Photorejuvenation induced by 5-aminolevulinic acid photodynamic therapy in patients with actinic keratosis: A histologic analysis

Journal of the American Academy of Dermatology

Volumn 62, Issue 1, 2010, Pages 85-95

  Park, Min Young ^a   Sohn, Seonghyang ^a   Lee, Eun So ^a   Kim, You Chan ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

histologic changes; photodynamic therapy; photorejuvenation

Indexed keywords

AMINOLEVULINIC ACID; COLLAGEN; FIBRILLIN 1; HALOGEN; INTERSTITIAL COLLAGENASE; LIQUID NITROGEN; MACROPHAGE ELASTASE; PROCOLLAGEN; PROCOLLAGEN TYPE 1; PROCOLLAGEN TYPE 3; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TROPOELASTIN; UNCLASSIFIED DRUG;

ACTINIC KERATOSIS; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CRYOTHERAPY; EPIDERMIS; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; MALE; PHOTOAGING; PHOTODYNAMIC THERAPY; PHOTOREJUVENATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REJUVENATION; SKIN BIOPSY; SKIN INFLAMMATION; SKINFOLD THICKNESS;

AGED; AGED, 80 AND OVER; AMINOLEVULINIC ACID; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KERATOSIS, ACTINIC; MALE; MATRIX METALLOPROTEINASES; MICROFILAMENT PROTEINS; MIDDLE AGED; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROCOLLAGEN; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REJUVENATION; TRANSFORMING GROWTH FACTOR BETA; TROPOELASTIN;

EID: 71649086747     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2009.06.025     Document Type: Article

References (25)

1. Gilchrest B.A. Biochemical and molecular changes in photodamaged skin. In: Gilchrest B.A. (Ed). Photodamage (1995), Blackwell Science Ltd, Cambridge 168-184
2. Touma D., Yaar M., Whitehead S., Konnikov N., and Gilchrest B.A. A trial of short incubation, broad-area photodynamic therapy for facial actinic keratoses and diffuse photodamage. Arch Dermatol 140 (2004) 33-40
3. Gold M.H., Bradshaw V.L., Boring M.M., Bridges T.M., and Biron J.A. Split-face comparison of photodynamic therapy with 5-aminolevulinic acid and intense pulsed light versus intense pulsed light alone for photodamage. Dermatol Surg 32 (2006) 795-801 discussion 801-803
4. Fisher G.J., Datta S., Wang Z., Li X.Y., Quan T., Chung J.H., et al. c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid. J Clin Invest 106 (2000) 663-670
5. Quan T., He T., Kang S., Voorhees J.J., and Fisher G.J. Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling. Am J Pathol 165 (2004) 741-751
6. Inagaki Y., Truter S., and Ramirez F. Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J Biol Chem 269 (1994) 14828-14834
7. Fisher G.J., Datta S.C., Talwar H.S., Wang Z.Q., Varani J., Kang S., et al. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 379 (1996) 335-339
8. Kahari V.M., and Saarialho-Kere U. Matrix metalloproteinases in skin. Exp Dermatol 6 (1997) 199-213
9. Sternlicht M.D., and Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 17 (2001) 463-516
10. Montagna W., Kirchner S., and Carlisle K. Histology of sun-damaged human skin. J Am Acad Dermatol 21 (1989) 907-918
11. Seo J.Y., Lee S.H., Youn C.S., Choi H.R., Rhie G.E., Cho K.H., et al. Ultraviolet radiation increases tropoelastin mRNA expression in the epidermis of human skin in vivo. J Invest Dermatol 116 (2001) 915-919
12. Bernstein E.F., Chen Y.Q., Tamai K., Shepley K.J., Resnik K.S., Zhang H., et al. Enhanced elastin and fibrillin gene expression in chronically photodamaged skin. J Invest Dermatol 103 (1994) 182-186
13. Chung J.H., Seo J.Y., Lee M.K., Eun H.C., Lee J.H., Kang S., et al. Ultraviolet modulation of human macrophage metalloelastase in human skin in vivo. J Invest Dermatol 119 (2002) 507-512
14. Szeimies R.M., Landthaler M., and Karrer S. Non-oncologic indications for ALA-PDT. J Dermatolog Treat 13 Suppl 1 (2002) S13-S18
15. Marmur E.S., Phelps R., and Goldberg D.J. Ultrastructural changes seen after ALA-IPL photorejuvenation: a pilot study. J Cosmet Laser Ther 7 (2005) 21-24
16. Orringer J.S., Hammerberg C., Hamilton T., Johnson T.M., Kang S., Sachs D.L., et al. Molecular effects of photodynamic therapy for photoaging. Arch Dermatol 144 (2008) 1296-1302
17. Kielty C.M., Woolley D.E., Whittaker S.P., and Shuttleworth C.A. Catabolism of intact fibrillin microfibrils by neutrophil elastase, chymotrypsin and trypsin. FEBS Lett 351 (1994) 85-89
18. Karrer S., Bosserhoff A.K., Weiderer P., Landthaler M., and Szeimies R.M. Influence of 5-aminolevulinic acid and red light on collagen metabolism of human dermal fibroblasts. J Invest Dermatol 120 (2003) 325-331
19. Chu E.S., Wong T.K., and Yow C.M. Photodynamic effect in medulloblastoma: downregulation of matrix metalloproteinases and human telomerase reverse transcriptase expressions. Photochem Photobiol Sci 7 (2008) 76-83
20. Massague J. The transforming growth factor-beta family. Annu Rev Cell Biol 6 (1990) 597-641
21. Hase T., Shinta K., Murase T., Tokimitsu I., Hattori M., Takimoto R., et al. Histological increase in inflammatory infiltrate in sun-exposed skin of female subjects: the possible involvement of matrix metalloproteinase-1 produced by inflammatory infiltrate on collagen degradation. Br J Dermatol 142 (2000) 267-273
22. Rijken F., Kiekens R.C., and Bruijnzeel P.L. Skin-infiltrating neutrophils following exposure to solar-simulated radiation could play an important role in photoageing of human skin. Br J Dermatol 152 (2005) 321-328
23. Robert A. Clinical trial of a novel non-thermal LED array for reversal of photoaging: clinical, histologic, and surface profilometric results. Lasers Surg Med 36 (2005) 85-91
24. Dover J.S., Bhatia A.C., Stewart B., and Arndt K.A. Topical 5-aminolevulinic acid combined with intense pulsed light in the treatment of photoaging. Arch Dermatol 141 (2005) 1247-1252
25. Lowe N.J., and Lowe P. Pilot study to determine the efficacy of ALA-PDT photo-rejuvenation for the treatment of facial ageing. J Cosmet Laser Ther 7 (2005) 159-162