Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2772-2774

  Xu, Kai ^a   Xiao, Zhiyan ^a   Tang, Yan Bo ^a   Huang, Li ^b   Chen, Chin Ho ^b   Ohkoshi, Emika ^c   Lee, Kuo Hsiung ^c,d  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNC Hamner Institute for Drug Safety Sciences   (United States)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

20S Proteasome inhibitors; Antiproliferative agents; Naphthoquinone derivatives

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; PI 083; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG DESIGN; DRUG SYNTHESIS;

ANTHRACYCLINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHOQUINONES; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 84862815656     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.086     Document Type: Article

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