Influence of variable domain glycosylation on anti-neutrophil cytoplasmic autoantibodies and anti-glomerular basement membrane autoantibodies

BMC Immunology

Volumn 13, Issue , 2012, Pages

  Xu, Peng Cheng ^a,b   Gou, Shen Ju ^a   Yang, Xiao Wei ^a   Cui, Zhao ^a   Jia, Xiao Yu ^a   Chen, Min ^a   Zhao, Ming Hui ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Anca; Anti gbm; Glycosylation; Variable region

Indexed keywords

AGGLUTININ; ANTI NEUTROPHIL CYTOPLASMIC AUTOANTIBODY; ASPARAGINE LINKED OLIGOSACCHARIDE; AUTOANTIBODY; GLOMERULUS BASEMENT MEMBRANE ANTIBODY; IMMUNOGLOBULIN G; MYELOBLASTIN; MYELOPEROXIDASE; SAMBUCUS NIGRA AGGLUTININ; SIALIC ACID; UNCLASSIFIED DRUG; ANTIGLOMERULAR BASEMENT MEMBRANE ANTIBODY; GRANULOCYTE COLONY STIMULATING FACTOR; HYBRID PROTEIN; INTERLEUKIN 3; MYELOPOIETIN; NEUTROPHIL CYTOPLASMIC ANTIBODY; PLANT LECTIN; RIBOSOME INACTIVATING PROTEIN; SAMBUCUS NIGRA LECTINS;

ADULT; AFFINITY CHROMATOGRAPHY; AGED; ANTIBODY BLOOD LEVEL; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLYCOSYLATION; HUMAN; IMMUNOAFFINITY CHROMATOGRAPHY; MALE; RESPIRATORY BURST; SAMBUCUS NIGRA; ADOLESCENT; ANCA ASSOCIATED VASCULITIS; ANTIBODY AFFINITY; ANTIGEN ANTIBODY COMPLEX; CASE CONTROL STUDY; CHEMISTRY; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MIDDLE AGED; NEUTROPHIL; PROTEIN BINDING;

ADOLESCENT; ADULT; AGED; ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIBODY AFFINITY; ANTIGEN-ANTIBODY COMPLEX; AUTOANTIBODIES; CASE-CONTROL STUDIES; FEMALE; GLYCOSYLATION; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN VARIABLE REGION; INTERLEUKIN-3; MALE; MIDDLE AGED; NEUTROPHILS; PLANT LECTINS; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; RESPIRATORY BURST; RIBOSOME INACTIVATING PROTEINS; YOUNG ADULT;

EID: 84862816834     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-13-10     Document Type: Article

References (47)

1. Jennette JC, Falk RJ. Small-vessel vasculitis. N Engl J Med 1997, 337:1512-1523. 10.1056/NEJM199711203372106, 9366584.
2. Short AK, Esnault VL, Lockwood CM. Anti-neutrophil cytoplasm antibodies and anti-glomerular basement membrane antibodies: two coexisting distinct autoreactivities detectable in patients with rapidly progressive glomerulonephritis. Am J Kidney Dis 1995, 26:439-445. 10.1016/0272-6386(95)90489-1, 7544065.
3. Hellmark T, Niles JL, Collins AB, McCluskey RT, Brunmark C. Comparison of anti-GBM antibodies in sera with or without ANCA. J Am Soc Nephrol 1997, 8:376-385.
4. Parekh RB, Dwek RA, Sutton BJ, et al. Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature 1985, 316:452-457. 10.1038/316452a0, 3927174.
5. Takahashi N, Ishii I, Ishihara H, et al. Comparative structural study of the N-linked oligosaccharides of human normal and pathological immunoglobulin G. Biochemistry 1987, 26:1137-1144. 10.1021/bi00378a023, 3567160.
6. Holland M, Takada K, Okumoto T, et al. Hypogalactosylation of serum IgG in patients with ANCA-associated systemic vasculitis. Clin Exp Immunol 2002, 129:183-190. 10.1046/j.1365-2249.2002.01864.x, 1906423, 12100039.
7. Espy C, Morelle W, Kavian N, et al. Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's). Arthritis Rheum 2011, 63:2105-2115. 10.1002/art.30362, 21437874.
8. Donadel G, Calabro A, Sigounas G, et al. Human polyreactive and monoreactive antibodies: effect of glycosylation on antigen binding. Glycobiology 1994, 4:491-496. 10.1093/glycob/4.4.491, 7827411.
9. Rudd PM, Leatherbarrow RJ, Rademacher TW, Dwek RA. Diversification of the IgG molecule by oligosaccharides. Mol Immunol 1991, 28:1369-1378. 10.1016/0161-5890(91)90039-M, 1749386.
10. Huang L, Biolsi S, Bales KR, Kuchibhotla U. Impact of variable domain glycosylation on antibody clearance: an LC/MS characterization. Anal Biochem 2006, 349:197-207. 10.1016/j.ab.2005.11.012, 16360109.
11. Malhotra R, Wormald MR, Rudd PM, et al. Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein. Nat Med 1995, 1:237-243. 10.1038/nm0395-237, 7585040.
12. van Timmeren MM, van der Veen BS, Stegeman CA, et al. IgG glycan hydrolysis attenuates ANCA-mediated glomerulonephritis. J Am Soc Nephrol 2010, 21:1103-1114. 10.1681/ASN.2009090984, 3152232, 20448018.
13. Kusakabe K, Kanaya K, Sato S, Kato M, Mochizuki K, et al. Accumulation enhancement of human monoclonal antibody HB4C5 to lung tumor xenografts by N-deglycosylation. J Nucl Med 1994, 35:289-295.
14. Co MS, Scheinberg DA, Avdalovic NM, et al. Genetically engineered deglycosylation of the variable domain increases the affinity of an anti-CD33 monoclonal antibody. Mol Immunol 1993, 30:1361-1367. 10.1016/0161-5890(93)90097-U, 8232322.
15. Kato M, Mochizuki K, Hashizume S, et al. Activity enhancement of a lung cancer-associated human monoclonal antibody HB4C5 by N-deglycosylation. Hum Antibodies Hybridomas 1993, 4:9-14.
16. Matsuuchi L, Sharon J, Morrison SL. An analysis of heavy chain glycopeptides of hybridoma antibodies: correlation between antibody specificity and sialic acid content. J Immunol 1981, 127:2188-2190.
17. Tachibana H, Shirahata S, Murakami H. Generation of specificity-variant antibodies by alteration of carbohydrate in light chain of human monoclonal antibodies. Biochem Biophys Res Commun 1992, 189:625-632. 10.1016/0006-291X(92)92246-T, 1472033.
18. Coloma MJ, Trinh RK, Martinez AR, Morrison SL. Position effects of variable region carbohydrate on the affinity and in vivo behavior of an anti-(1- > 6) dextran antibody. J Immunol 1999, 162:2162-2170.
19. Shibuya N, Goldstein IJ, Broekaert WF, et al. The elderberry (Sambucus nigra L.) bark lectin recognizes the Neu5Ac(alpha 2-6)Gal/GalNAc sequence. J Biol Chem 1987, 262:1596-1601.
20. Stadlmann J, Weber A, Pabst M, et al. A close look at human IgG sialylation and subclass distribution after lectin fractionation. Proteomics 2009, 9:4143-4153. 10.1002/pmic.200800931, 19688751.
21. Dalziel M, McFarlane I, Axford JS. Lectin analysis of human immunoglobulin G N-glycan sialylation. Glycoconj J 1999, 16:801-807. 10.1023/A:1007183915921, 11133020.
22. Rademacher TW. Network theory of glycosylation-etiologic and pathogenic implications of changes in IgG glycoform levels in autoimmunity. Semin Cell Biol 1991, 2:327-337.
23. Holland M, Yagi H, Takahashi N, et al. Differential glycosylation of polyclonal IgG, IgG-Fc and IgG-Fab isolated from the sera of patients with ANCA-associated systemic vasculitis. Biochim Biophys Acta 2006, 1760:669-677. 10.1016/j.bbagen.2005.11.021, 16413679.
24. Guhr T, Bloem J, Derksen NI. Enrichment of sialylated IgG by lectin fractionation does not enhance the efficacy of immunoglobulin G in a murine model of immune thrombocytopenia. PLoS One 2011, 6:e21246. 10.1371/journal.pone.0021246, 3121734, 21731683.
25. Endo T, Wright A, Morrison SL, Kobata A. Glycosylation of the variable region of immunoglobulin G--site specific maturation of the sugar chains. Mol Immunol 1995, 32:931-940. 10.1016/0161-5890(95)00078-S, 7476998.
26. Kinoshita N, Ohno M, Nishiura T, et al. Glycosylation at the Fab portion of myeloma immunoglobulin G and increased fucosylated biantennary sugar chains: structural analysis by high-performance liquid chromatography and antibody-lectin enzyme immunoassay using Lens culinaris agglutinin. Cancer Res 1991, 51:5888-5892.
27. Jennette JC, Falk RJ, Andrassy K, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum 1994, 37:187-192. 10.1002/art.1780370206, 8129773.
28. Zhao MH, Lockwood CM. A comprehensive method to purify three major ANCA antigens: proteinase 3, myeloperoxidase and bactericidal/permeability-increasing protein from human neutrophil granule acid extract. J Immunol Methods 1996, 197:121-130. 10.1016/0022-1759(96)00123-8, 8890899.
29. Cui Z, Zhao MH, Xin G, Wang HY. Characteristics and Prognosis of Chinese Patients with Anti-Glomerular Basement Membrane Disease. Nephron Clin Pract 2005, 99:c49-c55. 10.1159/000083133, 15637429.
30. Franco Fraguas L, Carlsson J, Lönnberg M. Lectin affinity chromatography as a tool to differentiate endogenous and recombinant erythropoietins. J Chromatogr A 2008, 1212:82-88. 10.1016/j.chroma.2008.10.036, 18976769.
31. Mimura Y, Ashton PR, Takahashi N, Harvey DJ, Jefferis R. Contrasting glycosylation profiles between Fab and Fc of a human IgG protein studied by electrospray ionization mass spectrometry. J Immunol Methods 2007, 326:116-126. 10.1016/j.jim.2007.07.014, 17714731.
32. Xu PC, Chen M, Cui Z, Zhao MH. Influence of myeloperoxidase by anti-myeloperoxidase antibodies and its association with the disease activity in microscopic polyangiitis. Rheumatology (Oxford) 2010, 49:2068-2075.
33. Kettritz R, Schreiber A, Luft FC, Haller H. Role of mitogen-activated protein kinases in activation of human neutrophils by antineutrophil cytoplasmic antibodies. J Am Soc Nephrol 2001, 12:37-46.
34. Borza DB, Netzer KO, Leinonen A, et al. The goodpasture autoantigen. Identification of multiple cryptic epitopes on the NC1 domain of the alpha3(IV) collagen chain. J Biol Chem 2000, 275:6030-6037. 10.1074/jbc.275.8.6030, 10681598.
35. Yang R, Hellmark T, Zhao J, et al. Antigen and epitope specificity of anti-glomerular basement membrane antibodies in patients with goodpasture disease with or without anti-neutrophil cytoplasmic antibodies. J Am Soc Nephrol 2007, 18:1338-1343. 10.1681/ASN.2006111210, 17329569.
36. Luqmani RA, Bacon PA, Moots RJ, et al. Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis. QJM 1994, 87:671-678.
37. Zhang Z, Pan H, Chen X. Mass spectrometry for structural characterization of therapeutic antibodies. Mass Spectrom Rev 2009, 28:147-176. 10.1002/mas.20190, 18720354.
38. Zhu D, McCarthy H, Ottensmeier CH, et al. Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma. Blood 2002, 99:2562-2568. 10.1182/blood.V99.7.2562, 11895794.
39. Derry CJ, Dunn MJ, Rees AJ, Pusey CD. Restricted specificity of the autoantibody response in Goodpasture's syndrome demonstrated by two-dimensional western blotting. Clin Exp Immunol 1991, 86:457-463. 10.1111/j.1365-2249.1991.tb02953.x, 1554214, 1747953.
40. Malle E, Buch T, Grone HJ. Myeloperoxidase in kidney disease. Kidney Int 2003, 64:1956-1967. 10.1046/j.1523-1755.2003.00336.x, 14633118.
41. Franssen CF, Stegeman CA, Kallenberg CG, et al. Antiproteinase 3-and antimyeloperoxidase-associated vasculitis. Kidney Int 2000, 57:2195-2206. 10.1046/j.1523-1755.2000.00080.x, 10844589.
42. Gala FA, Morrison SL. V region carbohydrate and antibody expression. J Immunol 2004, 172:5489-5494.
43. Berek C. The development of B cells and the B-cell repertoire in the microenvironment of the germinal center. Immunol Rev 1992, 126:5-19. 10.1111/j.1600-065X.1992.tb00628.x, 1597320.
44. Tomlinson IM, Walter G, Jones PT, et al. The imprint of somatic hypermutation on the repertoire of human germline V genes. J Mol Biol 1996, 256:813-817. 10.1006/jmbi.1996.0127, 8601832.
45. Cox JP, Tomlinson IM, Winter G. A directory of human germ-line V kappa segments reveals a strong bias in their usage. Eur J Immunol 1994, 24:827-836. 10.1002/eji.1830240409, 8149953.
46. Walter G, Tomlinson IM, Dear PH, et al. Comparison of the human germline and rearranged VH repertoire reveals complementarity between germline variability and somatic mutation. Ann N Y Acad Sci 1995, 764:180-182.
47. Dunn-Walters D, Boursier L, Spencer J. Effect of somatic hypermutation on potential N-glycosylation sites in human immunoglobulin heavy chain variable regions. Mol Immunol 2000, 37:107-113. 10.1016/S0161-5890(00)00038-9, 10865109.