALE; IMAGE ENHANCEMENT; MICE; MICE, NUDE; MICROSCOPY; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; SKIN AGING;

EID: 84862818543     PISSN: 15721000     EISSN: 18731597     Source Type: Journal    
DOI: 10.1016/j.pdpdt.2011.12.006     Document Type: Article

References (25)

1. Fisher G.J., Kang S., Varani J., et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol 2002, 138:1462-1470.
2. Scharffetter-Kochanek K., Wlaschek M., Brenneisen P., Schauen M., Blaudschun R., Wenk J. UV-induced reactive oxygen species in photocarcinogenesis and photoaging. Biol Chem 1997, 378:1247-1257.
3. Callaghan T.M., Wilhelm K.P. A review of ageing and an examination of clinical methods in the assessment of ageing skin. Part I: cellular and molecular perspectives of skin ageing. Int J Cosmet Sci 2008, 30:313-322.
4. Dougherty T.J. An update on photodynamic therapy applications. J Clin Laser Med Surg 2002, 20:3-7.
5. Huang Z. A review of progress in clinical photodynamic therapy. Technol Cancer Res Treat 2005, 4:283-293.
6. Babilas P., Szeimies R.M. The use of photodynamic therapy in dermatology. G Ital Dermatol Venereol 2010, 145:613-630.
7. Wang X.L., Wang H.W., Guo M.X., Xu S.Z. Treatment of skin cancer and pre-cancer using topical ALA-PDT - a single hospital experience. Photodiagnosis Photodyn Ther 2008, 5:127-133.
8. Goldberg D.J. Photodynamic therapy in skin rejuvenation. Clin Dermatol 2008, 26:608-613.
9. Bruscino N.R.R., Dindelli M., Ghersetich I., Lotti T. Therapeutic Hotline: 1. Facial skin rejuvenation in a patient treated with photodynamic therapy for actinic keratosis. Dermatol Ther 2010, 23:86-89.
10. Kohl E., Torezan L.A., Landthaler M., Szeimies R.M. Aesthetic effects of topical photodynamic therapy. J Eur Acad Dermatol Venereol 2010, 24:1261-1269.
11. Wu S., Li H., Zhang X. Monitoring photo-thermal response and collagen remodeling of mouse skin with multiphoton microscopy. Chin Opt Lett 2010, 8:784-786.
12. Sugata K., Osanai O., Sano T., Takema Y. Evaluation of photoaging in facial skin by multiphoton laser scanning microscopy. Skin Res Technol 2011, 17:1-3.
13. Zoumi A., Yeh A., Tromberg B.J. Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence. Proc Natl Acad Sci USA 2002, 99:11014-11019.
14. Han M., Giese G., Bille J. Second harmonic generation imaging of collagen fibrils in cornea and sclera. Opt Express 2005, 13:5791-5797.
15. Brown E., McKee T., diTomaso E., et al. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat Med 2003, 9:796-800.
16. Zipfel W.R., Williams R.M., Christie R., Nikitin A.Y., Hyman B.T., Webb W.W. Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation. Proc Natl Acad Sci USA 2003, 100:7075-7080.
17. Huang Z., Zhuo S., Chen J., Chen R., Jiang X. Multiphoton microscopic imaging of adipose tissue based on second-harmonic generation and two-photon excited fluorescence. Scanning 2008, 30:452-456.
18. Kirkpatrick N.D., Brewer M.A., Utzinger U. Endogenous optical biomarkers of ovarian cancer evaluated with multiphoton microscopy. Cancer Epidemiol Biomarkers Prev 2007, 16:2048-2057.
19. Luo T., Chen J.X., Zhuo S.M., Lu K.C., Jiang X.S., Liu Q.G. Visualization of collagen regeneration in mouse dorsal skin using second harmonic generation microscopy. Laser Phys 2009, 19:478-482.
20. Peres P.S., Terra V.A., Guarnier F.A., Cecchini R., Cecchini A.L. Photoaging and chronological aging profile: Understanding oxidation of the skin. J Photochem Photobiol B 2011, 103:93-97.
21. Robinson D.J., de Bruijn H.S., van der Veen N., Stringer M.R., Brown S.B., Star W.M. Protoporphyrin IX fluorescence photobleaching during ALA-mediated photodynamic therapy of UVB-induced tumors in hairless mouse skin. Photochem Photobiol 1999, 69:61-70.
22. Orringer J.S., Hammerberg C., Hamilton T., et al. Molecular effects of photodynamic therapy for photoaging. Arch Dermatol 2008, 144:1296-1302.
23. Park M.Y., Sohn S., Lee E.S., Kim Y.C. Photorejuvenation induced by 5-aminolevulinic acid photodynamic therapy in patients with actinic keratosis: a histologic analysis. J Am Acad Dermatol 2010, 62:85-95.
24. Marmur E.S., Phelps R., Goldberg D.J. Ultrastructural changes seen after ALA-IPL photorejuvenation: a pilot study. J Cosmet Laser Ther 2005, 7:21-24.
25. Issa M.C., Piñeiro-Maceira J., Vieira M.T., et al. Photorejuvenation with topical methyl aminolevulinate and red light: a randomized, prospective, clinical, histopathologic, and morphometric study. Dermatol Surg 2010, 36:39-48.